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WO1999010763A1 - Sample holder which can process data and method for analysing samples - Google Patents

Sample holder which can process data and method for analysing samples Download PDF

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Publication number
WO1999010763A1
WO1999010763A1 PCT/EP1998/005227 EP9805227W WO9910763A1 WO 1999010763 A1 WO1999010763 A1 WO 1999010763A1 EP 9805227 W EP9805227 W EP 9805227W WO 9910763 A1 WO9910763 A1 WO 9910763A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
sample holder
data
electronic circuit
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1998/005227
Other languages
German (de)
French (fr)
Inventor
Ulrich Schenck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jenoptik AG
Carl Zeiss Jena GmbH
Original Assignee
VEB Carl Zeiss Jena GmbH
Carl Zeiss Jena GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VEB Carl Zeiss Jena GmbH, Carl Zeiss Jena GmbH filed Critical VEB Carl Zeiss Jena GmbH
Priority to EP98946366A priority Critical patent/EP1034450A1/en
Publication of WO1999010763A1 publication Critical patent/WO1999010763A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/34—Microscope slides, e.g. mounting specimens on microscope slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G01N2035/00742—Type of codes
    • G01N2035/00782—Type of codes reprogrammmable code

Definitions

  • the invention relates to a data processing-capable microscopy sample holder and to a method for analyzing microscopic samples and data processing-compatible microcospice sample holders.
  • sample carriers are used to hold samples or preparations that can be examined microscopically or in another way, in particular non-destructively.
  • the preparations / samples can e.g. are tissue parts or fluids of the human body that are to be examined for cancer detection.
  • sample carriers are labeled. So far, the sample carriers have been provisionally labeled with a pen immediately after the sample has been applied to them, and only later, when they are examined in the laboratory, provided with permanent identification. It is common for this to be done with special pens directly on the sample holder or on labels that are attached to the sample holder. Label stickers with machine-readable bar codes are also increasingly being used. Please refer to the article "AccuMed International, Inc. Meeting in the Challenges in Cervical Cancer Screening: The AcCell Series 2000 Automated Slide Handling and Data Management System", published in Acta Cytol. 40, No.l, 1 996, S 26-30.
  • the machine-readable label stickers already allow the sample holder concerned to be automatically recognized at the various work stations, but they are not used to record or process further data.
  • the data belonging to the preparation or the case, such as patient data, examination results etc., must be stored separately on paper or in a database. Even in the case of EDP networking of the various stations of the examination with the database, the spatial separation of the sample carrier from the associated data is disadvantageous, since access to the database requires access to the data network.
  • the object of the present invention is therefore to provide a data processing-capable sample carrier and a method for analyzing samples which offer expanded possibilities for data storage.
  • the data processing-capable microscopy sample carrier has two areas, a first area of which is intended for the permanent acceptance of a microscopic sample and a second area is used to identify the sample, and an electronic circuit designed as a microchip with a writable, readable, non-volatile memory fitted.
  • the sample carrier is advantageously a flat plate.
  • at least one area can be transparent to the wavelength range of an analysis device.
  • the analysis device is an optical microscope
  • the sample carrier can be made of glass, for example.
  • the electronic circuit is advantageously implemented as a microchip.
  • the electronic circuit can essentially consist of a microchip (for example a "smart chip") with a non-volatile memory.
  • the electronic circuit can be equipped with contacts which can be used to write and read data into and out of the circuit.
  • the writing in and reading out of data can be implemented in another way, in particular inductively, capacitively or optically.
  • the data need not be text data alone.
  • the data can also contain image information and / or speech information relating to the sample.
  • the electronic circuit can include a microprocessor.
  • the memory can contain a control program for the microprocessor.
  • the memory can then also contain an application program for analyzing the sample by the electronic circuit.
  • the electronic circuit can be detachably connected to the sample holder.
  • the sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample holder, data and / or programs relating to the sample being stored in the second area in the electronic circuit.
  • the sample carrier can advantageously be used in such a way that the electronic circuit is read out in a data processing system and that read out data and / or programs are used for an analysis, for example in medical diagnostics.
  • sample holder according to the invention results from the fact that the sample and the electronic circuit on the sample holder according to the invention have a defined spatial relationship to one another. Distances or dimensions of structures (for example of conductor tracks of a chip of the electronic circuit) can be used as calibration objects for the analysis device, for example for determining the optical magnification. Furthermore, the chip surface be used for a brightness or color balance of the analysis device. Then complex additional calibration objects can be omitted.
  • the invention has a number of further advantages.
  • the sample can be identified exchanger easier and more reliable than is possible in the prior Tech ⁇ technology.
  • the data is always translated together with the Probetragern because sample and associated data on the same samples exchanger, so that separation is prevented in different units befin ⁇ .
  • the formation can thus be transported patient in ⁇ "paperless” together with the sample, and it can be a smart and economic control of the sample flow can be realized.
  • FIG. 1 shows a first exemplary embodiment of the sample carrier according to the invention
  • the sample transducer has two regions 1 and 2, of which the first portion 1 to the On ⁇ exception of sample 1 1 is determined and the second area 2 for the identification of Pro ⁇ be 1 1 is used, wherein the second region 2 having a writable and elec tronic readable ⁇ circuit 21 is provided.
  • the sample holder is designed as a flat plate.
  • the electronic circuit 21 is implemented as a microchip, which is equipped with contacts 210, with the aid of which the writing and reading of data into and from the circuit 21 is made possible.
  • the circuit 21 contains the circuit components required for reading in and reading out and a correspondingly designed memory 21 1 for recording and storing the data.
  • the memory is a non-volatile rewritable memory which is known per se.
  • the electronic circuit 21 can be assigned to the sample holder permanently or only temporarily.
  • the data are sample-related and / or patient-related data.
  • the data to be stored in the memory 21 1 are not limited to text data such as accompanying information (identification of the sample, type of sample, patient or personal data). If there is sufficient storage capacity, storage space can be provided to accommodate a variety of additional data. Examples for this are:
  • Coordinates of reference points for the microscope on the sample surface - coordinate-specific assignments of examinations and examination results (multi-dimensional mapping information) such as Cell landscapes, nuclear, gene or protein landscapes, images of the samples.
  • the electronic circuit 21 additionally contains a microprocessor.
  • the memory 21 1 contains an operating program assigned to the microprocessor.
  • an application program is contained in the memory 21 1, which is used to analyze the sample in question.
  • each sample carrier carries the software associated with sample 1 with it, which additionally increases the reliability of sample analyzes carried out at distributed locations.
  • the electronic circuit 21 is equipped with a unit for querying an access authorization for access to the data contained in the electronic circuit 21.
  • a "password query” implemented in this way, data protection can be taken into account on the one hand, and on the other hand the data can be better protected against unauthorized changes.
  • sample-related data are written into a writable and readable electronic circuit 21 attached to the sample holder, the sample holder being able to be manipulated as desired after the analysis, for example for archiving purposes.
  • a sample applied to the sample holder e.g. Tissue sample, microscopically imaged for analysis and the microscopic image graphically processed in a microprocessor and the graphically processed image information written into the electronic circuit.
  • the sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample carrier, data relating to the sample being stored in the electronic circuit.
  • the sample carrier according to the invention can also be used for the automated examination of the samples. Then the examination devices (e.g. microscope) are to be equipped with appropriate control devices which can access the data stored in the microchips.
  • the examination devices e.g. microscope
  • appropriate control devices which can access the data stored in the microchips.
  • the examination device 5 here consists of a microscope which is coupled to a camera.
  • the microchip 21 is written with data and the data is read out by a data reader / writer 6, which is assigned to the examination device 5.
  • the data reader / writer 6 can be coupled to the examination device 5 (online processing) or can be implemented separately (offline processing).
  • the data input / output or control of the device can take place via a data processing system 7, which can be designed as a computer with peripheral devices.
  • the sample carrier can advantageously be used in such a way that the content of the memory 21 1 of the electronic circuit 21 is read in a data processing system and that the content read out is evaluated there for analysis. Furthermore, the sample carrier according to the invention can also be used advantageously in personnel training. For example, interactive lessons can be designed based on the data contained in the microchip of the sample holder.
  • the sample holder according to the invention is multimedia-capable.

