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UY25262A1 - 5-derivados sustituidos del ácido micofenolico - Google Patents

5-derivados sustituidos del ácido micofenolico

Info

Publication number
UY25262A1
UY25262A1 UY25262A UY25262A UY25262A1 UY 25262 A1 UY25262 A1 UY 25262A1 UY 25262 A UY25262 A UY 25262A UY 25262 A UY25262 A UY 25262A UY 25262 A1 UY25262 A1 UY 25262A1
Authority
UY
Uruguay
Prior art keywords
lower alkyl
halo
aryl
substituted derivatives
mycophenolic acid
Prior art date
Application number
UY25262A
Other languages
English (en)
Inventor
Alicia C Garcia
Ann Marir Waltos
Eric B Sjogren
John W Petterson Jr
David J Morgan Jr
Ronald C Hawley
Dean R Artris
Teresa A T Martin
Maria T L Hernandez
Mario F Zertuche
Robert J Weikert
David B Smith
John C Rohloff
David G Loughhead
Francisco X T Murra
Fidencio F Andrade
Peter H Nelson
Todd R Elworthy
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of UY25262A1 publication Critical patent/UY25262A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Derivados de 3-oxoisobenzofurano útiles para el tratamiento de inmuno, inflamación, proliferación tumoral y viral. Los compuestos de fórmula (I) donde R1 es H o C(O)R10 es alquiloinferior, arilo, NH-arilo y Z es seleccionado de las fórmulas ZA aZH; por ejemploZA donde Z1 es H, alquilo inferior, halo o CF3; Z2 es H, OH, alquilo inferior, arilo o CH2-Z13, donde Z13 es halo , CN, arilo o heteroarilo, Z3 es H, OH, alquilo inferior, alcoxi inferior, halo, fenil; Z4 es OH, alquilo inferior, alcoxi, halo, etc
UY25262A 1994-02-18 1998-11-23 5-derivados sustituidos del ácido micofenolico UY25262A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/198,749 US5493030A (en) 1994-02-18 1994-02-18 5-substituted derivatives of mycophenolic acid

Publications (1)

Publication Number Publication Date
UY25262A1 true UY25262A1 (es) 2001-01-31

Family

ID=22734662

Family Applications (2)

Application Number Title Priority Date Filing Date
UY23910A UY23910A1 (es) 1994-02-18 1995-02-16 Procedimiento para la preparacion de 5- derivados sustitutivos del acido micofenolico
UY25262A UY25262A1 (es) 1994-02-18 1998-11-23 5-derivados sustituidos del ácido micofenolico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY23910A UY23910A1 (es) 1994-02-18 1995-02-16 Procedimiento para la preparacion de 5- derivados sustitutivos del acido micofenolico

Country Status (29)

Country Link
US (2) US5493030A (es)
EP (1) EP0745073B1 (es)
JP (1) JPH09509174A (es)
CN (1) CN1141038A (es)
AT (1) ATE194608T1 (es)
AU (1) AU1875495A (es)
BR (1) BR9506819A (es)
CA (1) CA2183530A1 (es)
CO (1) CO4340734A1 (es)
DE (1) DE69517957T2 (es)
DK (1) DK0745073T3 (es)
ES (1) ES2149971T3 (es)
FI (1) FI963218L (es)
GR (1) GR3033864T3 (es)
GT (1) GT199500007A (es)
HR (1) HRP950070B1 (es)
IL (2) IL124139A (es)
IS (1) IS4264A (es)
MX (1) MX9603478A (es)
MY (1) MY112804A (es)
PE (1) PE22996A1 (es)
PH (1) PH31441A (es)
PT (1) PT745073E (es)
SI (1) SI0745073T1 (es)
SV (1) SV1995000007A (es)
TW (1) TW384288B (es)
UY (2) UY23910A1 (es)
WO (1) WO1995022538A1 (es)
ZA (1) ZA951299B (es)

