AU2001291893A1 - Use of substituted imidazo(1,2-a)pyridine-, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments - Google Patents

Use of substituted imidazo(1,2-a)pyridine-, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments

Info

Publication number: AU2001291893A1
Authority: AU; Australia
Prior art keywords: imidazo; pyrazine; pyrimidine; pyridine; nos
Prior art date: 2000-10-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU2001291893A

Other versions

AU2001291893B8 (en

AU2001291893B2 (en

AU2001291893B9 (en

Inventor

Hagen-Heinrich Hennies

Corinna Maul

Johannes Schneider

Bernd Sundermann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Gruenenthal GmbH

Original Assignee

Gruenenthal GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-13

Filing date

2001-10-10

Publication date

2002-06-27

2000-10-13 Priority claimed from DE10050663A external-priority patent/DE10050663A1/en

2001-10-10 Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH

2002-06-27 Publication of AU2001291893A1 publication Critical patent/AU2001291893A1/en

2006-05-18 Publication of AU2001291893B2 publication Critical patent/AU2001291893B2/en

2006-06-15 Publication of AU2001291893B8 publication Critical patent/AU2001291893B8/en

2006-11-09 Application granted granted Critical

2006-11-09 Publication of AU2001291893B9 publication Critical patent/AU2001291893B9/en

2021-10-10 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

239000003814 drug Substances 0.000 title 1
BKDDBTSRIQDISJ-UHFFFAOYSA-N imidazo[1,2-a]pyrazin-3-amine Chemical class C1=NC=CN2C(N)=CN=C21 BKDDBTSRIQDISJ-UHFFFAOYSA-N 0.000 title 1
UTCSSFWDNNEEBH-UHFFFAOYSA-N imidazo[1,2-a]pyridine Chemical class C1=CC=CC2=NC=CN21 UTCSSFWDNNEEBH-UHFFFAOYSA-N 0.000 title 1
INSWZAQOISIYDT-UHFFFAOYSA-N imidazo[1,2-a]pyrimidine Chemical class C1=CC=NC2=NC=CN21 INSWZAQOISIYDT-UHFFFAOYSA-N 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1

AU2001291893A 2000-10-13 2001-10-10 Use of substituted imidazo(1,2-a)pyridine-, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments Ceased AU2001291893B9 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10050663A DE10050663A1 (en)	2000-10-13	2000-10-13	Use of substituted imidazo [1,2-a] pyridine, pyrimidine and pyrazin-3-yl amine derivatives for the production of medicaments for NOS inhibition
DE10050663.1		2000-10-13
PCT/EP2001/011701 WO2002030428A1 (en)	2000-10-13	2001-10-10	Use of substituted imidazo[1,2-a]pyridine-, imidazo[1,2-a]pyrimidine and imidazo[1,2-a]pyrazine-3-yl-amine derivatives for producing nos-inhibiting medicaments

Publications (4)

Publication Number	Publication Date
AU2001291893A1 true AU2001291893A1 (en)	2002-06-27
AU2001291893B2 AU2001291893B2 (en)	2006-05-18
AU2001291893B8 AU2001291893B8 (en)	2006-06-15
AU2001291893B9 AU2001291893B9 (en)	2006-11-09

Family

ID=7659598

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU9189301A Pending AU9189301A (en)	2000-10-13	2001-10-10	Use of substituted imidazo(1,2-A)pyridine-, imidazo(1,2-A)pyrimidine and imidazo(1,2-A)pyrazine-3-YL-amine derivatives for producing NOS-inhibiting medicaments
AU2001291893A Ceased AU2001291893B9 (en)	2000-10-13	2001-10-10	Use of substituted imidazo(1,2-a)pyridine-, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AU9189301A Pending AU9189301A (en)	2000-10-13	2001-10-10	Use of substituted imidazo(1,2-A)pyridine-, imidazo(1,2-A)pyrimidine and imidazo(1,2-A)pyrazine-3-YL-amine derivatives for producing NOS-inhibiting medicaments

Country Status (17)

