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EA200601654A1 - Ингибиторы интегразы вич - Google Patents

Ингибиторы интегразы вич

Info

Publication number
EA200601654A1
EA200601654A1 EA200601654A EA200601654A EA200601654A1 EA 200601654 A1 EA200601654 A1 EA 200601654A1 EA 200601654 A EA200601654 A EA 200601654A EA 200601654 A EA200601654 A EA 200601654A EA 200601654 A1 EA200601654 A1 EA 200601654A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
hiv
integrase inhibitors
hiv integrase
prevent
Prior art date
Application number
EA200601654A
Other languages
English (en)
Inventor
Вей Хан
Мелисса Эгбертсон
Джон С. Уэй
Линхан Чжуан
Ровена Д. Рузек
Дебра С. Перлоу
Ванесса Э. Облигейдо
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA200601654A1 publication Critical patent/EA200601654A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Гидрокси(тетра- или гекса-)гидронафтиридиндионовые соединения формулы I являются ингибиторами интегразы ВИЧ и ингибиторами репликации ВИЧ, где значения Х, X, Rи Rопределены в описании. Соединения могут быть использованы для предупреждения и лечения заражения ВИЧ и для предупреждения, замедления наступления и лечения СПИДа. Соединения используются против заражения ВИЧ и СПИД как сами по себе, так и в виде фармацевтически приемлемых солей. Соединения и их соли могут быть использованы как ингредиенты в фармацевтических композициях, необязательно в комбинации с другими противовирусными агентами, иммуномодуляторами, антибиотиками или вакцинами.
EA200601654A 2004-03-09 2005-03-09 Ингибиторы интегразы вич EA200601654A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55162504P 2004-03-09 2004-03-09
US63313404P 2004-12-03 2004-12-03
PCT/US2005/007730 WO2005087767A1 (en) 2004-03-09 2005-03-09 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
EA200601654A1 true EA200601654A1 (ru) 2007-02-27

Family

ID=34962221

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200601654A EA200601654A1 (ru) 2004-03-09 2005-03-09 Ингибиторы интегразы вич

Country Status (15)

