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WO2002011672A3 - Transgenic mice containing ubiquitin protein ligase e3 gene disruptions - Google Patents

Transgenic mice containing ubiquitin protein ligase e3 gene disruptions Download PDF

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Publication number
WO2002011672A3
WO2002011672A3 PCT/US2001/024441 US0124441W WO0211672A3 WO 2002011672 A3 WO2002011672 A3 WO 2002011672A3 US 0124441 W US0124441 W US 0124441W WO 0211672 A3 WO0211672 A3 WO 0211672A3
Authority
WO
WIPO (PCT)
Prior art keywords
transgenic mice
protein ligase
ubiquitin protein
mice containing
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/024441
Other languages
French (fr)
Other versions
WO2002011672A2 (en
Inventor
Michael W Leviten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deltagen Inc
Original Assignee
Deltagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deltagen Inc filed Critical Deltagen Inc
Priority to AU2001281052A priority Critical patent/AU2001281052A1/en
Publication of WO2002011672A2 publication Critical patent/WO2002011672A2/en
Anticipated expiration legal-status Critical
Publication of WO2002011672A3 publication Critical patent/WO2002011672A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • C12Y603/02019—Ubiquitin-protein ligase (6.3.2.19), i.e. ubiquitin-conjugating enzyme
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an ubiquitin ligase EC gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.
PCT/US2001/024441 2000-08-07 2001-08-03 Transgenic mice containing ubiquitin protein ligase e3 gene disruptions Ceased WO2002011672A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281052A AU2001281052A1 (en) 2000-08-07 2001-08-03 Transgenic mice containing ubiquitin protein ligase e3 gene disruptions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22346100P 2000-08-07 2000-08-07
US60/223,461 2000-08-07

Publications (2)

Publication Number Publication Date
WO2002011672A2 WO2002011672A2 (en) 2002-02-14
WO2002011672A3 true WO2002011672A3 (en) 2003-07-10

Family

ID=22836594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024441 Ceased WO2002011672A2 (en) 2000-08-07 2001-08-03 Transgenic mice containing ubiquitin protein ligase e3 gene disruptions

Country Status (2)

Country Link
AU (1) AU2001281052A1 (en)
WO (1) WO2002011672A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1436409A2 (en) * 2001-09-07 2004-07-14 Massachusetts Institute Of Technology Lanthanide binding tags

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012962A1 (en) * 1995-10-04 1997-04-10 Cold Spring Harbor Laboratory Ubiquitin ligases, and uses related thereto
WO1999040201A1 (en) * 1998-02-05 1999-08-12 Astrazeneca Uk Limited Protein
WO2000012679A1 (en) * 1998-08-28 2000-03-09 New York University Novel ubiquitin ligases as therapeutic targets
WO2000032787A1 (en) * 1998-12-01 2000-06-08 The University Of Leeds Therapeutic agents comprising an e3 ubiquitin ligase for use in degenerative disorders
WO2000034447A2 (en) * 1998-12-10 2000-06-15 Signal Pharmaceuticals, Inc. Human ubiquitin ligase e3 for the modulation of nf-kappa b

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997012962A1 (en) * 1995-10-04 1997-04-10 Cold Spring Harbor Laboratory Ubiquitin ligases, and uses related thereto
WO1999040201A1 (en) * 1998-02-05 1999-08-12 Astrazeneca Uk Limited Protein
WO2000012679A1 (en) * 1998-08-28 2000-03-09 New York University Novel ubiquitin ligases as therapeutic targets
WO2000032787A1 (en) * 1998-12-01 2000-06-08 The University Of Leeds Therapeutic agents comprising an e3 ubiquitin ligase for use in degenerative disorders
WO2000034447A2 (en) * 1998-12-10 2000-06-15 Signal Pharmaceuticals, Inc. Human ubiquitin ligase e3 for the modulation of nf-kappa b

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALBERTS B ET AL: "MOLECULAR BIOLOGY OF THE CELL, PASSAGE", MOLECULAR BIOLOGY OF THE CELL, NEW YORK, GARLAND PUBLISHING, US, 1994, XP002227010, ISBN: 0-8153-1620-8 *
D'ADREA ET AL: "relieving the itch", NATURE GENETICS, NEW YORK, NY, US, vol. 18, no. 2, February 1998 (1998-02-01), pages 97 - 99, XP002103348, ISSN: 1061-4036 *
KWON YONG TAE ET AL: "Construction and analysis of mouse strains lacking the ubiquitin ligase UBR1 (E3alpha) of the N-end rule pathway.", MOLECULAR AND CELLULAR BIOLOGY, vol. 21, no. 23, December 2001 (2001-12-01), pages 8007 - 8021, XP001071151, ISSN: 0270-7306 *
KWON YONG TAE ET AL: "The mouse and human genes encoding the recognition component of the N-end rule pathway.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 14, 7 July 1998 (1998-07-07), July 7, 1998, pages 7898 - 7903, XP002232703, ISSN: 0027-8424 *
PATTON E E ET AL: "Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 14, no. 6, June 1998 (1998-06-01), pages 236 - 243, XP002136980, ISSN: 0168-9525 *
PERRY ET AL: "the itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice", NATURE GENETICS, NEW YORK, NY, US, vol. 18, no. 2, February 1998 (1998-02-01), pages 143 - 146, XP002103109, ISSN: 1061-4036 *
ROLFE M ET AL: "The ubiquitin-mediated proteolytic pathway as a therapeutic area", JOURNAL OF MOLECULAR MEDICINE, SPRINGER VERLAG, DE, vol. 75, 1997, pages 5 - 17, XP002082283, ISSN: 0946-2716 *
STELLA MARIA CRISTINA ET AL: "HGF: A multifunctional growth factor controlling cell scattering.", INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 31, no. 12, December 1999 (1999-12-01), pages 1357 - 1362, XP001146229, ISSN: 1357-2725 *
WEISSMAN A M: "Regulating protein degradation by ubiquitination", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 18, no. 4, 1 April 1997 (1997-04-01), pages 189 - 198, XP004058356, ISSN: 0167-5699 *

Also Published As

Publication number Publication date
WO2002011672A2 (en) 2002-02-14
AU2001281052A1 (en) 2002-02-18

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