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WO2000018362A1 - Hair growth stimulant - Google Patents

Hair growth stimulant Download PDF

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Publication number
WO2000018362A1
WO2000018362A1 PCT/ZA1999/000102 ZA9900102W WO0018362A1 WO 2000018362 A1 WO2000018362 A1 WO 2000018362A1 ZA 9900102 W ZA9900102 W ZA 9900102W WO 0018362 A1 WO0018362 A1 WO 0018362A1
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
gestagen
composition
hair
progesterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ZA1999/000102
Other languages
French (fr)
Inventor
Gavin Deon Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PETERSEN SHARLEEN CARON
Original Assignee
PETERSEN SHARLEEN CARON
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PETERSEN SHARLEEN CARON filed Critical PETERSEN SHARLEEN CARON
Priority to AU64349/99A priority Critical patent/AU6434999A/en
Publication of WO2000018362A1 publication Critical patent/WO2000018362A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Definitions

  • This invention relates to a pharmaceutical composition for the therapeutic and prophylactic treatment of hair loss and extends to a composition for use in the manufacture of such a pharmaceutical composition and to a method of treating hair loss.
  • Baldness or the loss of hair is a condition which affects many men, particularly in later life. This is known as male pattern baldness. Hair loss can also result from any one of a number of disease treatment regimes, the most common being chemotherapy which is used to treat certain forms of cancer. Whatever the cause, hair loss often causes psychological problems.
  • compositions which do, at least partially, stimulate hair growth tend to have, as active ingredients, alpha-reductase inhibitors and one such composition utilises a vitamin A complex.
  • Gestagens a group of female sex hormones produced during the ovarian cycle and during pregnancy, have been used as a contraceptive where they act by simulating pregnancy and preventing ovulation.
  • the primary gestagens are oestrogens and progesterones. When so used the gestagens are administered orally in tablet form or they are injected intramuscularly to avoid having to ingest an oral dose most days of the ovarian cycle.
  • Gestagens are also used in certain circumstances to combat hurstitutness or excessive body hair. In such cases it is also ingested orally. To the best of the applicant's knowledge, there are no cases of gestagens being used to promote or stimulate hair growth.
  • a pharmaceutical composition for use in treating hair loss comprising a gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable to an area where stimulation of hair growth is desired.
  • the gestagen is also provided for the gestagen to be an oestrogen, preferably a synthetic oestrogen.
  • the gestagen is a progesterone, preferably a synthetic progesterone, further preferably medroxyprogesterone, and particularly medroxyprogesterone acetate.
  • adjuvants and additives are commonly found in lotions, particularly hair lotions, shampoos, hair conditioners and the like.
  • composition to be usable for therapeutic and/or prophylactic treatment of hair loss.
  • said pharmaceutical composition to an area of said mammal where stimulation of hair growth is desired.
  • the gestagen is also provided for the gestagen to be an oestrogen, preferably a synthetic oestrogen.
  • the gestagen is a progesterone, preferably a synthetic progesterone, further preferably medroxyprogesterone, and particularly medroxyprogesterone acetate.
  • adjuvants and additives are commonly found in lotions, particularly hair lotions, shampoos, hair conditioners and the like.
  • composition to be usable for therapeutic and/or prophylactic treatment of hair loss.
  • a method of treating hair loss in a mammal comprising topically administering, to said mammal, a composition comprising a gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable.
  • the gestagen is also provided for the gestagen to be an oestrogen, preferably a synthetic oestrogen.
  • the gestagen is a progesterone, preferably a synthetic progesterone, further preferably medroxyprogesterone, and particularly medroxyprogesterone acetate.
  • adjuvants and additives are commonly found in lotions, particularly hair lotions, shampoos, hair conditioners and the like.
  • composition to be usable for therapeutic and/or prophylactic treatment of hair loss.
  • synthetically manufactured medroxyprogesterone acetate is used as the active ingredient or gestagen.
  • the shampoo is used in the normal way to wash one's hair.
  • regular twice weekly washing resulted in an increase in hair density and an increase in the rate of hair growth.
  • synthetically manufactured medroxyprogesterone acetate is mixed with polyethylene glycol and water.
  • concentration of medroxyprogesterone acetate is between 0.1% and 5% by volume.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

This invention relates to a composition for stimulating hair growth. The composition uses, as an active ingredient, a gestagen, preferably synthetic medroxyprogesterone acetate. The active ingredient is mixed with such adjuvants and additives as are necessary to render it topically applicable as a lotion or a shampoo. The invention extends to a method of treating hair loss.

