[go: up one dir, main page]

WO2006031358A3 - Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses - Google Patents

Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses Download PDF

Info

Publication number
WO2006031358A3
WO2006031358A3 PCT/US2005/029097 US2005029097W WO2006031358A3 WO 2006031358 A3 WO2006031358 A3 WO 2006031358A3 US 2005029097 W US2005029097 W US 2005029097W WO 2006031358 A3 WO2006031358 A3 WO 2006031358A3
Authority
WO
WIPO (PCT)
Prior art keywords
lens
methods
compound
dendritic
isocysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/029097
Other languages
French (fr)
Other versions
WO2006031358A2 (en
Inventor
Mark W Grinstaff
Michael A Carnahan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperbranch Medical Technology Inc
Original Assignee
Hyperbranch Medical Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology Inc filed Critical Hyperbranch Medical Technology Inc
Publication of WO2006031358A2 publication Critical patent/WO2006031358A2/en
Publication of WO2006031358A3 publication Critical patent/WO2006031358A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J201/00—Adhesives based on unspecified macromolecular compounds
    • C09J201/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The present invention provides compositions and methods for sealing a wound and preparing a lens. The methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine-, cysteine-, isocysteine-residue or other nucleophilic group attached to the periphery of the dendrimer: Addition of a compound containing two or more electrophilic groups such as aldehydes, activated esters, or acrylates to the lysine-, cysteine-, or isocysteine-capped dendrimers produces a polymeric compound that can form a seal or a lens. Another aspect of the invention relates to a method of treating disease using the pharmaceutical compositions of the invention. Other aspects of the invention relate to kits for sealing a wound or preparing a lens, delivery devices, and methods for controlling the polymerization of a hydrogel system.
PCT/US2005/029097 2004-08-13 2005-08-15 Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses Ceased WO2006031358A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60169104P 2004-08-13 2004-08-13
US60/601691 2004-08-13

Publications (2)

Publication Number Publication Date
WO2006031358A2 WO2006031358A2 (en) 2006-03-23
WO2006031358A3 true WO2006031358A3 (en) 2006-11-16

Family

ID=36060486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029097 Ceased WO2006031358A2 (en) 2004-08-13 2005-08-15 Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses

Country Status (1)

Country Link
WO (1) WO2006031358A2 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512729B2 (en) 1996-08-27 2013-08-20 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8951989B2 (en) 2009-04-09 2015-02-10 Actamax Surgical Materials, Llc Hydrogel tissue adhesive having reduced degradation time
US8962025B2 (en) 2006-08-02 2015-02-24 Baxter International Inc. Rapidly acting dry sealant and methods for use and manufacture
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
EP1796746B1 (en) 2004-10-07 2011-05-04 E.I. Du Pont De Nemours And Company Polysaccharide-based polymer tissue adhesive for medical use
CA2627459C (en) 2005-10-25 2011-08-09 Evonik Degussa Gmbh Preparations containing hyperbranched polymers
DE102005051334A1 (en) * 2005-10-25 2007-06-21 Degussa Gmbh Preparation, useful e.g. as a hardening agent and catalyst, and in cosmetics and medicines, comprises a low-molecular substance and a hyperbranched polymer having a hydrophilic core containing polyester unit and hydrophobic terminal group
CA2635374C (en) 2006-01-11 2015-12-08 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
EP2023941B1 (en) 2006-04-24 2016-12-21 Incept, LLC Protein crosslinkers, crosslinking methods and applications thereof
JP5539725B2 (en) 2006-11-27 2014-07-02 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー Branched end reactants and polymer hydrogel tissue adhesives produced therefrom
CA2673166C (en) 2007-01-25 2015-09-22 Hyperbranch Medical Technology, Inc. Applicators for multiple component formulations and the like, and methods of use thereof
US8426492B2 (en) 2007-11-14 2013-04-23 Actamax Surgical Materials, Llc Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US7862538B2 (en) 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
WO2010059279A2 (en) 2008-11-19 2010-05-27 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
WO2011002956A1 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Aldehyde-functionalized polysaccharides
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
BR112012014773A2 (en) 2009-12-16 2015-11-03 Baxter Healthcare Sa hemostatic composite sponge, method for making a hemostatic composite sponge, and use of said sponge
SA111320355B1 (en) 2010-04-07 2015-01-08 Baxter Heathcare S A Hemostatic sponge
US8211450B2 (en) 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
CN103037847B (en) 2010-06-01 2016-01-20 巴克斯特国际公司 For the preparation of the method for dry, stable hemostatic composition
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP4249059B1 (en) 2011-06-28 2025-07-30 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
EP2739252A4 (en) 2011-08-05 2015-08-12 Forsight Vision4 Inc Small molecule delivery with implantable therapeutic device
CA2848385C (en) 2011-09-16 2021-10-26 Forsight Vision4, Inc. Methods and apparatus to exchange a fluid of an implantable device
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
AU2012318257B2 (en) 2011-10-11 2015-10-01 Baxter Healthcare S.A. Hemostatic compositions
HK1201212A1 (en) 2011-10-11 2015-08-28 Baxter International Inc Hemostatic compositions
TWI548417B (en) 2011-10-27 2016-09-11 巴克斯特國際公司 Hemostatic composition
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
WO2013131520A2 (en) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Pressurized container containing haemostatic paste
DE102012006946A1 (en) * 2012-04-10 2013-10-10 Stratley Ag Process for the preparation of caprolactam
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
JP6390873B2 (en) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス Dry composition expanded under reduced pressure and syringe for holding the same
EP3027659B1 (en) 2013-07-29 2020-12-09 Actamax Surgical Materials LLC Low swell tissue adhesive and sealant formulations
BR112016013322B1 (en) 2013-12-11 2020-07-21 Ferrosan Medical Devices A/S methods for preparing a dry composition and for reconstituting a dry composition, dry composition, use of a dry composition, and, kit
JP6581194B2 (en) 2014-07-15 2019-09-25 フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． Ocular implant delivery device and method
CA2960309A1 (en) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
EP3217924B1 (en) 2014-11-10 2025-07-16 ForSight Vision4, Inc. Expandable drug delivery devices
KR20170117384A (en) 2014-12-10 2017-10-23 인셉트, 엘엘씨 Hydrogel drug delivery implants
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US11369591B2 (en) 2015-05-12 2022-06-28 Incept, Llc Drug delivery from hydrogels
RU2717356C2 (en) 2015-07-03 2020-03-23 Ферросан Медикал Дивайсиз А/С Syringe for holding vacuum in storage state
WO2017087902A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
JP2018536484A (en) 2015-11-25 2018-12-13 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ Shape-changing drug delivery device and method
MX2018012021A (en) 2016-04-05 2019-01-24 Forsight Vision4 Inc Implantable ocular drug delivery devices.
EP3293188B1 (en) * 2016-09-13 2019-04-10 Henkel AG & Co. KGaA Silanes and curable compositions comprising said silanes
CA3038075A1 (en) 2016-09-23 2018-03-29 Incept, Llc Intracameral drug delivery depots
AU2018372806B2 (en) 2017-11-21 2024-05-30 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
JP7395113B2 (en) 2018-05-09 2023-12-11 フェロサン メディカル デバイシーズ エイ／エス Method of preparing a hemostatic composition
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
CN115414360A (en) * 2022-08-30 2022-12-02 上海交通大学医学院附属仁济医院 Application of all-trans retinoic acid combined with antibiotics in the treatment of periprosthetic infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6224898B1 (en) * 2000-03-23 2001-05-01 The United States Of America As Represented By The Secretary Of The Army Antimicrobial dendrimer nanocomposites and a method of treating wounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6224898B1 (en) * 2000-03-23 2001-05-01 The United States Of America As Represented By The Secretary Of The Army Antimicrobial dendrimer nanocomposites and a method of treating wounds

