[go: up one dir, main page]

WO2002032331A8 - Microstructures permettant de traiter et de conditionner la peau - Google Patents

Microstructures permettant de traiter et de conditionner la peau

Info

Publication number
WO2002032331A8
WO2002032331A8 PCT/US2001/031977 US0131977W WO0232331A8 WO 2002032331 A8 WO2002032331 A8 WO 2002032331A8 US 0131977 W US0131977 W US 0131977W WO 0232331 A8 WO0232331 A8 WO 0232331A8
Authority
WO
WIPO (PCT)
Prior art keywords
skin
microelements
exfoliated
enhance
skin cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/031977
Other languages
English (en)
Other versions
WO2002032331A2 (fr
WO2002032331A3 (fr
Inventor
Faiz Feisal Sherman
Vladimir Gartstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Priority to CA002422907A priority Critical patent/CA2422907C/fr
Priority to DE60126637T priority patent/DE60126637T2/de
Priority to AU2002213167A priority patent/AU2002213167A1/en
Priority to EP01981530A priority patent/EP1326673B1/fr
Priority to JP2002535570A priority patent/JP4676128B2/ja
Publication of WO2002032331A2 publication Critical patent/WO2002032331A2/fr
Publication of WO2002032331A3 publication Critical patent/WO2002032331A3/fr
Anticipated expiration legal-status Critical
Publication of WO2002032331A8 publication Critical patent/WO2002032331A8/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D26/00—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers
    • A45D26/0004—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers by abrasion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/54—Chiropodists' instruments, e.g. pedicure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)

Abstract

L'invention concerne une méthode et un appareil améliorés se présentant sous forme d'un système qui permet d'améliorer l'apparence et la santé de la peau, la peau étant nettoyée (ou exfoliée) et conditionnée pour utiliser des microéléments fixés sur un élément de base ou un timbre portatif. On règle les dimensions des microéléments de façon à éliminer un certain nombre de couches de cellules de la peau, et à accumuler ces cellules avec d'autres substances étrangères dans des zones situées entre lesdits microéléments. On peut également appliquer un composé de conditionnement ou un agent thérapeutique actif pour exfolier la peau et l'améliorer. La quantité de cellules de la peau accumulées représente, en outre, une quantité maximum auto-définie qui ne peut être sensiblement dépassée sans se soucier du nombre de tentatives de réutilisation de l'appareil à microstructures par un utilisateur.
PCT/US2001/031977 2000-10-16 2001-10-15 Microstructures permettant de traiter et de conditionner la peau Ceased WO2002032331A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002422907A CA2422907C (fr) 2000-10-16 2001-10-15 Microstructures permettant de traiter et de conditionner la peau
DE60126637T DE60126637T2 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur behandlung und aufbereitung der haut
AU2002213167A AU2002213167A1 (en) 2000-10-16 2001-10-15 Microstructures for treating and conditioning skin
EP01981530A EP1326673B1 (fr) 2000-10-16 2001-10-15 Microstructures permettant de traiter et de conditionner la peau
JP2002535570A JP4676128B2 (ja) 2000-10-16 2001-10-15 皮膚処理及びコンディショニング用微細構造

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24073000P 2000-10-16 2000-10-16
US24078700P 2000-10-16 2000-10-16
US60/240,730 2000-10-16
US60/240,787 2000-10-16

Publications (3)

Publication Number Publication Date
WO2002032331A2 WO2002032331A2 (fr) 2002-04-25
WO2002032331A3 WO2002032331A3 (fr) 2002-09-06
WO2002032331A8 true WO2002032331A8 (fr) 2003-11-13

Family

ID=26933655

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/031977 Ceased WO2002032331A2 (fr) 2000-10-16 2001-10-15 Microstructures permettant de traiter et de conditionner la peau
PCT/US2001/031978 Ceased WO2002032480A2 (fr) 2000-10-16 2001-10-15 Microstructures permettant de distribuer des compositions de maniere cutanee a la peau

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/031978 Ceased WO2002032480A2 (fr) 2000-10-16 2001-10-15 Microstructures permettant de distribuer des compositions de maniere cutanee a la peau

Country Status (10)