Description

HAIR GROWTH STIMULANT
FIELD OF THE INVENTION
This invention relates to a pharmaceutical composition for the therapeutic and prophylactic treatment of hair loss and extends to a composition for use in the manufacture of such a pharmaceutical composition and to a method of treating hair loss.
BACKGROUND TO THE INVENTION
Baldness or the loss of hair is a condition which affects many men, particularly in later life. This is known as male pattern baldness. Hair loss can also result from any one of a number of disease treatment regimes, the most common being chemotherapy which is used to treat certain forms of cancer. Whatever the cause, hair loss often causes psychological problems.
A vast number of proprietary remedies claiming to promote hair growth are marketed but very few of these achieve the desired results. Compositions which do, at least partially, stimulate hair growth tend to have, as active ingredients, alpha-reductase inhibitors and one such composition utilises a vitamin A complex.
Gestagens, a group of female sex hormones produced during the ovarian cycle and during pregnancy, have been used as a contraceptive where they act by simulating pregnancy and preventing ovulation. The primary gestagens are oestrogens and progesterones. When so used the gestagens are administered orally in tablet form or they are injected intramuscularly to avoid having to ingest an oral dose most days of the ovarian cycle. Gestagens are also used in certain circumstances to combat hurstitutness or excessive body hair. In such cases it is also ingested orally. To the best of the applicant's knowledge, there are no cases of gestagens being used to promote or stimulate hair growth.
OBJECT OF THE INVENTION
It is an object of this invention to provide a pharmaceutical composition for use in the treatment of hair loss, to provide a composition for use in the manufacture of such a pharmaceutical composition and to provide a method of treating hair loss and particularly male pattern baldness.
SUMMARY OF THE INVENTION
in accordance with this invention there is provided a pharmaceutical composition for use in treating hair loss said composition comprising a gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable to an area where stimulation of hair growth is desired.
There is also provided for the gestagen to be an oestrogen, preferably a synthetic oestrogen. Alternatively there is provided for the gestagen to be a progesterone, preferably a synthetic progesterone, further preferably medroxyprogesterone, and particularly medroxyprogesterone acetate.
There is further provided for the adjuvants and additives to be such as are commonly found in lotions, particularly hair lotions, shampoos, hair conditioners and the like.
There is also provided for the composition to be usable for therapeutic and/or prophylactic treatment of hair loss.
In accordance with another aspect of this invention there is provided the use of a gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable in a method of preparing a pharmaceutical composition for use in a method of treating hair loss in a mammal comprising topically applying WO 00/18362 " d " PCT/ZA99/00102
said pharmaceutical composition to an area of said mammal where stimulation of hair growth is desired.
There is also provided for the gestagen to be an oestrogen, preferably a synthetic oestrogen. Alternatively there is provided for the gestagen to be a progesterone, preferably a synthetic progesterone, further preferably medroxyprogesterone, and particularly medroxyprogesterone acetate.
There is further provided for the adjuvants and additives to be such as are commonly found in lotions, particularly hair lotions, shampoos, hair conditioners and the like.
There is also provided for the composition to be usable for therapeutic and/or prophylactic treatment of hair loss.
According to another aspect of the invention there is provided a method of treating hair loss in a mammal comprising topically administering, to said mammal, a composition comprising a gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable.
There is also provided for the gestagen to be an oestrogen, preferably a synthetic oestrogen. Alternatively there is provided for the gestagen to be a progesterone, preferably a synthetic progesterone, further preferably medroxyprogesterone, and particularly medroxyprogesterone acetate.
There is further provided for the adjuvants and additives to be such as are commonly found in lotions, particularly hair lotions, shampoos, hair conditioners and the like.
There is also provided for the composition to be usable for therapeutic and/or prophylactic treatment of hair loss.
DESCRIPTION OF EMBODIMENTS
In a first preferred embodiment of the invention synthetically manufactured medroxyprogesterone acetate is used as the active ingredient or gestagen. This as mixed with a commercially available hair shampoo in a concentration of between 0.1% and 5% by volume. The shampoo is used in the normal way to wash one's hair. In trial experiments performed by the applicant, regular twice weekly washing resulted in an increase in hair density and an increase in the rate of hair growth.
in a second preferred embodiment of the invention, synthetically manufactured medroxyprogesterone acetate is mixed with polyethylene glycol and water. The concentration of medroxyprogesterone acetate is between 0.1% and 5% by volume. This composition is applied to the scalp of an individual suffering from hair loss twice weekly and it is rubbed in well. It has been found that this treatment produces significant hair growth.

