[go: up one dir, main page]

DE60113557D1 - Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut - Google Patents

Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut

Info

Publication number
DE60113557D1
DE60113557D1 DE60113557T DE60113557T DE60113557D1 DE 60113557 D1 DE60113557 D1 DE 60113557D1 DE 60113557 T DE60113557 T DE 60113557T DE 60113557 T DE60113557 T DE 60113557T DE 60113557 D1 DE60113557 D1 DE 60113557D1
Authority
DE
Germany
Prior art keywords
skin
microelements
composition
microstructures
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60113557T
Other languages
English (en)
Other versions
DE60113557T2 (de
Inventor
Vladimir Gartstein
Feisal Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corium LLC
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of DE60113557D1 publication Critical patent/DE60113557D1/de
Publication of DE60113557T2 publication Critical patent/DE60113557T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D26/00—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers
    • A45D26/0004—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers by abrasion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/20—Surgical instruments, devices or methods for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/54—Chiropodists' instruments, e.g. pedicure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60113557T 2000-10-16 2001-10-15 Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut Expired - Lifetime DE60113557T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24073000P 2000-10-16 2000-10-16
US24078700P 2000-10-16 2000-10-16
US240730P 2000-10-16
US240787P 2000-10-16
PCT/US2001/031978 WO2002032480A2 (en) 2000-10-16 2001-10-15 Microstructures for delivering a composition cutaneously to skin

Publications (2)

Publication Number Publication Date
DE60113557D1 true DE60113557D1 (de) 2005-10-27
DE60113557T2 DE60113557T2 (de) 2006-07-13

Family

ID=26933655

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60113557T Expired - Lifetime DE60113557T2 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut
DE60126637T Expired - Lifetime DE60126637T2 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur behandlung und aufbereitung der haut

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60126637T Expired - Lifetime DE60126637T2 (de) 2000-10-16 2001-10-15 Mikrostrukturen zur behandlung und aufbereitung der haut

Country Status (10)

Country Link
US (4) US6821281B2 (de)
EP (2) EP1326673B1 (de)
JP (2) JP4676128B2 (de)
CN (2) CN100528259C (de)
AT (2) ATE304878T1 (de)
AU (2) AU2002213168A1 (de)
CA (2) CA2422907C (de)
DE (2) DE60113557T2 (de)
ES (2) ES2281450T3 (de)
WO (2) WO2002032480A2 (de)

