UY26113A1 - Forma polimórfica de sal del ácido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidina-2,4-diona - Google Patents
Forma polimórfica de sal del ácido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidina-2,4-dionaInfo
- Publication number
- UY26113A1 UY26113A1 UY26113A UY26113A UY26113A1 UY 26113 A1 UY26113 A1 UY 26113A1 UY 26113 A UY26113 A UY 26113A UY 26113 A UY26113 A UY 26113A UY 26113 A1 UY26113 A1 UY 26113A1
- Authority
- UY
- Uruguay
- Prior art keywords
- provides
- thiazolidine
- ethoxy
- amino
- methyl
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical class OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 238000002329 infrared spectrum Methods 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 238000001237 Raman spectrum Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- SUFUKZSWUHZXAV-BTJKTKAUSA-N rosiglitazone maleate Chemical compound [H+].[H+].[O-]C(=O)\C=C/C([O-])=O.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O SUFUKZSWUHZXAV-BTJKTKAUSA-N 0.000 abstract 1
- 238000000279 solid-state nuclear magnetic resonance spectrum Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Forma polimórfíca de sal del ácido maleico de 5-[4-[2-(N-metil-N-(2-piridil)amino)etoxi]bencil]tiazolidina-2,4-diona, caracterizada porque: (i ) proporciona un espectro infrarrojo que contiene picos a 1.360, 1.326, 1.241, 714 y 669 cm-1; y/o (ii) proporciona un espectro Raman que contiene picos a 1.581, 768, 670, 271 y 226 cm-1; y/o (iii) proporciona un espectro de resonancia magnética nuclear en estado sólido que contiene picos de desplazamientos químicos, particularmente un espectro infrarrojo; y/o (iv)proporciona un patrón de difracción de rayos X a través de polvo (XRPD) que contiene picos. Procedimiento para preparar dicha sal, caracterizado porque se calienta una suspensión lechosa de la sal en etanol acuoso. Al igual que una composición farmacéutica que comprende una cantidad eficaz y no tóxica de dicho polimorfo, y un vehículo farmcéuticamente aceptable para su como una sustancia terapéutica activa, por ejemplo para el tratamiento y/o profilaxis de diabetes mellitus, condiciones asociadas con diabetes mellitus y ciertas complicaciones de las mismas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9909075.5A GB9909075D0 (en) | 1999-04-20 | 1999-04-20 | Novel pharmaceutical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY26113A1 true UY26113A1 (es) | 2000-12-29 |
Family
ID=10851922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY26113A UY26113A1 (es) | 1999-04-20 | 2000-04-19 | Forma polimórfica de sal del ácido maleico de 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidina-2,4-diona |
Country Status (42)
| Country | Link |
|---|---|
| EP (2) | EP1411054A1 (es) |
| JP (2) | JP4283450B2 (es) |
| KR (1) | KR100677815B1 (es) |
| CN (2) | CN1327446A (es) |
| AP (1) | AP1680A (es) |
| AR (2) | AR023563A1 (es) |
| AT (1) | ATE262524T1 (es) |
| AU (1) | AU773112B2 (es) |
| BG (1) | BG65428B1 (es) |
| BR (1) | BR0009898A (es) |
| CA (1) | CA2370270A1 (es) |
| CO (1) | CO5170420A1 (es) |
| CZ (1) | CZ300934B6 (es) |
| DE (1) | DE60009276T2 (es) |
| DK (1) | DK1173437T3 (es) |
| DZ (1) | DZ3163A1 (es) |
| EA (1) | EA004769B1 (es) |
| EG (1) | EG23946A (es) |
| ES (1) | ES2214267T3 (es) |
| GB (1) | GB9909075D0 (es) |
| HK (1) | HK1045304B (es) |
| HR (1) | HRP20010771B1 (es) |
| HU (1) | HUP0200785A3 (es) |
| IL (1) | IL146077A0 (es) |
| MA (1) | MA26784A1 (es) |
| MX (1) | MXPA01010695A (es) |
| MY (1) | MY125209A (es) |
| NO (1) | NO320573B1 (es) |
| NZ (1) | NZ515164A (es) |
| OA (1) | OA11867A (es) |
| PE (1) | PE20010047A1 (es) |
| PL (1) | PL351115A1 (es) |
| PT (1) | PT1173437E (es) |
| RS (1) | RS50137B (es) |
| SI (1) | SI1173437T1 (es) |
| SK (1) | SK284990B6 (es) |
| TR (1) | TR200103041T2 (es) |
| TW (1) | TWI291463B (es) |
| UA (1) | UA72245C2 (es) |
| UY (1) | UY26113A1 (es) |
| WO (1) | WO2000063206A2 (es) |
| ZA (1) | ZA200108721B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9909075D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0006133D0 (en) | 2000-03-14 | 2000-05-03 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB0014005D0 (en) * | 2000-06-08 | 2000-08-02 | Smithkline Beecham Plc | Novel pharmaceutical |