Country Link
US (4) US7108681B2 (fr)
EP (2) EP1326673B1 (fr)
JP (2) JP2004516868A (fr)
CN (2) CN100427159C (fr)
AT (2) ATE304878T1 (fr)
AU (2) AU2002213167A1 (fr)
CA (2) CA2422909C (fr)
DE (2) DE60126637T2 (fr)
ES (2) ES2250493T3 (fr)
WO (2) WO2002032331A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7416541B2 (en) 1999-06-09 2008-08-26 Corium International, Inc. Intracutaneous microneedle array apparatus
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
AU8511601A (en) * 2000-08-21 2002-03-04 Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
ES2324461T3 (es) * 2000-10-13 2009-08-07 Alza Corporation Aparato y procedimiento para perforar la piel con microprotuberancias.
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
AU2002237703A1 (en) * 2000-11-09 2002-06-18 Biovalve Technologies, Inc. Microneedle adapter
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
EP1256316A1 (fr) 2001-05-07 2002-11-13 Move2Health B.V. Dispositif portable muni d'un capteur d'accélération et méthode d'engendrer des instructions ou des conseils
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
AU2002333636A1 (en) * 2001-09-14 2003-04-01 The Procter And Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024290A1 (fr) * 2001-09-14 2003-03-27 The Procter & Gamble Company Procede d'exfoliation de la peau a l'aide de microstructures etroitement serrees et appareil afferent
CA2464994A1 (fr) * 2001-10-29 2003-06-26 Becton, Dickinson And Company Procede et dispositif d'administration d'une substance
WO2003048031A2 (fr) * 2001-11-30 2003-06-12 Alza Corporation Procedes et appareils de formation de grilles de microprojections
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6916120B2 (en) * 2002-01-30 2005-07-12 Adc Telecommunications, Inc. Fiber optic connector and method
AU2003220143A1 (en) 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
DE10219523A1 (de) * 2002-05-02 2003-11-13 Wella Ag Verfahren zur technischen Produktion haar- oder hautkosmetischer Produkte unter Verwendung von Apparaturen mit Mikrostruktureinheiten
WO2004009172A1 (fr) * 2002-07-19 2004-01-29 3M Innovative Properties Company Dispositifs a microaiguilles et appareils d'application de microaiguilles
EP1531896B1 (fr) * 2002-08-29 2016-07-20 Becton Dickinson and Company Matrices de microprotuberances et procede permettant d'utiliser ces matrices pour l'administration de substances a un tissu
US7449307B2 (en) * 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
DE50209306D1 (de) 2002-12-31 2007-03-08 Abbott Lab Vascular Entpr Ltd Katheter mit einem flexibleren Bereich zwischen Schaft und Spitze sowie Verfahren zu seiner Herstellung
US7087063B2 (en) * 2003-02-19 2006-08-08 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Abrasion device and method
US7226457B2 (en) * 2003-02-19 2007-06-05 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Epidermal sampling apparatus and method
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20040227199A1 (en) * 2003-05-15 2004-11-18 Toshiba Kikai Kabushiki Kaisha Minute flow passage and micro-chemical chip including the same
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7477938B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US7507228B2 (en) 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US7486989B2 (en) 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7477940B2 (en) * 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US7477939B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
US7476222B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7477941B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
WO2005007020A2 (fr) 2003-07-03 2005-01-27 Corium International, Inc. Pansement, dispositif d'administration d'ingredient et dispositif de fixation intraveineux et procede associe
CN1842355A (zh) * 2003-08-26 2006-10-04 阿尔扎公司 用于皮内细胞植入的装置和方法
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
EP1713533A4 (fr) * 2003-11-21 2008-01-23 Univ California Procede et dispositif permettant de perforer une surface afin d'extraire, d'analyser et/ou d'administrer une substance, au moyen de micro-aiguilles
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
WO2005075016A1 (fr) * 2004-02-03 2005-08-18 Hisamitsu Pharmaceutical Co., Inc. Interface pour applicateur medical transdermique
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US7591618B2 (en) * 2004-02-25 2009-09-22 Agency For Science, Technology And Research Machining method for micro abraders and micro abraders produced thereby
US7611481B2 (en) * 2004-03-24 2009-11-03 Corium International, Inc. Transdermal delivery device
US20080082090A1 (en) * 2004-04-01 2008-04-03 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
GB2438372A (en) * 2006-05-25 2007-11-28 Ball Burnishing Mach Tools A procedure for cosmetic treatment of skin by sliding a tool over the skin