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  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The invention relates to a sample holder which can process data. The inventive sample holder has two areas (1, 2); a first area (1) for receiving the sample (11) and a second area (2) for identifying the sample. Said second area (2) is provided with a writeable, readable, non-volatile memory (211), for example a smart chip.

Description

Titeltitle

Datenverarbeitungsfahiger Probentrager und Verfahren zur Analyse von ProbenData processing capable sample holder and method for analyzing samples

Gebiet der Erfindung Die Erfindung bezieht sich auf einen datenverarbeitungsfahigen Mikroskopie- Probentrager und auf ein Verfahren zur Analyse mikroskopierbarer Proben und zu den Proben gehöriger datenverarbeitungsfahiger Mikrokospie-Probentrager.FIELD OF THE INVENTION The invention relates to a data processing-capable microscopy sample holder and to a method for analyzing microscopic samples and data processing-compatible microcospice sample holders.

Stand der TechnikState of the art

Derartige Probentrager dienen der Aufnahme von Proben bzw. Präparaten, die mikroskopisch oder auf andere Weise, insbesondere zerstorungslos zu untersuchen sind. Bei den Präparaten/Proben kann es sich z.B. um Gewebeteile oder Flüssigkeiten des menschlichen Korpers handeln, die etwa zur Krebserkennung zu untersuchen sind.Such sample carriers are used to hold samples or preparations that can be examined microscopically or in another way, in particular non-destructively. The preparations / samples can e.g. are tissue parts or fluids of the human body that are to be examined for cancer detection.

