[go: up one dir, main page]

WO1992008697A3 - DERIVES DE LA 9-HALOGENE-11β-HYDROXYPROSTAGLANDINE, PROCEDES DE FABRICATION ET APPLICATION COMME MEDICAMENT - Google Patents

DERIVES DE LA 9-HALOGENE-11β-HYDROXYPROSTAGLANDINE, PROCEDES DE FABRICATION ET APPLICATION COMME MEDICAMENT Download PDF

Info

Publication number
WO1992008697A3
WO1992008697A3 PCT/DE1991/000881 DE9100881W WO9208697A3 WO 1992008697 A3 WO1992008697 A3 WO 1992008697A3 DE 9100881 W DE9100881 W DE 9100881W WO 9208697 A3 WO9208697 A3 WO 9208697A3
Authority
WO
WIPO (PCT)
Prior art keywords
radical
halogen
producing
medicament
hydroxy prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1991/000881
Other languages
German (de)
English (en)
Other versions
WO1992008697A2 (fr
Inventor
Bernd Buchmann
Werner Skuballa
Karl-Heinz Thierauch
Peter Verhallen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to EP91919671A priority Critical patent/EP0510154B1/fr
Priority to DE59105459T priority patent/DE59105459D1/de
Priority to AU88726/91A priority patent/AU650074B2/en
Publication of WO1992008697A2 publication Critical patent/WO1992008697A2/fr
Publication of WO1992008697A3 publication Critical patent/WO1992008697A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a pour objet des dérivés de la 9-halogène-11β-hydroxyprostaglandine de formule (I) où Z désigne les restes (a) ou (b), Hal désigne un atome de chlore ou de fluor α-ou β-stable, R1 désigne le reste CH¿2?OH ou (c) avec R?2¿ signifiant un atome d'hydrogène, un reste alkyle, cycloalkyle, aryle ou hétérocyclique, ou R1 désigne le reste (d), avec R3 signifiant un reste acide ou le reste R?2, et R4¿ désigne un groupe cycloalkyle et, si R2 signifie un atome d'hydrogène, leurs sels avec des bases physiologiquement acceptables et leurs clathrates de la cyclodextrine, et elle a également pour objet des procédés pour leur préparation ainsi que leur application pharmaceutique.
PCT/DE1991/000881 1990-11-09 1991-11-08 DERIVES DE LA 9-HALOGENE-11β-HYDROXYPROSTAGLANDINE, PROCEDES DE FABRICATION ET APPLICATION COMME MEDICAMENT Ceased WO1992008697A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP91919671A EP0510154B1 (fr) 1990-11-09 1991-11-08 DERIVES DE LA 9-HALOGENE-11(Beta)-HYDROXYPROSTAGLANDINE, PROCEDES DE FABRICATION ET APPLICATION COMME MEDICAMENT
DE59105459T DE59105459D1 (de) 1990-11-09 1991-11-08 9-HALOGEN-11(Beta)-HYDROXY-PROSTAGLANDINDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL.
AU88726/91A AU650074B2 (en) 1990-11-09 1991-11-08 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4036140A DE4036140A1 (de) 1990-11-09 1990-11-09 9-halogen-11ss-hydroxy-prostaglandinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DEP4036140.3 1990-11-09

Publications (2)

Publication Number Publication Date
WO1992008697A2 WO1992008697A2 (fr) 1992-05-29
WO1992008697A3 true WO1992008697A3 (fr) 1992-07-23

Family

ID=6418184

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1991/000881 Ceased WO1992008697A2 (fr) 1990-11-09 1991-11-08 DERIVES DE LA 9-HALOGENE-11β-HYDROXYPROSTAGLANDINE, PROCEDES DE FABRICATION ET APPLICATION COMME MEDICAMENT

Country Status (8)

Country Link
EP (1) EP0510154B1 (fr)
JP (1) JPH05503713A (fr)
AT (1) ATE122339T1 (fr)
AU (1) AU650074B2 (fr)
CA (1) CA2073462A1 (fr)
DE (2) DE4036140A1 (fr)
HU (1) HUT61726A (fr)
WO (1) WO1992008697A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229048A1 (de) * 1992-08-31 1994-03-03 Schering Ag Ester von 9-Chlor-Prostaglandinen, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
DE4229050A1 (de) * 1992-08-31 1994-03-03 Schering Ag Neue 9-Chlor-Prostaglandin-Ester und -amide
DE59308617D1 (de) * 1992-08-31 1998-07-02 Schering Ag 9-chlor-prostaglandin-ester und -amide und ihre verwendung für die herstellung von arzneimitteln
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
JP3579448B2 (ja) * 1993-12-29 2004-10-20 大正製薬株式会社 プロスタグランジン誘導体、その塩およびその使用
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US6395786B1 (en) * 1998-05-25 2002-05-28 Taisho Pharmaceutical Co., Ltd. Sleep inducing agent
PT1211242E (pt) * 1999-09-10 2010-02-10 Taisho Pharmaceutical Co Ltd Derivados de prostaglandina