Families Citing this family (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
AU8511601A (en) * 2000-08-21 2002-03-04 Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
KR20030068136A (ko) * 2000-10-13 2003-08-19 알자 코포레이션 미세 돌기부로 피부를 천공하기 위한 장치 및 방법
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) * 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
WO2002045771A2 (en) * 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
EP1256316A1 (de) 2001-05-07 2002-11-13 Move2Health B.V. Tragbare Vorrichtung mit einem Beschleunigungssensor und ein Verfahren zur Erzeugung von Befehlen oder Ratschläge
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
SE0102736D0 (sv) * 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US6881203B2 (en) * 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
WO2003024290A1 (en) * 2001-09-14 2003-03-27 The Procter & Gamble Company Method of exfoliation of skin using closely-packed microstructures and apparatus therefor
JP2005503210A (ja) * 2001-09-14 2005-02-03 ザ プロクター アンド ギャンブル カンパニー 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造
US20030093040A1 (en) * 2001-10-29 2003-05-15 Mikszta John A. Method and device for the delivery of a substance
EP1485317A2 (de) * 2001-11-30 2004-12-15 Alza Corporation Verfahren und vorrichtungen zur herstellung von mikroprojektoranordnungen
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6916120B2 (en) * 2002-01-30 2005-07-12 Adc Telecommunications, Inc. Fiber optic connector and method
US8116860B2 (en) 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
WO2003077970A2 (en) * 2002-03-11 2003-09-25 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
DE10219523A1 (de) * 2002-05-02 2003-11-13 Wella Ag Verfahren zur technischen Produktion haar- oder hautkosmetischer Produkte unter Verwendung von Apparaturen mit Mikrostruktureinheiten
KR101323980B1 (ko) * 2002-07-19 2013-10-30 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로 니들 장치, 마이크로 니들 장치를 사용하는 방법 및 마이크로 니들 장치를 송출하는 방법
AU2003270011B8 (en) * 2002-08-29 2009-03-05 Becton, Dickinson And Company Substance delivery via rotating microabrading surface
US7449307B2 (en) * 2002-10-28 2008-11-11 Transform Pharmaceuticals, Inc. Raised surface assay plate
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
DE50209306D1 (de) 2002-12-31 2007-03-08 Abbott Lab Vascular Entpr Ltd Katheter mit einem flexibleren Bereich zwischen Schaft und Spitze sowie Verfahren zu seiner Herstellung
US7226457B2 (en) * 2003-02-19 2007-06-05 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Epidermal sampling apparatus and method
US7087063B2 (en) * 2003-02-19 2006-08-08 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Abrasion device and method
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US20040227199A1 (en) * 2003-05-15 2004-11-18 Toshiba Kikai Kabushiki Kaisha Minute flow passage and micro-chemical chip including the same
US7572405B2 (en) * 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
US7480530B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US7479133B2 (en) * 2003-06-30 2009-01-20 Johnson & Johnson Consumer Companies, Inc. Methods of treating acne and rosacea with galvanic generated electricity
US7476222B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of reducing the appearance of pigmentation with galvanic generated electricity
US7477938B2 (en) 2003-06-30 2009-01-13 Johnson & Johnson Cosumer Companies, Inc. Device for delivery of active agents to barrier membranes
US7477940B2 (en) * 2003-06-30 2009-01-13 J&J Consumer Companies, Inc. Methods of administering an active agent to a human barrier membrane with galvanic generated electricity
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US7477941B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of exfoliating the skin with electricity
US7507228B2 (en) 2003-06-30 2009-03-24 Johnson & Johnson Consumer Companies, Inc. Device containing a light emitting diode for treatment of barrier membranes
US7486989B2 (en) 2003-06-30 2009-02-03 Johnson & Johnson Consumer Companies, Inc. Device for delivery of oxidizing agents to barrier membranes
US7477939B2 (en) * 2003-06-30 2009-01-13 Johnson & Johnson Consumer Companies, Inc. Methods of treating a wound with galvanic generated electricity
EP1648363B1 (de) 2003-07-03 2019-03-06 Corium International, Inc. Wundverband, vorrichtung zur inhaltsstoffzuführung und iv-hold-down sowie verfahren im zusammenhang damit
WO2005018731A1 (en) * 2003-08-26 2005-03-03 Alza Corporation Device and method for intradermal cell implantation
US8353861B2 (en) * 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
US7753888B2 (en) * 2003-11-21 2010-07-13 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
WO2005075016A1 (ja) * 2004-02-03 2005-08-18 Hisamitsu Pharmaceutical Co., Inc. 経皮薬物投与装置用インタフェース
JP2007523771A (ja) * 2004-02-23 2007-08-23 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの成形方法
US7591618B2 (en) * 2004-02-25 2009-09-22 Agency For Science, Technology And Research Machining method for micro abraders and micro abraders produced thereby
