[go: up one dir, main page]

WO2002011672A3 - Souris transgeniques contenant des disruptions du gene de l'ubiquitine-proteine ligase e3 - Google Patents

Souris transgeniques contenant des disruptions du gene de l'ubiquitine-proteine ligase e3 Download PDF

Info

Publication number
WO2002011672A3
WO2002011672A3 PCT/US2001/024441 US0124441W WO0211672A3 WO 2002011672 A3 WO2002011672 A3 WO 2002011672A3 US 0124441 W US0124441 W US 0124441W WO 0211672 A3 WO0211672 A3 WO 0211672A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
protein ligase
ubiquitin protein
mice containing
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024441
Other languages
English (en)
Other versions
WO2002011672A2 (fr
Inventor
Michael W Leviten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deltagen Inc
Original Assignee
Deltagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc filed Critical Deltagen Inc
Priority to AU2001281052A priority Critical patent/AU2001281052A1/en
Publication of WO2002011672A2 publication Critical patent/WO2002011672A2/fr
Anticipated expiration legal-status Critical
Publication of WO2002011672A3 publication Critical patent/WO2002011672A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des animaux transgéniques, ainsi que des compositions et des procédés liés à la caractérisation de la fonction génique. En particulier, l'invention se rapporte à des souris transgéniques présentant des mutations dans un gène de l'ubiquitine ligase E3. Les souris transgéniques précitées sont utiles comme modèles de maladies et pour identifier des agents modulant l'expression génique et la fonction génique, et comme traitements potentiels de divers états maladifs.
PCT/US2001/024441 2000-08-07 2001-08-03 Souris transgeniques contenant des disruptions du gene de l'ubiquitine-proteine ligase e3 Ceased WO2002011672A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281052A AU2001281052A1 (en) 2000-08-07 2001-08-03 Transgenic mice containing ubiquitin protein ligase e3 gene disruptions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22346100P 2000-08-07 2000-08-07
US60/223,461 2000-08-07

Publications (2)

Publication Number Publication Date
WO2002011672A2 WO2002011672A2 (fr) 2002-02-14
WO2002011672A3 true WO2002011672A3 (fr) 2003-07-10

Family

ID=22836594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024441 Ceased WO2002011672A2 (fr) 2000-08-07 2001-08-03 Souris transgeniques contenant des disruptions du gene de l'ubiquitine-proteine ligase e3

Country Status (2)

Country Link
AU (1) AU2001281052A1 (fr)
WO (1) WO2002011672A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003027122A2 (fr) * 2001-09-07 2003-04-03 Massachusetts Insitute Of Technology Marqueurs de liaison de lanthanides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012962A1 (fr) * 1995-10-04 1997-04-10 Cold Spring Harbor Laboratory Ubiquitine ligases et utilisations associees
WO1999040201A1 (fr) * 1998-02-05 1999-08-12 Astrazeneca Uk Limited Proteine
WO2000012679A1 (fr) * 1998-08-28 2000-03-09 New York University Nouvelles ubiquitine ligases utiles comme cibles therapeutiques
WO2000032787A1 (fr) * 1998-12-01 2000-06-08 The University Of Leeds Agents therapeutiques a base d'e3 ubiquitine ligase destines a etre utilises dans des affections degeneratives
WO2000034447A2 (fr) * 1998-12-10 2000-06-15 Signal Pharmaceuticals, Inc. COMPOSES ET METHODES PERMETTANT DE MODULER L'ACTIVATION DE NF-λB

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012962A1 (fr) * 1995-10-04 1997-04-10 Cold Spring Harbor Laboratory Ubiquitine ligases et utilisations associees
WO1999040201A1 (fr) * 1998-02-05 1999-08-12 Astrazeneca Uk Limited Proteine
WO2000012679A1 (fr) * 1998-08-28 2000-03-09 New York University Nouvelles ubiquitine ligases utiles comme cibles therapeutiques
WO2000032787A1 (fr) * 1998-12-01 2000-06-08 The University Of Leeds Agents therapeutiques a base d'e3 ubiquitine ligase destines a etre utilises dans des affections degeneratives
WO2000034447A2 (fr) * 1998-12-10 2000-06-15 Signal Pharmaceuticals, Inc. COMPOSES ET METHODES PERMETTANT DE MODULER L'ACTIVATION DE NF-λB