Claims

1. A pharmaceutical composition for use in treating hair loss comprising a gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable to an area where stimulation of hair growth is desired.
2. A pharmaceutical composition as claimed in claim 1 in which the gestagen is an oestrogen.
3. A pharmaceutical composition as claimed in claim 2 in which the oestrogen is a synthetic oestrogen.
4. A pharmaceutical composition as claimed in claim 1 in which the gestagen is a progesterone.
5. A pharmaceutical composition as claimed in claim 4 in which the progesterone is a synthetic progesterone.
6. A pharmaceutical composition as claimed in claim 5 in which the synthetic progesterone is medroxyprogesterone.
7. A pharmaceutical composition as claimed in claim 6 in which the medroxyprogesterone is medroxyprogesterone acetate.
8. A pharmaceutical composition as claimed in any one of the previous claims in which the adjuvants and additives are such as are commonly found in cosmetic preparations, particularly hair lotions, shampoos, hair conditioners and the like.
9. A pharmaceutical composition as claimed in any one of the previous claims in which the composition is usable for therapeutic and/or prophylactic treatment of hair loss.
10. A pharmaceutical composition substantially as herein described with reference to and as embodied in the preferred embodiments of the invention.
11. A gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable for use in a method of preparing a pharmaceutical composition for use in a method of treating hair loss in a mammal comprising topically applying said pharmaceutical composition to an area of said mammal where stimulation of hair growth is desired.
12. The use as claimed in claim 11 in which the gestagen is an oestrogen.
13. The use as claimed in claim 12 in which the oestrogen is a synthetic oestrogen.
14. The use as claimed in claim 11 in which in which the gestagen is a progesterone.
15. The use as claimed in claim 14 in which the progesterone is a synthetic progesterone.
16. The use as claimed in claim 15 in which the synthetic progesterone is medroxyprogesterone.
17. The use as claimed in claim 16 in which the medroxyprogesterone is medroxyprogesterone acetate.
18. The use as claimed in any one of the previous claims in which the adjuvants and additives are such as are commonly found in cosmetic preparations, particularly hair lotions, shampoos, hair conditioners and the like.
19. The use as claimed in any one of the previous claims in which the composition is usable for therapeutic and/or prophylactic treatment of hair loss.
20. A gestagen or a pharmaceutically acceptable salt or ester thereof together with such adjuvants and additives as are necessary to render the composition topically applicable for use in a method of preparing a pharmaceutical composition substantially as herein described with reference to and as embodied in the preferred embodiments of the invention.
21. A method of treating hair loss in a mammal comprising topically administering, to said mammal, a pharmaceutical composition as claimed in any one of claims 1 to 10.
PCT/ZA1999/000102 1998-09-28 1999-09-28 Hair growth stimulant Ceased WO2000018362A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU64349/99A AU6434999A (en) 1998-09-28 1999-09-28 Hair growth stimulant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA987846 1998-09-28
ZA98/7846 1998-09-28

Publications (1)

Publication Number Publication Date
WO2000018362A1 true WO2000018362A1 (en) 2000-04-06

