MX2011006475A - Ftalazinona y analogos relacionados como moduladores de sirtuina. - Google Patents
Ftalazinona y analogos relacionados como moduladores de sirtuina.Info
- Publication number
- MX2011006475A MX2011006475A MX2011006475A MX2011006475A MX2011006475A MX 2011006475 A MX2011006475 A MX 2011006475A MX 2011006475 A MX2011006475 A MX 2011006475A MX 2011006475 A MX2011006475 A MX 2011006475A MX 2011006475 A MX2011006475 A MX 2011006475A
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- sirtuin
- disorders
- phthalazinone
- related analogs
- Prior art date
Links
- 102000011990 Sirtuin Human genes 0.000 title 1
- 108050002485 Sirtuin Proteins 0.000 title 1
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical compound C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000011010 flushing procedure Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002438 mitochondrial effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000035882 stress Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
Abstract
Se proveen en la presente novedosos compuestos de modulación de sirtuina y métodos de uso de los mismos; se pueden usar los compuestos de modulación de sirtuina para aumentar la vida media de una célula y tratar y/o evitar una extensa variedad de enfermedades y trastornos que incluyen, por ejemplo, enfermedades o trastornos relacionados con el envejecimiento o estrés, diabetes, obesidad, enfermedades neurodegenerativas, enfermedad cardiovascular, trastornos de coagulación sanguínea, inflamación, cáncer y/o sofocación así como enfermedades o trastornos que se beneficiarían de la actividad mitocóndrica incrementada; se proveen también composiciones que comprenden un compuesto de modulación de sirtuina en combinación con otro agente terapéutico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20196608P | 2008-12-16 | 2008-12-16 | |
| PCT/US2009/068255 WO2010077947A1 (en) | 2008-12-16 | 2009-12-16 | Phthalazinone and related analogs as sirtuin modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011006475A true MX2011006475A (es) | 2011-09-15 |
Family
ID=42310145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011006475A MX2011006475A (es) | 2008-12-16 | 2009-12-16 | Ftalazinona y analogos relacionados como moduladores de sirtuina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20130190309A1 (es) |
| EP (1) | EP2373646A4 (es) |
| JP (1) | JP2012512254A (es) |
| KR (1) | KR20110102468A (es) |
| CN (1) | CN102317284A (es) |
| AU (1) | AU2009333251A1 (es) |
| BR (1) | BRPI0922597A8 (es) |
| CA (1) | CA2747158A1 (es) |
| MX (1) | MX2011006475A (es) |
| SG (1) | SG172154A1 (es) |
| WO (1) | WO2010077947A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685970B2 (en) | 2008-05-01 | 2014-04-01 | GlaxoSmithKline, LLC | Quinolines and related analogs as sirtuin modulators |
| EP2315763B1 (en) | 2008-07-03 | 2016-06-01 | Glaxosmithkline LLC | Benzimidazoles and related analogs as sirtuin modulators |
| RU2527269C2 (ru) | 2008-09-29 | 2014-08-27 | Cертрис Фармасьютикалз, Инк. | Аналоги хроменона в качестве модуляторов сиртуина |
| MX2012004995A (es) | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| CN102898378A (zh) * | 2012-11-16 | 2013-01-30 | 江苏先声药业有限公司 | 一类酞嗪酮衍生物及其应用 |
| US10172915B2 (en) | 2013-10-20 | 2019-01-08 | Duke University | Methods and compositions for activation of sirtuins with Annexin A1 peptides |
| CN104151311B (zh) * | 2014-01-13 | 2017-01-04 | 华中师范大学 | 一类稠环化合物或其药学上可接受的盐及其制备方法和应用 |
| WO2017003723A1 (en) | 2015-07-01 | 2017-01-05 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| CN109415345B (zh) * | 2016-06-29 | 2022-01-11 | 豪夫迈·罗氏有限公司 | 基于哒嗪酮的广谱抗流感抑制剂 |
| EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
| CN109134429B (zh) * | 2017-08-10 | 2021-06-01 | 中国科学院上海药物研究所 | 酞嗪酮类化合物、其制备方法、药物组合物及用途 |
| EP3978480A4 (en) * | 2019-05-29 | 2023-10-25 | ST Pharm Co., Ltd. | PHTHALAZINONE COMPOUNDS AND USE THEREOF |
| WO2021026672A1 (en) | 2019-08-09 | 2021-02-18 | Novartis Ag | Heterocyclic wdr5 inhibitors as anti-cancer compounds |
| WO2021257857A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Naphthyridinone compounds as jak2 v617f inhibitors |
| US11753413B2 (en) | 2020-06-19 | 2023-09-12 | Incyte Corporation | Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors |
| WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
| CA3188639A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
| US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
| EP4298099A1 (en) | 2021-02-25 | 2024-01-03 | Incyte Corporation | Spirocyclic lactams as jak2 v617f inhibitors |
| JP2025509672A (ja) | 2022-03-17 | 2025-04-11 | インサイト・コーポレイション | Ｊａｋ２ ｖ６１７ｆ阻害剤としての三環式尿素化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7390820B2 (en) * | 2003-08-25 | 2008-06-24 | Amgen Inc. | Substituted quinolinone derivatives and methods of use |
| WO2007109154A2 (en) * | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| US20080021063A1 (en) * | 2006-07-18 | 2008-01-24 | Kazantsev Aleksey G | Compositions and methods for modulating sirtuin activity |
| KR101763674B1 (ko) * | 2007-01-22 | 2017-08-01 | 지티엑스, 인코포레이티드 | 핵 수용체에 결합하는 물질 |
-
2009
- 2009-12-16 WO PCT/US2009/068255 patent/WO2010077947A1/en not_active Ceased
- 2009-12-16 SG SG2011043536A patent/SG172154A1/en unknown
- 2009-12-16 CA CA2747158A patent/CA2747158A1/en not_active Abandoned
- 2009-12-16 JP JP2011542402A patent/JP2012512254A/ja not_active Withdrawn
- 2009-12-16 MX MX2011006475A patent/MX2011006475A/es not_active Application Discontinuation
- 2009-12-16 US US13/139,965 patent/US20130190309A1/en not_active Abandoned
- 2009-12-16 AU AU2009333251A patent/AU2009333251A1/en not_active Abandoned
- 2009-12-16 CN CN2009801568902A patent/CN102317284A/zh active Pending
- 2009-12-16 BR BRPI0922597A patent/BRPI0922597A8/pt not_active IP Right Cessation
- 2009-12-16 EP EP09836888A patent/EP2373646A4/en not_active Withdrawn
- 2009-12-16 KR KR1020117016541A patent/KR20110102468A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20130190309A1 (en) | 2013-07-25 |
| AU2009333251A1 (en) | 2011-07-07 |
| SG172154A1 (en) | 2011-07-28 |
| EP2373646A4 (en) | 2012-07-18 |
| CN102317284A (zh) | 2012-01-11 |
| CA2747158A1 (en) | 2010-07-08 |
| JP2012512254A (ja) | 2012-05-31 |
| BRPI0922597A2 (pt) | 2018-06-05 |
| KR20110102468A (ko) | 2011-09-16 |
| BRPI0922597A8 (pt) | 2018-09-25 |
| EP2373646A1 (en) | 2011-10-12 |
| WO2010077947A1 (en) | 2010-07-08 |
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