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NO20080457L - Chemical connections - Google Patents

Chemical connections

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Publication number
NO20080457L
NO20080457L NO20080457A NO20080457A NO20080457L NO 20080457 L NO20080457 L NO 20080457L NO 20080457 A NO20080457 A NO 20080457A NO 20080457 A NO20080457 A NO 20080457A NO 20080457 L NO20080457 L NO 20080457L
Authority
NO
Norway
Prior art keywords
compound
ikk2
directed
compounds
formula
Prior art date
Application number
NO20080457A
Other languages
Norwegian (no)
Inventor
Qi Jin
Christopher E Neipp
Sonia M Thomas
Jeffrey K Kerns
Michael Lindenmuth
Xichen Lin
Hong Nie
Jianghe Deng
Guoliang Lin
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20080457L publication Critical patent/NO20080457L/en

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Abstract

Foreliggende oppfinnelse er rettet mot nye indolkarboksamidderivater. Spesifikt er oppfinnelsen rettet mot forbindelser ifølge formel I: Formel (I) hvor RI, R2, R3, U og V er definert nedenfor, og mot farmasøytisk akseptable salter derav. Forbindelsene ifølge oppfinnelsen er inhibitorer av IKK2 og kan være nyttige i behandlingen av forstyrrelser assosiert med uheldig IKK2 (også kjent som IKKP) aktivitet, slik som reumatoid artritt, astma og COPD (kronisk obstruktiv lungesykdom). Oppfinnelsen er følgelig ytterligere rettet mot farmasøytiske sammensetninger omfattende en forbindelse ifølge oppfinnelsen. Oppfinnelsen er også ytterligere rettet mot fremgangsmåter for å inhibere IKK2-aktivitet og behandling av forstyrrelser assosiert dermed, ved anvendelse av en forbindelse ifølge foreliggende oppfinnelse eller en farmasøytisk sammensetning omfattende en forbindelse ifølge oppfinnelsen.The present invention is directed to novel indolecarboxamide derivatives. Specifically, the invention is directed to compounds of formula I: Formula (I) wherein R1, R2, R3, U and V are defined below, and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and may be useful in the treatment of disorders associated with adverse IKK2 (also known as IKKP) activity, such as rheumatoid arthritis, asthma and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is also further directed to methods for inhibiting IKK2 activity and the treatment of disorders associated therewith, using a compound of the present invention or a pharmaceutical composition comprising a compound of the invention.

NO20080457A 2005-06-30 2008-01-24 Chemical connections NO20080457L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69525605P 2005-06-30 2005-06-30
PCT/US2006/025402 WO2007005534A2 (en) 2005-06-30 2006-06-28 Chemical compounds

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EP (1) EP1896014A4 (en)
JP (1) JP5059756B2 (en)
KR (1) KR20080021077A (en)
CN (1) CN101247804B (en)
AR (1) AR055343A1 (en)
AU (1) AU2006266028B2 (en)
BR (1) BRPI0611674A2 (en)
CA (1) CA2613068A1 (en)
EA (1) EA014083B1 (en)
IL (1) IL187786A0 (en)
MA (1) MA29566B1 (en)
MX (1) MX2007016541A (en)
NO (1) NO20080457L (en)
NZ (1) NZ563687A (en)
PE (1) PE20070173A1 (en)
TW (1) TWI380973B (en)
UA (1) UA99699C2 (en)
WO (1) WO2007005534A2 (en)
ZA (1) ZA200709948B (en)

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PE20081889A1 (en) * 2007-03-23 2009-03-05 Smithkline Beecham Corp INDOL CARBOXAMIDES AS INHIBITORS OF IKK2
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