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WO1999010763A1 - Support d'echantillons pouvant etre traite par informatique et procede d'analyse des echantillons - Google Patents

Support d'echantillons pouvant etre traite par informatique et procede d'analyse des echantillons Download PDF

Info

Publication number
WO1999010763A1
WO1999010763A1 PCT/EP1998/005227 EP9805227W WO9910763A1 WO 1999010763 A1 WO1999010763 A1 WO 1999010763A1 EP 9805227 W EP9805227 W EP 9805227W WO 9910763 A1 WO9910763 A1 WO 9910763A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
sample holder
data
electronic circuit
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/005227
Other languages
German (de)
English (en)
Inventor
Ulrich Schenck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenoptik AG
Carl Zeiss Jena GmbH
Original Assignee
VEB Carl Zeiss Jena GmbH
Carl Zeiss Jena GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VEB Carl Zeiss Jena GmbH, Carl Zeiss Jena GmbH filed Critical VEB Carl Zeiss Jena GmbH
Priority to EP98946366A priority Critical patent/EP1034450A1/fr
Publication of WO1999010763A1 publication Critical patent/WO1999010763A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00782—Type of codes reprogrammmable code

Definitions

  • the invention relates to a data processing-capable microscopy sample holder and to a method for analyzing microscopic samples and data processing-compatible microcospice sample holders.
  • sample carriers are used to hold samples or preparations that can be examined microscopically or in another way, in particular non-destructively.
  • the preparations / samples can e.g. are tissue parts or fluids of the human body that are to be examined for cancer detection.
  • sample carriers are labeled. So far, the sample carriers have been provisionally labeled with a pen immediately after the sample has been applied to them, and only later, when they are examined in the laboratory, provided with permanent identification. It is common for this to be done with special pens directly on the sample holder or on labels that are attached to the sample holder. Label stickers with machine-readable bar codes are also increasingly being used. Please refer to the article "AccuMed International, Inc. Meeting in the Challenges in Cervical Cancer Screening: The AcCell Series 2000 Automated Slide Handling and Data Management System", published in Acta Cytol. 40, No.l, 1 996, S 26-30.
  • the machine-readable label stickers already allow the sample holder concerned to be automatically recognized at the various work stations, but they are not used to record or process further data.
  • the data belonging to the preparation or the case, such as patient data, examination results etc., must be stored separately on paper or in a database. Even in the case of EDP networking of the various stations of the examination with the database, the spatial separation of the sample carrier from the associated data is disadvantageous, since access to the database requires access to the data network.
  • the object of the present invention is therefore to provide a data processing-capable sample carrier and a method for analyzing samples which offer expanded possibilities for data storage.
  • the data processing-capable microscopy sample carrier has two areas, a first area of which is intended for the permanent acceptance of a microscopic sample and a second area is used to identify the sample, and an electronic circuit designed as a microchip with a writable, readable, non-volatile memory fitted.
  • the sample carrier is advantageously a flat plate.
  • at least one area can be transparent to the wavelength range of an analysis device.
  • the analysis device is an optical microscope
  • the sample carrier can be made of glass, for example.
  • the electronic circuit is advantageously implemented as a microchip.
  • the electronic circuit can essentially consist of a microchip (for example a "smart chip") with a non-volatile memory.
  • the electronic circuit can be equipped with contacts which can be used to write and read data into and out of the circuit.
  • the writing in and reading out of data can be implemented in another way, in particular inductively, capacitively or optically.
  • the data need not be text data alone.
  • the data can also contain image information and / or speech information relating to the sample.
  • the electronic circuit can include a microprocessor.
  • the memory can contain a control program for the microprocessor.
  • the memory can then also contain an application program for analyzing the sample by the electronic circuit.
  • the electronic circuit can be detachably connected to the sample holder.
  • the sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample holder, data and / or programs relating to the sample being stored in the second area in the electronic circuit.
  • the sample carrier can advantageously be used in such a way that the electronic circuit is read out in a data processing system and that read out data and / or programs are used for an analysis, for example in medical diagnostics.
  • sample holder according to the invention results from the fact that the sample and the electronic circuit on the sample holder according to the invention have a defined spatial relationship to one another. Distances or dimensions of structures (for example of conductor tracks of a chip of the electronic circuit) can be used as calibration objects for the analysis device, for example for determining the optical magnification. Furthermore, the chip surface be used for a brightness or color balance of the analysis device. Then complex additional calibration objects can be omitted.
  • the invention has a number of further advantages.
