WO1996001846B1 - Proinsulin peptide compounds for detecting and treating type i diabetes - Google Patents
Proinsulin peptide compounds for detecting and treating type i diabetesInfo
- Publication number
- WO1996001846B1 WO1996001846B1 PCT/US1995/008596 US9508596W WO9601846B1 WO 1996001846 B1 WO1996001846 B1 WO 1996001846B1 US 9508596 W US9508596 W US 9508596W WO 9601846 B1 WO9601846 B1 WO 9601846B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- proinsulin
- arg
- ser
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Abstract
Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.
Claims
-46-
AMENDED CLAIMS
[received by the International Bureau on 5 February 1996 (05.02.96); original claims unchanged; new claims 33-42 added; (2 pages)]
31. The method of claim 29, wherein the agent is a compound derived from human proinsulin.
32. The method of claim 29, wherein the compound comprises an amino acid sequence comprising the formula:
Yl-P^aa)n-(SerTrιx)-Pro-Lys-(Ser/Thr)-Arg-Arg-(Glu/Asp)-(Zaa)m-Y2
wherein Xaa and Zaa, which may or may not be present, represent amino acid residues, n and m are integers from 1 to 15, Yi is hydrogen or an amino-derivative group and Y2 is hydrogen or a carboxy-derivative group.
33. Use of a proinsulin peptide compound which modulates an immunological response by T cells of Type I diabetic subjects for the manufacture of a medicament for inhibiting the development or progression of Type I diabetes in a subject.
34. The use of claim 33, wherein the compound is identical or substantially similar to a region of proinsulin that spans the junction between the B chain and the C peptide of proinsulin.
35. The use of claim 33, wherein the compound is derived from human proinsulin.
36. The use of claim 33, wherein the compound comprises an amino acid sequence comprising the formula:
Y 1 -(Xaa)n-(Ser Tr-r)-Pro-Lys-(Ser Thr)-Arg-Arg-(GluAsp)-(Zaa)rn- Y2
wherein Xaa and Zaa, which may or may not be present, represent amino acid residues, n and m are integers from 1 to 15, Y1 is hydrogen or an amino-derivative group and Y2 is hydrogen or a carboxy-derivative group.
37. The use of claim 36, wherein the compound is 10-35 amino acids in length.
38. The use of claim 36, wherein the compound is 10-20 amino acids in length.
39. The use of claim 36, wherein the compound is 12-17 amino acids in length.
40. The use of claim 33. where in the compound comprises an amino acid sequence:
-47-
Y i -Gly-Phe-Phe-Tyr-(Ser Trιr)-Pro-Lys-(Ser/Trιr)-Arg-Arg-(Glu/Asp)-Ala- Glu-(Glu/Asp)-Leu-Gln-Val-Gly-Y2
41. The use of claim 33 , wherein the compound is a modified form of a proinsulin peptide.
42. The use of claim 33, which comprises a tolerogenic amount of the proinsulin peptide compound.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8504435A JPH10505821A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for the detection and treatment of type I diabetes - Patents.com |
| DK95926642T DK0788512T3 (en) | 1994-07-08 | 1995-07-07 | Proinsulin Peptide Compounds for the Detection and Treatment of Type I Diabetes |
| DE69508605T DE69508605T2 (en) | 1994-07-08 | 1995-07-07 | PROINSULIN PEPTIDE COMPOUNDS FOR DETECTING AND TREATING TYPE I DIABETES |
| AU30947/95A AU3094795A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
| MX9700198A MX9700198A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes. |
| EP95926642A EP0788512B1 (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27222094A | 1994-07-08 | 1994-07-08 | |
| US08/272,220 | 1994-07-08 | ||
| US47270495A | 1995-06-06 | 1995-06-06 | |
| US08/472,704 | 1995-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996001846A1 WO1996001846A1 (en) | 1996-01-25 |
| WO1996001846B1 true WO1996001846B1 (en) | 1996-03-07 |
Family
ID=26955374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/008596 Ceased WO1996001846A1 (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030220229A1 (en) |
| EP (1) | EP0788512B1 (en) |
| JP (1) | JPH10505821A (en) |
| CN (1) | CN1157621A (en) |
| AT (1) | ATE178074T1 (en) |
| AU (1) | AU3094795A (en) |
| CA (1) | CA2194548A1 (en) |
| DE (1) | DE69508605T2 (en) |
| DK (1) | DK0788512T3 (en) |
| ES (1) | ES2130629T3 (en) |
| MX (1) | MX9700198A (en) |
| WO (1) | WO1996001846A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637130T2 (en) | 1995-02-20 | 2008-02-21 | The Walter And Eliza Hall Institute Of Medical Research, Parkville | IMMUNOREACTIVE AND IMMUNOTHERAPEUTIC MOLECULES THAT INTERACT IN INDIVIDUALS WITH INSULIN-DEPENDENT DIABETES MELLITUS |
| SE520392C2 (en) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specific peptides for the treatment of diabetes mellitus |
| AUPO269996A0 (en) * | 1996-10-01 | 1996-10-24 | Walter And Eliza Hall Institute Of Medical Research, The | A method of prophylaxis and treatment |
| ES2331342B1 (en) * | 2006-05-22 | 2010-10-13 | Consejo Superior Investg.Cientificas | USE OF PROINSULIN FOR THE PREPARATION OF A NEUROPROTECTING PHARMACEUTICAL COMPOSITION, THERAPEUTIC COMPOSITION CONTAINING IT AND ITS APPLICATIONS. |