Family

ID=25587241

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ZA1999/000102 Ceased WO2000018362A1 (en) 1998-09-28 1999-09-28 Hair growth stimulant

Country Status (2)

Country Link
AU (1) AU6434999A (en)
WO (1) WO2000018362A1 (en)

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE727044A (en) * 1968-01-17 1969-07-17
DE2757024A1 (en) * 1977-12-21 1979-06-28 Juergen Prof Dr Med Tamm Hair and skin cosmetics - contg. 11-alpha-hydroxy-progesterone
DE2840144A1 (en) * 1978-09-15 1980-03-27 Goedecke Ag Topical antiandrogen contg. progesterone and a gestagen - synergistic mixt. effective even against severe local hormone disturbances such as alopecia
US4272508A (en) * 1979-03-30 1981-06-09 Jurgen Tamm Cosmetics for treatment of hair and skin
EP0123528A1 (en) * 1983-04-19 1984-10-31 Christopher Harry Dr. Mortimer Pharmaceutical composition for the treatment of hair loss
GB2144991A (en) * 1983-08-11 1985-03-20 Yoshiaki Oshima Hair growth promotor
EP0163489A1 (en) * 1984-05-22 1985-12-04 Christopher Harry Dr. Mortimer Treatment of female hair loss
JPS61183209A (en) * 1985-02-09 1986-08-15 Lion Corp Hair tonic
DE3535509A1 (en) * 1985-10-02 1987-04-09 Schering Ag Pharmaceutical products
WO1996001099A1 (en) * 1994-07-06 1996-01-18 Sinvent As Composition for treatment of male hair loss
JPH0873327A (en) * 1994-09-03 1996-03-19 Hideyo Uji Hair-growing agent composition
JPH0873328A (en) * 1994-09-05 1996-03-19 Hideyo Uji Hair-growing agent composition
DE19534209A1 (en) * 1995-09-15 1997-03-20 Jenapharm Gmbh Hormonal agent for the treatment of the skin

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE727044A (en) * 1968-01-17 1969-07-17
DE2757024A1 (en) * 1977-12-21 1979-06-28 Juergen Prof Dr Med Tamm Hair and skin cosmetics - contg. 11-alpha-hydroxy-progesterone
DE2840144A1 (en) * 1978-09-15 1980-03-27 Goedecke Ag Topical antiandrogen contg. progesterone and a gestagen - synergistic mixt. effective even against severe local hormone disturbances such as alopecia
US4272508A (en) * 1979-03-30 1981-06-09 Jurgen Tamm Cosmetics for treatment of hair and skin
EP0123528A1 (en) * 1983-04-19 1984-10-31 Christopher Harry Dr. Mortimer Pharmaceutical composition for the treatment of hair loss
GB2144991A (en) * 1983-08-11 1985-03-20 Yoshiaki Oshima Hair growth promotor
EP0163489A1 (en) * 1984-05-22 1985-12-04 Christopher Harry Dr. Mortimer Treatment of female hair loss
JPS61183209A (en) * 1985-02-09 1986-08-15 Lion Corp Hair tonic
DE3535509A1 (en) * 1985-10-02 1987-04-09 Schering Ag Pharmaceutical products
WO1996001099A1 (en) * 1994-07-06 1996-01-18 Sinvent As Composition for treatment of male hair loss
JPH0873327A (en) * 1994-09-03 1996-03-19 Hideyo Uji Hair-growing agent composition
JPH0873328A (en) * 1994-09-05 1996-03-19 Hideyo Uji Hair-growing agent composition
DE19534209A1 (en) * 1995-09-15 1997-03-20 Jenapharm Gmbh Hormonal agent for the treatment of the skin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198639, Derwent World Patents Index; Class D21, AN 1986-255369, XP002132195 *
DATABASE WPI Section Ch Week 199621, Derwent World Patents Index; Class B01, AN 1996-205417, XP002132196 *
PATENT ABSTRACTS OF JAPAN vol. 1996, no. 07 31 July 1996 (1996-07-31) *

Also Published As

Publication number Publication date
AU6434999A (en) 2000-04-17

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