Country	Link
US (1)	US20040023972A1 (en)
EP (1)	EP1326613B2 (en)
JP (1)	JP2004510820A (en)
AT (1)	ATE268179T1 (en)
AU (2)	AU9189301A (en)
CA (1)	CA2425672A1 (en)
DE (2)	DE10050663A1 (en)
DK (1)	DK1326613T4 (en)
ES (1)	ES2220810T5 (en)
HU (1)	HUP0303350A3 (en)
MX (1)	MXPA03003200A (en)
NZ (1)	NZ525779A (en)
PL (1)	PL361807A1 (en)
PT (1)	PT1326613E (en)
SI (1)	SI1326613T2 (en)
TR (1)	TR200401545T4 (en)
WO (1)	WO2002030428A1 (en)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10117184A1 (en) *	2001-04-05	2002-10-17	Gruenenthal Gmbh	Substituted imidazole [1,2-a] pyridin-3-yl amide and amine compounds
DE10117183A1 (en) *	2001-04-05	2002-10-10	Gruenenthal Gmbh	Use of substituted imidazo [1,2-a] pyridine compounds as medicaments
DE10132726A1 (en) *	2001-07-05	2003-02-27	Gruenenthal Gmbh	Use of substituted gamma-lactone compounds as drugs
KR20050008691A (en)	2002-04-19	2005-01-21	셀룰러 지노믹스 아이엔씨	Imidazo[1,2-a]Pyrazin-8-ylamines Method Of Making And Method Of Use Thereof
DE10240735A1 (en) *	2002-08-29	2004-03-18	Eberhard-Karls-Universität Tübingen Universitätsklinikum	Regulating human endostatin expression, e.g. for treating CNS disorders or tumors, using nitrogen monoxide signal cascade modulators
US7312341B2 (en)	2002-09-09	2007-12-25	Cgi Pharmaceuticals, Inc.	6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
US7160885B2 (en)	2003-02-10	2007-01-09	Cgi Pharmaceuticals, Inc.	Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
WO2005014599A1 (en)	2003-06-04	2005-02-17	Cellular Genomics, Inc.	Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
US7393848B2 (en)	2003-06-30	2008-07-01	Cgi Pharmaceuticals, Inc.	Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
WO2005019220A2 (en)	2003-08-11	2005-03-03	Cellular Genomics Inc.	Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity
WO2005046559A2 (en) *	2003-11-06	2005-05-26	Lifescan, Inc.	Drug delivery pen with event notification means
DE102004021716A1 (en) *	2004-04-30	2005-12-01	Grünenthal GmbH	Substituted imidazo [1,2-a] pyridine compounds and drugs containing substituted imidazo [1,2-a] pyridine compounds
CA2570073A1 (en) *	2004-06-09	2005-12-22	Oncalis Ag	Protein kinase inhibitors
DE102004044884A1 (en) *	2004-09-14	2006-05-24	Grünenthal GmbH	Substituted bicyclic imidazo-3-yl-amine compounds
US7923041B2 (en) *	2005-02-03	2011-04-12	Signum Biosciences, Inc.	Compositions and methods for enhancing cognitive function
DE102005019181A1 (en) *	2005-04-25	2006-10-26	Novartis Ag	New indene compound are peptide-deformylase inhibitors useful e.g. to treat or prevent diseases mediated by metalloproteinase activity and peptide-deformylase activity
US7777040B2 (en)	2005-05-03	2010-08-17	Cgi Pharmaceuticals, Inc.	Certain substituted ureas, as modulators of kinase activity
WO2006125101A2 (en) *	2005-05-20	2006-11-23	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
WO2007028051A2 (en) *	2005-09-02	2007-03-08	Abbott Laboratories	Novel imidazo based heterocycles
CA2634923C (en)	2005-12-23	2015-05-05	Ariad Pharmaceuticals, Inc.	Acetylenic bicyclic heteroaryl compounds useful as kinase inhibitors
DK2029602T3 (en) *	2006-05-31	2010-08-09	Galapagos Nv	Triazolopyrazine compounds that can be used to treat degenerative and inflammatory diseases
DE102006028862A1 (en) *	2006-06-23	2007-12-27	Merck Patent Gmbh	3-amino-imidazo [1,2-a] pyridine
WO2008016648A2 (en) *	2006-08-01	2008-02-07	Cytokinetics, Incorporated	Certain chemical entities, compositions and methods
US8227603B2 (en) *	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
AU2007281468B2 (en) *	2006-08-02	2012-12-06	Cytokinetics, Incorporated	Certain chemical entities, compositions and methods
US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
DE102006048728A1 (en) *	2006-10-16	2008-04-17	Merck Patent Gmbh	3-amino-imidazo {1,2-a] pyridine
EP1964840A1 (en)	2007-02-28	2008-09-03	sanofi-aventis	Imidazo[1,2-a]pyridines and their use as pharmaceuticals
CN101652069A (en) *	2007-03-27	2010-02-17	艾博特公司	Novel imidazo-based heterocycles
US7851484B2 (en) *	2007-03-30	2010-12-14	Cytokinetics, Inc.	Certain chemical entities, compositions, and methods
WO2008134553A1 (en) *	2007-04-26	2008-11-06	Xenon Pharmaceuticals Inc.	Methods of using bicyclic compounds in treating sodium channel-mediated diseases
GB0708188D0 (en) *	2007-04-27	2007-06-06	Merck Sharp & Dohme	Therapeutic compounds
DE102007040336A1 (en) *	2007-08-27	2009-03-05	Johann Wolfgang Goethe-Universität Frankfurt am Main	New inhibitors of 5-lipoxygenase and their uses
DE102007048716A1 (en)	2007-10-11	2009-04-23	Merck Patent Gmbh	Imidazo [1,2-a] pyrimidine derivatives
WO2009061856A1 (en) *	2007-11-09	2009-05-14	The Salk Instituite For Biological Studies	Non-nucleoside reverse transcriptase inhibitors
BRPI0820171B8 (en)	2007-11-16	2021-05-25	Rigel Pharmaceuticals Inc	carboxamide, sulfonamide and amine compounds for metabolic disorders, pharmaceutical composition, and use thereof
EP2231666B1 (en) *	2007-12-12	2015-07-29	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds for metabolic disorders
WO2009102468A1 (en)	2008-02-13	2009-08-20	Cgi Pharmaceuticals, Inc.	6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
CA2722139C (en) *	2008-04-23	2017-04-11	Rigel Pharmaceuticals, Inc.	Carboxamide compounds for the treatment of metabolic disorders
WO2010032195A1 (en) *	2008-09-16	2010-03-25	Csir	Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
US8450321B2 (en)	2008-12-08	2013-05-28	Gilead Connecticut, Inc.	6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