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030377A1 (fr) * 1979-12-10 1981-06-17 Schering Aktiengesellschaft Dérivés 9-chlorés de prostaglandines, procédé pour leur préparation et utilisation comme médicaments
WO1989003384A1 (fr) * 1987-10-07 1989-04-20 Pharmacia Ab Derives de prostaglandine servant au traitement du glaucome ou de l'hypertension oculaire
EP0299914B1 (fr) * 1987-07-17 1993-04-07 Schering Aktiengesellschaft Dérivés de prostaglandines 9-halogène (Z), leur procédé de préparation et leur application thérapeutique

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU624078B2 (en) * 1987-07-17 1992-06-04 Schering Aktiengesellschaft Berlin Und Bergkamen 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs
DE4024347A1 (de) * 1990-07-27 1992-01-30 Schering Ag Cyclopentanderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030377A1 (fr) * 1979-12-10 1981-06-17 Schering Aktiengesellschaft Dérivés 9-chlorés de prostaglandines, procédé pour leur préparation et utilisation comme médicaments
EP0299914B1 (fr) * 1987-07-17 1993-04-07 Schering Aktiengesellschaft Dérivés de prostaglandines 9-halogène (Z), leur procédé de préparation et leur application thérapeutique
WO1989003384A1 (fr) * 1987-10-07 1989-04-20 Pharmacia Ab Derives de prostaglandine servant au traitement du glaucome ou de l'hypertension oculaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Prostaglandins, Band 11, Nr. 1, Januar 1976; W.L. MILLER et a.: "Relative biological activity of certain prostaglandis and their enantiomers", Seiten 77-84, siehe Seite 80, Tabelle 1 *

Also Published As

Publication number Publication date
HU9202260D0 (en) 1992-10-28
DE59105459D1 (de) 1995-06-14
AU8872691A (en) 1992-06-11
EP0510154A1 (fr) 1992-10-28
WO1992008697A2 (fr) 1992-05-29
HUT61726A (en) 1993-03-01
EP0510154B1 (fr) 1995-05-10
JPH05503713A (ja) 1993-06-17
ATE122339T1 (de) 1995-05-15
AU650074B2 (en) 1994-06-09
DE4036140A1 (de) 1992-05-14
CA2073462A1 (fr) 1992-05-10

Similar Documents

Publication Publication Date Title
IE882189L (en) 9-Halogen-(Z) prostaglandin derivatives, process for their production and their use as pharmaceutical agents
ATE254609T1 (de) Aminothiazolderivate, sie enthaltende arzneimittel und zwischenprodukte in der herstellung dieser verbindungen
WO1993010091A3 (fr) Derives de piperidine acide acetique utilises comme inhibiteurs de l'agregation des plaquettes hematiques dependante du fibrinogene
AU569983B2 (en) Xanthine derivatives
AU570067B2 (en) Chromanylalkoxybenzyl substituted thiazolidines
HUT61742A (en) Process for producing cyclic amide derivatives and pharmaceutical compositions comprising same
ATE120644T1 (de) Verwendung von 1,3-oxathiolanalogen von nukleosiden zur herstellung eines arzneimittels zur behandlung von hepatitis-b.
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
AU747521C (en) Cycloalkene derivatives, process for producing the same, and use
HUT36816A (en) Process for producing benzopirane derivatives
TW368501B (en) 7-(2-aminoethyl)-benzothiazolones
BG101402A (en) Apoliprotein-b synthesis inhibitors
HU9401372D0 (en) Vitamin d derivatives pharmaceutical compositions contaning them and process for producing them
HUT59394A (en) Process for producing piperazine derivatives and pharmaceutical compositions comprising same
WO1992008697A3 (fr) DERIVES DE LA 9-HALOGENE-11β-HYDROXYPROSTAGLANDINE, PROCEDES DE FABRICATION ET APPLICATION COMME MEDICAMENT
HUT62563A (en) Process for producing 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydroproin derivatives and pharmaceutical compositions comprising same
FI901659A0 (fi) 3,5-dihydroxi-6,8-nonadiensyror och derivat som kolesterol saenkande aemnen.
HUT50337A (en) Process for producing benzoxazine derivatives and pharmaceutical compositions comprising the compounds
EP0139440A3 (fr) Composés de pyridinium
ATE42295T1 (de) Penem-derivate, verfahren zu deren herstellung, ihre verwendung und pharmazeutische zusammensetzungen.
ATE123487T1 (de) Derivate der kaffeinsäure und sie enthaltende pharmazeutische zusammensetzungen.
IS3887A (is) Lyfjablanda til þess að lækka háan blóðþrýsting, aðferð til framleiðslu hennar og notkunar sem lyfs
ES2009553A6 (es) Procedimiento de preparacion de nuevos derivados del acido 2-(2,3-dihidrido-2-oxo-3-benzofuranil)-acetico.
ES488388A1 (es) Procedimiento de preparacion de derivados hidroxilados del tiazol
DE3879058D1 (de) 4-piperidincarboxamid-derivate.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA HU JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 2073462

Country of ref document: CA

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA HU JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU NL SE

WWE Wipo information: entry into national phase

Ref document number: 1991919671

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1991919671

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1991919671

Country of ref document: EP