EP1748815B1 (fr) 2004-05-27 2009-09-16 Abbott Laboratories Catheter presentant un premier et un second tube de fil-guide et espace entre ces tubes
US7785439B2 (en) 2004-09-29 2010-08-31 Abbott Laboratories Vascular Enterprises Limited Method for connecting a catheter balloon with a catheter shaft of a balloon catheter
US7527606B2 (en) * 2004-05-27 2009-05-05 Abbott Laboratories Catheter having main body portion with coil-defined guidewire passage
US7658723B2 (en) 2004-05-27 2010-02-09 Abbott Laboratories Catheter having plurality of stiffening members
US7628769B2 (en) 2004-05-27 2009-12-08 Abbott Laboratories Catheter having overlapping stiffening members
US7794448B2 (en) 2004-05-27 2010-09-14 Abbott Laboratories Multiple lumen catheter and method of making same
US7785318B2 (en) 2004-05-27 2010-08-31 Abbott Laboratories Catheter having plurality of stiffening members
US7815627B2 (en) * 2004-05-27 2010-10-19 Abbott Laboratories Catheter having plurality of stiffening members
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
US8417352B2 (en) * 2004-10-19 2013-04-09 Meagan Medical, Inc. System and method for stimulating sensory nerves
CA2584722C (fr) * 2004-10-19 2016-09-20 Jens Schouenborg Procede et elements de stimulation electrique de recepteur sensoriel cutanes
US7373820B1 (en) 2004-11-23 2008-05-20 James Terry L Accelerometer for data collection and communication
US20080307849A1 (en) * 2004-11-26 2008-12-18 Agency For Science, Technology And Research Method And Apparatus For Forming Microstructures
CN101072668B (zh) 2004-12-07 2011-08-31 3M创新有限公司 模制微型针的方法
CA2589730C (fr) * 2004-12-10 2014-03-25 3M Innovative Properties Company Dispositif medical
WO2006075689A1 (fr) * 2005-01-14 2006-07-20 Fujikura Ltd. Instrument d'administration de medicament et procede de production associe
WO2006083681A2 (fr) * 2005-01-31 2006-08-10 Alza Corporation Microprojections recouvertes presentant une variabilite reduite et procede pour produire lesdites microprojections
CA2602259A1 (fr) * 2005-03-29 2006-10-05 Arkal Medical, Inc. Dispositifs, systemes, procedes et outils pour la surveillance continue du glucose
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
GB0509863D0 (en) * 2005-05-16 2005-06-22 Cambridge Biostability Ltd Apparatus for administrating substances into a body
DE602006016279D1 (de) * 2005-06-27 2010-09-30 3M Innovative Properties Co Mikronadelkartuschenanordnung
AU2006265810B2 (en) * 2005-07-01 2012-02-09 C.R. Bard, Inc. Indwelling urinary drainage catheter
US8376984B2 (en) * 2005-07-14 2013-02-19 Terry L. James Apparatus, system, and method to deliver optimal elements in order to enhance the aesthetic appearance of the skin
DE102005040251A1 (de) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
JP4908893B2 (ja) * 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
US20090171314A1 (en) * 2006-04-20 2009-07-02 Ferguson Dennis E Molded articles comprising microneedle arrays
CA2650193A1 (fr) * 2006-04-25 2007-11-08 Alza Corporation Application d'un reseau de microsaillies, les microsaillies etant faconnees pour accroitre la charge medicamenteuse
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
WO2008013282A1 (fr) * 2006-07-27 2008-01-31 Toppan Printing Co., Ltd. Procédé de production d'une micro-aiguille
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US9820888B2 (en) 2006-09-26 2017-11-21 Smith & Nephew, Inc. Wound dressing
EP2081528B1 (fr) * 2006-09-26 2018-11-14 T.J. Smith & Nephew, Limited Pansement de type quadrillé
AU2008209537B2 (en) 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090048493A1 (en) * 2007-08-17 2009-02-19 James Terry L Health and Entertainment Device for Collecting, Converting, Displaying and Communicating Data
EP2205169B1 (fr) * 2007-09-28 2016-11-16 The Queen's University of Belfast Méthode et dispositif d'administration
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US7676332B2 (en) 2007-12-27 2010-03-09 Kersh Risk Management, Inc. System and method for processing raw activity energy expenditure data
RU2450914C1 (ru) * 2008-05-23 2012-05-20 Дзе Жиллетт Компани Бритва, содержащая трехмерный микроструктурированный абразивный материал
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
US10232129B2 (en) 2008-12-02 2019-03-19 Allergan, Inc. Injection device
US7982087B2 (en) * 2009-01-09 2011-07-19 Smith & Nephew, Inc. Wound dressing
USD648439S1 (en) * 2009-01-09 2011-11-08 Smith & Nephew, Inc. Wound dressing
GB0902368D0 (en) 2009-02-13 2009-04-01 Smith & Nephew Wound packing
EP2408521B1 (fr) * 2009-03-17 2014-06-25 Cardio Thrive, Inc Défibrillateur externe
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
ES2634667T3 (es) * 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
US20110266724A1 (en) * 2009-05-08 2011-11-03 Hoowaki, Llc Method for manufacturing microstructured metal or ceramic parts from feedstock