WO2005094526A2 (en) 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US20080082090A1 (en) * 2004-04-01 2008-04-03 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
GB2438372A (en) * 2006-05-25 2007-11-28 Ball Burnishing Mach Tools A procedure for cosmetic treatment of skin by sliding a tool over the skin
US7794448B2 (en) 2004-05-27 2010-09-14 Abbott Laboratories Multiple lumen catheter and method of making same
US7658723B2 (en) 2004-05-27 2010-02-09 Abbott Laboratories Catheter having plurality of stiffening members
US7815627B2 (en) * 2004-05-27 2010-10-19 Abbott Laboratories Catheter having plurality of stiffening members
US7628769B2 (en) 2004-05-27 2009-12-08 Abbott Laboratories Catheter having overlapping stiffening members
WO2005118045A1 (en) * 2004-05-27 2005-12-15 Abbott Laboratories Catheter having main body portion with coil-defined guidewire passage
US7785318B2 (en) 2004-05-27 2010-08-31 Abbott Laboratories Catheter having plurality of stiffening members
US7785439B2 (en) 2004-09-29 2010-08-31 Abbott Laboratories Vascular Enterprises Limited Method for connecting a catheter balloon with a catheter shaft of a balloon catheter
EP1748815B1 (de) 2004-05-27 2009-09-16 Abbott Laboratories katheter mit erster und zweiter führungsdrahtröhre und dazwischenliegender lücke
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US20060100584A1 (en) * 2004-08-10 2006-05-11 Orest Olejnik Needleless microprotrusion elastoplast system
US8417352B2 (en) * 2004-10-19 2013-04-09 Meagan Medical, Inc. System and method for stimulating sensory nerves
CN101124010B (zh) * 2004-10-19 2012-09-26 国际复原科技公司（贸易用名Rs医药公司） 皮肤感觉感受器的电刺激方法和装置
US7373820B1 (en) 2004-11-23 2008-05-20 James Terry L Accelerometer for data collection and communication
WO2006057619A1 (en) * 2004-11-26 2006-06-01 Agency For Science, Technology And Research Method and apparatus for forming microstructures
JP2008522875A (ja) 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルの成形方法
CA2589730C (en) * 2004-12-10 2014-03-25 3M Innovative Properties Company Medical device
JPWO2006075689A1 (ja) * 2005-01-14 2008-06-12 久光製薬株式会社 医薬物運搬用器具とその製造方法
AU2006211176A1 (en) * 2005-01-31 2006-08-10 Alza Corporation Coated microprojections having reduced variability and method for producing same
US8280476B2 (en) * 2005-03-29 2012-10-02 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
GB0509863D0 (en) * 2005-05-16 2005-06-22 Cambridge Biostability Ltd Apparatus for administrating substances into a body
CA2613114C (en) 2005-06-27 2015-02-24 3M Innovative Properties Company Microneedle cartridge assembly and method of applying
US8137309B2 (en) * 2005-07-01 2012-03-20 C.R. Brad, Inc. Indwelling urinary drainage catheter
US8376984B2 (en) * 2005-07-14 2013-02-19 Terry L. James Apparatus, system, and method to deliver optimal elements in order to enhance the aesthetic appearance of the skin
DE102005040251A1 (de) * 2005-08-24 2007-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Transcorneales System zur Abgabe eines Arzneimittel-Wirkstoffes
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20080154107A1 (en) * 2006-12-20 2008-06-26 Jina Arvind N Device, systems, methods and tools for continuous glucose monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
JP4908893B2 (ja) * 2006-03-30 2012-04-04 久光製薬株式会社 医薬物運搬用器具とその製造方法及び医薬物運搬用器具製造用金型の製造方法
EP2076312A4 (de) * 2006-04-20 2013-09-04 3M Innovative Properties Co Geformte artikel mit mikronadel-anordnungen
AU2007244831A1 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with sculptured microprojections for high drug loading
US8250729B2 (en) * 2006-07-12 2012-08-28 University Of Utah Research Foundation 3D fabrication of needle tip geometry and knife blade
EP2789363B1 (de) 2006-07-27 2016-11-02 Toppan Printing Co., Ltd. Verfahren zur Herstellung einer Mikronadel
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US8680360B2 (en) * 2006-09-26 2014-03-25 Smith & Nephew Inc. Lattice dressing
US9820888B2 (en) 2006-09-26 2017-11-21 Smith & Nephew, Inc. Wound dressing
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20080312518A1 (en) * 2007-06-14 2008-12-18 Arkal Medical, Inc On-demand analyte monitor and method of use
US20090048493A1 (en) * 2007-08-17 2009-02-19 James Terry L Health and Entertainment Device for Collecting, Converting, Displaying and Communicating Data
CN101808588B (zh) * 2007-09-28 2012-12-19 贝尔法斯特女王大学 递送装置及方法
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
US7676332B2 (en) 2007-12-27 2010-03-09 Kersh Risk Management, Inc. System and method for processing raw activity energy expenditure data
JP5301659B2 (ja) * 2008-05-23 2013-09-25 ザ ジレット カンパニー 三次元ミクロ構造表皮剥離材を備えるかみそり
US8150525B2 (en) 2008-08-27 2012-04-03 Johnson & Johnson Consumer Companies, Inc. Treatment of hyperhydrosis
PL2384210T3 (pl) 2008-12-02 2018-01-31 Allergan Inc Urządzenie do iniekcji
USD648439S1 (en) * 2009-01-09 2011-11-08 Smith & Nephew, Inc. Wound dressing
US7982087B2 (en) * 2009-01-09 2011-07-19 Smith & Nephew, Inc. Wound dressing
GB0902368D0 (en) 2009-02-13 2009-04-01 Smith & Nephew Wound packing
US8781576B2 (en) 2009-03-17 2014-07-15 Cardiothrive, Inc. Device and method for reducing patient transthoracic impedance for the purpose of delivering a therapeutic current
