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HN2009001131A - Derivados de 2,3-dihidroimidazol [1,2-c] quinazolinas sustituidas de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis - Google Patents

Derivados de 2,3-dihidroimidazol [1,2-c] quinazolinas sustituidas de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis

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Publication number
HN2009001131A
HN2009001131A HN2009001131A HN2009001131A HN2009001131A HN 2009001131 A HN2009001131 A HN 2009001131A HN 2009001131 A HN2009001131 A HN 2009001131A HN 2009001131 A HN2009001131 A HN 2009001131A HN 2009001131 A HN2009001131 A HN 2009001131A
Authority
HN
Honduras
Prior art keywords
treatment
dihydroimidazol
angiogenesis
hyperproliferative disorders
kinazolines
Prior art date
Application number
HN2009001131A
Other languages
English (en)
Inventor
Hentemann Martin
Wood Jill
Scott William
Michels Martin
Marie Campbell Ann
Rowley Bruce
Redman Aniko
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39492563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HN2009001131(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of HN2009001131A publication Critical patent/HN2009001131A/es

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    • C07D487/04Ortho-condensed systems
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/53751,4-Oxazines, e.g. morpholine
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    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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Abstract

ESTA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE 2,3- DIHIDROIMIDAZOL [1,2-C] QUINAZOLINA, CON COMPOSICIONES FARMACEUTICAS QUE CONTIENEN A DICHOS COMPUESTOS Y CON EL USO DE DICHOS COMPUESTOS O COMPOSICIONES EN LA INHIBICION Y EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS CON LA ACTIVIDAD DE LA FOSFOTIDILINOSITOL-3-QUINASA (P13K), EN PARTICULAR CON EL TRATMIENTO DE TRASTORNOS HIPERPROLIFERATIVOS Y/O DE ANGIOGENESIS, COMO AGENTE UNICO O EN COMBINACIONES CON OTROS INGREDIENTES ACTIVOS.
HN2009001131A 2006-12-05 2009-06-04 Derivados de 2,3-dihidroimidazol [1,2-c] quinazolinas sustituidas de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis HN2009001131A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87309006P 2006-12-05 2006-12-05

Publications (1)

Publication Number Publication Date
HN2009001131A true HN2009001131A (es) 2012-02-06

Family

ID=39492563

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2009001131A HN2009001131A (es) 2006-12-05 2009-06-04 Derivados de 2,3-dihidroimidazol [1,2-c] quinazolinas sustituidas de utilidad en el tratamiento de trastornos hiperproliferativos y enfermedades asociadas con la angiogenesis

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EP (1) EP2096919B1 (es)
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KR (1) KR101501785B1 (es)
CN (4) CN115724847A (es)
AR (1) AR064106A1 (es)
AU (1) AU2007328008B2 (es)
BR (1) BRPI0720178B8 (es)
CA (1) CA2671614C (es)
CL (1) CL2007003508A1 (es)
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CR (1) CR10838A (es)
CU (1) CU23796B7 (es)
DK (1) DK2096919T3 (es)
DO (1) DOP2009000135A (es)
EA (1) EA018839B1 (es)
EC (1) ECSP099387A (es)
ES (1) ES2572189T3 (es)
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HN (1) HN2009001131A (es)
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MA (1) MA31283B1 (es)
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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009091550A2 (en) * 2008-01-14 2009-07-23 Bayer Healthcare Llc Sulfone substituted 2,3-dihydroimidazo [1,2-c] quinazoline derivatives useful for treating hyper-proliferative disorders and diseases with angiogenesis
EP2168583A1 (en) * 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma
EP2168582A1 (en) 2008-09-24 2010-03-31 Bayer Schering Pharma Aktiengesellschaft Combinations of substituted 2,3-dihydroimidazo[1,2-c]quinazolines
CA2735932C (en) * 2008-09-30 2013-07-09 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
EP2184276A1 (en) 2008-11-07 2010-05-12 Universite Paul Cezanne Aix-Marseille Iii Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors
EP2388252B1 (en) 2009-01-16 2013-07-24 Daiso Co., Ltd. Process for producing 2-hydroxymethylmorpholine salt
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
CA2796253A1 (en) 2010-04-16 2011-10-20 Bayer Intellectual Property Gmbh Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
JP2013538215A (ja) 2010-08-31 2013-10-10 エスエヌユー アールアンドディービー ファウンデーション PPARδアゴニストの胎児再プログラミング用途
UA113280C2 (xx) * 2010-11-11 2017-01-10 АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ
CA2817287A1 (en) 2010-11-11 2012-05-18 Bayer Intellectual Property Gmbh Arylaminoalcohol-substituted 2,3-dihydroimidazo[1,2-c]quinolines
CA2817312A1 (en) * 2010-11-11 2012-05-18 Bayer Intellectual Property Gmbh Alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazolines
JO3733B1 (ar) * 2011-04-05 2021-01-31 Bayer Ip Gmbh استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة
EP2508525A1 (en) * 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
BR112014031421A2 (pt) 2012-06-15 2017-06-27 Brigham & Womens Hospital Inc composições para tratamento de câncer e métodos para produção das mesmas
WO2014068070A1 (en) 2012-10-31 2014-05-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for preventing antiphospholipid syndrome (aps)
DK3150256T3 (da) * 2012-11-02 2020-08-24 Tg Therapeutics Inc Kombination af anti-cd20-antistof og pi3-kinaseselektiv hæmmer
CN103214489B (zh) * 2013-02-25 2016-10-26 中国人民解放军第二军医大学 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法
UA119537C2 (uk) * 2013-04-08 2019-07-10 Байєр Фарма Акцієнгезелльшафт ЗАСТОСУВАННЯ ЗАМІЩЕНИХ 2,3-ДИГІДРОІМІДАЗО[1,2-c]ХІНАЗОЛІНІВ ДЛЯ ЛІКУВАННЯ ЛІМФОМ
CN104557955B (zh) * 2013-10-23 2017-05-03 上海汇伦生命科技有限公司 作为PI3K/mTOR抑制剂的三环类化合物,其制备方法和用途
US20150148345A1 (en) * 2013-11-26 2015-05-28 Gilead Sciences, Inc. Therapies for treating myeloproliferative disorders
EP3077002B1 (en) * 2013-12-03 2020-04-22 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
EP3077003A1 (en) 2013-12-03 2016-10-12 Bayer Pharma Aktiengesellschaft Combination of pi3k-inhibitors
TWI533869B (zh) 2014-03-11 2016-05-21 國立中央大學 蒽醌[2,1-c][1,2,5]噻二唑-6,11-二酮化合物緩解疼痛的應用
TWI533871B (zh) 2014-03-11 2016-05-21 國立中央大學 萘并[2,3-f]喹喔啉-7,12-二酮化合物緩解疼痛的應用
FR3018813B1 (fr) * 2014-03-18 2016-04-15 Maco Pharma Sa Procede de synthese d'un derive de psoralene
WO2016059220A1 (en) 2014-10-16 2016-04-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Tcr-activating agents for use in the treatment of t-all
EP3018127A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
EP3018131A1 (en) * 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
KR20180013850A (ko) * 2015-03-09 2018-02-07 바이엘 파마 악티엔게젤샤프트 치환된 2,3-디히드로이미다조[1,2-c]퀴나졸린의 용도
CN107864625B (zh) * 2015-03-09 2021-05-28 拜耳制药股份公司 含有取代的2,3-二氢咪唑并[1,2-c]喹唑啉的组合产品
FR3033499A1 (fr) * 2015-03-11 2016-09-16 Centre Leon-Berard Composition pour le traitement des tumeurs neuroendocrines pancreatiques
EP4585597A1 (en) * 2015-07-02 2025-07-16 F. Hoffmann-La Roche AG Benzoxazepin oxazolidinone compounds and methods of use
CN105130998B (zh) * 2015-09-25 2017-07-28 苏州立新制药有限公司 库潘尼西的制备方法
CN105130997B (zh) * 2015-09-25 2017-12-05 苏州明锐医药科技有限公司 一种库潘尼西的制备方法
CA3016584A1 (en) 2016-03-08 2017-09-14 Bayer Pharma Aktiengesellschaft 2-amino-n-[7-methoxy-2,3-dihydroimidazo-[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamides
EP3219329A1 (en) 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
KR20220120711A (ko) * 2016-05-26 2022-08-30 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 폐혈관 질환 치료용 조성물 및 방법
WO2017211248A1 (zh) * 2016-06-08 2017-12-14 深圳市塔吉瑞生物医药有限公司 一种取代的咪唑并喹唑啉化合物及其药物组合物
CN109729716B (zh) 2016-09-23 2022-03-15 拜耳制药股份公司 Pi3k-抑制剂的组合产品
CN106177918A (zh) * 2016-09-30 2016-12-07 广州赛莱拉干细胞科技股份有限公司 一种间充质干细胞注射液及其制备方法和应用
CA3045041A1 (en) 2016-12-14 2018-06-21 Tarveda Therapeutics, Inc. Hsp90-targeting conjugates and formulations thereof
EP3585437B1 (en) 2017-02-24 2022-12-21 Bayer Pharma Aktiengesellschaft Combinations of copanlisib with anti-pd-1 antibody
WO2018215282A1 (en) 2017-05-26 2018-11-29 Bayer Pharma Aktiengesellschaft Combination of bub1 and pi3k inhibitors
EP3645005A1 (en) 2017-06-28 2020-05-06 Bayer Consumer Care AG Combination of a pi3k-inhibitor with an androgen receptor antagonist
WO2019010491A1 (en) * 2017-07-07 2019-01-10 University Of Pittsburgh-Of The Commonwealth System Of Higher Education COMBINATIONS OF MEDICINES FOR THE PROTECTION AGAINST THE DEATH OF NEURONAL CELLS
JP6916562B2 (ja) * 2017-08-11 2021-08-11 テリジーン リミテッドTeligene Ltd. 化合物、その薬学的に許容される塩、溶媒和物、立体異性体及び互変異性体、並びに薬物組成物、過剰増殖性障害治療剤、過剰増殖性障害予防剤、薬物、癌治療剤、癌予防剤、及びキナーゼシグナル伝達調節剤
PE20200958A1 (es) 2017-09-08 2020-09-24 Bayer Consumer Care Ag Solido liofilizado de copanlisib
EP3498266A1 (en) 2017-12-15 2019-06-19 Bayer Consumer Care AG Formulations of copanlisib
WO2019105734A1 (en) 2017-11-28 2019-06-06 Bayer Consumer Care Ag Combinations of copanlisib
WO2019105835A1 (en) 2017-11-29 2019-06-06 Bayer Consumer Care Ag Combinations of copanlisib and anetumab ravtansine
WO2019197269A1 (en) 2018-04-11 2019-10-17 Bayer Aktiengesellschaft Combinations of copanlisib with triazolone derivatives and their use in the treatment of cancer
CN108383849B (zh) * 2018-04-26 2020-11-06 浙江大学 咪唑并喹唑啉衍生物及其在抗肿瘤抗炎中的应用
CN108841318A (zh) * 2018-07-12 2018-11-20 中国科学院海洋研究所 一种自修复壳聚糖水凝胶防腐涂料及其合成方法
EP3843743A1 (en) 2018-08-28 2021-07-07 Bayer AS Combination of pi3k-inhibitors and targeted thorium conjugates
EP3866805A1 (en) 2018-10-16 2021-08-25 Bayer Aktiengesellschaft Combination of atr kinase inhibitors with 2,3-dihydroimidazo[1,2-c]quinazoline compounds
CN109516961B (zh) * 2018-12-25 2021-01-01 浙江大学 氨基喹唑啉酮和氨基异喹啉酮衍生物及其应用
WO2020164997A1 (en) 2019-02-12 2020-08-20 Bayer Aktiengesellschaft Combination of pi3k-inhibitors
WO2023139125A1 (en) 2022-01-18 2023-07-27 Synthon B.V. Improved process for preparation of copanlisib
WO2023218032A1 (en) 2022-05-13 2023-11-16 Synthon B.V. Solid forms of copanlisib salts