| CN103630692B (en) * | 2013-06-02 | 2015-05-06 | 马鞍山国声生物技术有限公司 | Colloidal gold immunochromatography kit for rapidly detecting urine C peptide and detecting method thereof |
| CN105829885B (en) * | 2013-10-17 | 2020-08-18 | 综合医院公司 | Methods of identifying subjects responsive to treatment for autoimmune disease and compositions for treating the disease |
| GB2559499A (en) * | 2014-02-25 | 2018-08-08 | Orban Tihamer | Immunomodulatory therapy for type 1 diabetes mellitus autoimmunity |
| GB2523399B (en) * | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
| GB201913408D0 (en) * | 2019-09-17 | 2019-10-30 | King S College London | Proinsulin peptides for type 1 diabetes |
| WO2025035125A1 (en) * | 2023-08-10 | 2025-02-13 | The Curators Of The University Of Missouri | Suppression of type 1 diabetes by intrathymic il-4 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5210872B2 (en) * | 1973-07-14 | 1977-03-26 | ||
| US4308181A (en) * | 1980-12-08 | 1981-12-29 | American Home Products Corporation | Polypeptide compositions |
| US4652548A (en) * | 1981-08-27 | 1987-03-24 | Eli Lilly And Company | Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin |
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| NL9001083A (en) * | 1990-05-04 | 1991-12-02 | Rijksuniversiteit | BETA-CELL ANTIGEN. |
| AU661828B2 (en) * | 1990-08-17 | 1995-08-10 | University Of Florida | Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus |
-
1995
- 1995-07-07 MX MX9700198A patent/MX9700198A/en not_active IP Right Cessation
- 1995-07-07 WO PCT/US1995/008596 patent/WO1996001846A1/en not_active Ceased
- 1995-07-07 EP EP95926642A patent/EP0788512B1/en not_active Revoked
- 1995-07-07 AT AT95926642T patent/ATE178074T1/en not_active IP Right Cessation
- 1995-07-07 CN CN95194541A patent/CN1157621A/en active Pending
- 1995-07-07 CA CA002194548A patent/CA2194548A1/en not_active Abandoned
- 1995-07-07 JP JP8504435A patent/JPH10505821A/en not_active Ceased
- 1995-07-07 DK DK95926642T patent/DK0788512T3/en active
- 1995-07-07 ES ES95926642T patent/ES2130629T3/en not_active Expired - Lifetime
- 1995-07-07 AU AU30947/95A patent/AU3094795A/en not_active Abandoned
- 1995-07-07 DE DE69508605T patent/DE69508605T2/en not_active Expired - Fee Related
-
2003
- 2003-01-16 US US10/346,563 patent/US20030220229A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Becker et al. | Action of derivatives of. mu.-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates | |
| KR880001701A (en) | Novel peptides | |
| WO1996001846B1 (en) | Proinsulin peptide compounds for detecting and treating type i diabetes | |
| Kern et al. | Biosynthesis of skin collagens in normal and diabetic mice | |
| Huisman et al. | Amino-acid composition of four different kinds of human haemoglobin | |
| EP0741869B1 (en) | Specific binding substances for antibodies and their use for immunoassays or vaccines | |
| DE2702699A1 (en) | NEW PEPTIDE DERIVATIVES AND METHODS OF MEASURING COLLAGENASE ACTIVITY USING THESE COMPOUNDS | |
| HUT53664A (en) | Process for producing enzyme inhibiting amino acid derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
| MX9700198A (en) | Proinsulin peptide compounds for detecting and treating type i diabetes. | |
| Air et al. | Studies on Marsupial Proteins IV. Amino Acid Sequence of Myoglobin From the Red Kangaroo, Megaleia Rufa | |
| DE69325943T3 (en) | Synthetic polypeptides of the hepatitis C virus, useful for the detection of the virus | |
| NO955067L (en) | FVII / TF peptides | |
| EP0916680A3 (en) | Lantibiotic related to Actagardine, process of preparation and use thereof | |
| Kurahashi et al. | Amylase secretion by parotid glands and pancreas of diabetic rats during feeding | |
| AU7597994A (en) | Peptide having inflammation affinity and radioactive diagnostic containing the same | |
| RODEWALD et al. | Homeothermic fish and hemoglobin: primary structure of the hemoglobin from bluefin tuna (Thunnus thynnus, Scromboidei) | |
| KR860000072A (en) | Manufacturing method of gonococcal vaccine | |
| Markussen et al. | Human monocomponent insulin: Chemistry and characteristics | |
| WO1997039029A3 (en) | An antigenic epitope of the a determinant of hepatitis b surface antigen and uses thereof | |
| EP0659883A3 (en) | Protein p140 and DNA encoding it. | |
| Kayser et al. | Affinity alkylation of bacterial delta 5-3-ketosteroid isomerase. Identification of the amino acid modified by steroidal 17 beta-oxiranes. | |
| WO1986001209A3 (en) | New p-phenylenediamine peptides and reactance containing them for the determination of proteases of the blood coagulation system | |
| Knecht et al. | Degradation of glomerular basement membrane in diabetes: I. Susceptibility of diabetic and nondiabetic basement membrane to proteolytic degradation of isolated glomeruli | |
| IE841192L (en) | Preparation of steroid esters | |
| Nute et al. | Complete sequence of the γ chain from the fetal hemoglobin of the baboon, Papio cynocephalus |