JP5563652B2 (ja) 2009-03-17 2014-07-30 カーディオスライヴ インコーポレイテッド 体外除細動器
US20120089232A1 (en) 2009-03-27 2012-04-12 Jennifer Hagyoung Kang Choi Medical devices with galvanic particulates
ES2634667T3 (es) * 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
US20110266724A1 (en) * 2009-05-08 2011-11-03 Hoowaki, Llc Method for manufacturing microstructured metal or ceramic parts from feedstock
US8764712B2 (en) * 2009-08-04 2014-07-01 Cook Medical Technologies Llc Micro-needle array and method of use thereof
US8062568B2 (en) * 2009-08-27 2011-11-22 Korea University Research And Business Foundation Nano pattern writer
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
KR20120091335A (ko) 2009-11-13 2012-08-17 존슨 앤드 존슨 컨수머 캄파니즈, 인코포레이티드 갈바닉 피부 치료 장치
US20110144591A1 (en) 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
US8454975B1 (en) 2010-01-11 2013-06-04 Elizabeth VanderVeer Method for enhancing skin appearance
AU2011246882B2 (en) 2010-04-28 2016-02-25 Sorrento Therapeutics, Inc. Nanopatterned medical device with enhanced cellular interaction
ES2636673T3 (es) 2010-04-28 2017-10-06 Kimberly-Clark Worldwide, Inc. Dispositivo para la administración de medicamentos contra la artritis reumatoide
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
EP2563451B1 (de) 2010-04-28 2017-11-01 Kimberly-Clark Worldwide, Inc. Medizinische vorrichtungen zur abgabe von sirna
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8854357B2 (en) * 2011-01-27 2014-10-07 Microsoft Corporation Presenting selectors within three-dimensional graphical environments
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
USD726326S1 (en) * 2011-08-15 2015-04-07 Stephen Schrammel Long term wound dressing
US20130072808A1 (en) * 2011-09-16 2013-03-21 Imtek Structured probes for neural applications
WO2013055638A1 (en) * 2011-10-12 2013-04-18 3M Innovative Properties Company Integrated microneedle array delivery system
US9427253B2 (en) * 2011-10-17 2016-08-30 Carefusion 303, Inc. Device for applying medical fluid to an area and for cutting within the area
US9550053B2 (en) 2011-10-27 2017-01-24 Kimberly-Clark Worldwide, Inc. Transdermal delivery of high viscosity bioactive agents
US11110066B2 (en) 2011-10-27 2021-09-07 Sorrento Therapeutics, Inc. Implantable devices for delivery of bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
US9492001B2 (en) * 2011-11-01 2016-11-15 Derma Dream Group Ltd. System and method for treating a surface
CN104219979A (zh) * 2012-04-12 2014-12-17 宝洁公司 皮肤剥脱装置和套盒
CN112933391A (zh) 2012-05-01 2021-06-11 高等教育联邦系统-匹兹堡大学 用于经皮插入的尖端负载的微针阵列
CA2896188C (en) 2012-12-21 2021-02-23 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
CN104575500B (zh) * 2013-10-24 2018-09-11 中国科学院苏州纳米技术与纳米仿生研究所 电子皮肤在语音识别上的应用、语音识别系统和方法
CN104555883A (zh) * 2013-10-24 2015-04-29 中国科学院苏州纳米技术与纳米仿生研究所 电子皮肤及其制作方法
EP2958533B8 (de) 2013-02-20 2022-02-16 Cytrellis Biosystems, Inc. Verfahren und vorrichtungen zur hautstraffung
US9962546B2 (en) 2013-02-21 2018-05-08 Meagan Medical, Inc. Cutaneous field stimulation with disposable and rechargeable components
US9861801B2 (en) * 2013-02-28 2018-01-09 Kimberly-Clark Worldwide, Inc. Drug delivery device
ES2921481T3 (es) 2013-03-12 2022-08-26 Corium Inc Aplicadores para microproyecciones
US10384046B2 (en) 2013-03-15 2019-08-20 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014144973A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
US10195409B2 (en) 2013-03-15 2019-02-05 Corium International, Inc. Multiple impact microprojection applicators and methods of use
KR102588615B1 (ko) * 2013-05-03 2023-10-11 사이트렐리스 바이오시스템즈, 인크. 피부 치료를 위한 마이크로클로져 및 관련 방법
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
JP2016517762A (ja) * 2013-05-23 2016-06-20 キンバリー クラーク ワールドワイド インコーポレイテッド 開放チャネル断面形状が改善されたマイクロニードル
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US9833630B2 (en) 2013-06-14 2017-12-05 Cardiothrive, Inc. Biphasic or multiphasic pulse waveform and method
US10149973B2 (en) 2013-06-14 2018-12-11 Cardiothrive, Inc. Multipart non-uniform patient contact interface and method of use
US9907970B2 (en) 2013-06-14 2018-03-06 Cardiothrive, Inc. Therapeutic system and method using biphasic or multiphasic pulse waveform
US10279189B2 (en) 2013-06-14 2019-05-07 Cardiothrive, Inc. Wearable multiphasic cardioverter defibrillator system and method
US9616243B2 (en) 2013-06-14 2017-04-11 Cardiothrive, Inc. Dynamically adjustable multiphasic defibrillator pulse system and method
US9656094B2 (en) 2013-06-14 2017-05-23 Cardiothrive, Inc. Biphasic or multiphasic pulse generator and method
US20160143660A1 (en) * 2013-06-26 2016-05-26 3M Innovative Properties Company Curette head and methods of use thereof
CA2920662A1 (en) 2013-08-09 2015-02-12 Cytrellis Biosystems, Inc. Methods and apparatuses for skin treatment using non-thermal tissue ablation
EP3082897A4 (de) 2013-12-19 2017-07-26 Cytrellis Biosystems, Inc. Verfahren und vorrichtungen zur manipulation von unterhautfett
US20150174386A1 (en) * 2013-12-19 2015-06-25 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
US20150201969A1 (en) * 2014-01-06 2015-07-23 Foot Innovations, Llc Skin Exfoliating Device