US8764712B2 (en) * 2009-08-04 2014-07-01 Cook Medical Technologies Llc Micro-needle array and method of use thereof
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
CN102711905B (zh) 2009-11-13 2015-06-17 强生消费者公司 流电皮肤治疗装置
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US8454975B1 (en) 2010-01-11 2013-06-04 Elizabeth VanderVeer Method for enhancing skin appearance
EP2563455A4 (fr) 2010-04-28 2014-02-19 Kimberly Clark Co Procédé d'augmentation de la perméabilité d'une barrière épithéliale
EP2563453B1 (fr) 2010-04-28 2017-02-08 Kimberly-Clark Worldwide, Inc. Dispositif médical à nanomotifs présentant une meilleure interaction cellulaire et procede de fabrication dudit dispositif
EP2563451B1 (fr) 2010-04-28 2017-11-01 Kimberly-Clark Worldwide, Inc. DISPOSITIFS MÉDICAUX POUR L'ADMINISTRATION D'ARNsi
EP2563450B1 (fr) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Dispositif pour administrer un médicament contre l'arthrite rhumatoïde
ES2719595T3 (es) 2010-05-04 2019-07-11 Corium Int Inc Método y dispositivo para la administración transdérmica de la hormona paratiroidea usando una matriz de microproyección
US8854357B2 (en) * 2011-01-27 2014-10-07 Microsoft Corporation Presenting selectors within three-dimensional graphical environments
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US8636696B2 (en) * 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
USD726326S1 (en) * 2011-08-15 2015-04-07 Stephen Schrammel Long term wound dressing
US20130072808A1 (en) * 2011-09-16 2013-03-21 Imtek Structured probes for neural applications
CN103874518A (zh) * 2011-10-12 2014-06-18 3M创新有限公司 一体化微针阵列递送系统
US9427253B2 (en) * 2011-10-17 2016-08-30 Carefusion 303, Inc. Device for applying medical fluid to an area and for cutting within the area
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
HUE058275T2 (hu) 2011-10-27 2022-07-28 Sorrento Therapeutics Inc Beültethetõ eszközök biológiailag hatásos szerek tobábbítására
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
US9492001B2 (en) * 2011-11-01 2016-11-15 Derma Dream Group Ltd. System and method for treating a surface
CN104219979A (zh) * 2012-04-12 2014-12-17 宝洁公司 皮肤剥脱装置和套盒
CN112933391A (zh) 2012-05-01 2021-06-11 高等教育联邦系统-匹兹堡大学 用于经皮插入的尖端负载的微针阵列
JP6865524B2 (ja) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド 治療剤を送達するためのマイクロアレイおよび使用方法
CN104555883A (zh) * 2013-10-24 2015-04-29 中国科学院苏州纳米技术与纳米仿生研究所 电子皮肤及其制作方法
CN104575500B (zh) * 2013-10-24 2018-09-11 中国科学院苏州纳米技术与纳米仿生研究所 电子皮肤在语音识别上的应用、语音识别系统和方法
AU2014219240B2 (en) 2013-02-20 2018-12-20 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
US9962546B2 (en) 2013-02-21 2018-05-08 Meagan Medical, Inc. Cutaneous field stimulation with disposable and rechargeable components
EP2961469A4 (fr) * 2013-02-28 2016-10-26 Kimberly Clark Co Dispositif d'administration de médicament
CA3130120A1 (fr) 2013-03-12 2014-10-09 Corium, Inc. Applicateurs de microprojection
ES2908339T3 (es) 2013-03-15 2022-04-28 Corium Inc Micromatriz para el suministro de un agente terapéutico y métodos de uso
US9962534B2 (en) 2013-03-15 2018-05-08 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2903763C (fr) 2013-03-15 2021-11-16 Corium International, Inc. Micro-reseau ayant des microstructures sans polymere, procedes de fabrication et procedes d'utilisation
EP4194028A1 (fr) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Applicateurs de microprojections a impacts multiples
EP3456300A1 (fr) * 2013-05-03 2019-03-20 Cytrellis Biosystems, Inc. Micro-pansements pour le traitement de la peau
CN105209104A (zh) * 2013-05-23 2015-12-30 金伯利-克拉克环球有限公司 具有改进的开放通道横截面几何形状的微针
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US20160143660A1 (en) * 2013-06-26 2016-05-26 3M Innovative Properties Company Curette head and methods of use thereof
JP2016529000A (ja) 2013-08-09 2016-09-23 サイトレリス バイオシステムズ，インコーポレーテッド 非熱組織切除を使用する皮膚治療のための方法及び機器
US20150174386A1 (en) * 2013-12-19 2015-06-25 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
EP3082897A4 (fr) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Procédés et dispositifs pour manipuler la graisse sous-cutanée
US20150201969A1 (en) * 2014-01-06 2015-07-23 Foot Innovations, Llc Skin Exfoliating Device
FR3018440B1 (fr) * 2014-03-14 2019-05-17 Alain FAVIE Dispositif pour la microdermabrasion et procede de microdermabrasion
CA2945502C (fr) * 2014-04-30 2018-01-02 Kimberly-Clark Worldwide, Inc. Reseau de micro-aiguilles drapees
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
KR101724655B1 (ko) 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
JP5967595B2 (ja) * 2014-09-08 2016-08-10 株式会社かいわ 穿刺器具
WO2016039333A1 (fr) * 2014-09-08 2016-03-17 株式会社かいわ Dispositif de piqûre
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
WO2016057297A1 (fr) * 2014-10-09 2016-04-14 Zoetis Services Llc Aiguille pour administrer un fluide de traitement à un oiseau aviaire, et ensemble et procédé associés
