[go: up one dir, main page]

UA88300C2 - Гидрогелевые композиции, которые содержат интерферон - Google Patents

Гидрогелевые композиции, которые содержат интерферон

Info

Publication number
UA88300C2
UA88300C2 UAA200611710A UAA200611710A UA88300C2 UA 88300 C2 UA88300 C2 UA 88300C2 UA A200611710 A UAA200611710 A UA A200611710A UA A200611710 A UAA200611710 A UA A200611710A UA 88300 C2 UA88300 C2 UA 88300C2
Authority
UA
Ukraine
Prior art keywords
interferon formulations
hydrogel
hydrogel interferon
interferon
formulations
Prior art date
Application number
UAA200611710A
Other languages
English (en)
Ukrainian (uk)
Inventor
Курто Мария Дорли Дель
Илария Дзамбальди
Сильвия Помпили
Пьерандреа Эспозито
Original Assignee
Эйрес Трейдинг С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эйрес Трейдинг С.А. filed Critical Эйрес Трейдинг С.А.
Publication of UA88300C2 publication Critical patent/UA88300C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к фармацевтическим полоксамерным гидрогелевым композициям, которые содержат интерферон и дополнительно содержат метионин. Гидрогелевые композиции обеспечивают пролонгированное высвобождение бета-интерферона. Описан способ их получения и применения.
UAA200611710A 2004-05-17 2005-05-13 Гидрогелевые композиции, которые содержат интерферон UA88300C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04076496 2004-05-17

Publications (1)

Publication Number Publication Date
UA88300C2 true UA88300C2 (ru) 2009-10-12

Family

ID=34928234

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200611710A UA88300C2 (ru) 2004-05-17 2005-05-13 Гидрогелевые композиции, которые содержат интерферон

Country Status (14)

Country Link
US (1) US7879320B2 (ru)
EP (1) EP1748788A1 (ru)
JP (1) JP2007538048A (ru)
KR (1) KR20070012464A (ru)
CN (1) CN1984673A (ru)
AR (1) AR048963A1 (ru)
AU (1) AU2005244448B2 (ru)
BR (1) BRPI0510654A (ru)
CA (1) CA2566364A1 (ru)
EA (1) EA012205B1 (ru)
NZ (1) NZ550926A (ru)
UA (1) UA88300C2 (ru)
WO (1) WO2005110466A1 (ru)
ZA (1) ZA200609412B (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI272948B (en) * 2003-05-01 2007-02-11 Ares Trading Sa HSA-free stabilized interferon liquid formulations
RS52218B (sr) * 2003-12-11 2012-10-31 Ares Trading S.A. Stabilizovane tečne formulacije interferona
EA010979B1 (ru) 2004-06-01 2008-12-30 Арес Трейдинг С.А. Стабилизированные жидкие препаративные формы интерферона
EP1893174A2 (en) * 2005-05-10 2008-03-05 Cytophil, Inc. Injectable hydrogels and methods of making and using same
JP2010525821A (ja) 2007-05-02 2010-07-29 アンブルックス，インコーポレイテッド 修飾ＩＦＮβポリペプチドおよびこれらの使用
KR100918645B1 (ko) * 2007-12-14 2009-09-25 포항공과대학교 산학협력단 하이드로겔의 상변화 원격 제어 방법 및 이를 이용한 약물전달 방법
HRP20120483T1 (hr) * 2007-12-20 2012-07-31 Merck@Serono@SA Formulacije peg interferona beta
CN101559036B (zh) * 2008-04-18 2012-02-08 上海医药工业研究院 一种阴道用避孕凝胶组合物及其制备方法和应用
ES2369101B2 (es) * 2010-05-07 2012-08-02 Universidade De Santiago De Compostela Sistema farmacéutico acuoso para la administración de fármacos en las uñas.
NZ609394A (en) * 2010-10-01 2014-11-28 Dow Agrosciences Llc Quantification and characterization of allergens
WO2013011503A1 (en) * 2011-07-20 2013-01-24 Theracoat Ltd. Production of thermoreversible hydrogels for therapeutic applications
CN102989035B (zh) * 2011-09-10 2014-12-17 浙江海正药业股份有限公司 一种应用于血管吻合术的水凝胶及其制备方法
CN102989036B (zh) * 2011-09-10 2015-10-21 浙江海正药业股份有限公司 应用于血管吻合术的含有肝素-泊洛沙姆复合物的水凝胶及其制备方法
RU2496478C1 (ru) * 2012-10-19 2013-10-27 Закрытое акционерное общество "ФИРН М" (ЗАО "ФИРН М") Состав в форме геля для лечения ран и ожогов различной этиологии, обеспечивающий условия для эпителизации
JP6527697B2 (ja) * 2013-01-28 2019-06-05 国立大学法人 熊本大学 タンパク質を安定化させたゲル状製剤
JP2016513653A (ja) * 2013-03-13 2016-05-16 インヴィヴォ セラピューティクス コーポレイションＩｎＶｉｖｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏｒｐｏｒａｔｉｏｎ ヒドロゲル中に共有結合により取り込むための架橋性トレハロースおよび使用方法
TW201609145A (zh) * 2013-12-25 2016-03-16 參天製藥股份有限公司 注射劑及形成緩釋（ｄｅｐｏｔ）之方法
WO2016054365A1 (en) * 2014-10-01 2016-04-07 Als Mountaiin Llc Pharmaceutical composition comprising aspirin, metformin, and serotonin with non-ionic surfactant
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
KR101943160B1 (ko) * 2016-10-06 2019-01-30 에이비온 주식회사 인터페론 베타 변이체의 안정화 제제
WO2019241985A1 (zh) * 2018-06-22 2019-12-26 温州医科大学 一种水凝胶、含其的药物组合物及其应用
CN110655660B (zh) * 2019-09-05 2020-10-20 北京科技大学 具有刺激响应性的单荧光分子白光发射水凝胶的制备方法
US12090205B2 (en) 2019-10-28 2024-09-17 Rochal Technologies Llc Poloxamer compositions with reduced sol-gel transition temperatures and methods of reducing the sol-gel transition temperature of poloxamer compositions
EP4005599A1 (en) * 2020-11-30 2022-06-01 Elkem Silicones France SAS Method for manufacturing a silicone elastomer article using a 3d printer
RU2768656C1 (ru) * 2021-09-10 2022-03-24 Илья Александрович Марков Противовирусное средство в жидкой форме и способ его приготовления
WO2025014745A2 (en) * 2023-07-07 2025-01-16 Saint Joseph's University Composite hydrogel wound dressings and methods of use thereof

