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UA99597C2 - Піримідилциклопентани як інгібітори акт протеїнкіназ - Google Patents

Піримідилциклопентани як інгібітори акт протеїнкіназ

Info

Publication number
UA99597C2
UA99597C2 UAA200900828A UAA200900828A UA99597C2 UA 99597 C2 UA99597 C2 UA 99597C2 UA A200900828 A UAA200900828 A UA A200900828A UA A200900828 A UAA200900828 A UA A200900828A UA 99597 C2 UA99597 C2 UA 99597C2
Authority
UA
Ukraine
Prior art keywords
protein kinase
kinase inhibitors
akt protein
cyclopenta
pyrimidines
Prior art date
Application number
UAA200900828A
Other languages
English (en)
Russian (ru)
Inventor
Ян С. Мітчелл
Джеймс Ф. Блейк
Руі Ксу
Ніколас С. Каллан
Денгмінг Ксіао
Кейт Лі Спенсер
Джозеф Р. Бенсік
Джун Ліанг
Браян Сафіна
Джун Лі
Крістін Шабо
Елі М. Веллес
Анна Л. БАНКА
Стефен Шлахтер
Original Assignee
Еррей Біофарма Інк.
Дженентек, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA99597(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Еррей Біофарма Інк., Дженентек, Інк. filed Critical Еррей Біофарма Інк.
Publication of UA99597C2 publication Critical patent/UA99597C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
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  • Oncology (AREA)
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  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)

Abstract

Даний винахід стосується сполук Формули І, включаючи їх таутомери, розділені енантіомери, діастереомери, сольвати, метаболіти, солі та фармацевтично прийнятні проліки. EMBED ISISServer I
UAA200900828A 2006-07-06 2007-07-05 Піримідилциклопентани як інгібітори акт протеїнкіназ UA99597C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81876206P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
UA99597C2 true UA99597C2 (uk) 2012-09-10

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200900828A UA99597C2 (uk) 2006-07-06 2007-07-05 Піримідилциклопентани як інгібітори акт протеїнкіназ

Country Status (31)

Country Link
US (3) US8003651B2 (uk)
EP (1) EP2049500B1 (uk)
JP (3) JP5268904B2 (uk)
KR (2) KR20150041164A (uk)
CN (2) CN101631778B (uk)
AR (1) AR061844A1 (uk)
AT (1) ATE523499T1 (uk)
AU (1) AU2007269052B2 (uk)
BR (1) BRPI0713555A2 (uk)
CA (1) CA2656618C (uk)
CL (1) CL2007001992A1 (uk)
CO (1) CO6160229A2 (uk)
CR (2) CR10601A (uk)
CY (1) CY1112142T1 (uk)
DK (1) DK2049500T3 (uk)
ES (1) ES2372955T3 (uk)
HR (1) HRP20110882T1 (uk)
IL (1) IL196051A (uk)
MA (1) MA30952B1 (uk)
MX (1) MX2008016203A (uk)
MY (1) MY147628A (uk)
NO (1) NO20090580L (uk)
NZ (1) NZ573979A (uk)
PL (1) PL2049500T3 (uk)
PT (1) PT2049500E (uk)
RS (1) RS52210B (uk)
RU (1) RU2481336C2 (uk)
SI (1) SI2049500T1 (uk)
TW (1) TWI428335B (uk)
UA (1) UA99597C2 (uk)
WO (1) WO2008006032A1 (uk)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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