AU2009325133B2 (en)	2008-12-08	2016-02-04	Gilead Connecticut, Inc.	Imidazopyrazine Syk inhibitors
KR101745732B1 (en)	2008-12-08	2017-06-12	질레드 코네티컷 인코포레이티드	Imidazopyrazine syk inhibitors
AU2010284254B2 (en)	2009-08-17	2015-09-17	Intellikine, Llc	Heterocyclic compounds and uses thereof
US20120263646A1 (en) *	2009-10-15	2012-10-18	Guerbet	Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
KR101717809B1 (en)	2010-03-11	2017-03-17	질레드 코네티컷 인코포레이티드	Imidazopyridines syk inhibitors
US9045474B2 (en)	2010-08-03	2015-06-02	The Regents Of The University Of California	Compounds and compositions for mitigating tissue damage and lethality
CN109316480A (en)	2011-07-13	2019-02-12	赛特凯恩蒂克公司	Combine ALS therapy
EP2776428A4 (en)	2011-11-11	2015-04-22	Intellikine Llc	Kinase inhibitor polymorphs
US9540366B2 (en)	2012-07-31	2017-01-10	Kyowa Hakko Kirin Co., Ltd.	Ring-fused heterocyclic compound
EP2983665A1 (en) *	2013-03-15	2016-02-17	The Regents of The University of California	Therapeutic agents and methods for the treatment of dna repair deficiency disorders
WO2015017466A1 (en)	2013-07-30	2015-02-05	Gilead Connecticut, Inc.	Formulation of syk inhibitors
WO2015017460A1 (en)	2013-07-30	2015-02-05	Gilead Connecticut, Inc.	Polymorph of syk inhibitors
JP6298539B2 (en)	2013-12-04	2018-03-20	ギリアードサイエンシーズ，インコーポレイテッド	How to treat cancer
US9290505B2 (en)	2013-12-23	2016-03-22	Gilead Sciences, Inc.	Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
UY35898A (en)	2013-12-23	2015-07-31	Gilead Sciences Inc	? SYK INHIBITING COMPOUNDS AND COMPOSITIONS THAT UNDERSTAND THEM ?.
SMT201900620T1 (en)	2014-02-13	2020-01-14	Incyte Corp	Cyclopropylamines as lsd1 inhibitors
WO2015123408A1 (en)	2014-02-13	2015-08-20	Incyte Corporation	Cyclopropylamines as lsd1 inhibitors
HUE046273T2 (en)	2014-02-13	2020-02-28	Incyte Corp	Cyclopropylamines as LSD1 Inhibitors
US9527835B2 (en)	2014-02-13	2016-12-27	Incyte Corporation	Cyclopropylamines as LSD1 inhibitors
TW201613925A (en)	2014-07-10	2016-04-16	Incyte Corp	Imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007727A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007731A1 (en)	2014-07-10	2016-01-14	Incyte Corporation	Imidazopyridines and imidazopyrazines as lsd1 inhibitors
EA201790086A1 (en)	2014-07-14	2017-07-31	Джилид Сайэнс, Инк.	COMBINATION FOR THE TREATMENT OF CANCER DISEASES
KR102410733B1 (en)	2014-08-29	2022-06-20	씨에이치디아이 파운데이션, 인코포레이티드	Probes for imaging huntingtin protein
CN107660205B (en)	2015-04-03	2021-08-27	因赛特公司	Heterocyclic compounds as LSD1 inhibitors
HUE070538T2 (en)	2015-08-12	2025-06-28	Incyte Holdings Corp	Salts of an lsd1 inhibitor
CA3021678A1 (en)	2016-04-22	2017-10-26	Incyte Corporation	Formulations of an lsd1 inhibitor
CN111051311A (en)	2017-08-25	2020-04-21	吉利德科学公司	Polymorphs of SYK inhibitors
US11530209B2 (en)	2017-10-04	2022-12-20	Dana-Farber Cancer Institute, Inc.	Small molecule inhibition of transcription factor SALL4 and uses thereof
CA3102279A1 (en)	2018-06-01	2019-12-05	Cornell University	Combination therapy for pi3k-associated disease or disorder
WO2020047198A1 (en)	2018-08-31	2020-03-05	Incyte Corporation	Salts of an lsd1 inhibitor and processes for preparing the same
AU2020225455A1 (en)	2019-02-22	2021-09-09	Kronos Bio, Inc.	Solid forms of condensed pyrazines as Syk inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4507294A (en) *	1982-03-08	1985-03-26	Schering Corp.	Imidazo[1,2-a]pyrazines
DE3269604D1 (en) *	1981-06-26	1986-04-10	Schering Corp	Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
GB8415540D0 (en) *	1984-06-18	1984-07-25	Fujisawa Pharmaceutical Co	Imidazoisoquinoline compounds
FR2638161B1 (en) *	1988-10-24	1991-01-11	Centre Nat Rech Scient	NOVEL BENZOYL-2 IMIDAZO (1,2-A) PYRIDINES AND SALTS THEREOF, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
MX22406A (en) †	1989-09-15	1994-01-31	Pfizer	NEW DERIVATIVES OF N-ARIL AND N-HETEROARILAMIDAS AND UREA AS INHIBITORS OF ACIL COENZYME A: ACIL TRANSFERASA DEL COLESTEROL (ACAT).
IE904346A1 (en) †	1989-12-04	1991-06-05	Searle & Co	IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
US5562921A (en) *	1994-07-15	1996-10-08	Sherman; Bernard C.	Stable solid pharmaceutical compositions containing enalapril maleate
KR19990007836A (en) *	1995-04-21	1999-01-25	다나까 테츠오	Fused Imidazo [1, 2-a] pyridine
WO1998039342A1 (en) †	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase
DE50006419D1 (en) †	1999-07-02	2004-06-17	Siemens Ag	METHOD FOR MONITORING AN INTERNAL COMBUSTION ENGINE OPERATOR
DE19948434A1 (en) *	1999-10-08	2001-06-07	Gruenenthal Gmbh	Substance library containing bicyclic imidazo-5-amines and / or bicyclic imidazo-3-amines
DE10019714A1 (en) †	2000-04-20	2002-01-10	Gruenenthal Gmbh	Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines
WO2002002557A2 (en) *	2000-06-30	2002-01-10	Neurogen Corporation	2-phenylimidazo[1,2-a]pyridine derivatives: a new class of gaba brain receptor ligands
DE10246890A1 (en) *	2002-10-08	2004-04-22	Grünenthal GmbH	New C-(imidazo-(1,2-a)-pyridin-3-yl)-methylamines, are nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, septic shock, neurodegenerative diseases, inflammatory pain or cancer
DE10247269A1 (en) *	2002-10-10	2004-04-22	Grünenthal GmbH	New C-(imidazo-(1,2-a)-pyridin-3-yl)-methylamines, are nitrogen monoxide synthase inhibitors useful e.g. for treating migraine, septic shock, neurodegenerative diseases, inflammatory pain or cancer