FR3018440B1 (fr) * 2014-03-14 2019-05-17 Alain FAVIE Dispositif pour la microdermabrasion et procede de microdermabrasion
KR101724251B1 (ko) 2014-04-30 2017-04-06 킴벌리-클라크 월드와이드, 인크. 도포식 현미침 조립체
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
KR101724655B1 (ko) 2014-06-02 2017-04-13 주식회사 아모라이프사이언스 마이크로 니들 패치 및 그의 제조 방법
EP3188714A1 (de) 2014-09-04 2017-07-12 Corium International, Inc. Mikrostrukturanordnung, verfahren zur herstellung und verfahren zur verwendung
JP5967595B2 (ja) * 2014-09-08 2016-08-10 株式会社かいわ 穿刺器具
WO2016039333A1 (ja) * 2014-09-08 2016-03-17 株式会社かいわ 穿刺器具
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
EP3203929A1 (de) * 2014-10-09 2017-08-16 Zoetis Services LLC Nadel zur abgabe einer behandlungsflüssigkeit an einen vogel und zugehörige anordnung und verfahren
USD762848S1 (en) * 2014-10-17 2016-08-02 Minas Theodore Coroneo Intravitreal injection device
EP3216482B1 (de) * 2014-11-06 2019-03-20 Toppan Printing Co., Ltd. Transdermale verabreichungsvorrichtung und verfahren zur herstellung einer transdermalen verabreichungsvorrichtung
JP6662296B2 (ja) * 2014-11-07 2020-03-11 凸版印刷株式会社 経皮投薬用針集成体及びその製造方法
KR102852547B1 (ko) 2014-11-14 2025-09-01 사이트렐리스 바이오시스템즈, 인크. 피부 절제를 위한 디바이스 및 방법
JP6906885B2 (ja) 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
US9986988B2 (en) 2014-11-27 2018-06-05 AOD Holdings, LLC Surgical retractor
CA2976544A1 (en) 2015-03-10 2016-09-15 Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company Multiple needle injector
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US9743949B2 (en) * 2015-04-22 2017-08-29 Medline Industries, Inc. Two-dimensional needle array device and method of use
CN104922791B (zh) * 2015-05-26 2018-10-26 上海交通大学 无创针灸贴片及其制备方法
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6606939B2 (ja) * 2015-09-17 2019-11-20 凸版印刷株式会社 経皮投与デバイス、および、経皮投与デバイスの製造方法
CH711561B1 (de) * 2015-09-24 2025-03-14 Regent Beleuchtungskoerper Ag Optische Schicht und Leuchte mit einer solchen.
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2019513070A (ja) 2016-03-01 2019-05-23 キトテック メディカル， インコーポレイテッド 創傷閉鎖のための微細構造に基づくシステム、装置および方法
KR20230117470A (ko) 2016-03-29 2023-08-08 사이트렐리스 바이오시스템즈, 인크. 미용 피부 리설페이싱용 디바이스 및 방법
JP2019510589A (ja) 2016-04-08 2019-04-18 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 吸引及び注入デバイス
US12370696B2 (en) 2016-08-10 2025-07-29 Hoowaki, Llc Gripping surface for manufactured articles
CN109922740B (zh) 2016-09-21 2022-08-23 希特利斯生物系统有限公司 用于美容皮肤重建的装置和方法
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
CN106963268A (zh) * 2017-04-27 2017-07-21 苏州纳通生物纳米技术有限公司 微型针在皮肤清洁中的应用
JP1601442S (de) * 2017-07-28 2018-04-09
CN107334495A (zh) 2017-08-24 2017-11-10 广州新诚生物科技有限公司 用于植发的可溶针以及其制作方法
WO2019046392A1 (en) * 2017-08-29 2019-03-07 Hoowaki, Llc MICROSTRUCTURED SURFACE HAVING A DISCRETE TOUCH AESTHETIC
USD886384S1 (en) * 2017-09-22 2020-06-02 Davinci Ii Csj, Llc Abrasive skin treatment device
USD872370S1 (en) * 2017-09-22 2020-01-07 Davinci Ii Csj, Llc Abrasive skin treatment device
US9968767B1 (en) 2017-10-10 2018-05-15 King Saud University Combination microarray patch for drug delivery and electrochemotherapy device
US10828500B2 (en) 2017-12-22 2020-11-10 Cardiothrive, Inc. External defibrillator
CN107976728A (zh) * 2017-12-28 2018-05-01 武汉华星光电技术有限公司 微结构、显示装置及其显示面板
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
KR102771674B1 (ko) 2018-11-21 2025-02-25 비브이더블유 인베스트 에이쥐 마이크로구조 표면
AU2020275934B2 (en) 2019-05-16 2025-09-25 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
US11369409B2 (en) * 2019-10-03 2022-06-28 Medline Industries, Lp System and method for fluid ingress control for a skin grafting system
CA3159272A1 (en) 2019-11-22 2021-05-27 Veradermics Incorporated Microneedle patch for immunostimulatory drug delivery
US11766548B2 (en) * 2020-01-21 2023-09-26 Korea Institute Of Science And Technology Phototherapeutic needle patches and methods of manufacturing the same
WO2021168479A1 (en) * 2020-02-19 2021-08-26 Kitotech Medical, Inc. Wound closure device for wide treatment areas
WO2022043956A1 (es) * 2020-08-31 2022-03-03 Universidad De Los Andes Dispositivo de dermoabrasión
USD1005504S1 (en) 2020-12-23 2023-11-21 Telebrands Corp. Abrasive skin treatment device
USD1017136S1 (en) 2020-12-23 2024-03-05 Telebrands Corp. Abrasive skin treatment device
USD1022327S1 (en) 2020-12-23 2024-04-09 International Edge, Inc. Foot file
CN114949592B (zh) * 2021-02-26 2025-03-28 中国科学院理化技术研究所 柔性离子导入美容装置
US12357804B2 (en) * 2021-03-01 2025-07-15 Deka Products Limited Partnership Medical agent dispensing systems, methods, and apparatuses
US12377219B2 (en) 2021-03-01 2025-08-05 Deka Products Limited Partnership Medical agent dispensing apparatuses, systems, and methods
USD1023468S1 (en) 2021-03-29 2024-04-16 Telebrands Corp. Foot file
KR102302034B1 (ko) * 2021-07-12 2021-09-13 김철하 고광택 손발톱 광택기가 함께 구비되는 발각질 제거기 및 전동용 발각질 제거 키트
WO2023042047A1 (en) * 2021-09-20 2023-03-23 3M Innovative Properties Company Non-adhesive medical attachment articles using microneedles
WO2024197125A1 (en) * 2023-03-21 2024-09-26 Trustees Of Tufts College Grooved microneedles for passive and active drug delivery

