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MX2009005925A - Compuestos inhibidores de fosfoinositida 3-quinasa y los metodos de uso. - Google Patents

Compuestos inhibidores de fosfoinositida 3-quinasa y los metodos de uso.

Info

Publication number
MX2009005925A
MX2009005925A MX2009005925A MX2009005925A MX2009005925A MX 2009005925 A MX2009005925 A MX 2009005925A MX 2009005925 A MX2009005925 A MX 2009005925A MX 2009005925 A MX2009005925 A MX 2009005925A MX 2009005925 A MX2009005925 A MX 2009005925A
Authority
MX
Mexico
Prior art keywords
methods
compounds
phosphoinositide
kinase inhibitor
formula
Prior art date
Application number
MX2009005925A
Other languages
English (en)
Inventor
Georgette Castanedo
Jennafer Dotson
Richard Goldsmith
Janet Gunzner
Tim Heffron
Simon Mathieu
Alan Olivero
Steven Staben
Daniel P Sutherlin
Vickie Tsui
Shumei Wang
Bing-Yan Zhu
Irina Chuckowree
Adrian FOLKES
Nan Chi Wan
Tracy Bayliss
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39403189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005925(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2009005925A publication Critical patent/MX2009005925A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Los compuestos de las Fórmulas Ia-d, donde X es S o O, mor es un grupo morfolino, y R3 es un grupo heteroarilo monocíclico e incluyendo los estereoisómeros, los isómeros geométricos. Los tautómeros, los solvatos, los metabolitos y las sales farmacéuticamente aceptables de él, son útiles para la modulación de la actividad de lípido quinasas incluyendo PI3K, y para el tratamiento de trastornos tales como el cáncer mediado por lípido quinasas. Se revelan los métodos para usar los compuestos de la Fórmula Ia-d para los diagnósticos in vivo, in situ e in vivo, la prevención o el tratamiento de tales trastornos en las células de mamíferos, o las condiciones patológicas. (ver fórmulas (Ic e Id)).
MX2009005925A 2006-12-07 2007-12-05 Compuestos inhibidores de fosfoinositida 3-quinasa y los metodos de uso. MX2009005925A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87342206P 2006-12-07 2006-12-07
PCT/US2007/086533 WO2008073785A2 (en) 2006-12-07 2007-12-05 Phosphoinositide 3-kinase inhibitor compounds and methods of use

Publications (1)

Publication Number Publication Date
MX2009005925A true MX2009005925A (es) 2009-08-12

Family

ID=39403189

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005925A MX2009005925A (es) 2006-12-07 2007-12-05 Compuestos inhibidores de fosfoinositida 3-quinasa y los metodos de uso.

Country Status (19)

Country Link
US (1) US9487533B2 (es)
EP (1) EP2114950B1 (es)
JP (1) JP5500990B2 (es)
KR (1) KR101507182B1 (es)
CN (1) CN101675053B (es)
AR (1) AR064154A1 (es)
AU (1) AU2007333243B2 (es)
BR (1) BRPI0717907A2 (es)
CA (1) CA2671845C (es)
CL (1) CL2007003523A1 (es)
ES (1) ES2571028T3 (es)
IL (1) IL199151A (es)
MX (1) MX2009005925A (es)
NO (1) NO342697B1 (es)
PE (1) PE20081353A1 (es)
RU (1) RU2470936C2 (es)
TW (1) TW200829594A (es)
WO (1) WO2008073785A2 (es)
ZA (1) ZA200904531B (es)

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TW200829594A (en) 2008-07-16
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IL199151A (en) 2017-01-31
IL199151A0 (en) 2010-03-28
KR20090106508A (ko) 2009-10-09
CA2671845A1 (en) 2008-06-19
EP2114950A2 (en) 2009-11-11
NO20092565L (no) 2009-09-07
AU2007333243B2 (en) 2013-03-14
CN101675053A (zh) 2010-03-17
US9487533B2 (en) 2016-11-08
US20080269210A1 (en) 2008-10-30
NO342697B1 (no) 2018-07-09
AU2007333243A1 (en) 2008-06-19
RU2470936C2 (ru) 2012-12-27
CL2007003523A1 (es) 2008-08-22
CN101675053B (zh) 2014-03-12
JP2010512337A (ja) 2010-04-22
KR101507182B1 (ko) 2015-03-30
RU2009125916A (ru) 2011-01-20
JP5500990B2 (ja) 2014-05-21
AR064154A1 (es) 2009-03-18
EP2114950B1 (en) 2016-03-09
WO2008073785A2 (en) 2008-06-19
WO2008073785A3 (en) 2008-08-28
ZA200904531B (en) 2010-09-29
BRPI0717907A2 (pt) 2013-11-05
CA2671845C (en) 2015-03-24

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