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MX2011006084A - Isoindolinona y analogos relacionados como moduladores de sirtuina. - Google Patents

Isoindolinona y analogos relacionados como moduladores de sirtuina.

Info

Publication number
MX2011006084A
MX2011006084A MX2011006084A MX2011006084A MX2011006084A MX 2011006084 A MX2011006084 A MX 2011006084A MX 2011006084 A MX2011006084 A MX 2011006084A MX 2011006084 A MX2011006084 A MX 2011006084A MX 2011006084 A MX2011006084 A MX 2011006084A
Authority
MX
Mexico
Prior art keywords
diseases
sirtuin
disorders
isoindolinone
related analogs
Prior art date
Application number
MX2011006084A
Other languages
English (en)
Inventor
Pui Yee Ng
Chi B Vu
Lauren Mcpherson
Charles Blum
Original Assignee
Sirtris Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc filed Critical Sirtris Pharmaceuticals Inc
Publication of MX2011006084A publication Critical patent/MX2011006084A/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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Abstract

En la presente se proporcionan novedosos compuestos moduladores de sirtuina y métodos para el uso de los mismos; los compuestos moduladores de sirtuina se pueden utilizar para aumentar la vida de una célula, y en el tratamiento y/o prevención de una amplia variedad de enfermedades y trastornos que incluyen, por ejemplo, enfermedades o trastornos relacionados con el envejecimiento o el estrés, diabetes, obesidad, enfermedades neurodegenerativas, enfermedad cardiovascular, trastornos en la coagulación de la sangre, inflamación, cáncer y/o enrojecimiento, así como enfermedades o trastornos que se beneficiarían de una incrementada actividad mitocondrial; también se proporcionan composiciones que comprenden un compuesto modulador de sirtuina en combinación con otro agente terapéutico.
MX2011006084A 2008-12-08 2009-12-08 Isoindolinona y analogos relacionados como moduladores de sirtuina. MX2011006084A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20126308P 2008-12-08 2008-12-08
PCT/US2009/067206 WO2010077686A1 (en) 2008-12-08 2009-12-08 Isoindolinone and related analogs as sirtuin modulators

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Publication Number Publication Date
MX2011006084A true MX2011006084A (es) 2011-09-06

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MX2011006084A MX2011006084A (es) 2008-12-08 2009-12-08 Isoindolinona y analogos relacionados como moduladores de sirtuina.

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US (1) US20110319411A1 (es)
EP (1) EP2373645A4 (es)
KR (1) KR20110098789A (es)
CN (1) CN102307871A (es)
AU (1) AU2009333543A1 (es)
BR (1) BRPI0922180A2 (es)
CA (1) CA2746221A1 (es)
MX (1) MX2011006084A (es)
SG (1) SG172001A1 (es)
WO (1) WO2010077686A1 (es)

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US8685970B2 (en) 2008-05-01 2014-04-01 GlaxoSmithKline, LLC Quinolines and related analogs as sirtuin modulators
EP2315763B1 (en) 2008-07-03 2016-06-01 Glaxosmithkline LLC Benzimidazoles and related analogs as sirtuin modulators
RU2527269C2 (ru) 2008-09-29 2014-08-27 Cертрис Фармасьютикалз, Инк. Аналоги хроменона в качестве модуляторов сиртуина
LT2464645T (lt) 2009-07-27 2017-10-25 Gilead Sciences, Inc. Kondensuoti heterocikliniai junginiai, kaip jonų kanalų moduliatoriai
MX2012004995A (es) 2009-10-29 2012-10-03 Sirtris Pharmaceuticals Inc Piridinas biciclicas y analogos como moduladores de sirtuina.
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