Family Cites Families (240)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1554510A (en) * 1924-04-23 1925-09-22 Elsie W Kirby Massaging device
US1770632A (en) 1928-07-02 1930-07-15 Arthur E Smith Ampul syringe
US2046240A (en) 1932-07-01 1936-06-30 Thomas W Bayley Abrasive article
US2434407A (en) 1946-01-05 1948-01-13 Hofe George Douglas Depilatory device
NL92403C (de) 1954-10-04
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3704194A (en) 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3873255A (en) 1971-01-27 1975-03-25 Johnson & Johnson Apparatus for producing nonwoven fabric
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2319591C2 (de) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medizinischer Apparat
FR2232331B1 (de) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (de) 1975-03-07 1978-12-27 Collo Gmbh Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl.
US4151240A (en) * 1976-10-19 1979-04-24 The Procter & Gamble Company Method for debossing and perforating a running ribbon of thermoplastic film
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4117841A (en) 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
US4342314A (en) 1979-03-05 1982-08-03 The Procter & Gamble Company Resilient plastic web exhibiting fiber-like properties
US4402696A (en) 1979-10-15 1983-09-06 Gulko Bruce N Folded applicator
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4509908A (en) 1981-02-02 1985-04-09 The Procter & Gamble Company Apparatus for uniformly debossing and aperturing a resilient plastic web
US4395215A (en) 1981-02-02 1983-07-26 The Procter & Gamble Company Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its construction
US4463045A (en) 1981-03-02 1984-07-31 The Procter & Gamble Company Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impression
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4460370A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication application cell
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US4556441A (en) 1983-01-24 1985-12-03 Faasse Jr Adrian L Pharmaceutical packaging method
US4515168A (en) * 1983-07-22 1985-05-07 Chester Martin H Clamp-on nerve stimulator and locator
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4708716A (en) 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US4695422A (en) 1984-02-16 1987-09-22 The Procter & Gamble Company Production of formed material by solid-state formation with a high-pressure liquid stream
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
JPH029755Y2 (de) * 1985-02-26 1990-03-12
US4904475A (en) 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4609518A (en) 1985-05-31 1986-09-02 The Procter & Gamble Company Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimensional forming structures
US4630603A (en) * 1986-02-13 1986-12-23 The Kendall Company Wound dressing
US4743249A (en) 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
AU597890B2 (en) 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US4842794A (en) 1987-07-30 1989-06-27 Applied Extrusion Technologies, Inc. Method of making apertured films and net like fabrics
US5061258A (en) 1987-08-07 1991-10-29 Martz Joel D Vapor permeable dressing with releasable medication
US4846821A (en) 1987-08-24 1989-07-11 The Procter & Gamble Company Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement
US4812305A (en) 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
SU1641346A1 (ru) 1987-12-08 1991-04-15 Мгту Им.Н.Э.Баумана Устройство дл электростимул ции
DK157899C (da) 1987-12-15 1990-09-03 Coloplast As Hudpladeprodukt
FR2625937B1 (fr) 1988-01-19 1993-04-30 Vuillaume Andre Procede et dispositif pour perforer un produit en feuille, et produit perfore ainsi obtenu
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3844247A1 (de) 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments
SU1667864A1 (ru) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Электростимул тор
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5531675A (en) 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
US5190558A (en) 1989-11-08 1993-03-02 Nec Corporation Method of eliminating stratum corneum from the skin and an instrument to be used therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5244711A (en) 1990-03-12 1993-09-14 Mcneil-Ppc, Inc. Apertured non-woven fabric
US5162043A (en) 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5139029A (en) 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
TW279133B (de) 1990-12-13 1996-06-21 Elan Med Tech
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5158073A (en) 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5252279A (en) 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5160315A (en) 1991-04-05 1992-11-03 Minnesota Mining And Manufacturing Company Combined adhesive strip and transparent dressing delivery system
TW273531B (en) 1991-08-14 1996-04-01 Chicopee Textile-like apertured plastic films
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5308625A (en) 1992-09-02 1994-05-03 Cygnus Therapeutic Systems Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
US5462743A (en) 1992-10-30 1995-10-31 Medipro Sciences Limited Substance transfer system for topical application
US5250067A (en) * 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
GB9305930D0 (en) 1993-03-22 1993-05-12 Moran Peter L Electrical circuit board
US6685682B1 (en) 1993-03-22 2004-02-03 3M Innovative Properties Company Carrier delivered dressing and method of manufacture
KR100355857B1 (ko) 1993-03-22 2003-03-31 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 접착성합성체드레싱및그제조방법
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
AU667766B2 (en) 1993-05-27 1996-04-04 Paul Hartmann Ag Hydrogel wound dressing product
US5330452A (en) 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5728089A (en) * 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5962011A (en) 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5536263A (en) * 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5503843A (en) 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
KR0134151B1 (ko) 1994-05-23 1998-04-14 이형도 인슐린 패치
FR2720003B1 (fr) * 1994-05-23 1998-06-26 Samsung Electro Mech Dispositif servant à inciser la peau pour une médication transcutanée.
KR0134152B1 (ko) 1994-05-23 1998-04-14 이형도 의약품 투여용 피부흠집 형성장치
US5851549A (en) 1994-05-25 1998-12-22 Becton Dickinson And Company Patch, with system and apparatus for manufacture
US5512219A (en) * 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5496304A (en) 1994-07-20 1996-03-05 University Of Utah Research Foundation Surgical marking pen
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) * 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
CA2205444A1 (en) 1994-12-09 1996-06-13 Novartis Ag Transdermal system
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
JP2713255B2 (ja) 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5730721A (en) 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
JP3430771B2 (ja) 1996-02-05 2003-07-28 株式会社デンソー 半導体力学量センサの製造方法