Solche Untersuchungen werden in medizinischen Laboratorien in großer Zahl durchgeführt. Hierbei besteht nun das Problem, daß die Proben sowie zugehörige Untersuchungsergebnisse über längere Zeit hinweg aufbewahrt werden müssen, etwa aus haftungsrechtlichen Gründen, damit sie für eventuelle Gegenuntersuchungen verfugbar sind. In vielen Fallen kommt heute hinzu, daß die Untersuchungen der Proben wegen der Aufwendigkeit und infolge der Arbeitsteiligkeit im Laborwesen an verschiedenen Orten durchgeführt werden und daher die Probentrager mit den Proben an verschiedene Stellen verbracht werden müssen.Such examinations are carried out in large numbers in medical laboratories. The problem now is that the samples and the associated test results have to be kept for a longer period of time, for example for reasons of liability law, so that they are available for possible counter-examinations. In many cases there is also the fact that the tests of the samples are carried out in different locations in laboratories because of the complexity and the division of labor, and therefore the sample carriers with the samples have to be moved to different places.

Aus diesen Gründen werden die Probentrager mit einer Kennzeichnung versehen. Bislang werden die Probentrager hierfür unmittelbar nach Beaufschlagung mit der Probe zunächst provisorisch mittels Schreibstift beschriftet und erst spater, bei der Untersuchung im Labor, mit einer dauerhaften Kennzeichnung versehen. Gangig ist hierfür eine Kennzeichnung mit speziellen Stiften direkt auf den Probentrager oder auf Etiket- ten, die auf den Probentrager aufgebracht werden. Zunehmend finden auch mit maschinenlesbaren Bar-Codes versehene Etikettenaufkleber Verwendung. Hierzu sei verwiesen auf den Artikel "AccuMed International, Inc. Meeting in the Challenges in Cervical Cancer Screening: The AcCell Series 2000 Auto- mated Slide Handling and Data Management System", erschienen in Acta Cytol. 40, No.l , 1 996, S 26-30.For these reasons, the sample carriers are labeled. So far, the sample carriers have been provisionally labeled with a pen immediately after the sample has been applied to them, and only later, when they are examined in the laboratory, provided with permanent identification. It is common for this to be done with special pens directly on the sample holder or on labels that are attached to the sample holder. Label stickers with machine-readable bar codes are also increasingly being used. Please refer to the article "AccuMed International, Inc. Meeting in the Challenges in Cervical Cancer Screening: The AcCell Series 2000 Automated Slide Handling and Data Management System", published in Acta Cytol. 40, No.l, 1 996, S 26-30.

Zwar erlauben die maschinenlesbaren Etikettenaufkleber bereits eine automatische Wiedererkennung des betreffenden Probentragers an den verschiedenen Stationen der Arbeit, sie dienen jedoch nicht der Aufnahme von weiteren Daten oder deren Verarbeitung. Die zum Präparat oder zum Fall gehörigen Daten wie Patientendaten, Untersuchungsergebnisse etc. müssen ortlich getrennt hiervon auf Papier oder in einer Datenbank angelegt werden. Selbst bei einer EDV-maßigen Vernetzung der verschiedenen Stationen der Untersuchung mit der Datenbank ist die raumliche Trennung des Proben- tragers von den dazugehörigen Daten nachteilig, da der Zugriff auf die Datenbank eine Zugangsmoglichkeit an das Datennetz voraussetzt.The machine-readable label stickers already allow the sample holder concerned to be automatically recognized at the various work stations, but they are not used to record or process further data. The data belonging to the preparation or the case, such as patient data, examination results etc., must be stored separately on paper or in a database. Even in the case of EDP networking of the various stations of the examination with the database, the spatial separation of the sample carrier from the associated data is disadvantageous, since access to the database requires access to the data network.

Beschreibung der Erfindung Aufgabe der vorliegenden Erfindung ist es daher, einen datenverarbeitungsfahigen Probentrager und ein Verfahren zur Analyse von Proben zu schaffen, die erweiterte Möglichkeiten der Datenspeicherung bieten.DESCRIPTION OF THE INVENTION The object of the present invention is therefore to provide a data processing-capable sample carrier and a method for analyzing samples which offer expanded possibilities for data storage.

Erfindungsgemaß ist der datenverarbeitungsfahige Mikroskopie-Probentrager mit zwei Bereichen, von denen ein erster Bereich zur dauerhaften Annahme einer mikroskopierbaren Probe bestimmt ist und ein zweiter Bereich zur Identifizierung der Probe dient, und mit einer als Mikrochip ausgebildeten elektronischen Schaltung mit einem beschreibbaren, lesbaren, nichtfluchtigen Speicher ausgestattet.According to the invention, the data processing-capable microscopy sample carrier has two areas, a first area of which is intended for the permanent acceptance of a microscopic sample and a second area is used to identify the sample, and an electronic circuit designed as a microchip with a writable, readable, non-volatile memory fitted.

Bei dem Probentrager handelt es sich vorteilhafterweise um ein ebenes Plattchen. Hierbei kann mindestens ein Bereich für den Wellenlangenbereich einer Analysevorrichtung durchlassig sein. Ist die Analysevorrichtung ein optisches Mikroskop, dann kann der Probentrager beispielsweise aus Glas gefertigt sein.The sample carrier is advantageously a flat plate. Here, at least one area can be transparent to the wavelength range of an analysis device. If the analysis device is an optical microscope, the sample carrier can be made of glass, for example.

