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WO2006031358A3 - Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques - Google Patents

Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques Download PDF

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Publication number
WO2006031358A3
WO2006031358A3 PCT/US2005/029097 US2005029097W WO2006031358A3 WO 2006031358 A3 WO2006031358 A3 WO 2006031358A3 US 2005029097 W US2005029097 W US 2005029097W WO 2006031358 A3 WO2006031358 A3 WO 2006031358A3
Authority
WO
WIPO (PCT)
Prior art keywords
lens
methods
compound
dendritic
isocysteine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/029097
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English (en)
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WO2006031358A2 (fr
Inventor
Mark W Grinstaff
Michael A Carnahan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hyperbranch Medical Technology Inc
Original Assignee
Hyperbranch Medical Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyperbranch Medical Technology Inc filed Critical Hyperbranch Medical Technology Inc
Publication of WO2006031358A2 publication Critical patent/WO2006031358A2/fr
Publication of WO2006031358A3 publication Critical patent/WO2006031358A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J201/00—Adhesives based on unspecified macromolecular compounds
    • C09J201/005—Dendritic macromolecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Eyeglasses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention a trait à des compositions et des procédés pour le scellement d'une plaie et la préparation d'une lentille. Les procédés de l'invention utilisent des macromolécules dendritiques formées par le traitement d'un composé dendritique avec de la lumière ou un composé de liaison. Dans certains modes de réalisation, les composés dendritiques ont un résidu de lysine, de cystéine, d'isocystéine ou autre groupe nucléophile lié à la périphérie du dendrimère. L'addition d'un composé contenant au moins deux groupes électrophiles tels que des aldéhydes, des esters activés, ou des acrylates aux dendrimères coiffés de lysine, de cystèine, ou d'isocystéine produit un composé polymérique qui peut former un scellement ou une lentille. Un autre mode de réalisation de l'invention a trait à un procédé de traitement de maladies mettant en oeuvre les compositions pharmaceutiques de l'invention. D'autres modes de réalisation de l'invention on trait à des trousses pour le scellement d'une plaie ou la préparation d'une lentille, de dispositifs d'administration, et à des procédés pour contrôler la polymérisation d'un système hydrogel.
PCT/US2005/029097 2004-08-13 2005-08-15 Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques Ceased WO2006031358A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60169104P 2004-08-13 2004-08-13
US60/601691 2004-08-13

Publications (2)

Publication Number Publication Date
WO2006031358A2 WO2006031358A2 (fr) 2006-03-23
WO2006031358A3 true WO2006031358A3 (fr) 2006-11-16

Family

ID=36060486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029097 Ceased WO2006031358A2 (fr) 2004-08-13 2005-08-15 Polymeres dendritiques, gels reticules, et leurs utilisations comme agents de scellement et lentilles ophtalmiques

Country Status (1)

Country Link
WO (1) WO2006031358A2 (fr)

Cited By (14)

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US8512729B2 (en) 1996-08-27 2013-08-20 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8951989B2 (en) 2009-04-09 2015-02-10 Actamax Surgical Materials, Llc Hydrogel tissue adhesive having reduced degradation time
US8962025B2 (en) 2006-08-02 2015-02-24 Baxter International Inc. Rapidly acting dry sealant and methods for use and manufacture
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing

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US7927626B2 (en) 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
EP1796746B1 (fr) 2004-10-07 2011-05-04 E.I. Du Pont De Nemours And Company Adhesif tissulaire polymere a base de polysaccharide destine a un usage medical
CA2627459C (fr) 2005-10-25 2011-08-09 Evonik Degussa Gmbh Preparation comprenant des polymeres hyperramifies
DE102005051334A1 (de) * 2005-10-25 2007-06-21 Degussa Gmbh Präparate umfassend hyperverzweigte Polymere
CA2635374C (fr) 2006-01-11 2015-12-08 Hyperbranch Medical Technology, Inc. Gels reticules comprenant des polyalkylene-imines et utilisation de ceux-ci en tant que dispositifs medicaux
EP2023941B1 (fr) 2006-04-24 2016-12-21 Incept, LLC Agents de réticulation de protéine, méthodes de réticulation et leurs applications
JP5539725B2 (ja) 2006-11-27 2014-07-02 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー 分岐末端反応物及びそれから製造されるポリマーヒドロゲル組織接着剤
CA2673166C (fr) 2007-01-25 2015-09-22 Hyperbranch Medical Technology, Inc. Applicateurs pour formulations a composants multiples et analogues et leurs procedes d'utilisation
US8426492B2 (en) 2007-11-14 2013-04-23 Actamax Surgical Materials, Llc Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US7862538B2 (en) 2008-02-04 2011-01-04 Incept Llc Surgical delivery system for medical sealant
US8551136B2 (en) 2008-07-17 2013-10-08 Actamax Surgical Materials, Llc High swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
WO2010059279A2 (fr) 2008-11-19 2010-05-27 E. I. Du Pont De Nemours And Company Adhésif de type hydrogel pour tissus formés à partir de polysaccharide aminé et de polyéther à plusieurs bras fonctionnalisé par aldéhyde
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
WO2011002956A1 (fr) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Polysaccharides fonctionnalisés par aldéhyde
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
BR112012014773A2 (pt) 2009-12-16 2015-11-03 Baxter Healthcare Sa esponja de compósito hemostática, método para fabricar uma esponja de compósito hemostática, e, uso da referida esponja
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
US8211450B2 (en) 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
CN103037847B (zh) 2010-06-01 2016-01-20 巴克斯特国际公司 用于制备干燥、稳定的止血组合物的方法
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
EP4249059B1 (fr) 2011-06-28 2025-07-30 ForSight Vision4, Inc. Un appareil pour collecter un échantillon de fluide à partir d'une chambre réservoir d'un dispositif thérapeutique pour l'oeil
EP2739252A4 (fr) 2011-08-05 2015-08-12 Forsight Vision4 Inc Administration de petites molécules à l'aide d'un dispositif thérapeutique implantable
CA2848385C (fr) 2011-09-16 2021-10-26 Forsight Vision4, Inc. Methodes et appareil d'echange d'un fluide d'un dispositif implantable
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
AU2012318257B2 (en) 2011-10-11 2015-10-01 Baxter Healthcare S.A. Hemostatic compositions
HK1201212A1 (en) 2011-10-11 2015-08-28 Baxter International Inc Hemostatic compositions
TWI548417B (zh) 2011-10-27 2016-09-11 巴克斯特國際公司 止血組成物
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
WO2013116061A1 (fr) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Procédés et instrument pour l'insertion et le retrait de dispositifs thérapeutiques
WO2013131520A2 (fr) 2012-03-06 2013-09-12 Ferrosan Medical Devices A/S Récipient mis sous pression contenant de la pâte hémostatique
DE102012006946A1 (de) * 2012-04-10 2013-10-10 Stratley Ag Verfahren zur Herstellung von Caprolactam
US9968603B2 (en) 2013-03-14 2018-05-15 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
JP6390873B2 (ja) 2013-06-21 2018-09-19 フェッローサン メディカル ディバイス エー／エス 減圧膨張させた乾燥組成物およびそれを保持するためのシリンジ
EP3027659B1 (fr) 2013-07-29 2020-12-09 Actamax Surgical Materials LLC Adhésif pour tissu à faible gonflement et formulations d'obturant
BR112016013322B1 (pt) 2013-12-11 2020-07-21 Ferrosan Medical Devices A/S métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit
JP6581194B2 (ja) 2014-07-15 2019-09-25 フォーサイト・ビジョン フォー・インコーポレーテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ４， Ｉｎｃ． 眼用インプラント送達装置および方法
CA2960309A1 (fr) 2014-10-13 2016-04-21 Ferrosan Medical Devices A/S Composition seche destinee a etre utilisee en hemostase et cicatrisation de plaie
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
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KR20170117384A (ko) 2014-12-10 2017-10-23 인셉트, 엘엘씨 히드로겔 약물 전달 임플란트
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
US11369591B2 (en) 2015-05-12 2022-06-28 Incept, Llc Drug delivery from hydrogels
RU2717356C2 (ru) 2015-07-03 2020-03-23 Ферросан Медикал Дивайсиз А/С Шприц для удерживания вакуума в состоянии хранения
WO2017087902A1 (fr) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Structures poreuses pour dispositifs d'administration de médicament à libération prolongée
JP2018536484A (ja) 2015-11-25 2018-12-13 インセプト・リミテッド・ライアビリティ・カンパニーＩｎｃｅｐｔ，Ｌｌｃ 形状変化する薬物送達デバイス及び方法
MX2018012021A (es) 2016-04-05 2019-01-24 Forsight Vision4 Inc Dispositivos de administracion de farmacos oculares implantables.
EP3293188B1 (fr) * 2016-09-13 2019-04-10 Henkel AG & Co. KGaA Silanes et compositions durcissables comprenant lesdits silanes
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JP7395113B2 (ja) 2018-05-09 2023-12-11 フェロサン メディカル デバイシーズ エイ／エス 止血組成物を調製する方法
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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512729B2 (en) 1996-08-27 2013-08-20 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8962025B2 (en) 2006-08-02 2015-02-24 Baxter International Inc. Rapidly acting dry sealant and methods for use and manufacture
US9370485B2 (en) 2007-07-09 2016-06-21 Incept, Llc Hydrogel polymeric compositions and methods
US9533069B2 (en) 2008-02-29 2017-01-03 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US8563027B2 (en) 2009-02-12 2013-10-22 Incept, Llc Drug delivery through hydrogel plugs
US8951989B2 (en) 2009-04-09 2015-02-10 Actamax Surgical Materials, Llc Hydrogel tissue adhesive having reduced degradation time
US8852646B2 (en) 2009-12-15 2014-10-07 Incept, Llc Particulate implants and biodegradable fiducial markers
US9308283B2 (en) 2009-12-15 2016-04-12 Incept, Llc Implants and biodegradable fiducial markers
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9265858B2 (en) 2012-06-12 2016-02-23 Ferrosan Medical Devices A/S Dry haemostatic composition
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof

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