| SI1448559T1 (sl) * | 2001-11-21 | 2007-06-30 | Smithkline Beecham Plc | 5-(4-(2-(n-metil-n-(2-piridil)amino)etoksi)benzil-tiazolidin-2,4-dion- benzensulfonat; postopek za njegovo pripravo; njegovi polimorfi i, ii, iii; in njegova uporaba kot farmacevtska uäśinkovina |
| KR100450700B1 (ko) * | 2002-03-22 | 2004-10-01 | 주식회사종근당 | 티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물 |
| US20050105328A1 (en) * | 2003-11-17 | 2005-05-19 | Ho Chiahua | Perpendicular MRAM with high magnetic transition and low programming current |
| CZ298424B6 (cs) * | 2005-05-24 | 2007-09-26 | Zentiva, A. S. | Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel |
| EP1842850A1 (en) * | 2006-03-23 | 2007-10-10 | Sandoz AG | Rosiglitazone hydrochloride hemihydrate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0306228B1 (en) * | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| GB9909075D0 (en) * | 1999-04-20 | 1999-06-16 | Smithkline Beecham Plc | Novel pharmaceutical |
-
1999
- 1999-04-20 GB GBGB9909075.5A patent/GB9909075D0/en not_active Ceased
-
2000
- 2000-04-18 PE PE2000000362A patent/PE20010047A1/es not_active Application Discontinuation
- 2000-04-18 MY MYPI20001653A patent/MY125209A/en unknown
- 2000-04-19 RS YUP-816/01A patent/RS50137B/sr unknown
- 2000-04-19 AT AT00920895T patent/ATE262524T1/de not_active IP Right Cessation
- 2000-04-19 EP EP20030079072 patent/EP1411054A1/en not_active Withdrawn
- 2000-04-19 CN CN00801933A patent/CN1327446A/zh active Pending
- 2000-04-19 BR BR0009898-1A patent/BR0009898A/pt not_active Application Discontinuation
- 2000-04-19 SI SI200030340T patent/SI1173437T1/xx unknown
- 2000-04-19 PL PL00351115A patent/PL351115A1/xx unknown
- 2000-04-19 HU HU0200785A patent/HUP0200785A3/hu unknown
- 2000-04-19 SK SK1489-2001A patent/SK284990B6/sk not_active IP Right Cessation
- 2000-04-19 UY UY26113A patent/UY26113A1/es not_active Application Discontinuation
- 2000-04-19 HK HK02105155.8A patent/HK1045304B/en not_active IP Right Cessation
- 2000-04-19 CO CO00028928A patent/CO5170420A1/es not_active Application Discontinuation
- 2000-04-19 CZ CZ20013758A patent/CZ300934B6/cs not_active IP Right Cessation
- 2000-04-19 KR KR1020017013423A patent/KR100677815B1/ko not_active Expired - Fee Related
- 2000-04-19 EG EG20000501A patent/EG23946A/xx active
- 2000-04-19 WO PCT/GB2000/001527 patent/WO2000063206A2/en not_active Ceased
- 2000-04-19 AP APAP/P/2001/002332A patent/AP1680A/en active
- 2000-04-19 AU AU41311/00A patent/AU773112B2/en not_active Ceased
- 2000-04-19 MX MXPA01010695A patent/MXPA01010695A/es active IP Right Grant
- 2000-04-19 DZ DZ003163A patent/DZ3163A1/xx active
- 2000-04-19 HR HR20010771A patent/HRP20010771B1/xx not_active IP Right Cessation
- 2000-04-19 CN CNA2007101427470A patent/CN101125851A/zh active Pending
- 2000-04-19 EP EP00920895A patent/EP1173437B1/en not_active Expired - Lifetime
- 2000-04-19 DE DE60009276T patent/DE60009276T2/de not_active Expired - Lifetime
- 2000-04-19 UA UA2001117791A patent/UA72245C2/uk unknown
- 2000-04-19 NZ NZ515164A patent/NZ515164A/xx not_active IP Right Cessation
- 2000-04-19 OA OA1200100269A patent/OA11867A/en unknown
- 2000-04-19 PT PT00920895T patent/PT1173437E/pt unknown
- 2000-04-19 ES ES00920895T patent/ES2214267T3/es not_active Expired - Lifetime
- 2000-04-19 AR ARP000101864A patent/AR023563A1/es not_active Application Discontinuation
- 2000-04-19 CA CA002370270A patent/CA2370270A1/en not_active Abandoned
- 2000-04-19 AR ARP000101869A patent/AR023567A1/es unknown
- 2000-04-19 JP JP2000612296A patent/JP4283450B2/ja not_active Expired - Fee Related
- 2000-04-19 DK DK00920895T patent/DK1173437T3/da active
- 2000-04-19 EA EA200101102A patent/EA004769B1/ru not_active IP Right Cessation
- 2000-04-19 IL IL14607700A patent/IL146077A0/xx unknown
- 2000-04-19 TR TR2001/03041T patent/TR200103041T2/xx unknown
- 2000-04-24 TW TW089107634A patent/TWI291463B/zh not_active IP Right Cessation
-
2001
- 2001-10-19 NO NO20015105A patent/NO320573B1/no not_active IP Right Cessation
- 2001-10-19 MA MA26370A patent/MA26784A1/fr unknown
- 2001-10-23 ZA ZA200108721A patent/ZA200108721B/en unknown
- 2001-11-20 BG BG106120A patent/BG65428B1/bg unknown
-
2009
- 2009-02-17 JP JP2009033833A patent/JP2009161544A/ja active Pending
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RDES | Application refused |
Effective date: 20090924 |