Vorteilhafterweise ist die elektronische Schaltung als Mikrochip realisiert. Die elektronische Schaltung kann im wesentlichen aus einem Mikrochip (z.B. einem "Smart-Chip") mit einem nichtfluchtigen Speicher bestehen. Die elektronische Schaltung kann mit Kontakten ausgestattet sein, mit deren Hilfe das Einschreiben und Auslesen von Daten in die bzw. aus der Schaltung möglich ist. Ebenso können das Einschreiben und das Auslesen von Daten auf andere Weise realisiert sein, insbesondere induktiv, kapazitiv oder optisch.The electronic circuit is advantageously implemented as a microchip. The electronic circuit can essentially consist of a microchip (for example a "smart chip") with a non-volatile memory. The electronic circuit can be equipped with contacts which can be used to write and read data into and out of the circuit. Likewise, the writing in and reading out of data can be implemented in another way, in particular inductively, capacitively or optically.

Bei den Daten muß es sich nicht alleine um Textdaten handeln. Zusatzlich können die Daten auch Bildinformation und/oder Sprachinformation bezuglich der Probe enthalten.The data need not be text data alone. In addition, the data can also contain image information and / or speech information relating to the sample.

Die elektronische Schaltung kann einen Mikroprozessor enthalten. In diesem Fall kann der Speicher ein Steuerprogramm für den Mikroprozessor enthalten. Weiterhin kann der Speicher dann auch ein Anwendungsprogramm zur Analyse der Probe durch die elektronische Schaltung enthalten.The electronic circuit can include a microprocessor. In this case, the memory can contain a control program for the microprocessor. Furthermore, the memory can then also contain an application program for analyzing the sample by the electronic circuit.

Die elektronische Schaltung kann mit dem Probentrager losbar verbunden sein.The electronic circuit can be detachably connected to the sample holder.

Beim erfindungsgemaßen Verfahren zur Analyse von Proben mit einem Analysegerat und einem mit diesem Gerat verwendbaren datenverarbeitungsfahigen Probentrager wird in eine am Probentrager angebrachte beschreibbare und lesbare elektronische Schaltung eine auf die Probe bezogene Information eingeschrieben; der Probentrager ist nach der Analyse beliebig manipulierbar, beispielsweise für ArchivierungszweckeIn the method according to the invention for the analysis of samples with an analysis device and a data processing-compatible sample holder that can be used with this device, information relating to the sample is written into a writable and readable electronic circuit attached to the sample holder; the sample holder can be manipulated as desired after the analysis, for example for archiving purposes

Der erfindungsgemaße Probentrager kann zur Analyse von Proben verwendet werden, die in einem ersten Bereich des Probentagers aufgebracht sind, wobei in dem zweiten Bereich in der elektronischen Schaltung die Probe betreffende Daten und/oder Programme gespeichert sind.The sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample holder, data and / or programs relating to the sample being stored in the second area in the electronic circuit.

Vorteilhafterweiser kann der Probentrager so verwendet werden, daß die elektronische Schaltung in einer Datenverarbeitungsanlage ausgelesen wird und daß ausgelesene Daten und/oder Programme für eine Analyse beispielsweise in der medizinischen Diagnostik verwendet werden.The sample carrier can advantageously be used in such a way that the electronic circuit is read out in a data processing system and that read out data and / or programs are used for an analysis, for example in medical diagnostics.

Eine weitere Verwendung ergibt sich für den erfindungsgemaßen Probentrager aus der Tatsache, daß Probe und elektronische Schaltung auf den erfindungsgemaßen Proben- trager in definierter raumlicher Beziehung zueinander stehen. Abstände oder Abmessungen von Strukturen (etwa von Leiterbahnen eines Chips der elektronischen Schaltung) können als Kalibrierungsobjekte für die Analysevorrichtung verwendet werden, z.B. zur Ermittlung der optischen Vergrößerung. Desweiteren kann die Chipoberflache für einen Helligkeits- oder Farbabgleich der Analysevorrichtung herangezogen werden. Dann können aufwendige zusatzliche Kalibrierungsobjekte entfallen.Another use for the sample holder according to the invention results from the fact that the sample and the electronic circuit on the sample holder according to the invention have a defined spatial relationship to one another. Distances or dimensions of structures (for example of conductor tracks of a chip of the electronic circuit) can be used as calibration objects for the analysis device, for example for determining the optical magnification. Furthermore, the chip surface be used for a brightness or color balance of the analysis device. Then complex additional calibration objects can be omitted.

Die Erfindung ist mit einer Vielzahl weiterer Vorteile verbunden. So können die Proben- trager einfacher und zuverlässiger identifiziert werden, als dies beim Stand der Tech¬ nik möglich ist. Zudem sind die Daten stets zusammen mit den Probetragern verfugbar, da sich Probe und zugehörige Daten auf ein und demselben Probentrager befin¬ den, so daß eine Trennung auf verschiedene Einheiten vermieden wird. Die Patientenin¬ formation kann somit "papierfrei" zusammen mit der Probe transportiert werden, und es kann eine intelligente und ökonomische Steuerung des Probenflusses realisiert werden.The invention has a number of further advantages. Thus, the sample can be identified exchanger easier and more reliable than is possible in the prior Tech ¬ technology. In addition, the data is always translated together with the Probetragern because sample and associated data on the same samples exchanger, so that separation is prevented in different units befin ¬. The formation can thus be transported patient in ¬ "paperless" together with the sample, and it can be a smart and economic control of the sample flow can be realized.