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US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6811998B2 (en) * 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US7214754B2 (en) * 1999-12-13 2007-05-08 Ppg Industries Ohio, Inc. Polymerizable polyol (allyl carbonate) compositions
US7179791B2 (en) 2001-01-11 2007-02-20 Duke University Inhibiting GS-FDH to modulate NO bioactivity
AU2003261354A1 (en) * 2002-08-02 2004-02-23 The Regents Of The University Of California New uses for inhibitors of inosine monophosphate dehydrogenase
US7427636B2 (en) * 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US20090247488A1 (en) * 2003-04-25 2009-10-01 Carina Cannizzaro Anti-inflammatory phosphonate compounds
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
US7407965B2 (en) * 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
EP1620109A2 (en) * 2003-04-25 2006-02-01 Gilead Sciences, Inc. Kinase inhibitor phosphonate conjugates
US7429565B2 (en) 2003-04-25 2008-09-30 Gilead Sciences, Inc. Antiviral phosphonate analogs
US7432261B2 (en) * 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7300924B2 (en) * 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
WO2005023791A2 (en) * 2003-09-11 2005-03-17 Sandoz Ag Process for the production of mycophenolate mofetil
WO2005044308A1 (en) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
WO2005044279A1 (en) * 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
US20050153990A1 (en) * 2003-12-22 2005-07-14 Watkins William J. Phosphonate substituted kinase inhibitors
MXPA06006899A (es) * 2003-12-22 2006-09-04 Gilead Sciences Inc Derivados de carbovir y abacavir 4'-sustituidos asi como compuestos relacionados con actividad antiviral de virus de inmunodeficiencia humana y virus de la hepatitis c.
BRPI0418031A (pt) * 2003-12-22 2007-04-17 Gilead Sciences Inc inibidores de quinase fosfonato-substituìdos
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
HRP20070078A2 (hr) 2004-07-27 2007-05-31 Gilead Sciences Fosfonatni analozi spojeva koji inhibiraju hiv
CA2585353A1 (en) * 2004-10-26 2006-05-04 Gilead Sciences, Inc. Phosphonate derivatives of mycophenolic acid
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
CN101422424B (zh) * 2007-10-31 2012-10-24 王世亮 霉酚酸类药物植入剂及其制备方法和应用
PT2307435E (pt) * 2008-07-08 2012-09-19 Gilead Sciences Inc Sais de compostos inibidores de vih
US9492426B2 (en) * 2011-09-21 2016-11-15 The Texas A&M University System Mycophenolic acid analogues as anti-tumor chemosensitizing agents
CN105271935B (zh) * 2015-11-03 2017-06-30 陶祖岐 一种生活垃圾制成的装饰板和包装箱板
US10603299B2 (en) 2016-06-02 2020-03-31 Steven Baranowitz Prevention and treatment of viral infections
CA3026241A1 (en) 2016-06-02 2017-12-07 Steven Baranowitz Prevention and treatment of viral infections
US12011429B2 (en) 2016-06-02 2024-06-18 Steven Baranowitz Prevention and treatment of viral infections
WO2019027920A1 (en) 2017-08-01 2019-02-07 Gilead Sciences, Inc. CRYSTALLINE FORMS OF ETHYL ((S) - (((((2R, 5R) -5- (6-AMINO-9H-PURIN-9-YL) -4-FLUORO-2,5-DIHYDROFURAN-2-YL) OXY ) METHYL) (PHENOXY) PHOSPHORYL) -L-ALANINATE (GS-9131) FOR THE TREATMENT OF VIRAL INFECTIONS

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Also Published As

Publication number Publication date
JPH09509174A (ja) 1997-09-16
TW384288B (en) 2000-03-11
UY23910A1 (es) 1995-03-06
SV1995000007A (es) 1996-02-28
GR3033864T3 (en) 2000-10-31
FI963218A0 (fi) 1996-08-16
HRP950070A2 (en) 1997-06-30
ATE194608T1 (de) 2000-07-15
MX9603478A (es) 1997-12-31
EP0745073A1 (en) 1996-12-04
FI963218A7 (fi) 1996-10-11
DK0745073T3 (da) 2000-09-18
IL112665A0 (en) 1995-05-26
PH31441A (en) 1998-11-03
CO4340734A1 (es) 1996-07-30
DE69517957D1 (de) 2000-08-17
PT745073E (pt) 2000-12-29
GT199500007A (es) 1996-08-10
CA2183530A1 (en) 1995-08-24
SI0745073T1 (en) 2000-12-31
AU1875495A (en) 1995-09-04
FI963218L (fi) 1996-10-11
EP0745073B1 (en) 2000-07-12
BR9506819A (pt) 1997-09-09
US5633279A (en) 1997-05-27
IS4264A (is) 1995-08-19
ES2149971T3 (es) 2000-11-16
IL124139A (en) 2000-02-29
CN1141038A (zh) 1997-01-22
PE22996A1 (es) 1996-06-04
US5493030A (en) 1996-02-20
MY112804A (en) 2001-09-29
ZA951299B (en) 1996-08-16
WO1995022538A1 (en) 1995-08-24
DE69517957T2 (de) 2001-01-25
HRP950070B1 (en) 2001-02-28
IL112665A (en) 1999-05-09

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Legal Events

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Effective date: 20110321