2000
- 2000-10-13 DE DE10050663A patent/DE10050663A1/en not_active Withdrawn
2001
- 2001-10-10 PL PL36180701A patent/PL361807A1/en not_active Application Discontinuation
- 2001-10-10 EP EP01972099A patent/EP1326613B2/en not_active Expired - Lifetime
- 2001-10-10 TR TR2004/01545T patent/TR200401545T4/en unknown
- 2001-10-10 SI SI200130161T patent/SI1326613T2/en unknown
- 2001-10-10 WO PCT/EP2001/011701 patent/WO2002030428A1/en not_active Ceased
- 2001-10-10 JP JP2002533869A patent/JP2004510820A/en active Pending
- 2001-10-10 NZ NZ525779A patent/NZ525779A/en unknown
- 2001-10-10 MX MXPA03003200A patent/MXPA03003200A/en active IP Right Grant
- 2001-10-10 DK DK01972099T patent/DK1326613T4/en active
- 2001-10-10 AU AU9189301A patent/AU9189301A/en active Pending
- 2001-10-10 AU AU2001291893A patent/AU2001291893B9/en not_active Ceased
- 2001-10-10 AT AT01972099T patent/ATE268179T1/en not_active IP Right Cessation
- 2001-10-10 CA CA002425672A patent/CA2425672A1/en not_active Abandoned
- 2001-10-10 PT PT01972099T patent/PT1326613E/en unknown
- 2001-10-10 ES ES01972099T patent/ES2220810T5/en not_active Expired - Lifetime
- 2001-10-10 DE DE50102490T patent/DE50102490D1/en not_active Expired - Fee Related
- 2001-10-10 HU HU0303350A patent/HUP0303350A3/en unknown
2003
- 2003-04-11 US US10/411,402 patent/US20040023972A1/en not_active Abandoned

