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UA99699C2 - Indole carboxamide derivatives and pharmaceutical composition comprising thereof - Google Patents

Indole carboxamide derivatives and pharmaceutical composition comprising thereof

Info

Publication number
UA99699C2
UA99699C2 UAA200714940A UAA200714940A UA99699C2 UA 99699 C2 UA99699 C2 UA 99699C2 UA A200714940 A UAA200714940 A UA A200714940A UA A200714940 A UAA200714940 A UA A200714940A UA 99699 C2 UA99699 C2 UA 99699C2
Authority
UA
Ukraine
Prior art keywords
compound
pharmaceutical composition
directed
ikk2
carboxamide derivatives
Prior art date
Application number
UAA200714940A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Жианг Денг
Джеффри К. Кернс
Ки Жин
Гуолианг Лин
Сишень Лин
Майкл Линденмус
Кристофер Э. Неипп
Хонг НИЕ
Соня М. Томас
Катрин Л. Виддоусон
Original Assignee
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of UA99699C2 publication Critical patent/UA99699C2/en

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
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  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
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Abstract

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I, where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.(I).
UAA200714940A 2005-06-30 2006-06-28 Indole carboxamide derivatives and pharmaceutical composition comprising thereof UA99699C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69525605P 2005-06-30 2005-06-30

Publications (1)

Publication Number Publication Date
UA99699C2 true UA99699C2 (en) 2012-09-25

Family

ID=37605008

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200714940A UA99699C2 (en) 2005-06-30 2006-06-28 Indole carboxamide derivatives and pharmaceutical composition comprising thereof

Country Status (19)

Country Link
EP (1) EP1896014A4 (en)
JP (1) JP5059756B2 (en)
KR (1) KR20080021077A (en)
CN (1) CN101247804B (en)
AR (1) AR055343A1 (en)
AU (1) AU2006266028B2 (en)
BR (1) BRPI0611674A2 (en)
CA (1) CA2613068A1 (en)
EA (1) EA014083B1 (en)
IL (1) IL187786A0 (en)
MA (1) MA29566B1 (en)
MX (1) MX2007016541A (en)
NO (1) NO20080457L (en)
NZ (1) NZ563687A (en)
PE (1) PE20070173A1 (en)
TW (1) TWI380973B (en)
UA (1) UA99699C2 (en)
WO (1) WO2007005534A2 (en)
ZA (1) ZA200709948B (en)

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PE20081889A1 (en) * 2007-03-23 2009-03-05 Smithkline Beecham Corp INDOL CARBOXAMIDES AS INHIBITORS OF IKK2
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