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UA99150C2 - Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств - Google Patents

Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств

Info

Publication number
UA99150C2
UA99150C2 UAA201005122A UAA201005122A UA99150C2 UA 99150 C2 UA99150 C2 UA 99150C2 UA A201005122 A UAA201005122 A UA A201005122A UA A201005122 A UAA201005122 A UA A201005122A UA 99150 C2 UA99150 C2 UA 99150C2
Authority
UA
Ukraine
Prior art keywords
traumatic stress
stress disorders
treating post
tetrahydroquinoline derivatives
alkyl
Prior art date
Application number
UAA201005122A
Other languages
English (en)
Ukrainian (uk)
Inventor
Франсуа Жанк
Original Assignee
Актелион Фармасьютикалс Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40467356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99150(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Актелион Фармасьютикалс Лтд filed Critical Актелион Фармасьютикалс Лтд
Publication of UA99150C2 publication Critical patent/UA99150C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Данное изобретение относится к применению производных тетрагидрохинолина формулы IIa,гдеRи Rкаждый независимо означает С-Салкоксигруппу,Rозначает арил(С-С)алкил или гетероарил(С-С)алкил, иRозначает С-Салкил,или фармацевтически приемлемым солям указанных соединений для получения лекарственного средства, предназначенного для профилактики или лечения посттравматических стрессовых расстройств.
UAA201005122A 2007-10-10 2008-10-09 Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств UA99150C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2007054130 2007-10-10

Publications (1)

Publication Number Publication Date
UA99150C2 true UA99150C2 (ru) 2012-07-25

Family

ID=40467356

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201005122A UA99150C2 (ru) 2007-10-10 2008-10-09 Производные тетрагидрохинолина для лечения посттравматических стрессовых расстройств

Country Status (27)

Country Link
US (1) US9532985B2 (ru)
EP (1) EP2207550B1 (ru)
JP (1) JP5883222B2 (ru)
KR (1) KR101733247B1 (ru)
CN (1) CN101820878B (ru)
AR (1) AR068768A1 (ru)
AU (1) AU2008309194B2 (ru)
BR (1) BRPI0818617A2 (ru)
CA (1) CA2699504C (ru)
CY (1) CY1114799T1 (ru)
DK (1) DK2207550T3 (ru)
EA (1) EA017443B1 (ru)
ES (1) ES2444418T3 (ru)
HR (1) HRP20140214T1 (ru)
IL (1) IL204838A (ru)
MA (1) MA31800B1 (ru)
MX (1) MX2010003711A (ru)
MY (1) MY153044A (ru)
NZ (1) NZ585086A (ru)
PE (1) PE20091010A1 (ru)
PL (1) PL2207550T3 (ru)
PT (1) PT2207550E (ru)
SI (1) SI2207550T1 (ru)
TW (1) TWI428129B (ru)
UA (1) UA99150C2 (ru)
WO (1) WO2009047723A2 (ru)
ZA (1) ZA201003251B (ru)

