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WO1999066063A3 - Conjugues de folates nucleosidiques et non nucleosidiques - Google Patents

Conjugues de folates nucleosidiques et non nucleosidiques Download PDF

Info

Publication number
WO1999066063A3
WO1999066063A3 PCT/US1999/013565 US9913565W WO9966063A3 WO 1999066063 A3 WO1999066063 A3 WO 1999066063A3 US 9913565 W US9913565 W US 9913565W WO 9966063 A3 WO9966063 A3 WO 9966063A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleosidic
folate conjugates
conjugates
folate
mononucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/013565
Other languages
English (en)
Other versions
WO1999066063A2 (fr
WO1999066063A9 (fr
Inventor
Muthiah Manoharan
Balkrishen Bhat
Phillip Dan Cook
Andrei P Guzaev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/098,166 external-priority patent/US6528631B1/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Priority to AU45706/99A priority Critical patent/AU4570699A/en
Publication of WO1999066063A2 publication Critical patent/WO1999066063A2/fr
Publication of WO1999066063A3 publication Critical patent/WO1999066063A3/fr
Publication of WO1999066063A9 publication Critical patent/WO1999066063A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention porte sur des conjugués de folates oligonucléotidiques, les folates étant conjugués à un plusieurs sites sur un oligonucléotide comprenant les sites de liaison nucléobase et internucléotide 2'-, 3'-, 5'. Le folate peut être lié par le carboxylate α ou η, éventuellement par un groupe de liaison. L'invention porte également sur des procédés de synthèse régiospécifiques des conjugués, et sur des séquences de liaison nucléosidiques et non nucléosidiques conjuguées à l'acide folique et aux folates correspondants.
PCT/US1999/013565 1998-06-16 1999-06-16 Conjugues de folates nucleosidiques et non nucleosidiques Ceased WO1999066063A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45706/99A AU4570699A (en) 1998-06-16 1999-06-16 Nucleosidic and non-nucleosidic folate conjugates

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/098,166 1998-06-16
US09/098,166 US6528631B1 (en) 1993-09-03 1998-06-16 Oligonucleotide-folate conjugates
US09/275,505 1999-03-24
US09/275,505 US6335434B1 (en) 1998-06-16 1999-03-24 Nucleosidic and non-nucleosidic folate conjugates

Publications (3)

Publication Number Publication Date
WO1999066063A2 WO1999066063A2 (fr) 1999-12-23
WO1999066063A3 true WO1999066063A3 (fr) 2000-04-20
WO1999066063A9 WO1999066063A9 (fr) 2000-06-08

Family

ID=26794295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013565 Ceased WO1999066063A2 (fr) 1998-06-16 1999-06-16 Conjugues de folates nucleosidiques et non nucleosidiques

Country Status (3)

Country Link
US (2) US6335434B1 (fr)
AU (1) AU4570699A (fr)
WO (1) WO1999066063A2 (fr)

Families Citing this family (312)

* Cited by examiner, † Cited by third party
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US6861514B2 (en) 2005-03-01
US6335434B1 (en) 2002-01-01

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