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BRPI0611674A2 - chemical compounds - Google Patents

chemical compounds

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Publication number
BRPI0611674A2
BRPI0611674A2 BRPI0611674-4A BRPI0611674A BRPI0611674A2 BR PI0611674 A2 BRPI0611674 A2 BR PI0611674A2 BR PI0611674 A BRPI0611674 A BR PI0611674A BR PI0611674 A2 BRPI0611674 A2 BR PI0611674A2
Authority
BR
Brazil
Prior art keywords
compound
directed
ikk2
compounds
activity
Prior art date
Application number
BRPI0611674-4A
Other languages
Portuguese (pt)
Inventor
Jianghe Deng
Jeffrey K Kerns
Qi Jin
Guoliang Lin
Xichen Lin
Michael Lindenmuth
Christopher E Neipp
Hong Nie
Sonia M Thomas
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BRPI0611674A2 publication Critical patent/BRPI0611674A2/en

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P9/08—Vasodilators for multiple indications
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Virology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
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Abstract

COMPOSTOS QUÍMICOS. A invenção é dirigida aos novos derivados de indol carboxamida. Especificamente, a invenção é dirigida aos compostos de acordo com a fórmula I: onde R1, R2, R3, U e V são definidos abaixo, e aos seus sais farmaceuticamente aceitáveis. Os compostos da invenção são inibidores da IKK2 e podem ser úteis no tratamento de distúrbios associados com a atividade da IKK2 (também conhecida como IKKI<225>) inapropriada, tais como a artrite reumatóide, a asma, e a DPOC (doença pulmonar obstrutiva crônica> . Desse modo, a invenção é adicionalmente dirigida às composições farmacêuticas que compreendem um composto da invenção. A invenção ainda é adicionalmente dirigida aos métodos de inibição da atividade da IKK2 e tratamento de distúrbios associados com ela usando um composto da invenção ou uma composição farmacêutica que compreende um composto da invenção.CHEMICAL COMPOUNDS. The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to the compounds according to formula I: where R 1, R 2, R 3, U and V are defined below, and their pharmaceutically acceptable salts. The compounds of the invention are inhibitors of IKK2 and may be useful in treating disorders associated with inappropriate IKK2 (also known as IKKI <225>) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Thus, the invention is further directed to pharmaceutical compositions comprising a compound of the invention The invention is further directed to methods of inhibiting IKK2 activity and treating disorders associated therewith using a compound of the invention or a pharmaceutical composition. which comprises a compound of the invention.

BRPI0611674-4A 2005-06-30 2006-06-28 chemical compounds BRPI0611674A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69525605P 2005-06-30 2005-06-30
PCT/US2006/025402 WO2007005534A2 (en) 2005-06-30 2006-06-28 Chemical compounds

Publications (1)

Publication Number Publication Date
BRPI0611674A2 true BRPI0611674A2 (en) 2009-04-28

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BRPI0611674-4A BRPI0611674A2 (en) 2005-06-30 2006-06-28 chemical compounds

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EP (1) EP1896014A4 (en)
JP (1) JP5059756B2 (en)
KR (1) KR20080021077A (en)
CN (1) CN101247804B (en)
AR (1) AR055343A1 (en)
AU (1) AU2006266028B2 (en)
BR (1) BRPI0611674A2 (en)
CA (1) CA2613068A1 (en)
EA (1) EA014083B1 (en)
IL (1) IL187786A0 (en)
MA (1) MA29566B1 (en)
MX (1) MX2007016541A (en)
NO (1) NO20080457L (en)
NZ (1) NZ563687A (en)
PE (1) PE20070173A1 (en)
TW (1) TWI380973B (en)
UA (1) UA99699C2 (en)
WO (1) WO2007005534A2 (en)
ZA (1) ZA200709948B (en)

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WO2007076286A2 (en) * 2005-12-16 2007-07-05 Smithkline Beecham Corporation Chemical compounds
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