USD762848S1 (en) * 2014-10-17 2016-08-02 Minas Theodore Coroneo Intravitreal injection device
JP6020771B2 (ja) * 2014-11-06 2016-11-02 凸版印刷株式会社 経皮投与デバイス、および、経皮投与デバイスの製造方法
JP6662296B2 (ja) * 2014-11-07 2020-03-11 凸版印刷株式会社 経皮投薬用針集成体及びその製造方法
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
AU2015346141B2 (en) 2014-11-14 2021-07-22 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
US9986988B2 (en) 2014-11-27 2018-06-05 AOD Holdings, LLC Surgical retractor
EP3268063A4 (fr) 2015-03-10 2018-10-31 Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company Injecteur à aiguilles multiples
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US9743949B2 (en) 2015-04-22 2017-08-29 Medline Industries, Inc. Two-dimensional needle array device and method of use
CN104922791B (zh) * 2015-05-26 2018-10-26 上海交通大学 无创针灸贴片及其制备方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6606939B2 (ja) * 2015-09-17 2019-11-20 凸版印刷株式会社 経皮投与デバイス、および、経皮投与デバイスの製造方法
CH711561B1 (de) * 2015-09-24 2025-03-14 Regent Beleuchtungskoerper Ag Optische Schicht und Leuchte mit einer solchen.
WO2017066768A1 (fr) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Administration de médicament bioactif multicomposant et libération contrôlée dans la peau par des dispositifs de matrice de micro-aiguilles
WO2017120322A1 (fr) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Administration ciblant le microenvironnement cutané et visant à renforcer les réponses immunitaires et autres
EP3422958A1 (fr) 2016-03-01 2019-01-09 Kitotech Medical, Inc. Systèmes, appareil et procédés à base de microstructure pour fermeture de plaie
US11166743B2 (en) 2016-03-29 2021-11-09 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
WO2017176476A1 (fr) 2016-04-08 2017-10-12 Allergan, Inc. Dispositif d'aspiration et d'injection
US12370696B2 (en) 2016-08-10 2025-07-29 Hoowaki, Llc Gripping surface for manufactured articles
AU2017330298B2 (en) 2016-09-21 2022-09-29 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
US20210251628A1 (en) * 2020-02-19 2021-08-19 KitoTech Medical, Inc Elastic and flexible wound closure device
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
CN106963268A (zh) * 2017-04-27 2017-07-21 苏州纳通生物纳米技术有限公司 微型针在皮肤清洁中的应用
JP1601442S (fr) * 2017-07-28 2018-04-09
CN107334495A (zh) * 2017-08-24 2017-11-10 广州新诚生物科技有限公司 用于植发的可溶针以及其制作方法
US20190062155A1 (en) * 2017-08-29 2019-02-28 Hoowaki, Llc Microstructured surface having discrete touch aesthetics
USD872370S1 (en) * 2017-09-22 2020-01-07 Davinci Ii Csj, Llc Abrasive skin treatment device
USD886384S1 (en) * 2017-09-22 2020-06-02 Davinci Ii Csj, Llc Abrasive skin treatment device
US9968767B1 (en) 2017-10-10 2018-05-15 King Saud University Combination microarray patch for drug delivery and electrochemotherapy device
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
CN107976728A (zh) * 2017-12-28 2018-05-01 武汉华星光电技术有限公司 微结构、显示装置及其显示面板
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
EP3883619A1 (fr) 2018-11-21 2021-09-29 BVW Holding AG Surface microstructurée
CA3138521A1 (fr) 2019-05-16 2020-11-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Reseaux de microaiguilles ayant des caracteristiques de contre-depouille pour l'administration cutanee et non cutanee de medicaments
US11369409B2 (en) * 2019-10-03 2022-06-28 Medline Industries, Lp System and method for fluid ingress control for a skin grafting system
US12005220B2 (en) 2019-11-22 2024-06-11 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
US11766548B2 (en) * 2020-01-21 2023-09-26 Korea Institute Of Science And Technology Phototherapeutic needle patches and methods of manufacturing the same
US20230329738A1 (en) * 2020-08-31 2023-10-19 Universidad De Los Andes Dermabrasion device
USD1017136S1 (en) 2020-12-23 2024-03-05 Telebrands Corp. Abrasive skin treatment device
USD1022327S1 (en) 2020-12-23 2024-04-09 International Edge, Inc. Foot file
USD1005504S1 (en) 2020-12-23 2023-11-21 Telebrands Corp. Abrasive skin treatment device
CN114949592B (zh) * 2021-02-26 2025-03-28 中国科学院理化技术研究所 柔性离子导入美容装置
US12357804B2 (en) * 2021-03-01 2025-07-15 Deka Products Limited Partnership Medical agent dispensing systems, methods, and apparatuses
EP4301433A1 (fr) 2021-03-01 2024-01-10 DEKA Products Limited Partnership Appareils, systèmes et procédés d'administration d'agent médical
USD1023468S1 (en) 2021-03-29 2024-04-16 Telebrands Corp. Foot file
KR102302034B1 (ko) * 2021-07-12 2021-09-13 김철하 고광택 손발톱 광택기가 함께 구비되는 발각질 제거기 및 전동용 발각질 제거 키트
WO2023042047A1 (fr) * 2021-09-20 2023-03-23 3M Innovative Properties Company Articles de fixation médicaux non adhésifs utilisant des micro-aiguilles
WO2024197125A1 (fr) * 2023-03-21 2024-09-26 Trustees Of Tufts College Micro-aiguilles rainurées à des fins d'administration passive et active de médicaments

