[go: up one dir, main page]

WO2008078725A1 - チアゼピン誘導体 - Google Patents

チアゼピン誘導体 Download PDF

Info

Publication number
WO2008078725A1
WO2008078725A1 PCT/JP2007/074780 JP2007074780W WO2008078725A1 WO 2008078725 A1 WO2008078725 A1 WO 2008078725A1 JP 2007074780 W JP2007074780 W JP 2007074780W WO 2008078725 A1 WO2008078725 A1 WO 2008078725A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
substituent group
independently selected
substituents independently
halogeno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/074780
Other languages
English (en)
French (fr)
Inventor
Toru Hasegawa
Tsuyoshi Shinozuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Priority to EP07860009A priority Critical patent/EP2119719A1/en
Priority to JP2008551103A priority patent/JPWO2008078725A1/ja
Publication of WO2008078725A1 publication Critical patent/WO2008078725A1/ja
Priority to US12/493,056 priority patent/US20100004221A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

　本発明は、優れた１１β－ヒドロキシステロイドデヒドロゲナーゼタイプ１阻害作用を有する一般式（Ｉ）で表されるチアゼピン誘導体又はその薬理上許容される塩に関する。［式中、Ｒ１は、水素原子、Ｃ１－Ｃ６アルキル基等；Ｒ２は、Ｃ１－Ｃ６アルキル基、Ｃ１－Ｃ６ハロゲン化アルキル基、Ｃ１－Ｃ６ヒドロキシアルキル基等；Ｒ３は、水素原子又はＣ１－Ｃ６アルキル基；Ｒ４は、置換基群ａから選択される基で独立に１乃至５個置換されていてもよいＣ６－Ｃ１０アリール基又は置換基群ａから選択される基で独立に１乃至３個置換されていてもよい複素環基；置換基群ａは、ハロゲン原子、Ｃ１－Ｃ６アルキル基、置換基群ｂから選択される基で独立に１乃至５個置換されていてもよいＣ６－Ｃ１０アリール基等；置換基群ｂは、ハロゲン原子、Ｃ１－Ｃ６アルキル基、Ｃ１－Ｃ６ハロゲン化アルキル基等］
PCT/JP2007/074780 2006-12-26 2007-12-25 チアゼピン誘導体 Ceased WO2008078725A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07860009A EP2119719A1 (en) 2006-12-26 2007-12-25 Thiazepine derivative
JP2008551103A JPWO2008078725A1 (ja) 2006-12-26 2007-12-25 チアゼピン誘導体
US12/493,056 US20100004221A1 (en) 2006-12-26 2009-06-26 Thiazepine derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006348763 2006-12-26
JP2006-348763 2006-12-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/493,056 Continuation US20100004221A1 (en) 2006-12-26 2009-06-26 Thiazepine derivative

Publications (1)

Publication Number Publication Date
WO2008078725A1 true WO2008078725A1 (ja) 2008-07-03

Family

ID=39562514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/074780 Ceased WO2008078725A1 (ja) 2006-12-26 2007-12-25 チアゼピン誘導体

Country Status (5)

Country Link
US (1) US20100004221A1 (ja)
EP (1) EP2119719A1 (ja)
JP (1) JPWO2008078725A1 (ja)
TW (1) TW200835502A (ja)
WO (1) WO2008078725A1 (ja)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007756A1 (ja) 2009-07-13 2011-01-20 武田薬品工業株式会社 複素環化合物及びその用途
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012144478A1 (ja) 2011-04-19 2012-10-26 第一三共株式会社 テトラヒドロチアゼピン誘導体
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2746277A1 (en) 2012-12-19 2014-06-25 Basf Se Fungicidal imidazolyl and triazolyl compounds
US8822699B2 (en) 2010-09-02 2014-09-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796381A1 (fr) * 1999-07-12 2001-01-19 Hoechst Marion Roussel Inc Derives bicycliques de thioazepine ou de caprolactame, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
US6521666B1 (en) 1998-01-20 2003-02-18 Tanabe Seiyaku Co., Ltd. Inhibitors of α4 mediated cell adhesion
WO2003065983A2 (en) 2002-02-01 2003-08-14 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
EP1445253A1 (en) 2001-11-16 2004-08-11 Yamanouchi Pharmaceutical Co. Ltd. 4,4-difluoro-1, 2, 3, 4-tetrahydro-5h-1-benzazepine derivatives or salts thereof
WO2004089367A1 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Pharmaceutical use of substituted 1,2,4-triazoles
WO2004089380A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Pharmaceutical use of fused 1,2,4-triazoles
WO2005080397A2 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders
JP2006502162A (ja) * 2002-09-04 2006-01-19 ブリストル−マイヤーズ　スクイブ　カンパニー 成長ホルモン分泌促進剤として有用なヘテロ環状芳香族化合物
WO2006030805A1 (ja) * 2004-09-16 2006-03-23 Astellas Pharma Inc. トリアゾール誘導体またはその塩
JP2006522750A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501405B2 (en) * 2003-04-11 2009-03-10 High Point Pharmaceuticals, Llc Combination therapy using an 11β-hydroxysteroid dehydrogenase type 1 inhibitor and an antihypertensive agent for the treatment of metabolic syndrome and related diseases and disorders