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512729B2 (en) 1996-08-27 2013-08-20 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8962025B2 (en) 2006-08-02 2015-02-24 Baxter International Inc. Rapidly acting dry sealant and methods for use and manufacture
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8951989B2 (en) 2009-04-09 2015-02-10 Actamax Surgical Materials, Llc Hydrogel tissue adhesive having reduced degradation time
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US9308283B2 (en) 2009-12-15 2016-04-12 Incept, Llc Implants and biodegradable fiducial markers
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof

Also Published As

Publication number Publication date
WO2006031358A2 (en) 2006-03-23

Similar Documents

Publication Publication Date Title
WO2006031358A3 (en) Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
WO2007082061A3 (en) Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
JP2008508959A5 (en)
JP2019504140A5 (en)
ATE493136T1 (en) NEW ONE-STEP PROCESS FOR PRODUCING CROSS-LINKED POLY(ALLYLAMIN) POLYMERS
WO2005041900A3 (en) Polyamine polymers
WO2007048105A3 (en) Curable bone substitute
WO2009091728A3 (en) Polymerizable contact lens formulations and contact lenses obtained therefrom
RU2013114406A (en) DRUG-RESISTANT DRUG FORM THAT CONTAINS AN Anionic POLYMER
BRPI0509366B8 (en) pharmaceutical composition, pharmaceutical kit, and, use of a pharmaceutical composition
JP2019527262A5 (en)
ATE491729T1 (en) METHOD FOR PRODUCING WATER-ABSORBING POLYMER PARTICLES BY POLYMERIZING DROPS OF A MONOMER SOLUTION
WO2009051373A3 (en) Methacrylic copolymer, method for preparing the same and methacrylic resin composition using thereof
MY152868A (en) Method for producing water-absorbent polymer particles with a higher permeability by polymerising droplets of a monomer solution
RU2012105121A (en) BINDER FOR CARRYING OUT THE MARKING OF THE ROADWAY, SUITABLE FOR QUICK RESUME OF TRANSPORT MOTION
CA2539770A1 (en) Hydrogel
WO2008107034A3 (en) Polymeric thickener composition
JP2010535071A5 (en)
AU2012328386B2 (en) Highly swellable polymers
MY184243A (en) Absorbent resin composition and method for producing same
RU2016123083A (en) SYSTEM AND METHOD OF USE OF ORGANIC CARE
EP3960779A4 (en) Monomer composition for contact lenses, polymer for contact lenses and method for producing same, and contact lens and method for producing same
Saber-Samandari et al. Effect of iron substitution in hydroxyapatite matrix on swelling properties of composite bead
WO2009044885A1 (en) Photocurable resin composition and method for producing the same
CA2452833A1 (en) Compositions capable of forming hydrogels in the eye

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase