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UA96965C2 - ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-с]ХИНАЗОЛИНА, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ И БОЛЕЗНЕЙ, СВЯЗАННЫХ С АНГИОГЕНЕЗОМ - Google Patents

ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-с]ХИНАЗОЛИНА, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ И БОЛЕЗНЕЙ, СВЯЗАННЫХ С АНГИОГЕНЕЗОМ

Info

Publication number
UA96965C2
UA96965C2 UAA200906701A UAA200906701A UA96965C2 UA 96965 C2 UA96965 C2 UA 96965C2 UA A200906701 A UAA200906701 A UA A200906701A UA A200906701 A UAA200906701 A UA A200906701A UA 96965 C2 UA96965 C2 UA 96965C2
Authority
UA
Ukraine
Prior art keywords
dihydroimidazo
proliferative
substituted derivatives
angiogenesis disorders
derivatives useful
Prior art date
Application number
UAA200906701A
Other languages
English (en)
Ukrainian (uk)
Inventor
Мартин Хентманн
Джилл Вуд
Вилльям Скотт
Мартин Михельс
Анн-Мари Кемпбелл
Анн-Мари Буллион
Р. Брюс Роули
Анико Редман
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39492563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96965(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of UA96965C2 publication Critical patent/UA96965C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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  • Transplantation (AREA)
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  • Orthopedic Medicine & Surgery (AREA)

Abstract

Настоящее изобретение касается новых соединений 2,3-дигидроимидазо[1,2-с]хиназолина, фармацевтических композиций, которые содержат такие соединения, и использования этих соединений или композиций для ингибирования фосфотидилинозитол-3-киназы (РИ3К) и лечения болезней, связанных с активностью фосфотидилинозитол-3-киназы (РИ3К), в частности лечения гиперпролиферативных нарушений и/или нарушений ангиогенеза, как отдельного агента или в комбинации с другими активными компонентами.
UAA200906701A 2006-12-05 2007-12-05 ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-с]ХИНАЗОЛИНА, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ И БОЛЕЗНЕЙ, СВЯЗАННЫХ С АНГИОГЕНЕЗОМ UA96965C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87309006P 2006-12-05 2006-12-05

Publications (1)

Publication Number Publication Date
UA96965C2 true UA96965C2 (ru) 2011-12-26

Family

ID=39492563

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200906701A UA96965C2 (ru) 2006-12-05 2007-12-05 ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-с]ХИНАЗОЛИНА, ПОЛЕЗНЫЕ ДЛЯ ЛЕЧЕНИЯ ГИПЕРПРОЛИФЕРАТИВНЫХ НАРУШЕНИЙ И БОЛЕЗНЕЙ, СВЯЗАННЫХ С АНГИОГЕНЕЗОМ

Country Status (41)

Country Link
US (3) US8466283B2 (ru)
EP (1) EP2096919B1 (ru)
JP (1) JP5326092B2 (ru)
KR (1) KR101501785B1 (ru)
CN (4) CN115724847A (ru)
AR (1) AR064106A1 (ru)
AU (1) AU2007328008B2 (ru)
BR (1) BRPI0720178B8 (ru)
CA (1) CA2671614C (ru)
CL (1) CL2007003508A1 (ru)
CO (1) CO6220908A2 (ru)
CR (1) CR10838A (ru)
CU (1) CU23796B7 (ru)
DK (1) DK2096919T3 (ru)
DO (1) DOP2009000135A (ru)
EA (1) EA018839B1 (ru)
EC (1) ECSP099387A (ru)
ES (1) ES2572189T3 (ru)
GT (1) GT200900154A (ru)
HN (1) HN2009001131A (ru)
HU (1) HUE028773T2 (ru)
IL (1) IL198273A (ru)
JO (1) JO3147B1 (ru)
MA (1) MA31283B1 (ru)
MX (1) MX2009006001A (ru)
MY (1) MY157944A (ru)
NO (1) NO342348B1 (ru)
NZ (1) NZ577342A (ru)
PA (1) PA8759601A1 (ru)
PE (1) PE20081444A1 (ru)
PL (1) PL2096919T3 (ru)
RS (1) RS56045B1 (ru)
SG (1) SG177170A1 (ru)
SI (1) SI2096919T1 (ru)
SV (1) SV2009003288A (ru)
TN (1) TN2009000137A1 (ru)
TW (1) TWI406662B (ru)
UA (1) UA96965C2 (ru)
UY (1) UY30761A1 (ru)
WO (1) WO2008070150A1 (ru)
ZA (1) ZA200904691B (ru)

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JP5940078B2 (ja) * 2010-11-11 2016-06-29 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ アリールアミノアルコール−置換２，３−ジヒドロイミダゾ［１，２−ｃ］キノリン
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JO3733B1 (ar) * 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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