  • the sample can be identified exchanger easier and more reliable than is possible in the prior Tech ⁇ technology.
  • the data is always translated together with the Probetragern because sample and associated data on the same samples exchanger, so that separation is prevented in different units befin ⁇ .
  • the formation can thus be transported patient in ⁇ "paperless” together with the sample, and it can be a smart and economic control of the sample flow can be realized.
  • FIG. 1 shows a first exemplary embodiment of the sample carrier according to the invention
  • the sample transducer has two regions 1 and 2, of which the first portion 1 to the On ⁇ exception of sample 1 1 is determined and the second area 2 for the identification of Pro ⁇ be 1 1 is used, wherein the second region 2 having a writable and elec tronic readable ⁇ circuit 21 is provided.
  • the sample holder is designed as a flat plate.
  • the electronic circuit 21 is implemented as a microchip, which is equipped with contacts 210, with the aid of which the writing and reading of data into and from the circuit 21 is made possible.
  • the circuit 21 contains the circuit components required for reading in and reading out and a correspondingly designed memory 21 1 for recording and storing the data.
  • the memory is a non-volatile rewritable memory which is known per se.
  • the electronic circuit 21 can be assigned to the sample holder permanently or only temporarily.
  • the data are sample-related and / or patient-related data.
  • the data to be stored in the memory 21 1 are not limited to text data such as accompanying information (identification of the sample, type of sample, patient or personal data). If there is sufficient storage capacity, storage space can be provided to accommodate a variety of additional data. Examples for this are:
  • Coordinates of reference points for the microscope on the sample surface - coordinate-specific assignments of examinations and examination results (multi-dimensional mapping information) such as Cell landscapes, nuclear, gene or protein landscapes, images of the samples.
  • the electronic circuit 21 additionally contains a microprocessor.
  • the memory 21 1 contains an operating program assigned to the microprocessor.
  • an application program is contained in the memory 21 1, which is used to analyze the sample in question.
  • each sample carrier carries the software associated with sample 1 with it, which additionally increases the reliability of sample analyzes carried out at distributed locations.
  • the electronic circuit 21 is equipped with a unit for querying an access authorization for access to the data contained in the electronic circuit 21.
  • a "password query” implemented in this way, data protection can be taken into account on the one hand, and on the other hand the data can be better protected against unauthorized changes.
  • sample-related data are written into a writable and readable electronic circuit 21 attached to the sample holder, the sample holder being able to be manipulated as desired after the analysis, for example for archiving purposes.
  • a sample applied to the sample holder e.g. Tissue sample, microscopically imaged for analysis and the microscopic image graphically processed in a microprocessor and the graphically processed image information written into the electronic circuit.
  • the sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample carrier, data relating to the sample being stored in the electronic circuit.
  • the sample carrier according to the invention can also be used for the automated examination of the samples. Then the examination devices (e.g. microscope) are to be equipped with appropriate control devices which can access the data stored in the microchips.
  • the examination devices e.g. microscope
  • appropriate control devices which can access the data stored in the microchips.
  • the examination device 5 here consists of a microscope which is coupled to a camera.
  • the microchip 21 is written with data and the data is read out by a data reader / writer 6, which is assigned to the examination device 5.
  • the data reader / writer 6 can be coupled to the examination device 5 (online processing) or can be implemented separately (offline processing).
  • the data input / output or control of the device can take place via a data processing system 7, which can be designed as a computer with peripheral devices.
  • the sample carrier can advantageously be used in such a way that the content of the memory 21 1 of the electronic circuit 21 is read in a data processing system and that the content read out is evaluated there for analysis. Furthermore, the sample carrier according to the invention can also be used advantageously in personnel training. For example, interactive lessons can be designed based on the data contained in the microchip of the sample holder.
  • the sample holder according to the invention is multimedia-capable.

Landscapes

  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un support d'échantillons pouvant être traité par informatique. Ce support présente deux zones (1, 2), la première (1) étant destinée à recevoir l'échantillon (11) et la seconde (2) à identifier l'échantillon (11). La seconde zone (2) est équipée d'une mémoire non volatile (211), pouvant être lue et écrite, p.ex. une puce intelligente.
PCT/EP1998/005227 1997-08-21 1998-08-18 Support d'echantillons pouvant etre traite par informatique et procede d'analyse des echantillons Ceased WO1999010763A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP98946366A EP1034450A1 (fr) 1997-08-21 1998-08-18 Support d'echantillons pouvant etre traite par informatique et procede d'analyse des echantillons