Kurze Beschreibung der Zeichnungen In den der Erläuterung der Erfindung dienenden Zeichnungen zeigenBRIEF DESCRIPTION OF THE DRAWINGS In the drawings used to explain the invention

Fig.1 ein erstes Ausfuhrungsbeispiel des erfindungsgemaßen Probentragers1 shows a first exemplary embodiment of the sample carrier according to the invention

Fig.2 den erfindungsgemaßen Probentrager in der Verwendung zur Analyse2 shows the sample carrier according to the invention in use for analysis

Ausführliche Beschreibung der ZeichnungDetailed description of the drawing

Fig.1 zeigt einen erfindungsgemaßen datenverarbeitungsfahigen Probentrager. Der Probentrager weist zwei Bereiche 1 und 2 auf, von denen der erste Bereich 1 zur Auf¬ nahme der Probe 1 1 bestimmt ist und der zweite Bereich 2 zur Identifizierung der Pro¬ be 1 1 dient, wobei der zweite Bereich 2 mit einer beschreibbaren und lesbaren elek¬ tronischen Schaltung 21 ausgestattet ist. Der Probentrager ist hier als ebenes Plattchen ausgebildet.1 shows a data processing-compatible sample carrier according to the invention. The sample transducer has two regions 1 and 2, of which the first portion 1 to the On ¬ exception of sample 1 1 is determined and the second area 2 for the identification of Pro ¬ be 1 1 is used, wherein the second region 2 having a writable and elec tronic readable ¬ circuit 21 is provided. The sample holder is designed as a flat plate.

Die elektronische Schaltung 21 ist als Mikrochip realisiert, welcher mit Kontakten 21 0 ausgestattet ist, mit deren Hilfe das Einschreiben und Auslesen von Daten in die bzw. aus der Schaltung 21 ermöglicht wird. Die Schaltung 21 enthalt die für das Einlesen und Auslesen erforderlichen Schaltungskomponenten sowie einen entsprechend aus- gelegten Speicher 21 1 zur Aufnahme und Speicherung der Daten. Bei dem Speicher handelt es sich um einen an sich bekannten nichtfluchtigen wiederbeschreibbaren Speicher. Die elektronische Schaltung 21 kann dem Probentrager dauernd oder nur temporar zugeordnet sein.The electronic circuit 21 is implemented as a microchip, which is equipped with contacts 210, with the aid of which the writing and reading of data into and from the circuit 21 is made possible. The circuit 21 contains the circuit components required for reading in and reading out and a correspondingly designed memory 21 1 for recording and storing the data. The memory is a non-volatile rewritable memory which is known per se. The electronic circuit 21 can be assigned to the sample holder permanently or only temporarily.

Bei den Daten handelt es sich um probenbezogene und/oder patientenbezogene Daten. Die in dem Speicher 21 1 abzuspeichernden Daten sind nicht auf Textdaten wie Begiei- tinformation (Kennzeichnung der Probe, Art der Probe, Patienten- bzw. Personaldaten) beschrankt. Bei ausreichender Speicherkapazität kann Speicherplatz zur Aufnahme einer Vielfalt weiterer Daten vorgesehen sein. Beispiele hierfür sind:The data are sample-related and / or patient-related data. The data to be stored in the memory 21 1 are not limited to text data such as accompanying information (identification of the sample, type of sample, patient or personal data). If there is sufficient storage capacity, storage space can be provided to accommodate a variety of additional data. Examples for this are:

Fragestellung und Untersuchungsauftrag, Informationen über Untersuchungsweg und -technik, Untersuchungsergebnisse, - Berichtsdaten,Question and examination order, information about examination method and technique, examination results, - report data,

Organisationsdaten.Organizational data.

Darüber hinaus ist es auch vorteilhaft, graphische Daten zu speichern, die im Verlauf einer Untersuchung der Probe durch Mikroskop und nachgeschalteter Bildverarbeitung erzeugt werden. Dies ist insbesondere dann von Interesse, wenn ein komplizierter oder zeitaufwendiger Untersuchungsverlauf festgehalten werden soll, so daß dieser zu einem anderen Zeitpunkt wiederholbar ist. Beispiele für graphische Daten sind:In addition, it is also advantageous to store graphical data which are generated in the course of an examination of the sample by means of a microscope and subsequent image processing. This is of particular interest if a complicated or time-consuming course of the examination is to be recorded, so that it can be repeated at another time. Examples of graphic data are:

Koordinaten von Bezugspunkten für das Mikroskop auf der Probenoberflache, - koordinatenspezifische Zuordnungen von Untersuchungen und Untersuchungsergebnissen (mehrdimensionale Mappmg-Information) wie z.B. Zellandschaften (cell maps), Kern-, Gen- oder Proteinlandschaften, Bilder der Proben.Coordinates of reference points for the microscope on the sample surface, - coordinate-specific assignments of examinations and examination results (multi-dimensional mapping information) such as Cell landscapes, nuclear, gene or protein landscapes, images of the samples.