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521666B1 (en) 1998-01-20 2003-02-18 Tanabe Seiyaku Co., Ltd. Inhibitors of α4 mediated cell adhesion
FR2796381A1 (fr) * 1999-07-12 2001-01-19 Hoechst Marion Roussel Inc Derives bicycliques de thioazepine ou de caprolactame, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
EP1445253A1 (en) 2001-11-16 2004-08-11 Yamanouchi Pharmaceutical Co. Ltd. 4,4-difluoro-1, 2, 3, 4-tetrahydro-5h-1-benzazepine derivatives or salts thereof
WO2003065983A2 (en) 2002-02-01 2003-08-14 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
JP2006502162A (ja) * 2002-09-04 2006-01-19 ブリストル−マイヤーズ　スクイブ　カンパニー 成長ホルモン分泌促進剤として有用なヘテロ環状芳香族化合物
WO2004089367A1 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Pharmaceutical use of substituted 1,2,4-triazoles
WO2004089380A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Pharmaceutical use of fused 1,2,4-triazoles
JP2006522747A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 縮合１，２，４−トリアゾールの薬学的使用
JP2006522750A (ja) * 2003-04-11 2006-10-05 ノボ　ノルディスク　アクティーゼルスカブ 代謝性症候群ならびに関連の疾患および障害を治療するために、１１β−ヒドロキシステロイドデヒドロゲナーゼ１型阻害剤および抗高血圧剤を使用する併用療法
WO2005080397A2 (en) * 2004-02-18 2005-09-01 Astrazeneca Ab Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders
WO2006030805A1 (ja) * 2004-09-16 2006-03-23 Astellas Pharma Inc. トリアゾール誘導体またはその塩

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
BIOORG. MED. CHEM. LETT., vol. 15, 2005, pages 1863 - 1865
ENDOCRINOLOGY, vol. 142, 2001, pages 1371
J. MED. CHEM., vol. 43, 2000, pages 4388 - 4397
J. ORG. CHEM., vol. 68, 2003, pages 2030 - 2033
JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, 2002, pages 3813
NATURE, vol. 414, 2001, pages 782
SCIENCE, vol. 294, 2001, pages 2166
T. W. GREENE ET AL.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
THE AMERICAN JOURNAL OF MEDICINE, vol. 108, 2000, pages 23
THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 89, 2004, pages 2601
THE JOURNAL OF CLINICAL INVESTIGATION, vol. 112, 2003, pages 83
THE LANCET, vol. 365, 2005, pages 1415
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, A WILEY-INTERSCIENCE PUBLICATION

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007756A1 (ja) 2009-07-13 2011-01-20 武田薬品工業株式会社 複素環化合物及びその用途
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011157827A1 (de) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
WO2011161030A1 (de) 2010-06-21 2011-12-29 Sanofi Heterocyclisch substituierte methoxyphenylderivate mit oxogruppe, verfahren zu ihrer herstellung und ihre verwendung als gpr40 rezeptor modulatoren
WO2012010413A1 (de) 2010-07-05 2012-01-26 Sanofi Aryloxy-alkylen-substituierte hydroxy-phenyl-hexinsäuren, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004269A1 (de) 2010-07-05 2012-01-12 Sanofi ( 2 -aryloxy -acetylamino) - phenyl - propionsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
WO2012004270A1 (de) 2010-07-05 2012-01-12 Sanofi Spirocyclisch substituierte 1,3-propandioxidderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US8822699B2 (en) 2010-09-02 2014-09-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8901309B2 (en) 2010-09-02 2014-12-02 Takeda Pharmaceutical Company Limited Fused triazoles for the treatment or prophylaxis of mild cognitive impairment
WO2012144478A1 (ja) 2011-04-19 2012-10-26 第一三共株式会社 テトラヒドロチアゼピン誘導体
US8927536B2 (en) 2011-04-19 2015-01-06 Daiichi Sankyo Company, Limited Tetrahydrothiazepine derivative
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2746277A1 (en) 2012-12-19 2014-06-25 Basf Se Fungicidal imidazolyl and triazolyl compounds

Also Published As

Publication number Publication date
EP2119719A1 (en) 2009-11-18
JPWO2008078725A1 (ja) 2010-04-30
US20100004221A1 (en) 2010-01-07
TW200835502A (en) 2008-09-01

Similar Documents

Publication Publication Date Title
WO2008078725A1 (ja) チアゼピン誘導体
TW200606137A (en) Urea derivatives
WO2008087933A1 (ja) ＩκＢキナーゼβ阻害活性を有する新規インドール誘導体
EP1700856A4 (en) thiazole
WO2008114817A1 (ja) 新規なアデニン化合物
WO2009069736A1 (ja) 含窒素化合物
WO2008108378A3 (en) Bicyclic oxomorpholine derivative
WO2004101528A3 (en) Isoquinoline derivatives and their use as gfat inhibitors
WO2008093674A1 (ja) キナーゼ阻害活性を有する新規チアジアゾール誘導体
EP1541559A4 (en) 5-SUBSTITUTED ISOQUINOLINE DERIVATIVE
WO2008120759A1 (ja) ウレア化合物およびその用途
WO2008123469A1 (ja) ６員環アミド化合物およびその用途
WO2005037781A3 (fr) Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
WO2008114819A1 (ja) 新規アデニン化合物
WO2008126901A1 (ja) 含窒素複素環化合物およびそれを含有する医薬組成物
WO2008111604A1 (ja) 新規なベンジル（ヘテロサイクリックメチル）アミン構造を有するピリミジン化合物及びこれを含有する医薬
TW200745034A (en) New compounds
TW200745032A (en) Novel heterobicyclic derivatives
NO20072753L (no) 3-Etylidenhydrazinosubstituerte heterocykliske forbindelser som trombopoietinreseptoraktivatorer
WO2008114812A1 (ja) Jak阻害剤
WO2009063990A1 (ja) ベンズアゼピノン化合物
WO2008105526A1 (ja) マクロ環状化合物
WO2008139845A1 (ja) 新規アミド誘導体
WO2009001730A1 (ja) βセクレターゼ阻害活性を有する新規化合物
EP2036905A4 (en) Pyridylisoxazole derivative

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07860009

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2008551103

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007860009

Country of ref document: EP