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
DE3380726D1 (en) * 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
JPS5959629A (ja) * 1982-09-27 1984-04-05 Nippon Chem Res Kk 効力持続性組成物
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4469228A (en) * 1983-05-31 1984-09-04 Schering Corporation Interferon kit
US4636383A (en) * 1984-08-29 1987-01-13 Schering Corporation Interferon-cyclaradine combination
US4959314A (en) * 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US5116943A (en) * 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4879111A (en) * 1986-04-17 1989-11-07 Cetus Corporation Treatment of infections with lymphokines
US5266310A (en) * 1987-09-17 1993-11-30 Boehringer Ingelheim International Gmbh Stabilization of therapeutically active proteins in pharmaceutical preparations
US4965195A (en) * 1987-10-26 1990-10-23 Immunex Corp. Interleukin-7
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
EP0386960A3 (en) * 1989-03-07 1991-10-23 American Cyanamid Company Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
IT1244511B (it) 1991-04-15 1994-07-15 Isi Ist Sierovaccinogeno Ital Idrogeli a base di policarbossilati sintetici e proteine per il rilascio controllato di farmaci e procedimento per la loro preparazione.
IT1272252B (it) 1994-05-16 1997-06-16 Applied Research Systems Formulazioni liquide di interferone beta
TW426523B (en) * 1995-04-06 2001-03-21 Hoffmann La Roche Interferon solution
ZA9610374B (en) * 1995-12-11 1997-06-23 Elan Med Tech Cartridge-based drug delivery device
CA2275587C (en) * 1996-12-20 2006-10-24 Alza Corporation Injectable depot gel composition and method of preparing the composition
US6013253A (en) * 1997-08-15 2000-01-11 Amgen, Inc. Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist
IL135186A0 (en) * 1997-09-23 2001-05-20 Rentschler Biotechnologie Bmgh LIQUID INTERFERON-β FORMULATIONS
EP1037995A1 (en) * 1997-12-08 2000-09-27 Genentech, Inc. Human interferon-epsilon: a type 1 interferon
CA2565375A1 (en) 1998-04-28 1999-11-04 Applied Research Systems Ars Holding N.V. Polyol-ifn-beta conjugates
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
DE60040225D1 (en) 1999-07-13 2008-10-23 Bolder Biotechnology Inc Erythropoietin immunglobulin fusionsproteine
US6531122B1 (en) * 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
CN1175901C (zh) 1999-12-06 2004-11-17 天津华立达生物工程有限公司 一种稳定的干扰素水溶液
US6465425B1 (en) * 2000-02-10 2002-10-15 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
US6723606B2 (en) 2000-06-29 2004-04-20 California Institute Of Technology Aerosol process for fabricating discontinuous floating gate microelectronic devices
KR100396983B1 (ko) 2000-07-29 2003-09-02 이강춘 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
AU2002219198B2 (en) 2000-12-27 2006-06-29 Ares Trading S.A. Lipid microparticles by cryogenic micronization
US6887462B2 (en) * 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
MXPA04003640A (es) * 2001-10-16 2005-04-11 Rxkinetix Inc Formulaciones de proteina de alta concentracion y metodo de fabricacion.
JP2005517012A (ja) 2002-02-08 2005-06-09 アルカーメス コントロールド セラピューティクス，インコーポレイテッド 持続放出のためのポリマーベース組成物
JP4610154B2 (ja) * 2002-05-30 2011-01-12 大塚製薬株式会社 注射用製剤
US20040037809A1 (en) 2002-06-28 2004-02-26 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of interferon beta
TWI272948B (en) * 2003-05-01 2007-02-11 Ares Trading Sa HSA-free stabilized interferon liquid formulations
AR044302A1 (es) * 2003-05-13 2005-09-07 Ares Trading Sa Formulaciones con proteinas liquidas estabilizadas en recipientes farmaceuticos
RS52218B (sr) * 2003-12-11 2012-10-31 Ares Trading S.A. Stabilizovane tečne formulacije interferona
EA010979B1 (ru) 2004-06-01 2008-12-30 Арес Трейдинг С.А. Стабилизированные жидкие препаративные формы интерферона

Also Published As

Publication number Publication date
US7879320B2 (en) 2011-02-01
US20070248674A1 (en) 2007-10-25
BRPI0510654A (pt) 2007-11-20
AU2005244448A1 (en) 2005-11-24
EA200602137A1 (ru) 2007-04-27
AU2005244448B2 (en) 2011-03-17
CA2566364A1 (en) 2005-11-24
CN1984673A (zh) 2007-06-20
AR048963A1 (es) 2006-06-14
KR20070012464A (ko) 2007-01-25
EA012205B1 (ru) 2009-08-28
EP1748788A1 (en) 2007-02-07
JP2007538048A (ja) 2007-12-27
NZ550926A (en) 2010-01-29
ZA200609412B (en) 2008-07-30
WO2005110466A1 (en) 2005-11-24

Similar Documents

Publication Publication Date Title
UA88300C2 (ru) Гидрогелевые композиции, которые содержат интерферон
IL220480A0 (en) 1-benzyl-pyrimidine-2,4-dione derivatives as dipeptidyl peptidase inhibitors , preparation method thereof, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments
ZA200705750B (en) Compositions and methods for stabilizing active pharmaceutical ingredients
MX2007003078A (es) Compuestos de imidazoquinolina.
AU2003274681A1 (en) Dosage form comprising high dose high soluble active ingredient as modified release and low dose active ingredient as immediate release
IL171683A (en) Immunosuppressive Compounds, Medicinal Products Containing Them and Their Use in the Preparation of Medication for Treatment
IL231576A (en) Derivatives of adamantyl-acetamide, the pharmaceutical compositions containing them and their use in the preparation of medicines
MX2007010996A (es) Nuevas composiciones de liposomas.
IL174647A (en) Pyrazolopyridines and analogs thereof, pharmaceutical compositions comprising them and their use in the manufacture of medicaments
WO2006051103A3 (en) Stable formulations of peptides
PL377854A1 (pl) Farmaceutyczne preparaty donosowe oraz sposoby ich stosowania
WO2005065657A3 (en) Solid compositions of low-solubility drugs and poloxamers
IL164217A0 (en) Pharmaceutical compositions containing water-soluble propofol and methods of administering same
MXPA05011718A (es) Formulaciones liquidas de interferon estabilizadas y libres de albumina de suero humano.
WO2005018605A3 (en) Novel formulation of ropinirole
MXPA03010054A (es) Composiciones que comprenden lopinavir y metodos para aumentar la biodisponibilidad de agentes farmaceuticos.
NO20065860L (no) Stabiliserte flytende interferonformuleringer
IL180900A0 (en) Immunogenic complexes, preparation method thereof and use of same in pharmaceutical compositions
MXPA05007287A (es) Formulacion y metodos para el tratamiento de trombocitemia.
WO2005034857A8 (en) Methods and compositions comprising diamines as new anti-tubercular therapeutics
WO2005048993A3 (en) Minimization of drug oxidation in drug irradiated excipients formulations
IL179177A (en) A pharmaceutical product including acyclovir and delivery compound, dosage unit, use of acyclovir in the preparation of the pharmaceutical product, use of the pharmaceutical product in the preparation of a drug and a method for the preparation of the pharmaceutical product
DE602005008607D1 (de) Im mund zerfallende pharmazeutische zusammensetzung mit risperidon
WO2005123113A3 (en) Interferon compositions and methods of use thereof
GB2410187B (en) Pharmaceutical formulations comprising ß-2 adrenoreceptor agonists and xanthines