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALBERTS B ET AL: "MOLECULAR BIOLOGY OF THE CELL, PASSAGE", MOLECULAR BIOLOGY OF THE CELL, NEW YORK, GARLAND PUBLISHING, US, 1994, XP002227010, ISBN: 0-8153-1620-8 *
D'ADREA ET AL: "relieving the itch", NATURE GENETICS, NEW YORK, NY, US, vol. 18, no. 2, February 1998 (1998-02-01), pages 97 - 99, XP002103348, ISSN: 1061-4036 *
KWON YONG TAE ET AL: "Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.", MOLECULAR AND CELLULAR BIOLOGY, vol. 21, no. 23, December 2001 (2001-12-01), pages 8007 - 8021, XP001071151, ISSN: 0270-7306 *
KWON YONG TAE ET AL: "The mouse and human genes encoding the recognition component of the N-end rule pathway.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 14, 7 July 1998 (1998-07-07), July 7, 1998, pages 7898 - 7903, XP002232703, ISSN: 0027-8424 *
PATTON E E ET AL: "Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 14, no. 6, June 1998 (1998-06-01), pages 236 - 243, XP002136980, ISSN: 0168-9525 *
PERRY ET AL: "the itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice", NATURE GENETICS, NEW YORK, NY, US, vol. 18, no. 2, February 1998 (1998-02-01), pages 143 - 146, XP002103109, ISSN: 1061-4036 *
ROLFE M ET AL: "The ubiquitin-mediated proteolytic pathway as a therapeutic area", JOURNAL OF MOLECULAR MEDICINE, SPRINGER VERLAG, DE, vol. 75, 1997, pages 5 - 17, XP002082283, ISSN: 0946-2716 *
STELLA MARIA CRISTINA ET AL: "HGF: A multifunctional growth factor controlling cell scattering.", INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 31, no. 12, December 1999 (1999-12-01), pages 1357 - 1362, XP001146229, ISSN: 1357-2725 *
WEISSMAN A M: "Regulating protein degradation by ubiquitination", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 18, no. 4, 1 April 1997 (1997-04-01), pages 189 - 198, XP004058356, ISSN: 0167-5699 *

Also Published As

Publication number Publication date
WO2002011672A2 (fr) 2002-02-14
AU2001281052A1 (en) 2002-02-18

Similar Documents

Publication Publication Date Title
WO2002079440A8 (fr) Souris transgeniques contenant des ruptures du gene gpcr5-1
WO2002079424A3 (fr) SOURIS TRANSGENIQUES CONTENANT DES DISRUPTIONS DE GENES Gβ3GALT2
WO2002046390A3 (fr) Souris transgeniques a disruptions geniques de tyrosine phosphatase rptpb
WO2002079438A3 (fr) Disruptions du gene ogr1, compositions et procedes associes
WO2003026401A3 (fr) Disruptions du gene kv3.3b du canal potassique, compositions et methodes associees
WO2002079439A3 (fr) Souris transgeniques presentant des disruptions du gene mglur7 du recepteur de glutamate metabotropique
WO2003026395A3 (fr) Disruptions geniques mo54, compositions et procedes correspondants
WO2002045498A3 (fr) Souris transgenique presentant des disruptions geniques ciblees de proteine canal
WO2001067855A3 (fr) Souris transgeniques contenant des interruptions de genes ciblees
WO2002081658A3 (fr) Souris transgeniques comportant des disruptions geniques sur le canal des ions calcium cacnb4
WO2002040662A3 (fr) Souris transgenique contenant des disruptions geniques ciblees
WO2002011672A3 (fr) Souris transgeniques contenant des disruptions du gene de l'ubiquitine-proteine ligase e3
WO2002037957A3 (fr) Souris transgeniques contenant des disruptions geniques de la proteine kinase de perk
WO2002001950A3 (fr) Souris transgeniques contenant des interruptions de genes cibles
WO2002079412A3 (fr) Souris transgenique presentant des disruption geniques dues a la presence d'une enzyme de desubiquitination de type usp3
WO2002003788A3 (fr) Souris transgeniques contenant des disruptions ciblees du gene de la phosphatase
WO2002003793A3 (fr) Souris transgeniques contenant des disruptions genetiques ciblees
WO2003026403A3 (fr) Disruptions du gene ctsz, compositions et methodes correspondantes
WO2002057438A3 (fr) Souris transgeniques contenant des disruptions geniques de proteine interagissant avec le recepteur de retinoide x
WO2002079420A3 (fr) Disruptions d'un gene de protease de type adam, compositions et procedes connexes
WO2002085094A3 (fr) Souris transgeniques porteuses de disruptions dans un gene de l'acylphosphatase
WO2002048346A3 (fr) Souris transgeniques contenant des disruptions geniques d'une proteine a ancrage membranaire specifique du cerveau
WO2002079378A3 (fr) Souris transgeniques contenant des fractionnements de proteine transmembranaire de type gpcr
WO2002046391A3 (fr) Souris transgeniques contenant des interruptions de gene nor1
WO2002003787A3 (fr) Souris transgéniques contenant des disruptions géniques ciblées

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP