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NO20090580L - Syklopenta[D]pyrimidiner som AKT-proteinkinaseinhibitorer - Google Patents

Syklopenta[D]pyrimidiner som AKT-proteinkinaseinhibitorer

Info

Publication number
NO20090580L
NO20090580L NO20090580A NO20090580A NO20090580L NO 20090580 L NO20090580 L NO 20090580L NO 20090580 A NO20090580 A NO 20090580A NO 20090580 A NO20090580 A NO 20090580A NO 20090580 L NO20090580 L NO 20090580L
Authority
NO
Norway
Prior art keywords
protein kinase
kinase inhibitors
cyclopenta
pyrimidines
akt protein
Prior art date
Application number
NO20090580A
Other languages
English (en)
Inventor
Dengming Xiao
Ian S Mitchell
James F Blake
Brian Safina
Jun Liang
Stephen T Schlachter
Rui Xu
Nicholas C Kallan
Keith Lee Spencer
Josef R Bencsik
Jun Li
Christine Chabot
Eli M Wallace
Anna L Banka
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20090580(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of NO20090580L publication Critical patent/NO20090580L/no

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

Den foreliggende oppfinnelse tilveiebringer forbindelser med formel I inkludert tautomerer, oppløste enantiomerer, diastereomerer, solvater, metabolitter, salter og farmasøytisk akseptable prolegemidler derav. Det er også tilveiebrakt fremgangsmåter for anvendelse av forbindelsene ifølge denne oppfinnelsen som AKT-proteinkinaseinhibitorer, og for behandling av hyperproliferative sykdommer, slik som kreft.
NO20090580A 2006-07-06 2009-02-05 Syklopenta[D]pyrimidiner som AKT-proteinkinaseinhibitorer NO20090580L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81876206P 2006-07-06 2006-07-06
PCT/US2007/072876 WO2008006032A1 (en) 2006-07-06 2007-07-05 Cyclopenta [d] pyrimidines as akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20090580L true NO20090580L (no) 2009-04-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20090580A NO20090580L (no) 2006-07-06 2009-02-05 Syklopenta[D]pyrimidiner som AKT-proteinkinaseinhibitorer

Country Status (31)

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US (3) US8003651B2 (no)
EP (1) EP2049500B1 (no)
JP (3) JP5268904B2 (no)
KR (2) KR101527232B1 (no)
CN (2) CN103288753A (no)
AR (1) AR061844A1 (no)
AT (1) ATE523499T1 (no)
AU (1) AU2007269052B2 (no)
BR (1) BRPI0713555A2 (no)
CA (1) CA2656618C (no)
CL (1) CL2007001992A1 (no)
CO (1) CO6160229A2 (no)
CR (2) CR10601A (no)
CY (1) CY1112142T1 (no)
DK (1) DK2049500T3 (no)
ES (1) ES2372955T3 (no)
HR (1) HRP20110882T1 (no)
IL (1) IL196051A (no)
MA (1) MA30952B1 (no)
MX (1) MX2008016203A (no)
MY (1) MY147628A (no)
NO (1) NO20090580L (no)
NZ (1) NZ573979A (no)
PL (1) PL2049500T3 (no)
PT (1) PT2049500E (no)
RS (1) RS52210B (no)
RU (1) RU2481336C2 (no)
SI (1) SI2049500T1 (no)
TW (1) TWI428335B (no)
UA (1) UA99597C2 (no)
WO (1) WO2008006032A1 (no)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
MX2008016203A (es) 2006-07-06 2009-01-27 Array Biopharma Inc Ciclopenta [d] pirimidinas como inhibidores de la proteina cinasa akt.
JP5231411B2 (ja) * 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
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