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WO1992008697A3 - 9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT - Google Patents

9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT Download PDF

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Publication number
WO1992008697A3
WO1992008697A3 PCT/DE1991/000881 DE9100881W WO9208697A3 WO 1992008697 A3 WO1992008697 A3 WO 1992008697A3 DE 9100881 W DE9100881 W DE 9100881W WO 9208697 A3 WO9208697 A3 WO 9208697A3
Authority
WO
WIPO (PCT)
Prior art keywords
radical
halogen
producing
medicament
hydroxy prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1991/000881
Other languages
German (de)
French (fr)
Other versions
WO1992008697A2 (en
Inventor
Bernd Buchmann
Werner Skuballa
Karl-Heinz Thierauch
Peter Verhallen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to EP91919671A priority Critical patent/EP0510154B1/en
Priority to DE59105459T priority patent/DE59105459D1/en
Priority to AU88726/91A priority patent/AU650074B2/en
Publication of WO1992008697A2 publication Critical patent/WO1992008697A2/en
Publication of WO1992008697A3 publication Critical patent/WO1992008697A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to 9-halogen-11β-hydroxy prostaglandin derivatives of formula (I) in which Z is the radical (a) or (b), Hal is an α or β-fixed chlorine or fluorine atom, R1 is the radical CH¿2?OH or (c), R?2¿ is a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R1 is the radical (d), where R3 is an acid radical or the radical R?2 and R4¿ is a cycloalkyl group, and if R2 is a hydrogen atom, their salts with physiological acceptable bases and their cyclodextrin clathrates, process for producing them and their pharmaceutical use.
PCT/DE1991/000881 1990-11-09 1991-11-08 9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT Ceased WO1992008697A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP91919671A EP0510154B1 (en) 1990-11-09 1991-11-08 9-HALOGEN-11(Beta)-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT
DE59105459T DE59105459D1 (en) 1990-11-09 1991-11-08 9-HALOGEN-11 (Beta) -HYDROXY-PROSTAGLANDIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT.
AU88726/91A AU650074B2 (en) 1990-11-09 1991-11-08 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4036140A DE4036140A1 (en) 1990-11-09 1990-11-09 9-HALOGEN-11SS-HYDROXY-PROSTAGLANDIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
DEP4036140.3 1990-11-09

Publications (2)

Publication Number Publication Date
WO1992008697A2 WO1992008697A2 (en) 1992-05-29
WO1992008697A3 true WO1992008697A3 (en) 1992-07-23

Family

ID=6418184

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1991/000881 Ceased WO1992008697A2 (en) 1990-11-09 1991-11-08 9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT

Country Status (8)

Country Link
EP (1) EP0510154B1 (en)
JP (1) JPH05503713A (en)
AT (1) ATE122339T1 (en)
AU (1) AU650074B2 (en)
CA (1) CA2073462A1 (en)
DE (2) DE4036140A1 (en)
HU (1) HUT61726A (en)
WO (1) WO1992008697A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229048A1 (en) * 1992-08-31 1994-03-03 Schering Ag New ester(s) of 9-chloro-prostaglandin(s) - useful in treatment of glaucoma and as diuretic agents
DE4229050A1 (en) * 1992-08-31 1994-03-03 Schering Ag New esters and amides of 9-chloro-prostaglandins - useful, e.g., in treatment of glaucoma and as diuretic agents
DE59308617D1 (en) * 1992-08-31 1998-07-02 Schering Ag 9-CHLORINE PROSTAGLANDIN ESTERS AND AMIDES AND THEIR USE FOR THE PRODUCTION OF MEDICINAL PRODUCTS
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
JP3579448B2 (en) * 1993-12-29 2004-10-20 大正製薬株式会社 Prostaglandin derivatives, salts thereof and uses thereof
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
US6395786B1 (en) * 1998-05-25 2002-05-28 Taisho Pharmaceutical Co., Ltd. Sleep inducing agent
PT1211242E (en) * 1999-09-10 2010-02-10 Taisho Pharmaceutical Co Ltd Prostaglandin derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030377A1 (en) * 1979-12-10 1981-06-17 Schering Aktiengesellschaft 9-Chloro-prostaglandin derivatives, process for their preparation and use as medicines
WO1989003384A1 (en) * 1987-10-07 1989-04-20 Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
EP0299914B1 (en) * 1987-07-17 1993-04-07 Schering Aktiengesellschaft 9-halogen (z) prostaglandin derivatives, process for their production and their use as medicines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU624078B2 (en) * 1987-07-17 1992-06-04 Schering Aktiengesellschaft Berlin Und Bergkamen 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs
DE4024347A1 (en) * 1990-07-27 1992-01-30 Schering Ag CYCLOPENTANE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR PHARMACEUTICAL USE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0030377A1 (en) * 1979-12-10 1981-06-17 Schering Aktiengesellschaft 9-Chloro-prostaglandin derivatives, process for their preparation and use as medicines
EP0299914B1 (en) * 1987-07-17 1993-04-07 Schering Aktiengesellschaft 9-halogen (z) prostaglandin derivatives, process for their production and their use as medicines
WO1989003384A1 (en) * 1987-10-07 1989-04-20 Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Prostaglandins, Band 11, Nr. 1, Januar 1976; W.L. MILLER et a.: "Relative biological activity of certain prostaglandis and their enantiomers", Seiten 77-84, siehe Seite 80, Tabelle 1 *

Also Published As

Publication number Publication date
HU9202260D0 (en) 1992-10-28
DE59105459D1 (en) 1995-06-14
AU8872691A (en) 1992-06-11
EP0510154A1 (en) 1992-10-28
WO1992008697A2 (en) 1992-05-29
HUT61726A (en) 1993-03-01
EP0510154B1 (en) 1995-05-10
JPH05503713A (en) 1993-06-17
ATE122339T1 (en) 1995-05-15
AU650074B2 (en) 1994-06-09
DE4036140A1 (en) 1992-05-14
CA2073462A1 (en) 1992-05-10

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