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UA98098C2 - ПРОИЗВОДНЫЕ ПИРИДИНОНА И ИХ ПРИМЕНЕНИЕ КАК ПОЛОЖИТЕЛЬНЫХ АЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 - Google Patents

ПРОИЗВОДНЫЕ ПИРИДИНОНА И ИХ ПРИМЕНЕНИЕ КАК ПОЛОЖИТЕЛЬНЫХ АЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2

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Publication number
UA98098C2
UA98098C2 UAA200703393A UAA200703393A UA98098C2 UA 98098 C2 UA98098 C2 UA 98098C2 UA A200703393 A UAA200703393 A UA A200703393A UA A200703393 A UAA200703393 A UA A200703393A UA 98098 C2 UA98098 C2 UA 98098C2
Authority
UA
Ukraine
Prior art keywords
mglur2
compounds
diseases
receptors
positive allosteric
Prior art date
Application number
UAA200703393A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ассан Жюльен Эмоге
Хозе Мария Суд-Нуньес
Гийом Альбер Жак Дюве
Кристель Мартин Болеа
Вантеа Нем
Терри Патрик Финн
Пуль Эманюэль Кристиан Ле
Жан-Филлипп Франсуа Кристиан Роше
Роберт Йоганнес Лютьенс
Original Assignee
Орто-МакНилл-Янссен Фармасутикала, Инк.
Аддекс Фарма Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-МакНилл-Янссен Фармасутикала, Инк., Аддекс Фарма Са filed Critical Орто-МакНилл-Янссен Фармасутикала, Инк.
Publication of UA98098C2 publication Critical patent/UA98098C2/ru

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Abstract

Изобретение касается новых соединений, в частности новых производных пиридинона формулы (I) X R1 N Y Y (I) R2 R3, где все радикалы определены в заявке.Соединения согласно изобретению являются положительными аллостерическими модуляторами метаботропных рецепторов субтипа 2 (mGluR2), которые могут быть использованы для лечения или профилактики неврологических и психиатрических расстройств, связанных с глютаматной дисфункцией, и болезней, связанных с метаботропными рецепторами субтипа mGluR2. В частности, такими болезнями являются болезни центральной нервной системы, как тревожность, шизофрения, мигрень, депрессия и эпилепсия.Изобретение также касается фармацевтических композиций, способов приготовления таких соединений и композиций, а также использование таких соединений для профилактики и лечения болезней, связанных с mGluR2.
UAA200703393A 2004-09-17 2005-09-16 ПРОИЗВОДНЫЕ ПИРИДИНОНА И ИХ ПРИМЕНЕНИЕ КАК ПОЛОЖИТЕЛЬНЫХ АЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ РЕЦЕПТОРОВ mGluR2 UA98098C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators
PCT/EP2005/054636 WO2006030032A1 (en) 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

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JP2013047254A (ja) 2013-03-07
JP2008513414A (ja) 2008-05-01
CA2581144A1 (en) 2006-03-23
ZA200703088B (en) 2008-08-27
AU2005284098A1 (en) 2006-03-23
EP1799646A1 (en) 2007-06-27
JP5723850B2 (ja) 2015-05-27

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