WO2003016266A1 - Composes $g(b)-cetoamides et leur utilisation medicinale - Google Patents
Composes $g(b)-cetoamides et leur utilisation medicinale Download PDFInfo
- Publication number
- WO2003016266A1 WO2003016266A1 PCT/JP2002/008211 JP0208211W WO03016266A1 WO 2003016266 A1 WO2003016266 A1 WO 2003016266A1 JP 0208211 W JP0208211 W JP 0208211W WO 03016266 A1 WO03016266 A1 WO 03016266A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compounds
- hiv agents
- hiv
- inhibitory activity
- integrase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001247346 | 2001-08-16 | ||
| JP2001-247346 | 2001-08-16 | ||
| JP2001-372066 | 2001-12-05 | ||
| JP2001372066 | 2001-12-05 | ||
| JP2002-151232 | 2002-05-24 | ||
| JP2002151232 | 2002-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2003016266A1 true WO2003016266A1 (fr) | 2003-02-27 |
Family
ID=27347336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2002/008211 Ceased WO2003016266A1 (fr) | 2001-08-16 | 2002-08-12 | Composes $g(b)-cetoamides et leur utilisation medicinale |
Country Status (2)
| Country | Link |
|---|---|
| PE (1) | PE20030434A1 (ja) |
| WO (1) | WO2003016266A1 (ja) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006520759A (ja) * | 2003-03-21 | 2006-09-14 | ハー・ルンドベック・アクチエゼルスカベット | 置換されたｐ−ジアミノベンゼン誘導体 |
| US7109186B2 (en) | 2002-07-09 | 2006-09-19 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7211572B2 (en) | 2003-08-13 | 2007-05-01 | Japan Tobacco Inc. | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| US7820818B2 (en) | 2002-08-30 | 2010-10-26 | Novartis Ag | Heteroaryl nitrile derivatives |
| US8609717B2 (en) | 2010-08-18 | 2013-12-17 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators |
| US9533976B2 (en) | 2013-02-22 | 2017-01-03 | Samumed, Llc | γ-diketones as WNT/β-catenin signaling pathway activators |
| US9795550B2 (en) | 2014-08-20 | 2017-10-24 | Samumed, Llc | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
| EP2344456B1 (en) * | 2008-08-29 | 2018-07-25 | Japan Tobacco Inc. | Novel potassium channel blocker |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07267903A (ja) * | 1994-03-31 | 1995-10-17 | Nagase & Co Ltd | 抗ｈｉｖ活性を有するフッ素含有化合物 |
| WO1999062520A1 (en) * | 1998-06-03 | 1999-12-09 | Merck & Co., Inc. | Hiv integrase inhibitors |
| WO2001096283A2 (en) * | 2000-06-16 | 2001-12-20 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
-
2002
- 2002-08-12 WO PCT/JP2002/008211 patent/WO2003016266A1/ja not_active Ceased
- 2002-08-15 PE PE2002000740A patent/PE20030434A1/es not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07267903A (ja) * | 1994-03-31 | 1995-10-17 | Nagase & Co Ltd | 抗ｈｉｖ活性を有するフッ素含有化合物 |
| WO1999062520A1 (en) * | 1998-06-03 | 1999-12-09 | Merck & Co., Inc. | Hiv integrase inhibitors |
| WO2001096283A2 (en) * | 2000-06-16 | 2001-12-20 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7109186B2 (en) | 2002-07-09 | 2006-09-19 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7820818B2 (en) | 2002-08-30 | 2010-10-26 | Novartis Ag | Heteroaryl nitrile derivatives |
| JP2006520759A (ja) * | 2003-03-21 | 2006-09-14 | ハー・ルンドベック・アクチエゼルスカベット | 置換されたｐ−ジアミノベンゼン誘導体 |
| US7906537B2 (en) | 2003-03-21 | 2011-03-15 | H. Lundbeck A/S | Substituted p-diaminobenzene derivatives |
| US7211572B2 (en) | 2003-08-13 | 2007-05-01 | Japan Tobacco Inc. | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| EP2042502A1 (en) | 2003-08-13 | 2009-04-01 | Japan Tobacco Inc. | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| EP2344456B1 (en) * | 2008-08-29 | 2018-07-25 | Japan Tobacco Inc. | Novel potassium channel blocker |
| US8609717B2 (en) | 2010-08-18 | 2013-12-17 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators |
| US8921413B2 (en) | 2010-08-18 | 2014-12-30 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as WNT/ β-catenin signaling pathway activators |
| US9303010B2 (en) | 2010-08-18 | 2016-04-05 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activators |
| US9493437B2 (en) | 2010-08-18 | 2016-11-15 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as Wnt/ β-catenin signaling pathway activators |
| US8629176B1 (en) | 2010-08-18 | 2014-01-14 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as WNT/ β-catenin signaling pathway activators |
| US10314832B2 (en) | 2010-08-18 | 2019-06-11 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as Wnt/β-catenin signaling pathway activators |
| US9884053B2 (en) | 2010-08-18 | 2018-02-06 | Samumed, Llc | β- and γ-diketones and γ-hydroxyketones as WNT/β-catenin signaling pathway activators |
| US9533976B2 (en) | 2013-02-22 | 2017-01-03 | Samumed, Llc | γ-diketones as WNT/β-catenin signaling pathway activators |
| US9951053B2 (en) | 2013-02-22 | 2018-04-24 | Samumed, Llc | γ-diketones as Wnt/β-catenin signaling pathway activators |
| US10457672B2 (en) | 2013-02-22 | 2019-10-29 | Samumed, Llc | γ-diketones as Wnt/β-catenin signaling pathway activators |
| US11034682B2 (en) | 2013-02-22 | 2021-06-15 | Samumed, Llc | Gamma-diketones as wnt/β-catenin signaling pathway activators |
| US11673885B2 (en) | 2013-02-22 | 2023-06-13 | Biosplice Therapeutics, Inc. | γ-diketones as Wnt/β-catenin signaling pathway activators |
| US9795550B2 (en) | 2014-08-20 | 2017-10-24 | Samumed, Llc | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
| US10434052B2 (en) | 2014-08-20 | 2019-10-08 | Samumed, Llc | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
| US11077046B2 (en) | 2014-08-20 | 2021-08-03 | Biosplice Therapeutics, Inc. | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
| US11839679B2 (en) | 2014-08-20 | 2023-12-12 | Biosplice Therapeutics, Inc. | Gamma-diketones for treatment and prevention of aging skin and wrinkles |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20030434A1 (es) | 2003-07-03 |
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