Family Cites Families (240)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1554510A (en) * 1924-04-23 1925-09-22 Elsie W Kirby Massaging device
US1770632A (en) * 1928-07-02 1930-07-15 Arthur E Smith Ampul syringe
US2046240A (en) * 1932-07-01 1936-06-30 Thomas W Bayley Abrasive article
US2434407A (en) * 1946-01-05 1948-01-13 Hofe George Douglas Depilatory device
BE541794A (fr) 1954-10-04
US3675766A (en) * 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3704194A (en) 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3873255A (en) * 1971-01-27 1975-03-25 Johnson & Johnson Apparatus for producing nonwoven fabric
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2319591C2 (de) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medizinischer Apparat
FR2232331B1 (fr) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (de) 1975-03-07 1978-12-27 Collo Gmbh Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl.
US4151240A (en) * 1976-10-19 1979-04-24 The Procter & Gamble Company Method for debossing and perforating a running ribbon of thermoplastic film
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4117841A (en) 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
US4342314A (en) 1979-03-05 1982-08-03 The Procter & Gamble Company Resilient plastic web exhibiting fiber-like properties
US4402696A (en) 1979-10-15 1983-09-06 Gulko Bruce N Folded applicator
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4395215A (en) * 1981-02-02 1983-07-26 The Procter & Gamble Company Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its construction
US4509908A (en) * 1981-02-02 1985-04-09 The Procter & Gamble Company Apparatus for uniformly debossing and aperturing a resilient plastic web
US4463045A (en) 1981-03-02 1984-07-31 The Procter & Gamble Company Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impression
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4460370A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication application cell
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US4556441A (en) 1983-01-24 1985-12-03 Faasse Jr Adrian L Pharmaceutical packaging method
US4515168A (en) * 1983-07-22 1985-05-07 Chester Martin H Clamp-on nerve stimulator and locator
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4708716A (en) 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4695422A (en) 1984-02-16 1987-09-22 The Procter & Gamble Company Production of formed material by solid-state formation with a high-pressure liquid stream
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
JPH029755Y2 (fr) * 1985-02-26 1990-03-12
US4904475A (en) * 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4609518A (en) 1985-05-31 1986-09-02 The Procter & Gamble Company Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimensional forming structures
US4630603A (en) * 1986-02-13 1986-12-23 The Kendall Company Wound dressing
US4743249A (en) * 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
AU597890B2 (en) 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US4842794A (en) 1987-07-30 1989-06-27 Applied Extrusion Technologies, Inc. Method of making apertured films and net like fabrics
US5061258A (en) 1987-08-07 1991-10-29 Martz Joel D Vapor permeable dressing with releasable medication
US4846821A (en) 1987-08-24 1989-07-11 The Procter & Gamble Company Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement
US4812305A (en) * 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
SU1641346A1 (ru) 1987-12-08 1991-04-15 Мгту Им.Н.Э.Баумана Устройство дл электростимул ции
DK157899C (da) 1987-12-15 1990-09-03 Coloplast As Hudpladeprodukt
FR2625937B1 (fr) 1988-01-19 1993-04-30 Vuillaume Andre Procede et dispositif pour perforer un produit en feuille, et produit perfore ainsi obtenu
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3844247A1 (de) 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments
SU1667864A1 (ru) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Электростимул тор
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5531675A (en) 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (fr) 1989-07-06 1991-01-06 Ronald J. Filipski Applicateur clinique en forme de fourchette
EP0429842B1 (fr) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Dispositif d'administration transcutanée de médicaments à base de protéine ou de peptide
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5190558A (en) * 1989-11-08 1993-03-02 Nec Corporation Method of eliminating stratum corneum from the skin and an instrument to be used therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5244711A (en) 1990-03-12 1993-09-14 Mcneil-Ppc, Inc. Apertured non-woven fabric
US5162043A (en) 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5139029A (en) 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
TW279133B (fr) 1990-12-13 1996-06-21 Elan Med Tech
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5158073A (en) * 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5252279A (en) 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5160315A (en) 1991-04-05 1992-11-03 Minnesota Mining And Manufacturing Company Combined adhesive strip and transparent dressing delivery system
TW273531B (en) 1991-08-14 1996-04-01 Chicopee Textile-like apertured plastic films
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5308625A (en) * 1992-09-02 1994-05-03 Cygnus Therapeutic Systems Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
US5462743A (en) 1992-10-30 1995-10-31 Medipro Sciences Limited Substance transfer system for topical application
US5250067A (en) * 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
US6685682B1 (en) * 1993-03-22 2004-02-03 3M Innovative Properties Company Carrier delivered dressing and method of manufacture
GB9305930D0 (en) 1993-03-22 1993-05-12 Moran Peter L Electrical circuit board
WO1994021207A2 (fr) * 1993-03-22 1994-09-29 Minnesota Mining And Manufacturing Company Pansement distribue avec cadre sans fenetre
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
NZ250994A (en) 1993-05-27 1995-09-26 Ndm Acquisition Corp Wound dressing comprising a hydrogel layer bound to a porous backing layer which is bound to a thin film layer by adhesive
US5330452A (en) 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5728089A (en) * 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (fr) 1993-10-22 2005-05-10 Giorgio Cirelli Dispositif d'injection
US5962011A (en) 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5503843A (en) * 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
KR0134151B1 (ko) 1994-05-23 1998-04-14 이형도 인슐린 패치
KR0134152B1 (ko) 1994-05-23 1998-04-14 이형도 의약품 투여용 피부흠집 형성장치
DE19518932C2 (de) * 1994-05-23 1999-03-18 Samsung Electro Mech Vorrichtung zur Perforation der Haut für die Vorbereitung einer transdermalen Medikation
CA2149836C (fr) 1994-05-23 1999-07-06 Sang Bae Choi Dispositif perforant pour administration transdermique
US5851549A (en) 1994-05-25 1998-12-22 Becton Dickinson And Company Patch, with system and apparatus for manufacture
US5512219A (en) 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5496304A (en) * 1994-07-20 1996-03-05 University Of Utah Research Foundation Surgical marking pen
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
AU4256496A (en) 1994-12-09 1996-06-26 Novartis Ag Transdermal system
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (fr) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Timbre micromecanique pour ameliorer l'administration de composes a travers la peau
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