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1997136470 DE19736470C2 (de) 1997-08-21 1997-08-21 Datenverarbeitungsfähiger Mikroskopie-Probenträger und Verfahren zur Analyse von mikroskopierbaren Proben
DE19736470.5 1997-08-21

Publications (1)

Publication Number Publication Date
WO1999010763A1 true WO1999010763A1 (fr) 1999-03-04

Family

ID=7839776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1998/005227 Ceased WO1999010763A1 (fr) 1997-08-21 1998-08-18 Support d'echantillons pouvant etre traite par informatique et procede d'analyse des echantillons

Country Status (3)

Country Link
EP (1) EP1034450A1 (fr)
DE (1) DE19736470C2 (fr)
WO (1) WO1999010763A1 (fr)

Cited By (7)

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US6735531B2 (en) * 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
US7083106B2 (en) 2003-09-05 2006-08-01 Cytyc Corporation Locally storing biological specimen data to a slide
JP2007093450A (ja) * 2005-09-29 2007-04-12 Olympus Corp 検査システムおよびこの検査対象物の保持具
US7435599B2 (en) 1998-09-18 2008-10-14 Cytyc Corporation Method and apparatus for preparing cytological specimens
US7984616B2 (en) 2002-11-06 2011-07-26 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Low-temperature storage of suspension samples in suspended sample chambers
AU2005259981B2 (en) * 2004-06-29 2012-01-12 Dako Denmark A/S Method of pre-treatment and staining of and support device for a biological sample
US8830574B2 (en) * 2006-03-13 2014-09-09 Ikonisys, Inc. System for read-write control of specimen analysis by automated microscope

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DE19905490A1 (de) * 1999-02-10 2000-08-17 Florian Lang Einrichtung zur Kennzeichnung von Objektträgern
DE19955729A1 (de) * 1999-11-15 2001-05-23 Hospitalia Dienstleistungs & B Kommunikationssystem für das Zusammenwirken von medizinischen Laboratorien und ärztlichen Behandlungseinrichtungen
US6746851B1 (en) 2000-01-14 2004-06-08 Lab Vision Corporation Method for automated staining of specimen slides
DE10010140A1 (de) * 2000-03-03 2001-09-13 Leica Microsystems Vorrichtung zur vorzugsweise automatischen Handhabung und/oder Bearbeitung von Objekten
DE10020704B4 (de) 2000-04-27 2006-09-28 Bioref Gmbh Biochip zur Archivierung und labormedizinischen Analyse von biologischem Probenmaterial, Verfahren zu dessen Herstellung sowie dessen Verwendung in diagnostischen Verfahren
DE10052834B4 (de) 2000-10-24 2019-09-19 Leica Biosystems Nussloch Gmbh Verfahren zur Behandlung von Objekten
DE10144925A1 (de) * 2001-09-12 2003-03-27 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Kryospeicherung
DE10060889A1 (de) * 2000-12-07 2002-06-27 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Kryospeicherung
ES2397721T3 (es) 2000-12-07 2013-03-11 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Procedimiento y dispositivo para el crioalmacenamiento
WO2002074898A2 (fr) * 2001-03-16 2002-09-26 Techne (Cambridge) Ltd Dispositif de regulation de temperature muni d'un bloc a gradient
DE10127221A1 (de) * 2001-05-23 2002-11-28 Lifebits Ag Träger für chemische, biochemische und biologische Substanzen
AT413640B (de) * 2001-09-05 2006-04-15 Ams Engineering Sticht Ges M B Verfahren zur entnahme einer probe aus einem system
DE10154843A1 (de) * 2001-11-08 2003-05-28 Microm Int Gmbh Verfahren und Vorrichtung zur Kennzeichnung von Objektträgern für mikrotomierte Gewebeproben und deren Bearbeitung
US6998270B2 (en) 2001-11-26 2006-02-14 Lab Vision Corporation Automated tissue staining system and reagent container
DE10240814A1 (de) * 2002-08-30 2004-03-25 Glocker, Michael O., Prof. Dr. Probenhalter, Informationssystem und Verfahren zur Speicherung von Informationen über auf einem Probenhalter befindliche Proben
DE10324329B4 (de) * 2003-05-29 2008-05-15 Leica Microsystems Cms Gmbh Objektträgervorrichtung zur Untersuchung mit einem Mikroskop
US20050094263A1 (en) * 2003-10-31 2005-05-05 Vincent Vaccarelli Microscope slide designed for educational purposes
DE102004024960A1 (de) * 2004-05-21 2005-12-15 Bruker Daltonik Gmbh Sicherung der Indentitäts- und Verarbeitungsdaten diagnostischer Proben
DE102004064072B4 (de) 2004-06-12 2020-06-10 Leica Microsystems Cms Gmbh Objektträgervorrichtung zur Aufnahme eines mit einem Mikroskop zu untersuchenden oder mit einem Laboranalysesystem zu analysierenden Objekts sowie Verfahren
DE102004031570B4 (de) 2004-06-12 2008-04-10 Leica Microsystems Cms Gmbh Objektträgervorrichtung zur Untersuchung mit einem Mikroskop
DE102004048099B4 (de) * 2004-09-30 2018-05-09 Carl Zeiss Microscopy Gmbh Mikroskop-Konfigurationsbestimmung
DE102005039949A1 (de) * 2005-08-24 2007-03-01 Olympus Soft Imaging Solutions Gmbh Optische Aufzeichnungs- und/oder Wiedergabeeinheit
US7848019B2 (en) * 2007-12-10 2010-12-07 Cytyc Corporation Microscope calibration apparatus and method and stage including calibration apparatus

