UA98946C2 - Phosphoinositide 3-kinase inhibitor compounds and methods of use - Google Patents
Phosphoinositide 3-kinase inhibitor compounds and methods of useInfo
- Publication number
- UA98946C2 UA98946C2 UAA200907051A UAA200907051A UA98946C2 UA 98946 C2 UA98946 C2 UA 98946C2 UA A200907051 A UAA200907051 A UA A200907051A UA A200907051 A UAA200907051 A UA A200907051A UA 98946 C2 UA98946 C2 UA 98946C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methods
- compounds
- phosphoinositide
- kinase inhibitor
- inhibitor compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 title 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000002632 lipids Chemical class 0.000 abstract 2
- 102000020233 phosphotransferase Human genes 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000038030 PI3Ks Human genes 0.000 abstract 1
- 108091007960 PI3Ks Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed., Ic, Id
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87344806P | 2006-12-07 | 2006-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA98946C2 true UA98946C2 (en) | 2012-07-10 |
Family
ID=41421545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200907051A UA98946C2 (en) | 2006-12-07 | 2007-12-05 | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101600720A (en) |
| UA (1) | UA98946C2 (en) |
| ZA (1) | ZA200904534B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010049595A1 (en) * | 2010-10-26 | 2012-04-26 | Merck Patent Gmbh | quinazoline derivatives |
| CN104718212B (en) * | 2012-10-10 | 2017-06-16 | 霍夫曼-拉罗奇有限公司 | Process for preparing thienopyrimidine compounds |
| CN111675692A (en) * | 2020-06-08 | 2020-09-18 | 浙江科技学院 | A kind of synthetic method of Ao Zesha star |
| WO2022068929A1 (en) * | 2020-09-30 | 2022-04-07 | 武汉人福创新药物研发中心有限公司 | Pyrimidinedione compound and use thereof |
| CN115135659B (en) * | 2021-01-15 | 2024-03-12 | 深圳微芯生物科技股份有限公司 | A class of morpholine derivatives and their preparation methods and applications |
| CN113754680B (en) * | 2021-09-28 | 2022-07-22 | 云白药征武科技(上海)有限公司 | Alpha fluoroacyl piperazine derivative and preparation and application thereof |
-
2007
- 2007-12-05 ZA ZA200904534A patent/ZA200904534B/en unknown
- 2007-12-05 CN CNA2007800510604A patent/CN101600720A/en active Pending
- 2007-12-05 UA UAA200907051A patent/UA98946C2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200904534B (en) | 2010-09-29 |
| CN101600720A (en) | 2009-12-09 |
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