Bei einem zweiten Ausfuhrungsbeispiel enthalt die elektronische Schaltung 21 zusatzlich einen Mikroprozessor. Der Speicher 21 1 enthalt ein dem Mikroprozessor zugeordnetes Betriebsprogramm. Zusatzlich ist im Speicher 21 1 ein Anwendungsprogramm enthalten, welches zur Analyse der betreffenden Probe dient.In a second exemplary embodiment, the electronic circuit 21 additionally contains a microprocessor. The memory 21 1 contains an operating program assigned to the microprocessor. In addition, an application program is contained in the memory 21 1, which is used to analyze the sample in question.

Somit fuhrt jeder Probentrager die der Probe 1 zugeordnete Software mit sich, was eine zusatzliche Erhöhung der Zuverlässigkeit von an verteilten Orten durchgeführten Proben-Analysen bewirkt.Thus, each sample carrier carries the software associated with sample 1 with it, which additionally increases the reliability of sample analyzes carried out at distributed locations.

Erforderlichenfalls ist die elektronische Schaltung 21 mit einer Einheit zur Abfrage ei- ner Zugangsberechtigung für einen Zugriff auf die in der elektronischen Schaltung 21 enthaltenen Daten ausgestattet. Mittels einer hierdurch realisierten "Password-Abfrage" kann einerseits dem Datenschutz Rechnung getragen werden, andererseits können die Daten besser vor unzulässiger Veränderung geschützt werden. Beim erfindungsgemaßen Verfahren zur Analyse von Proben mit einem mikroskopischen Gerat 3 und einem in dieses Gerat einsetzbaren oder einlegbaren datenverarbeitungsfahigen Probentrager werden in einer am Probentrager angebrachten beschreib- baren und lesbaren elektronischen Schaltung 21 probenbezogene Daten eingeschrieben, wobei der Probentrager nach der Analyse beliebig manipulierbar ist, beispielsweise für Archivierungszwecke.If necessary, the electronic circuit 21 is equipped with a unit for querying an access authorization for access to the data contained in the electronic circuit 21. By means of a "password query" implemented in this way, data protection can be taken into account on the one hand, and on the other hand the data can be better protected against unauthorized changes. In the method according to the invention for analyzing samples with a microscopic device 3 and a data processing-compatible sample holder that can be inserted or inserted into this device, sample-related data are written into a writable and readable electronic circuit 21 attached to the sample holder, the sample holder being able to be manipulated as desired after the analysis, for example for archiving purposes.

Vorteilhafterweise wird eine auf den Probetrager aufgebrachte Probe, z.B. Gewebepro- be, zur Analyse mikroskopisch abgebildet und das mikroskopische Abbild in einem Mikroprozessor grafisch verarbeitet und die grafisch verarbeitete Bildinformation in die elektronische Schaltung eingeschrieben.Advantageously, a sample applied to the sample holder, e.g. Tissue sample, microscopically imaged for analysis and the microscopic image graphically processed in a microprocessor and the graphically processed image information written into the electronic circuit.

Der erfindungsgemaße Probentrager kann zur Analyse von Proben verwendet werden, die in einem ersten Bereich des Probentragers aufgebracht sind, wobei in der elektronischen Schaltung die Probe betreffende Daten gespeichert sind.The sample carrier according to the invention can be used for the analysis of samples which are applied in a first area of the sample carrier, data relating to the sample being stored in the electronic circuit.

Der erfindungsgemaße Probentrager kann auch zur automatisierten Untersuchung der Proben eingesetzt werden. Dann sind die Untersuchungsvorrichtungen (z.B. Mikrosko- pe) mit entsprechenden Steuereinrichtungen auszustatten, welche auf die in den Mikrochips gespeicherten Daten zugreifen können.The sample carrier according to the invention can also be used for the automated examination of the samples. Then the examination devices (e.g. microscope) are to be equipped with appropriate control devices which can access the data stored in the microchips.

Fig.2 zeigt den erfindungsgemaßen Probentrager in der Verwendung zur Probenuntersuchung. Die Untersuchungsvorrichtung 5 besteht hier aus einem Mikroskop, welches mit einer Kamera gekoppelt ist. Das Beschreiben des Mikrochips 21 mit Daten und das Auslesen der Daten erfolgt durch ein Datenlese-/Schreibgerat 6, welches der Untersuchungsvorrichtung 5 zugeordnet ist.2 shows the sample holder according to the invention in use for sample analysis. The examination device 5 here consists of a microscope which is coupled to a camera. The microchip 21 is written with data and the data is read out by a data reader / writer 6, which is assigned to the examination device 5.

Das Datenlese-/Schreibgerat 6 kann mit der Untersuchungsvorrichtung 5 gekoppelt sein (online-Verarbeitung) oder separat davon realisiert sein (offline-Verarbeitung). Die Dateneingabe/-ausgabe bzw. Kontrolle der Vorrichtung kann über eine Datenverarbeitungsanlage 7 erfolgen, die als Computer mit Peripheriegeraten ausgestaltet sein kann.The data reader / writer 6 can be coupled to the examination device 5 (online processing) or can be implemented separately (offline processing). The data input / output or control of the device can take place via a data processing system 7, which can be designed as a computer with peripheral devices.

