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WO1996001846B1 - Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i - Google Patents

Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i

Info

Publication number
WO1996001846B1
WO1996001846B1 PCT/US1995/008596 US9508596W WO9601846B1 WO 1996001846 B1 WO1996001846 B1 WO 1996001846B1 US 9508596 W US9508596 W US 9508596W WO 9601846 B1 WO9601846 B1 WO 9601846B1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
proinsulin
arg
ser
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1995/008596
Other languages
English (en)
Other versions
WO1996001846A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to JP8504435A priority Critical patent/JPH10505821A/ja
Priority to DK95926642T priority patent/DK0788512T3/da
Priority to DE69508605T priority patent/DE69508605T2/de
Priority to AU30947/95A priority patent/AU3094795A/en
Priority to MX9700198A priority patent/MX9700198A/es
Priority to EP95926642A priority patent/EP0788512B1/fr
Publication of WO1996001846A1 publication Critical patent/WO1996001846A1/fr
Publication of WO1996001846B1 publication Critical patent/WO1996001846B1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

Composés de peptide de pro-insuline modulant une réponse immunologique par les lymphocyte T de sujets diabétiques du type I. Les composés de peptide de pro-insuline de cette invention sont préférablement extraits d'une région de pro-insuline qui couvre la jonction existant entre la chaîne B et le peptide C de la pro-insuline. On décrit également des compositions pharmaceutiques comprenant les composés de peptide de pro-insuline de cette invention. La réponse immunologique induite par un composé de peptide de pro-insuline peut servir d'indicateur pour détecter un diabète du type I chez un sujet et cette invention présente des dosages de diagnostic qui servent à rechercher le diabète du type I avec les composés de peptide de pro-insuline revendiqués. On décrit également des procédés qui permettent d'inhiber le développement ou la progression du diabète du type I chez un sujet et qui consistent à lui administrer un composé de peptide de pro-insuline.
PCT/US1995/008596 1994-07-08 1995-07-07 Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i Ceased WO1996001846A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP8504435A JPH10505821A (ja) 1994-07-08 1995-07-07 Ｉ型糖尿病の検出および処置のためのプロインスリンペプチド化合物
DK95926642T DK0788512T3 (da) 1994-07-08 1995-07-07 Proinsulinpeptidforbindelser til detektion og behandling af Type I-diabetes
DE69508605T DE69508605T2 (de) 1994-07-08 1995-07-07 Proinsulin-peptid-verbindungen für den nachweis und die behandlung von typ-i-diabetes
AU30947/95A AU3094795A (en) 1994-07-08 1995-07-07 Proinsulin peptide compounds for detecting and treating type i diabetes
MX9700198A MX9700198A (es) 1994-07-08 1995-07-07 Compuestos peptidos de proinsulina para detectar y tratar diabetes tipo 1.
EP95926642A EP0788512B1 (fr) 1994-07-08 1995-07-07 Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US27222094A 1994-07-08 1994-07-08
US08/272,220 1994-07-08
US47270495A 1995-06-06 1995-06-06
US08/472,704 1995-06-06

Publications (2)

Publication Number Publication Date
WO1996001846A1 WO1996001846A1 (fr) 1996-01-25
WO1996001846B1 true WO1996001846B1 (fr) 1996-03-07

Family

ID=26955374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/008596 Ceased WO1996001846A1 (fr) 1994-07-08 1995-07-07 Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i

Country Status (12)

Country Link
US (1) US20030220229A1 (fr)
EP (1) EP0788512B1 (fr)
JP (1) JPH10505821A (fr)
CN (1) CN1157621A (fr)
AT (1) ATE178074T1 (fr)
AU (1) AU3094795A (fr)
CA (1) CA2194548A1 (fr)
DE (1) DE69508605T2 (fr)
DK (1) DK0788512T3 (fr)
ES (1) ES2130629T3 (fr)
MX (1) MX9700198A (fr)
WO (1) WO1996001846A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69637130T2 (de) 1995-02-20 2008-02-21 The Walter And Eliza Hall Institute Of Medical Research, Parkville Immunoreaktive und immunotherapeutische moleküle welche in individuen mit insulin-abhängiger diabetes mellitus interagieren
SE520392C2 (sv) 1996-09-27 2003-07-01 Creative Peptides Sweden Ab C Specifika peptider för behandling av diabetes mellitus
AUPO269996A0 (en) * 1996-10-01 1996-10-24 Walter And Eliza Hall Institute Of Medical Research, The A method of prophylaxis and treatment
ES2331342B1 (es) * 2006-05-22 2010-10-13 Consejo Superior Investg.Cientificas Uso de la proinsulina para la elaboracion de una composicion farmaceutica neuroprotectora, composicion terapeutica que la contiene y sus aplicaciones.
CN103630692B (zh) * 2013-06-02 2015-05-06 马鞍山国声生物技术有限公司 快速检测尿液c肽的胶体金免疫层析试剂盒及其检测方法
CN105829885B (zh) * 2013-10-17 2020-08-18 综合医院公司 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物
GB2559499A (en) * 2014-02-25 2018-08-08 Orban Tihamer Immunomodulatory therapy for type 1 diabetes mellitus autoimmunity
GB2523399B (en) * 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
GB201913408D0 (en) * 2019-09-17 2019-10-30 King S College London Proinsulin peptides for type 1 diabetes
WO2025035125A1 (fr) * 2023-08-10 2025-02-13 The Curators Of The University Of Missouri Suppression du diabète de type 1 par il-4 intrathymique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5210872B2 (fr) * 1973-07-14 1977-03-26
US4308181A (en) * 1980-12-08 1981-12-29 American Home Products Corporation Polypeptide compositions
US4652548A (en) * 1981-08-27 1987-03-24 Eli Lilly And Company Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin
US5114844A (en) * 1989-03-14 1992-05-19 Yeda Research And Development Co., Ltd. Diagnosis and treatment of insulin dependent diabetes mellitus
NL9001083A (nl) * 1990-05-04 1991-12-02 Rijksuniversiteit Beta-cel antigeen.
AU661828B2 (en) * 1990-08-17 1995-08-10 University Of Florida Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus

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