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US8188082B2 (en) 2006-12-22 2012-05-29 Actelion Pharmaceuticals Ltd. 5,6,7,8-tetrahydro-imidazo[1,5-α]pyrazine derivatives
CN102076694A (zh) 2008-06-25 2011-05-25 埃科特莱茵药品有限公司 5，6，7，8-四氢-咪唑并[1，5-a]吡嗪化合物
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist
KR101802726B1 (ko) 2010-08-24 2017-11-29 액테리온 파마슈티칼 리미티드 오렉신 수용체 안타고니스트로서의 프롤린 술폰아미드 유도체
UA108510C2 (xx) 2010-09-22 2015-05-12 Eisai R&D Man Co Ltd Циклопропанова сполука
EP2638008B1 (en) 2010-11-10 2015-07-01 Actelion Pharmaceuticals Ltd Lactam derivatives useful as orexin receptor antagonists
WO2012085852A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
JP5987005B2 (ja) 2011-02-18 2016-09-06 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン拮抗薬として有用な新規なピラゾール及びイミダゾール誘導体
WO2012114252A1 (en) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Novel indole and pyrrolopyridine amides
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
EA024106B1 (ru) 2011-11-08 2016-08-31 Актелион Фармасьютиклз Лтд. Производные 2-(1,2,3-триазол-2-ил)бензамида и 3-(1,2,3-триазол-2-ил)пиколинамида
KR101689093B1 (ko) 2012-06-04 2016-12-22 액테리온 파마슈티칼 리미티드 벤즈이미다졸-프롤린 유도체
JP6244365B2 (ja) 2012-10-10 2017-12-06 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ［オルトビ−（ヘテロ−）アリール］−［２−（メタビ−（ヘテロ−）アリール）−ピロリジン−１−イル］−メタノン誘導体であるオレキシン受容体アンタゴニスト
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
WO2015083070A1 (en) 2013-12-03 2015-06-11 Actelion Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
MX366642B (es) 2013-12-04 2019-07-17 Idorsia Pharmaceuticals Ltd Uso de derivados de bencimidazol-prolina.
MX376164B (es) 2014-10-23 2025-03-07 Eisai R&D Man Co Ltd Composiciones y metodos para tratar el insomnio.
JP7179049B2 (ja) * 2017-08-01 2022-11-28 ベルゲン ファーマシューティカル、 エルエルシー オレキシン受容体拮抗薬の結晶形及びその製造方法並びに用途
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020007977A1 (en) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
TW202400149A (zh) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 經噻唑并芳基-甲基取代之環狀肼-n-甲醯胺衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE286500T1 (de) * 2000-03-14 2005-01-15 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisochinolin-derivate
BRPI0408681A (pt) * 2003-03-26 2006-03-28 Actelion Pharmaceuticals Ltd compostos, composições farmacêuticas, uso de um derivado da 1,2,3,4-tetraidroisoquinolina, método para tratar ou prevenir doenças, processo para a manufatura de composições farmacêuticas, e, uso de um ou mais compostos
RU2378257C2 (ru) * 2004-03-01 2010-01-10 Актелион Фармасьютиклз Лтд Замещенные производные 1,2,3,4-тетрагидроизохинолина
US7501395B2 (en) * 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
UA93903C2 (ru) 2006-03-15 2011-03-25 Актелион Фармасьютикалз Лтд Производные тетрагидроизохинолина для повышения функции памяти
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist

Also Published As

Publication number Publication date
KR20100065203A (ko) 2010-06-15
WO2009047723A2 (en) 2009-04-16
US20100234420A1 (en) 2010-09-16
HK1145440A1 (en) 2011-04-21
HRP20140214T1 (hr) 2014-04-11
WO2009047723A3 (en) 2009-05-28
TWI428129B (zh) 2014-03-01
EP2207550B1 (en) 2013-12-11
TW200932231A (en) 2009-08-01
EA017443B1 (ru) 2012-12-28
AU2008309194A1 (en) 2009-04-16
MA31800B1 (fr) 2010-10-01
CN101820878B (zh) 2012-02-01
CA2699504A1 (en) 2009-04-16
US9532985B2 (en) 2017-01-03
ES2444418T3 (es) 2014-02-25
PL2207550T3 (pl) 2014-05-30
DK2207550T3 (da) 2014-01-27
MY153044A (en) 2014-12-31
EA201000557A1 (ru) 2010-10-29
CA2699504C (en) 2015-11-24
BRPI0818617A2 (pt) 2015-04-07
CY1114799T1 (el) 2016-12-14
JP5883222B2 (ja) 2016-03-09
AU2008309194B2 (en) 2013-10-03
IL204838A (en) 2014-09-30
CN101820878A (zh) 2010-09-01
SI2207550T1 (sl) 2014-03-31
ZA201003251B (en) 2011-07-27
AR068768A1 (es) 2009-12-02
MX2010003711A (es) 2010-04-30
KR101733247B1 (ko) 2017-05-08
PT2207550E (pt) 2014-02-07
PE20091010A1 (es) 2009-08-08
IL204838A0 (en) 2010-11-30
EP2207550A2 (en) 2010-07-21
JP2011500550A (ja) 2011-01-06
NZ585086A (en) 2012-03-30

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