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WO2008100376A3 - Variants de troncature de sirt1 et procédés d'utilisation de ceux-ci - Google Patents

Variants de troncature de sirt1 et procédés d'utilisation de ceux-ci Download PDF

Info

Publication number
WO2008100376A3
WO2008100376A3 PCT/US2008/001032 US2008001032W WO2008100376A3 WO 2008100376 A3 WO2008100376 A3 WO 2008100376A3 US 2008001032 W US2008001032 W US 2008001032W WO 2008100376 A3 WO2008100376 A3 WO 2008100376A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
variants
disorders
sirtuin
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/001032
Other languages
English (en)
Other versions
WO2008100376A2 (fr
Inventor
Lei Jin
Yakov Korkhin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sirtris Pharmaceuticals Inc
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of WO2008100376A2 publication Critical patent/WO2008100376A2/fr
Publication of WO2008100376A3 publication Critical patent/WO2008100376A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de nouveaux variants de la sirtuine et des procédés d'utilisation de ceux-ci. Les variants de la sirtuine peuvent être utilisés pour faire augmenter la durée de vie d'une cellule, et traiter et/ou prévenir une vaste variété de maladies et de troubles, comprenant, par exemple, des maladies ou des troubles liés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, une maladie cardiovasculaire, des troubles de la coagulation sanguine, une inflammation, un cancer, et/ou des bouffées congestives ainsi que des maladies ou des troubles qui pourraient bénéficier d'une activité mitochondriale accrue. La présente invention propose également des compositions comprenant des variants de la sirtuine, facultativement en combinaison avec d'autres agents thérapeutiques.
PCT/US2008/001032 2007-02-15 2008-01-25 Variants de troncature de sirt1 et procédés d'utilisation de ceux-ci Ceased WO2008100376A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90159407P 2007-02-15 2007-02-15
US60/901,594 2007-02-15

Publications (2)

Publication Number Publication Date
WO2008100376A2 WO2008100376A2 (fr) 2008-08-21
WO2008100376A3 true WO2008100376A3 (fr) 2008-12-11

Family

ID=39690667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/001032 Ceased WO2008100376A2 (fr) 2007-02-15 2008-01-25 Variants de troncature de sirt1 et procédés d'utilisation de ceux-ci

Country Status (1)

Country Link
WO (1) WO2008100376A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2247299A4 (fr) * 2007-12-21 2012-06-06 Univ Rochester Cibles moléculaires pour le traitement d'une inflammation
EP2273992B1 (fr) 2008-05-01 2016-05-25 Glaxosmithkline LLC Quinoléines et analogues apparentés en tant que modulateurs de sirtuine
EA020578B1 (ru) 2008-07-03 2014-12-30 Сертрис Фармасьютикалз, Инк. Бензимидазолы и родственные аналоги в качестве модуляторов сиртуина
ES2517690T3 (es) 2008-09-29 2014-11-03 Glaxosmithkline Llc Quinazolinona, quinolona y análogos relacionados como moduladores de sirtuina
CN101619058A (zh) * 2009-01-08 2010-01-06 上海交通大学 一种苯并咪唑-4-酰胺型衍生物
GB0916889D0 (en) * 2009-09-28 2009-11-11 Univ York Splice variants
US9556201B2 (en) 2009-10-29 2017-01-31 Glaxosmithkline Llc Bicyclic pyridines and analogs as sirtuin modulators
JP2014524919A (ja) * 2011-07-13 2014-09-25 アイカーン スクール オブ メディシン アット マウント シナイ ＳＥＲＣＡ２ａのＳＵＭＯ化および心臓血管疾患
US9296754B2 (en) 2013-03-15 2016-03-29 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
WO2014151630A2 (fr) 2013-03-15 2014-09-25 Irm Llc Composés et compositions pour le traitement de maladies parasitaires
BR112016014004B1 (pt) 2013-12-19 2022-11-01 Novartis Ag Compostos para tratamento de doenças parasíticas, seus usos, e composições farmacêuticas
WO2023123225A1 (fr) * 2021-12-30 2023-07-06 南京紫珑生物科技有限公司 Application de la protéine sirt1-7 en immunothérapie

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064739A2 (fr) * 2003-01-16 2004-08-05 Elixir Pharmaceuticals, Inc. Essai de detection de substrat

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064739A2 (fr) * 2003-01-16 2004-08-05 Elixir Pharmaceuticals, Inc. Essai de detection de substrat

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 21 October 2004 (2004-10-21), "Human SIRT1, SEQ ID 1.", retrieved from EBI accession no. GSP:ADR16046 Database accession no. ADR16046 *
MILNE J C ET AL: "Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes", NATURE (LONDON), vol. 450, no. 7170, 29 November 2007 (2007-11-29), pages 712 - 716, XP002494515, ISSN: 0028-0836 *
SENAWONG T ET AL: "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 44, 31 October 2003 (2003-10-31), pages 43041 - 43050, XP002494514, ISSN: 0021-9258 *
TANNO M ET AL: "Nucleocytoplasmic shuttling of the NAD(+)-dependent histone deacetylase SIRT1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 9, 30 December 2006 (2006-12-30), pages 6823 - 6832, XP002494513, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2008100376A2 (fr) 2008-08-21

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