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WO1989008264A1 (fr) * 1988-03-04 1989-09-08 Ballies Uwe W Procede d'analyse automatique entierement selective du sang ou des composants du sang
EP0347579A2 (fr) * 1988-06-01 1989-12-27 Daimler-Benz Aerospace Aktiengesellschaft Dispositif comportant un support de structure particulière pour la réception, l'analyse et le traitement d'échantillons
EP0637750A2 (fr) * 1993-08-05 1995-02-08 Roche Diagnostics GmbH Procédé d'analyse des échantillons liquides
DE4417079A1 (de) * 1994-05-17 1995-12-07 Fraunhofer Ges Forschung Objektträger für Mikroskop
US5561556A (en) * 1994-04-21 1996-10-01 Compucyte Corporation Slide analysis system with slide having self contained microscope analysis information
WO1996036436A1 (fr) * 1995-04-25 1996-11-21 Irori Matrices programmables a distance et dotees de memoires, et leur utilisation

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DE2735077A1 (de) * 1977-08-04 1979-02-15 Eppendorf Geraetebau Netheler Messzelle
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WO1989008264A1 (fr) * 1988-03-04 1989-09-08 Ballies Uwe W Procede d'analyse automatique entierement selective du sang ou des composants du sang
EP0347579A2 (fr) * 1988-06-01 1989-12-27 Daimler-Benz Aerospace Aktiengesellschaft Dispositif comportant un support de structure particulière pour la réception, l'analyse et le traitement d'échantillons
EP0637750A2 (fr) * 1993-08-05 1995-02-08 Roche Diagnostics GmbH Procédé d'analyse des échantillons liquides
US5561556A (en) * 1994-04-21 1996-10-01 Compucyte Corporation Slide analysis system with slide having self contained microscope analysis information
DE4417079A1 (de) * 1994-05-17 1995-12-07 Fraunhofer Ges Forschung Objektträger für Mikroskop
WO1996036436A1 (fr) * 1995-04-25 1996-11-21 Irori Matrices programmables a distance et dotees de memoires, et leur utilisation

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6735531B2 (en) * 1996-10-07 2004-05-11 Lab Vision Corporation Method and apparatus for automatic tissue staining
US7435599B2 (en) 1998-09-18 2008-10-14 Cytyc Corporation Method and apparatus for preparing cytological specimens
US7984616B2 (en) 2002-11-06 2011-07-26 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Low-temperature storage of suspension samples in suspended sample chambers
US7083106B2 (en) 2003-09-05 2006-08-01 Cytyc Corporation Locally storing biological specimen data to a slide
US7395974B2 (en) 2003-09-05 2008-07-08 Cytyc Corporation Locally storing biological specimen data to a slide
AU2005259981B2 (en) * 2004-06-29 2012-01-12 Dako Denmark A/S Method of pre-treatment and staining of and support device for a biological sample
US8283176B2 (en) 2004-06-29 2012-10-09 Dako Denmark A/S Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device
JP2007093450A (ja) * 2005-09-29 2007-04-12 Olympus Corp 検査システムおよびこの検査対象物の保持具
US8830574B2 (en) * 2006-03-13 2014-09-09 Ikonisys, Inc. System for read-write control of specimen analysis by automated microscope

Also Published As

Publication number Publication date
DE19736470A1 (de) 1999-03-04
EP1034450A1 (fr) 2000-09-13
DE19736470C2 (de) 2001-02-22

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