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3644354A (en) 1968-09-16 1972-02-22 Sandoz Ag 5-substituted-2 3-dihydroimidazo(1 2-c)quinazolines
US4146718A (en) 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
JP3729343B2 (ja) * 2000-04-27 2005-12-21 アステラス製薬株式会社 縮合ヘテロアリール誘導体
PA8578001A1 (es) * 2002-08-07 2004-05-07 Warner Lambert Co Combinaciones terapeuticas de inhibidores de quinasa de erb b y terapias antineoplasicas
HRP20131159B1 (hr) * 2002-09-30 2019-11-01 Bayer Ip Gmbh Taljeni azol-pirimidin derivati
EP1635641B1 (en) * 2003-06-12 2009-03-25 Merck & Co., Inc. Mitotic kinesin inhibitors
AT412873B (de) 2004-02-20 2005-08-25 Aop Orphan Pharmaceuticals Ag Verfahren zur herstellung von anagrelid hydrochlorid
WO2007143483A2 (en) 2006-06-01 2007-12-13 Smithkline Beecham Corporation Combination of pazopanib and lapatinib for treating cancer
WO2008002039A1 (en) 2006-06-28 2008-01-03 Hanmi Pharm. Co., Ltd. Quinazoline derivatives for inhibiting the growth of cancer cell
EP2508525A1 (en) 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts

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