JP2713255B2 (ja) 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5730721A (en) * 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
JP3430771B2 (ja) 1996-02-05 2003-07-28 株式会社デンソー 半導体力学量センサの製造方法
JPH09215755A (ja) 1996-02-09 1997-08-19 Poritoronikusu:Kk 皮接治療具
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
ES2195151T3 (es) * 1996-06-18 2003-12-01 Alza Corp Dispositivo de mejora de aporte o de muestreo de agentes transdermicos.
DE19624578A1 (de) 1996-06-20 1998-01-08 Nancy L Divers Vorrichtung zur Hautpflege
DE69722414T2 (de) 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
WO1998011937A1 (fr) 1996-09-17 1998-03-26 Deka Products Limited Partnership Systeme d'administration de medicaments par transport
DE19649100A1 (de) 1996-11-27 1998-06-04 Lohmann Therapie Syst Lts Verfahren zur verlustarmen Herstellung wirkstoffhaltiger scheibenförmiger Formkörper und diese enthaltende transdermale therapeutische Systeme
ATE234649T1 (de) * 1996-12-20 2003-04-15 Alza Corp Vorrichtung und verfahren zur erhöhung des transdermalen wirkstoffeflusses
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5904712A (en) * 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) * 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6047208A (en) 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5938684A (en) * 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
DE69806963T2 (de) 1997-12-11 2002-11-21 Alza Corp., Mountain View Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
DE69839969D1 (de) 1997-12-11 2008-10-16 Alza Corp Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
ES2244106T3 (es) 1997-12-11 2005-12-01 Alza Corporation Dispositivo para mejorar el flujo transdermico de agentes.
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6024553A (en) 1997-12-22 2000-02-15 Mcneil-Ppc, Inc. Apparatus for supporting a starting web during formation of the apertured web
PT1041975E (pt) * 1997-12-22 2003-01-31 Alza Corp Membranas de controlo de taxa para dispositivos de fornecimento controlado de drogas
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6120792A (en) 1998-04-29 2000-09-19 Juni; Jack E. Medicated skin patch and method for its use
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
DE69921489T2 (de) 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
JP2000146777A (ja) 1998-09-08 2000-05-26 Matsushita Electric Ind Co Ltd 検体採取方法、検体採取装置、検体採取用容器、検体測定方法、検体測定装置および検体測定用容器
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
EP1003078A3 (fr) * 1998-11-17 2001-11-07 Corning Incorporated Procédé pour reproduire un motif nanométrique
JP4214584B2 (ja) 1998-11-27 2009-01-28 株式会社デンソー 半導体力学量センサおよびその製造方法
JP2002532165A (ja) 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
JP2000194142A (ja) 1998-12-25 2000-07-14 Fujitsu Ltd パタ―ン形成方法及び半導体装置の製造方法
JP2000232095A (ja) 1999-02-12 2000-08-22 Nippon Telegr & Teleph Corp <Ntt> 半導体表面の微細パターン形成方法
JP2000232971A (ja) 1999-02-15 2000-08-29 Arkray Inc 吸引浸出液採取方法および装置
US5997549A (en) 1999-02-16 1999-12-07 Sauceda; Charles J. Wart removing tool
US6132449A (en) 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6183770B1 (en) * 1999-04-15 2001-02-06 Acutek International Carrier patch for the delivery of agents to the skin
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
JP2000323461A (ja) 1999-05-11 2000-11-24 Nec Corp 微細パターン形成装置、その製造方法、および形成方法
JP4114761B2 (ja) 1999-05-14 2008-07-09 国立大学法人群馬大学 情報記録ディスク用スタンパー、その製造方法、情報記録ディスク、および情報記録ディスク製造方法
CA2376128C (fr) 1999-06-04 2009-01-06 Georgia Tech Research Corporation Dispositifs et procedes permettant d'ameliorer la penetration d'une microaiguille a travers des barrieres tissulaires
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
JP3654059B2 (ja) 1999-06-25 2005-06-02 松下電工株式会社 赤外線センサーの製造方法
JP3387897B2 (ja) 1999-08-30 2003-03-17 キヤノン株式会社 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20030093089A1 (en) * 1999-10-20 2003-05-15 Greenberg Ronald Allan Apparatus for variable micro abrasion of human tissue and/or hides using different size and types of abrasive particles
US6355054B1 (en) 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
ATE310561T1 (de) 1999-12-10 2005-12-15 Alza Corp Vorrichtung und verfahren zur verbesserung des mikronadel-haut-piercing
EP1239917B1 (fr) 1999-12-10 2005-05-11 ALZA Corporation Dispositif de traitement cutane pour administration transdermique prolongee d'un medicament
AU2088301A (en) 1999-12-16 2001-06-25 Alza Corporation Device for enhancing transdermal flux of sampled agents
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP4001311B2 (ja) 2000-06-01 2007-10-31 株式会社リコー 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP2002079499A (ja) * 2000-09-08 2002-03-19 Terumo Corp 針形状物の作製方法および作製された針
CA2357386C (fr) * 2000-09-15 2009-03-24 Timberjack Inc. Tete d'abattage a rotation elevee
AU2001296817B2 (en) * 2000-10-13 2006-05-11 Alza Corporation Microprotrusion member retainer for impact applicator
AU2001296827B2 (en) 2000-10-13 2005-11-17 Alza Corporation Microblade array impact applicator
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6533884B1 (en) * 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
JP3525177B2 (ja) 2000-11-14 2004-05-10 関西ティー・エル・オー株式会社 Ｘ線を用いた材料の加工方法
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
WO2002064193A2 (fr) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Appareils a microaiguilles et fabrication
US6508947B2 (en) 2001-01-24 2003-01-21 Xerox Corporation Method for fabricating a micro-electro-mechanical fluid ejector
JP3696513B2 (ja) 2001-02-19 2005-09-21 住友精密工業株式会社 針状体の製造方法
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
JP2004528900A (ja) 2001-04-20 2004-09-24 アルザ・コーポレーシヨン 有益な作用物質を含有するコーティングを有する微小突起アレイ
US6585742B2 (en) 2001-05-08 2003-07-01 Dowling B. Stough Wart removal method and device
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
DE60213976T2 (de) 2001-06-08 2007-04-26 Becton Dickinson And Co. Vorrichtung zur manipulation von nadeln oder polierarray
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US20040204669A1 (en) 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
JP5055672B2 (ja) 2001-07-31 2012-10-24 大日本印刷株式会社 薄膜パターン形成用スタンプ
JP4919446B2 (ja) 2001-08-09 2012-04-18 学校法人東京電機大学 微細溝加工方法及びその装置
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
WO2003024290A1 (fr) 2001-09-14 2003-03-27 The Procter & Gamble Company Procede d'exfoliation de la peau a l'aide de microstructures etroitement serrees et appareil afferent
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002333636A1 (en) 2001-09-14 2003-04-01 The Procter And Gamble Company Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030093028A1 (en) * 2001-11-09 2003-05-15 Michael Spiegel Appararus and method for magnetic induction of therapeutic electric fields
WO2003048031A2 (fr) 2001-11-30 2003-06-12 Alza Corporation Procedes et appareils de formation de grilles de microprojections
MXPA04007389A (es) 2002-02-04 2004-10-11 Becton Dickinson Co Dispositivo y metodo para entregar o retirar una substancia a traves de la piel.
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
TW200409657A (en) 2002-08-08 2004-06-16 Alza Corp Transdermal vaccine delivery device having coated microprotrusions
EP1531896B1 (fr) 2002-08-29 2016-07-20 Becton Dickinson and Company Matrices de microprotuberances et procede permettant d'utiliser ces matrices pour l'administration de substances a un tissu
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
AU2004285481A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
AU2004287414B2 (en) * 2003-10-31 2010-11-25 Alza Corporation Self-actuating applicator for microprojection array
AT500095B8 (de) 2004-01-23 2007-02-15 Braun Werner Mag Transdermales abgabesystem