Publication	Publication Date	Title
AU2001291893A1 (en)	2002-06-27	Use of substituted imidazo(1,2-a)pyridine-, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine-3-yl-amine derivatives for producing NOS-inhibiting medicaments
HUP0303350A3 (en)	2006-02-28	Use of substituted imidazo[1,2-a]pyridine-, imidazo[1,2-a]pyrimidine and imidazo[1,2-a]pyrazine-3-yl-amine derivatives for producing nos-inhibiting pharmaceutical compositions
EP1416935B8 (en)	2008-08-27	4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
SI1220856T1 (en)	2005-06-30	Pyrazolo(4,3-d)pyrimidine derivatives
AU2002214505A1 (en)	2002-05-21	New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
IL191960A (en)	2015-11-30	Imidazo[1,5-a]pyridine derivatives and pharmaceutical compositions comprising the same
HUP0400692A3 (en)	2007-09-28	Substituted 7h-pyrrolo[2,3-d]pyrimidine derivatives, their use and pharmaceutical compositions containing them
AU2002251546A1 (en)	2003-04-17	Pyrazolo[1,5-A]pyridines and medicines containing the same
NZ330988A (en)	1999-03-29	5h-thiazolo[3,2-a]pyrimidine derivatives used as neurological medicaments
HUP0500332A3 (en)	2009-12-28	Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h)-one derivatives, their use and pharmaceutical compositions containing them
AU2002229573A1 (en)	2002-07-01	Pharmaceutical formulation containing pyrazolo(4,3-D)pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives
IL160402A0 (en)	2004-07-25	Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido {1,2-a} pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo{1,2-pyrimidin-5 (1h) one derivatives
AU7588696A (en)	1997-06-11	Pyrido{2, 3-D} pyrimidine derivatives and pharmaceutical compositions thereof
IL156536A0 (en)	2004-01-04	Pyrazolo [3,4-d] pyrimidin-4-one derivatives and pharmaceutical compositions containing the same
AU5491699A (en)	2000-03-14	Process for the preparation of pyrrolo(2,3-d)pyrimidines
PL366858A1 (en)	2005-02-07	Use of substituted imidazo[1,2-a]-pyridine compounds as medicaments
HUP0003118A3 (en)	2002-11-28	Use of 2,7-substituted octahydro-1h-pyrido [1,2-a]pyrazine derivatives for production of pharmaceutical compositions
AU5426500A (en)	2001-01-02	Benzazepine derivatives, process for the preparation of the same and uses thereof
HU0103075D0 (en)	2001-10-28	Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one derivatives and intermediates thereof
AU2001284763A1 (en)	2002-02-18	Preparation of risperidone
AU2002215979A1 (en)	2002-06-03	Use of pyrazolo(4,3-D)pyrimidines
HU0003979D0 (en)	2000-12-28	Process for the preparation of 3-pyridylsulphonil-pyrazolo[4,3-d] pyrimidin-7-one derivatives and intermediates thereof
MXPA03008894A (en)	2003-12-08	Use of substituted imidazo[1,2-a]-pyridine-3-yl-amide and imidazo[1,2-a]-pyridine-3-yl-amine compounds as medicaments.
AU2002216033A1 (en)	2002-06-18	Use of pyrazolo(4,3-d)pyrimidines
AU2801500A (en)	2000-08-25	Method of producing substituted pyrimidine derivatives