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WO2008105058A1 - スルホンアミド化合物 - Google Patents

スルホンアミド化合物 Download PDF

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Publication number
WO2008105058A1
WO2008105058A1 PCT/JP2007/053567 JP2007053567W WO2008105058A1 WO 2008105058 A1 WO2008105058 A1 WO 2008105058A1 JP 2007053567 W JP2007053567 W JP 2007053567W WO 2008105058 A1 WO2008105058 A1 WO 2008105058A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
alkyl
hydrogen
alkenyl
halogeno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/053567
Other languages
English (en)
French (fr)
Inventor
Rintaro Yamada
Minoru Seto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Pharma Corp
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Priority to US12/526,000 priority Critical patent/US8415372B2/en
Priority to PCT/JP2007/053567 priority patent/WO2008105058A1/ja
Publication of WO2008105058A1 publication Critical patent/WO2008105058A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　Rhoキナーゼを強力に阻害する式（１）［Ａは含窒素飽和環を示し；ｍは０～２の整数を示し；ｎは１～４の整数を示し；Ｇ1は水素原子、塩素原子、水酸基、アルコキシ基、又はアミノ基を示し；Ｇ2はハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基などを示し；Ｇ3は水素原子、ハロゲン原子、水酸基、シアノ基、カルボキシ基、アルキル基、アルケニル基などを示し；Ｇ4は水酸基、又は－Ｎ(Ｒ1)(Ｒ2)（Ｒ1及びＲ2は水素原子、アルキル基、アラルキル基、アルケニル基、アルキニル基、又は飽和ヘテロ環基を示す）を示し；Ｇ5はＡの環構成炭素原子における置換基であり、水素原子、フッ素原子、又はアルキル基を示す］で表される化合物又はその塩、あるいはプロドラッグであるそれらの誘導体。
PCT/JP2007/053567 2007-02-27 2007-02-27 スルホンアミド化合物 Ceased WO2008105058A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/526,000 US8415372B2 (en) 2007-02-27 2007-02-27 Sulfonamide compound
PCT/JP2007/053567 WO2008105058A1 (ja) 2007-02-27 2007-02-27 スルホンアミド化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/053567 WO2008105058A1 (ja) 2007-02-27 2007-02-27 スルホンアミド化合物

Publications (1)

Publication Number Publication Date
WO2008105058A1 true WO2008105058A1 (ja) 2008-09-04

Family

ID=39720904

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/053567 Ceased WO2008105058A1 (ja) 2007-02-27 2007-02-27 スルホンアミド化合物

Country Status (2)

Country Link
US (1) US8415372B2 (ja)
WO (1) WO2008105058A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8232292B2 (en) 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
WO2012105674A1 (ja) 2011-02-04 2012-08-09 興和株式会社 緑内障予防又は治療のための薬物療法
WO2014192915A1 (ja) * 2013-05-30 2014-12-04 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
WO2017122666A1 (ja) * 2016-01-12 2017-07-20 国立大学法人 千葉大学 抗Ｍｙｌ９抗体
EP3461484B1 (en) 2013-03-15 2020-11-18 Aerie Pharmaceuticals, Inc. Dimesylate salts of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl, their combinations with prostaglandins and the use thereof in the treatment of ocular disorders

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CA2929545C (en) 2009-05-01 2019-04-09 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
WO2014199131A1 (en) * 2013-06-13 2014-12-18 Cipla Limited Fixed Dose Pharmaceutical Composition
EP3138843B1 (en) * 2014-04-28 2019-11-27 Medshine Discovery Inc. Isoquinolinesulfonyl derivative as rho kinase inhibitor
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
KR20190135027A (ko) 2017-03-31 2019-12-05 에어리 파마슈티컬즈, 인코포레이티드 아릴 시클로프로필-아미노-이소퀴놀리닐 아미드 화합물
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
US7964613B2 (en) 2007-02-28 2011-06-21 Asahi Kasei Pharma Corporation Sulfonamide compound
US8664243B2 (en) 2007-07-02 2014-03-04 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
US8232292B2 (en) 2007-07-02 2012-07-31 Asahi Kasei Pharma Corporation Sulfonamide compound and crystal thereof
KR20180023041A (ko) 2011-02-04 2018-03-06 코와 가부시키가이샤 녹내장 예방 또는 치료를 위한 약물 요법
JPWO2012105674A1 (ja) * 2011-02-04 2014-07-03 興和株式会社 緑内障予防又は治療のための薬物療法
WO2012105674A1 (ja) 2011-02-04 2012-08-09 興和株式会社 緑内障予防又は治療のための薬物療法
EP3461484B1 (en) 2013-03-15 2020-11-18 Aerie Pharmaceuticals, Inc. Dimesylate salts of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl, their combinations with prostaglandins and the use thereof in the treatment of ocular disorders
WO2014192915A1 (ja) * 2013-05-30 2014-12-04 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
JPWO2014192915A1 (ja) * 2013-05-30 2017-02-23 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
WO2017122666A1 (ja) * 2016-01-12 2017-07-20 国立大学法人 千葉大学 抗Ｍｙｌ９抗体
CN108431037A (zh) * 2016-01-12 2018-08-21 国立大学法人千叶大学 抗myl9抗体
JPWO2017122666A1 (ja) * 2016-01-12 2018-11-01 国立大学法人千葉大学 抗Ｍｙｌ９抗体
US10513561B2 (en) 2016-01-12 2019-12-24 National University Corporation Chiba University Anti-MYL9 antibody
CN108431037B (zh) * 2016-01-12 2021-12-17 国立大学法人千叶大学 抗myl9抗体

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