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7416541B2 (en) 1999-06-09 2008-08-26 Corium International, Inc. Intracutaneous microneedle array apparatus
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays

Also Published As

Publication number Publication date
CN1477983A (zh) 2004-02-25
WO2002032331A2 (fr) 2002-04-25
US20050090803A1 (en) 2005-04-28
ES2250493T3 (es) 2006-04-16
EP1326674B8 (fr) 2005-11-23
JP2004521669A (ja) 2004-07-22
CN1665561A (zh) 2005-09-07
US20060129174A1 (en) 2006-06-15
ATE353687T1 (de) 2007-03-15
US8216190B2 (en) 2012-07-10
EP1326673B1 (fr) 2007-02-14
US7108681B2 (en) 2006-09-19
CA2422909C (fr) 2009-02-24
AU2002213167A1 (en) 2002-04-29
US6821281B2 (en) 2004-11-23
US20020045859A1 (en) 2002-04-18
CA2422909A1 (fr) 2002-04-25
DE60113557T2 (de) 2006-07-13
EP1326674B1 (fr) 2005-09-21
CN100427159C (zh) 2008-10-22
JP4676128B2 (ja) 2011-04-27
EP1326674A2 (fr) 2003-07-16
CN100528259C (zh) 2009-08-19
EP1326673A2 (fr) 2003-07-16
CA2422907A1 (fr) 2002-04-25
AU2002213168A1 (en) 2002-04-29
WO2002032480A2 (fr) 2002-04-25
DE60126637D1 (de) 2007-03-29
DE60126637T2 (de) 2007-11-22
JP2004516868A (ja) 2004-06-10
WO2002032480A3 (fr) 2002-08-29
WO2002032331A3 (fr) 2002-09-06
WO2002032480A8 (fr) 2003-11-13
CA2422907C (fr) 2009-05-26
ES2281450T3 (es) 2007-10-01
ATE304878T1 (de) 2005-10-15
US20020045907A1 (en) 2002-04-18
DE60113557D1 (de) 2005-10-27

Similar Documents

Publication Publication Date Title
WO2002032331A8 (fr) Microstructures permettant de traiter et de conditionner la peau
WO2004003120A3 (fr) Produits a base de liquide ionique et leur procede d&#39;utilisation
AU2002231597A1 (en) Dressing material in addition to treatment solution for use with said dressing material
AU2003250059A1 (en) Use of silanes in cosmetic agents and methods for treating hair
SI1575597T1 (sl) Uporaba rimeksolona pri zdravljenju suhega očesa
AU2001293553A1 (en) Phosphatidylserine-carrying apoptosis-mimicking bodies and the use thereof in medical treatment
IL187513A0 (en) Use of (s,s)-reboxetine in the treatment of pain conditions and incontinence
DE60003015D1 (de) Schleifartikel, verfahren zur herstellung desselben, und schleifvorrichtung
AU2003300325A1 (en) Water repellent surface treatment and treated articles
AU2001293745A1 (en) Device and method for the surface treatment of workpieces
EP1607078A3 (fr) Pansement
WO2005115195A3 (fr) Tampons applicateurs
AU2002243363A1 (en) Use of aziridino-compounds in the treatment of immune dysfunctions
ZA200307475B (en) Carbamate compounds for use in the treatment of pain.
TWI348912B (en) Method and composition for treating skin wounds with epidermal growth factor
WO2005065362A3 (fr) Systeme et procede d&#39;abrasion de la peau
IL175579A0 (en) Epithelium treatment methods and devices for treating the epithelium
AU2003302915A1 (en) Waste-water filter, waste-water treatment device and method incorporating the waste-water filter
SG102679A1 (en) Surface treatment method and material treated by the method
GB0007217D0 (en) Materials and methods relating to the treatment of leukaemias
GB0106316D0 (en) Apparatus for use in the treatment of hair
GB2431578B (en) Apparatus and method for use in the treatment of hair
GB0310147D0 (en) A composition for use in the treatment of a skin condition in a subject
AU2001262341A1 (en) Use of alkylpolyglucosides as filtering agents in the viscose method
GB2380404B (en) Method and apparatus for use in treating hair

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ CZ DE DE DK DK DM DZ EC EE EE ES FI FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2422907

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001981530

Country of ref document: EP

Ref document number: 018172881

Country of ref document: CN

WWE Wipo information: entry into national phase

Ref document number: 2002535570

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2001981530

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 17/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION.

Free format text: IN PCT GAZETTE 17/2002 DUE TO A TECHNICAL PROBLEM AT THE TIME OF INTERNATIONAL PUBLICATION, SOME INFORMATION WAS MISSING (81). THE MISSING INFORMATION NOW APPEARS IN THE CORRECTED VERSION.

WWG Wipo information: grant in national office

Ref document number: 2001981530

Country of ref document: EP