Vorteilhafterweise kann der Probentrager so verwendet werden, daß der Inhalt des Speichers 21 1 der elektronischen Schaltung 21 in einer Datenverarbeitungsanlage gelesen wird und daß der ausgelesene Inhalt für eine Analyse dort ausgewertet wird. Ferner kann der erfindungsgemaße Probentrager auch vorteilhaft in der Personalschulung eingesetzt werden. So laßt sich z.B. ein interaktiver Unterricht basierend auf den im Mikrochip des Probentragers enthaltenen Daten gestalten.The sample carrier can advantageously be used in such a way that the content of the memory 21 1 of the electronic circuit 21 is read in a data processing system and that the content read out is evaluated there for analysis. Furthermore, the sample carrier according to the invention can also be used advantageously in personnel training. For example, interactive lessons can be designed based on the data contained in the microchip of the sample holder.

Durch die Möglichkeit der Speicherung und/oder Bearbeitung mehrerer Datenarten (Text, Bild, Sprache) auf dem Probentrager ist der erfindungsgemaße Probentrager multimediafahig. Due to the possibility of storing and / or processing several types of data (text, image, language) on the sample holder, the sample holder according to the invention is multimedia-capable.

Claims

Ansprüche Expectations 1 . Datenverarbeitungsfahiger Mikroskopie-Probentrager mit zwei Bereichen (1 , 2), dessen erster Bereich (1 ) zur dauerhaften Annahme einer mikroskopierbaren Probe (1 1 ) bestimmt ist, dessen zweiter Bereich (2) zur Identifizierung der Probe (1 1 ) dient und mit einer als Mikrochip ausgebildeten elektronischen Schaltung (21 ) mit einem beschreibbaren, lesbaren, nichtfluchtigen Speicher (21 1 ) ausge- stattet ist.1 . Data processing-capable microscope sample holder with two areas (1, 2), the first area (1) of which is intended for permanent acceptance of a microscopic sample (1 1), the second area (2) of which is used to identify the sample (1 1) and one electronic circuit (21) designed as a microchip is equipped with a writable, readable, non-volatile memory (21 1). 2. Probentrager nach Anspruch 1 , dadurch gekennzeichnet, daß der Speicher (21 1 ) zur nichtfluchtigen Speicherung von Meß- und Identifikationsdaten dient.2. Sample carrier according to claim 1, characterized in that the memory (21 1) is used for the non-volatile storage of measurement and identification data. 3. Probentrager nach Anspruch 1 oder 2 , dadurch gekennzeichnet, daß mindestens ein Bereich des Probentragers für den Wellenlangenbereich einer Analysevorrichtung durchlassig ist.3. Sample holder according to claim 1 or 2, characterized in that at least one area of the sample holder is permeable for the wavelength range of an analysis device. 4. Probentrager nach einem der vorhergehenden Ansprüche, dadurch gekennzeich- net, daß der Probentrager ein ebenes Plattchen ist.4. Sample holder according to one of the preceding claims, characterized in that the sample holder is a flat plate. 5. Probentrager nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die in dem zweiten Bereich (2) befindliche elektronische Schaltung (21 ) mit Kontakten (21 0) ausgestattet ist, mit deren Hilfe das Einschreiben von Daten in die elektonische Schaltung (21 ) und das Auslesen von Daten aus der elektronischen Schaltung (21 ) möglich ist.5. Sample carrier according to one of the preceding claims, characterized in that the electronic circuit (21) located in the second region (2) is equipped with contacts (21 0) with the aid of which data can be written into the electronic circuit (21). and reading out data from the electronic circuit (21) is possible. 6. Probentrager nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die Daten auch Bildinformation und/oder Sprachinformation von der Probe (1 1 ) aufweisen.6. Sample carrier according to one of the preceding claims, characterized in that the data also have image information and / or speech information from the sample (1 1). 7. Probentrager nach Anspruch 6, dadurch gekennzeichnet, daß die Bildinformation mikroskopisch erfaßte Bildinformation aufweist.7. Sample carrier according to claim 6, characterized in that the image information comprises microscopically acquired image information. 8. Probentrager nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, daß die elektronische Schaltung (21 ) einen Mikroprozessor aufweist. 8. Sample carrier according to one of the preceding claims, characterized in that the electronic circuit (21) has a microprocessor. 9. Probetrager nach einem der Ansprüche 4 bis 8, dadurch gekennzeichnet, daß in dem Speicher (21 1 ) Programme speicherbar sind.9. sample holder according to one of claims 4 to 8, characterized in that in the memory (21 1) programs can be stored. 1 0. Probentrager nach Anspruch 9, dadurch gekennzeichnet, daß die Programme Steuerprogramme und Verarbeitungsprogramme umfassen.1 0. sample carrier according to claim 9, characterized in that the programs include control programs and processing programs. 