UA98946C2 - Phosphoinositide 3-kinase inhibitor compounds and methods of use - Google Patents
Phosphoinositide 3-kinase inhibitor compounds and methods of useInfo
- Publication number
- UA98946C2 UA98946C2 UAA200907051A UAA200907051A UA98946C2 UA 98946 C2 UA98946 C2 UA 98946C2 UA A200907051 A UAA200907051 A UA A200907051A UA A200907051 A UAA200907051 A UA A200907051A UA 98946 C2 UA98946 C2 UA 98946C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- compounds
- phosphoinositide
- kinase inhibitor
- inhibitor compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000038030 PI3Ks Human genes 0.000 abstract 1
- 108091007960 PI3Ks Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Соединения формулы Ia-d, в которых X представляет собой S или О, mor представляет собой морфолиновую группу и Rпредставляет собой моноцикличную гетероарильную группу, включая их стереоизомеры, геометрические изомеры, таутомеры, сольваты, метаболиты и фармацевтически приемлемые соли, применимые для модулирования активности липидных киназ, включая PI3K, и для лечения нарушений, таких как рак, опосредствованных липидными киназами.Раскрыты способы применения соединений формулы Ia-d для диагностики in vitro, in situ i in vivo, профилактики или лечения таких нарушений в клетках млекопитающих или ассоциированных патологических состояний.Ic,Id.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87344806P | 2006-12-07 | 2006-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA98946C2 true UA98946C2 (en) | 2012-07-10 |
Family
ID=41421545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200907051A UA98946C2 (en) | 2006-12-07 | 2007-12-05 | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101600720A (ru) |
| UA (1) | UA98946C2 (ru) |
| ZA (1) | ZA200904534B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010049595A1 (de) * | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | Chinazolinderivate |
| CN104718212B (zh) * | 2012-10-10 | 2017-06-16 | 霍夫曼-拉罗奇有限公司 | 制备噻吩并嘧啶化合物的方法 |
| CN111675692A (zh) * | 2020-06-08 | 2020-09-18 | 浙江科技学院 | 一种奥泽沙星的合成方法 |
| WO2022068929A1 (zh) * | 2020-09-30 | 2022-04-07 | 武汉人福创新药物研发中心有限公司 | 嘧啶二酮类化合物及其用途 |
| CN115135659B (zh) * | 2021-01-15 | 2024-03-12 | 深圳微芯生物科技股份有限公司 | 一类吗啉衍生物及其制备方法和应用 |
| CN113754680B (zh) * | 2021-09-28 | 2022-07-22 | 云白药征武科技(上海)有限公司 | 一种α氟代酰基哌嗪衍生物及其制备和应用 |
-
2007
- 2007-12-05 ZA ZA200904534A patent/ZA200904534B/xx unknown
- 2007-12-05 CN CNA2007800510604A patent/CN101600720A/zh active Pending
- 2007-12-05 UA UAA200907051A patent/UA98946C2/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200904534B (en) | 2010-09-29 |
| CN101600720A (zh) | 2009-12-09 |
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