JPH09215755A (ja) 1996-02-09 1997-08-19 Poritoronikusu:Kk 皮接治療具
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
DE69719761T2 (de) 1996-06-18 2003-12-18 Alza Corp., Palo Alto Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
DE19624578A1 (de) 1996-06-20 1998-01-08 Nancy L Divers Vorrichtung zur Hautpflege
AU3880697A (en) 1996-07-03 1998-01-21 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
US5983136A (en) 1996-09-17 1999-11-09 Deka Products Limited Partnership System for delivery of drugs by transport
DE19649100A1 (de) 1996-11-27 1998-06-04 Lohmann Therapie Syst Lts Verfahren zur verlustarmen Herstellung wirkstoffhaltiger scheibenförmiger Formkörper und diese enthaltende transdermale therapeutische Systeme
WO1998028037A1 (en) * 1996-12-20 1998-07-02 Alza Corporation Device and method for enhancing transdermal agent flux
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US5904712A (en) 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6047208A (en) 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5938684A (en) * 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
KR100572539B1 (ko) 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
WO1999029365A1 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
KR100557261B1 (ko) 1997-12-11 2006-03-07 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6024553A (en) * 1997-12-22 2000-02-15 Mcneil-Ppc, Inc. Apparatus for supporting a starting web during formation of the apertured web
EP1041975B1 (de) 1997-12-22 2002-09-04 Alza Corporation Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6120792A (en) 1998-04-29 2000-09-19 Juni; Jack E. Medicated skin patch and method for its use
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
WO2000012173A1 (en) 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
JP2000146777A (ja) 1998-09-08 2000-05-26 Matsushita Electric Ind Co Ltd 検体採取方法、検体採取装置、検体採取用容器、検体測定方法、検体測定装置および検体測定用容器
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
EP1003078A3 (de) 1998-11-17 2001-11-07 Corning Incorporated Verfahren zur Vervielfältigung eines Nanomusters
JP4214584B2 (ja) 1998-11-27 2009-01-28 株式会社デンソー 半導体力学量センサおよびその製造方法
JP2002532165A (ja) 1998-12-18 2002-10-02 メドトロニック ミニメド インコーポレイテッド 医療装置と共に使われる、微小突刺し部材を備える挿入セット及びそのような挿入セットの使用方法
JP2000194142A (ja) 1998-12-25 2000-07-14 Fujitsu Ltd パタ―ン形成方法及び半導体装置の製造方法
JP2000232095A (ja) 1999-02-12 2000-08-22 Nippon Telegr & Teleph Corp <Ntt> 半導体表面の微細パターン形成方法
JP2000232971A (ja) 1999-02-15 2000-08-29 Arkray Inc 吸引浸出液採取方法および装置
US5997549A (en) 1999-02-16 1999-12-07 Sauceda; Charles J. Wart removing tool
US6132449A (en) 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6183770B1 (en) 1999-04-15 2001-02-06 Acutek International Carrier patch for the delivery of agents to the skin
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
JP2000323461A (ja) 1999-05-11 2000-11-24 Nec Corp 微細パターン形成装置、その製造方法、および形成方法
JP4114761B2 (ja) 1999-05-14 2008-07-09 国立大学法人群馬大学 情報記録ディスク用スタンパー、その製造方法、情報記録ディスク、および情報記録ディスク製造方法
EP1187653B1 (de) 1999-06-04 2010-03-31 Georgia Tech Research Corporation Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
JP3654059B2 (ja) 1999-06-25 2005-06-02 松下電工株式会社 赤外線センサーの製造方法
JP3387897B2 (ja) 1999-08-30 2003-03-17 キヤノン株式会社 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20030093089A1 (en) 1999-10-20 2003-05-15 Greenberg Ronald Allan Apparatus for variable micro abrasion of human tissue and/or hides using different size and types of abrasive particles
US6355054B1 (en) 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
EP1239917B1 (de) 1999-12-10 2005-05-11 ALZA Corporation Hautbehandlungsvorrichtung zur verlängerten transdermalen verabreichung von medikamenten
ES2253278T3 (es) 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
AU2088301A (en) 1999-12-16 2001-06-25 Alza Corporation Device for enhancing transdermal flux of sampled agents
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP4001311B2 (ja) 2000-06-01 2007-10-31 株式会社リコー 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
JP2002079499A (ja) * 2000-09-08 2002-03-19 Terumo Corp 針形状物の作製方法および作製された針
CA2357386C (en) 2000-09-15 2009-03-24 Timberjack Inc. High rotation felling head mechanism
MXPA03003303A (es) 2000-10-13 2004-12-13 Johnson & Johnson Retenedor del miembro de microprotrusion para aplicador de impacto.
CZ20031035A3 (cs) 2000-10-13 2004-02-18 Alza Corporation Nárazový aplikátor opatřený množinou mikročepelek
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US6533884B1 (en) * 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
JP3525177B2 (ja) 2000-11-14 2004-05-10 関西ティー・エル・オー株式会社 Ｘ線を用いた材料の加工方法
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US6508947B2 (en) 2001-01-24 2003-01-21 Xerox Corporation Method for fabricating a micro-electro-mechanical fluid ejector
JP3696513B2 (ja) 2001-02-19 2005-09-21 住友精密工業株式会社 針状体の製造方法
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
ATE444773T1 (de) 2001-04-20 2009-10-15 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
US6585742B2 (en) 2001-05-08 2003-07-01 Dowling B. Stough Wart removal method and device
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2002312380A1 (en) 2001-06-08 2002-12-23 Becton, Dickinson And Company Device for manipulating a needle or abrader array
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US20040204669A1 (en) 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
JP5055672B2 (ja) 2001-07-31 2012-10-24 大日本印刷株式会社 薄膜パターン形成用スタンプ
JP4919446B2 (ja) 2001-08-09 2012-04-18 学校法人東京電機大学 微細溝加工方法及びその装置
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
JP2005503210A (ja) 2001-09-14 2005-02-03 ザ プロクター アンド ギャンブル カンパニー 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造
WO2003024290A1 (en) 2001-09-14 2003-03-27 The Procter & Gamble Company Method of exfoliation of skin using closely-packed microstructures and apparatus therefor
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002327675A1 (en) 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030093028A1 (en) 2001-11-09 2003-05-15 Michael Spiegel Appararus and method for magnetic induction of therapeutic electric fields
EP1485317A2 (de) 2001-11-30 2004-12-15 Alza Corporation Verfahren und vorrichtungen zur herstellung von mikroprojektoranordnungen
MXPA04007389A (es) 2002-02-04 2004-10-11 Becton Dickinson Co Dispositivo y metodo para entregar o retirar una substancia a traves de la piel.
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6945952B2 (en) 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
AR040819A1 (es) 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
AU2003270011B8 (en) 2002-08-29 2009-03-05 Becton, Dickinson And Company Substance delivery via rotating microabrading surface
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
JP2007508914A (ja) 2003-10-24 2007-04-12 アルザ・コーポレーシヨン 経皮薬剤送達を促進するための装置及び方法
WO2005044333A2 (en) 2003-10-31 2005-05-19 Alza Corporation Self-actuating applicator for microprojection array
AT500095B8 (de) 2004-01-23 2007-02-15 Braun Werner Mag Transdermales abgabesystem