1 1 . Probentrager nach einem der vorherigen Ansprüche, dadurch gekennzeichnet, daß die elektronische Schaltung (21 ) losbar auf dem zweiten Bereich (2) des Probentragers angeordnet ist.1 1. Sample holder according to one of the preceding claims, characterized in that the electronic circuit (21) is removably arranged on the second region (2) of the sample holder. 1 2. Verfahren zur Analyse von mikroskopierbaren Proben (1 1 ) mit einem Analysegerat und einem mit diesem Gerat verwendbaren datenverarbeitungsfahigen Mikro- kospie-Probentrager nach Anspruch 1 , der die Probe (1 1 ) tragt, dadurch gekennzeichnet, daß in eine im Probentrager angebrachte beschreibbare und les- bare elektronische Schaltung (21 ) eine auf die Probe (1 1 ) bezogene Information eingeschrieben und nichtfluchtig gespeichert wird und daß der Probentrager nach der Analyse frei handhabbar ist.1 2. Method for the analysis of microscopic samples (1 1) with an analysis device and a data processing-capable micro-specie sample holder according to claim 1, which can be used with this device, and which carries the sample (1 1), characterized in that attached to one in the sample holder writable and readable electronic circuit (21) an information relating to the sample (11) is written in and stored in a non-volatile manner and that the sample holder can be freely handled after the analysis. 1 3. Verfahren nach Anspruch 1 2, dadurch gekennzeichnet, daß der Probentrager nach der Analyse für Archivierungszwecke verwendet wird.1 3. The method according to claim 1 2, characterized in that the sample holder is used after the analysis for archiving purposes. 1 4. Verfahren nach einem der Ansprüche 1 2 oder 1 3, dadurch gekennzeichnet, daß die Probe (1 1 ) zur Analyse mikroskopisch abgebildet, mikroskopische Bildinformation in einer Datenverarbeitungsanlage (6, 7) verarbeitet und die verarbeitete Bildinformation in die elektronische Schaltung (21 ) auslesbar eingeschrieben und nichtfluchtig gespeichert wird.1 4. The method according to any one of claims 1 2 or 1 3, characterized in that the sample (1 1) microscopically imaged for analysis, microscopic image information in a data processing system (6, 7) processed and the processed image information in the electronic circuit (21 ) is readable and stored in a non-volatile manner. 1 5. Verfahren nach Anspruch 14, dadurch gekennzeichnet, daß der Probentrager mit der elektronischen Schaltung (21 ), in der die Bildinformation der Probe (1 1 ) ge- speichert wird, unabhängig vom mikroskopischen Gerat in einer Datenverarbeitungsanlage (6, 7) verarbeitet wird.1 5. The method according to claim 14, characterized in that the sample carrier with the electronic circuit (21) in which the image information of the sample (1 1) is stored, processed independently of the microscopic device in a data processing system (6, 7) becomes. 1 6. Verfahren nach einem der Ansprüche 1 4 oder 1 5 , dadurch gekennzeichnet, daß die Bildinformation positionsbezogene Daten von ausgewählten Stellen der Probe (1 1 ) enthalt. 1 6. The method according to any one of claims 1 4 or 1 5, characterized in that the image information contains position-related data from selected locations of the sample (1 1). 7. Verfahren nach Anspruch 1 6, dadurch gekennzeichnet, daß die ausgewählten Stellen der Probe (1 1 ) mit Hilfe der positionsbezogenen Daten wiederauffindbar sind.7. The method according to claim 1 6, characterized in that the selected locations of the sample (1 1) can be found using the position-related data. 8. Verfahren nach einem der Ansprüche 1 2 bis 1 7, dadurch gekennzeichnet, daß aus einem nichtfluchtigen Speicher (21 1 ) der elektronischen Schaltung (21 ) Daten und Programme in eine Datenverarbeitungsanlage (6, 7) gelesen und für die Analyse ausgewertet werden und anzeigbar sind.8. The method according to any one of claims 1 2 to 1 7, characterized in that from a non-volatile memory (21 1) of the electronic circuit (21) data and programs in a data processing system (6, 7) read and evaluated for the analysis and can be displayed. 9 Verfahren nach einem der Ansprüche 1 2 bis 1 8, dadurch gekennzeichnet, daß die Daten auch graphisch bearbeitbare Bildinformation enthalten.9. The method according to any one of claims 1 2 to 1 8, characterized in that the data also contain graphically editable image information. 0 Verfahren nach einem der Ansprüche 1 2 bis 1 9, dadurch gekennzeichnet, daß die elektrische Schaltung (21 ) vom Probentrager abgetrennt und unabhängig vom Probentrager in einer Datenverarbeitungsanlage zur Auswertung verwendet wird.0 Method according to one of claims 1 2 to 1 9, characterized in that the electrical circuit (21) is separated from the sample holder and is used for evaluation in a data processing system independently of the sample holder. 1 . Verfahren nach einem der Ansprüche 1 2 bis 20, dadurch gekennzeichnet, daß die elektronische Schaltung (21 ) zur Kalibrierung einer Analysevorrichtung benutzt wird. 1 . Method according to one of Claims 1 2 to 20, characterized in that the electronic circuit (21) is used to calibrate an analysis device.
PCT/EP1998/005227 1997-08-21 1998-08-18 Sample holder which can process data and method for analysing samples Ceased WO1999010763A1 (en)

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