Country Link
US (1) US7598264B2 (ru)
EP (1) EP1725556A1 (ru)
JP (1) JP4625838B2 (ru)
KR (1) KR20070026414A (ru)
CN (1) CN1930160B (ru)
AU (1) AU2005222391B2 (ru)
CA (1) CA2558026C (ru)
CR (1) CR8569A (ru)
EA (1) EA200601654A1 (ru)
EC (1) ECSP066826A (ru)
IL (1) IL177858A0 (ru)
MA (1) MA28519B1 (ru)
NO (1) NO20064555L (ru)
NZ (1) NZ549449A (ru)
WO (2) WO2005087768A1 (ru)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
AU2005221864A1 (en) * 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
EP1725535A4 (en) 2004-03-09 2009-11-25 Merck & Co Inc HIV integrase
CA2557785A1 (en) * 2004-03-09 2005-10-06 Merck & Co. Inc. Hiv integrase inhibitors
EP2261218B1 (en) 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Imidazole compound for use as an intermediate in the production of cinnamide compounds
CA2580119A1 (en) 2004-10-26 2006-05-04 Eisai R & D Management Co., Ltd. Amorphous object of cinnamide compound
CA2634499A1 (en) * 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
JP4982482B2 (ja) * 2005-05-10 2012-07-25 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラ−ゼ阻害剤
JP4500854B2 (ja) * 2005-09-20 2010-07-14 Ｊｉｔｓｕｂｏ株式会社 分離用担体
ATE517899T1 (de) * 2005-10-04 2011-08-15 Angeletti P Ist Richerche Bio Hiv-integrasehemmer
JP2009513640A (ja) * 2005-10-27 2009-04-02 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼインヒビター
CA2628047A1 (en) * 2005-11-18 2007-05-24 Eisai R & D Management Co., Ltd. Process for production of cinnamide derivative
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
CA2645551C (en) 2006-03-16 2016-06-28 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
AU2007313293A1 (en) * 2006-10-18 2008-04-24 Merck & Co., Inc. HIV integrase inhibitors
US20080207900A1 (en) 2007-02-28 2008-08-28 Teiji Kimura Two cyclic oxomorphorin derivatives
WO2009009531A2 (en) 2007-07-09 2009-01-15 Concert Pharmaceuticals Inc. Pyrimidinecarboxamide derivatives for the treatment of hiv infections
AU2008292390B2 (en) 2007-08-31 2013-04-04 Eisai R & D Management Co., Ltd. Polycyclic compound
US7935815B2 (en) 2007-08-31 2011-05-03 Eisai R&D Management Co., Ltd. Imidazoyl pyridine compounds and salts thereof
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
WO2012009446A1 (en) 2010-07-16 2012-01-19 Concert Pharmaceuticals Inc. Novel pyrimidinecarboxamide derivatives
WO2012106472A1 (en) * 2011-02-02 2012-08-09 Fibrogen, Inc. Naphthyridine derivatives as inhibitors of hypoxia inducible factor (hif) hydroxylase
CN107898790B (zh) 2011-11-30 2024-06-21 埃默里大学 用于治疗或预防逆转录病毒和其它病毒感染的抗病毒jak抑制剂
US20150218164A1 (en) * 2012-07-25 2015-08-06 Merck Sharp & Dohme Corp. Substituted naphthyridinedione derivatives as hiv integrase inhibitors
HRP20180081T1 (hr) 2013-05-17 2018-02-23 Merck Sharp & Dohme Corp. Fuzionirani triciklični heterociklični spojevi kao inhibitori hiv integraze
ES2768658T3 (es) * 2013-09-27 2020-06-23 Merck Sharp & Dohme Derivados de quinolizina sustituidos útiles como inhibidores de integrasa del VIH
WO2016154527A1 (en) * 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Phosphate-substituted quinolizine derivatives useful as hiv integrase inhibitors
CA3075720A1 (en) * 2017-10-02 2019-04-11 Novartis Ag Method for preparing a pharmaceutical product
US20240300942A1 (en) * 2021-10-08 2024-09-12 Vrise Therapeutics Inc. Small molecules for treatement of cancer
MX2024007058A (es) * 2021-12-10 2024-06-24 Vrise Therapeutics Inc Derivados de 5,6,7,8-tetrahidro-2,6-naftiridina como terapeuticos contra el cancer.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380249B1 (en) * 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) * 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) * 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
JP2003503386A (ja) 1999-06-25 2003-01-28 メルク エンド カムパニー インコーポレーテッド １−（芳香族またはヘテロ芳香族置換）−３−（ヘテロ芳香族置換）−１，３−プロパンジオン類およびそれの使用
WO2002030426A1 (en) 2000-10-12 2002-04-18 Merck & Co., Inc. Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
DE60138635D1 (de) * 2000-10-12 2009-06-18 Merck & Co Inc Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
ES2274913T3 (es) 2000-10-12 2007-06-01 MERCK & CO., INC. Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de vih integrada.
WO2002036734A2 (en) 2000-10-12 2002-05-10 Merck & Co., Inc. Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors
WO2002070486A1 (en) * 2001-03-01 2002-09-12 Shionogi & Co., Ltd. Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
KR20100087209A (ko) * 2001-08-10 2010-08-03 시오노기세이야쿠가부시키가이샤 항바이러스제
JP4351053B2 (ja) * 2001-10-26 2009-10-28 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ジヒドロキシピリミジンカルボキサミド系ｈｉｖインテグラーゼ阻害薬
ATE318140T1 (de) * 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio N-substituierte hydroxypyrimidinoncarboxamid- hemmer der hiv-integrase
AU2003216049B2 (en) * 2002-01-17 2008-07-17 Merck Sharp & Dohme Corp. Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
AU2003218130A1 (en) * 2002-03-15 2003-09-29 Merck And Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
US7109186B2 (en) * 2002-07-09 2006-09-19 Bristol-Myers Squibb Company HIV integrase inhibitors
CA2495293A1 (en) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Azaisoquinoline derivatives as matrix metalloproteinase inhibitors
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
JP2006232849A (ja) * 2003-08-13 2006-09-07 Japan Tobacco Inc 含窒素縮合環化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用
AU2005221864A1 (en) * 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa HIV integrase inhibitors
EP1725535A4 (en) * 2004-03-09 2009-11-25 Merck & Co Inc HIV integrase
CA2557785A1 (en) * 2004-03-09 2005-10-06 Merck & Co. Inc. Hiv integrase inhibitors
JP4982482B2 (ja) 2005-05-10 2012-07-25 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラ−ゼ阻害剤

Also Published As

Publication number Publication date
AU2005222391A1 (en) 2005-09-22
NO20064555L (no) 2006-12-04
CN1930160B (zh) 2011-11-16
WO2005087768A1 (en) 2005-09-22
CR8569A (es) 2007-08-28
MA28519B1 (fr) 2007-04-03
AU2005222391B2 (en) 2010-11-11
US20070179196A1 (en) 2007-08-02
KR20070026414A (ko) 2007-03-08
EP1725556A1 (en) 2006-11-29
JP4625838B2 (ja) 2011-02-02
CN1930160A (zh) 2007-03-14
NZ549449A (en) 2009-05-31
IL177858A0 (en) 2006-12-31
WO2005087767A1 (en) 2005-09-22
ECSP066826A (es) 2006-11-24
JP2007528401A (ja) 2007-10-11
CA2558026C (en) 2010-12-14
CA2558026A1 (en) 2005-09-22
US7598264B2 (en) 2009-10-06

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