Also Published As

Publication number Publication date
US6821281B2 (en) 2004-11-23
US20050090803A1 (en) 2005-04-28
ES2250493T3 (es) 2006-04-16
AU2002213167A1 (en) 2002-04-29
ATE304878T1 (de) 2005-10-15
CA2422907A1 (en) 2002-04-25
CA2422909A1 (en) 2002-04-25
EP1326674A2 (de) 2003-07-16
US20020045907A1 (en) 2002-04-18
DE60126637T2 (de) 2007-11-22
DE60126637D1 (de) 2007-03-29
US8216190B2 (en) 2012-07-10
DE60113557T2 (de) 2006-07-13
EP1326673B1 (de) 2007-02-14
CN1665561A (zh) 2005-09-07
ATE353687T1 (de) 2007-03-15
AU2002213168A1 (en) 2002-04-29
WO2002032331A8 (en) 2003-11-13
JP2004521669A (ja) 2004-07-22
CN100528259C (zh) 2009-08-19
WO2002032331A3 (en) 2002-09-06
EP1326674B1 (de) 2005-09-21
ES2281450T3 (es) 2007-10-01
JP2004516868A (ja) 2004-06-10
WO2002032480A3 (en) 2002-08-29
WO2002032331A2 (en) 2002-04-25
US7108681B2 (en) 2006-09-19
CN100427159C (zh) 2008-10-22
EP1326673A2 (de) 2003-07-16
EP1326674B8 (de) 2005-11-23
WO2002032480A2 (en) 2002-04-25
CN1477983A (zh) 2004-02-25
US20020045859A1 (en) 2002-04-18
CA2422909C (en) 2009-02-24
CA2422907C (en) 2009-05-26
WO2002032480A8 (en) 2003-11-13
US20060129174A1 (en) 2006-06-15
JP4676128B2 (ja) 2011-04-27

Similar Documents

Publication Publication Date Title
DE60113557D1 (de) Mikrostrukturen zur kutanen verabreichung eines mittels auf die haut
CA2456626A1 (en) Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7211062B2 (en) Solid solution perforator for drug delivery and other applications
CA2490137C (en) Rapidly dissolving micro-perforator for drug delivery and other applications
AR046307A1 (es) Metodo de pretratamiento y sistema para mejorar la administracion transdermica de drogas
WO1998029134A3 (en) Microporation of tissue for delivery of bioactive agents
MXPA03003815A (es) Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos.
AU2002312380A1 (en) Device for manipulating a needle or abrader array
WO2005051455A3 (en) Ultrasound assisted transdermal vaccine delivery method and system
TW200600132A (en) Frequency assisted transdermal agent delivery method and system
AU3880697A (en) Multiple mechanical microporation of skin or mucosa
BR0312671A (pt) Dispositivo de microagulhas, método para utilizar um dispositivo de microagulhas, e, método para aplicar um dispositivo de microagulhas
TW200602099A (en) Apparatus and method for transdermal delivery of fentanyl-based agents
DE60325949D1 (de) Nadellose spritze zur subkutanen injektion von tropfen von flüssigen wirkstoffen
CA2584638A1 (en) Medical device for generating transient bubbles
KR20170134478A (ko) 인조 마이크로채널을 통해 불투막 또는 반투막을 통과하여 물질을 이동하기 위한 방법 및 시스템
Trelles et al. Transepidermal delivery of cosmeceuticals using radiofrequency and ultrasound: study of the penetration of a cosmetic gel in vivo by fluorescence microscopy
TW200621316A (en) Apparatus and method for transdermal delivery of vascular endothelial growth factors
TW200738252A (en) Apparatus and method for transdermal delivery of Epoetin-based agents
Begum et al. A comprehensive review on laser-assisted drug delivery
Lepselter et al. Ultrasound-assisted drug delivery in fractional cutaneous applications
Oni The Use of Fractionated Ablative Lasers as a Transdermal Microporation Technique
DE60027474D1 (de) Therapeutisches oder diagnostisches markierungsmittelverabreichungssystem zur perkutanen myokardialen reveskulerisation

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: CORIUM INTERNATIONAL, INC., REDWOOD CITY, CALIF.,

8364 No opposition during term of opposition