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UA88457C2 - Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью - Google Patents

Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью

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Publication number
UA88457C2
UA88457C2 UAA200605917A UAA200605917A UA88457C2 UA 88457 C2 UA88457 C2 UA 88457C2 UA A200605917 A UAA200605917 A UA A200605917A UA A200605917 A UAA200605917 A UA A200605917A UA 88457 C2 UA88457 C2 UA 88457C2
Authority
UA
Ukraine
Prior art keywords
immunostimulatory
nucleic acid
potency
enhanced
oligonucleotides
Prior art date
Application number
UAA200605917A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ойген Ульманн
Йорг Фолльмер
Артур М. Криг
Бернхард О. Нолль
Original Assignee
Коли Фармасьютикал Гмбх
Коли Фармасьютикал Груп, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Коли Фармасьютикал Гмбх, Коли Фармасьютикал Груп, Инк. filed Critical Коли Фармасьютикал Гмбх
Publication of UA88457C2 publication Critical patent/UA88457C2/ru

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Abstract

Изобретение относится к классу иммуностимулирующих нуклеиновых кислот, которые содержат иммуностимулирующий CpG-мотив и второй мотив, способный формировать вторичную структуру, включая дуплекс и структуры более высокого порядка, in vitro и in vivo. Иммуностимулирующие нуклеиновые кислоты по изобретению полезны как адъюванты при вакцинации, а также для индукции иммунного ответа, индукции экспрессии интерферона І типа (IFN), индукции экспрессии интерферона гамма (IFN-γ) и для лечения ряда состояний, включая аллергию, астму, инфекцию и рак.
UAA200605917A 2003-10-30 2004-10-29 Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью UA88457C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51619303P 2003-10-30 2003-10-30

Publications (1)

Publication Number Publication Date
UA88457C2 true UA88457C2 (ru) 2009-10-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200605917A UA88457C2 (ru) 2003-10-30 2004-10-29 Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью

Country Status (23)

Country Link
US (1) US8188254B2 (ru)
EP (2) EP1728863A3 (ru)
JP (1) JP2007509983A (ru)
KR (1) KR101107818B1 (ru)
CN (1) CN101454451A (ru)
AP (1) AP2006003611A0 (ru)
AU (2) AU2004285561C1 (ru)
BR (1) BRPI0416079A (ru)
CA (1) CA2540949A1 (ru)
CR (1) CR8423A (ru)
EA (1) EA008741B1 (ru)
EC (1) ECSP066589A (ru)
GE (1) GEP20094767B (ru)
IL (2) IL174428A0 (ru)
MA (1) MA28182A1 (ru)
NO (1) NO20061857L (ru)
NZ (2) NZ546475A (ru)
OA (1) OA13278A (ru)
SG (2) SG122973A1 (ru)
TN (1) TNSN06123A1 (ru)
UA (1) UA88457C2 (ru)
WO (1) WO2005042018A2 (ru)
ZA (2) ZA200602352B (ru)

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EP1678303A2 (en) 2006-07-12
GEP20094767B (en) 2009-09-10
EP1728863A2 (en) 2006-12-06
BRPI0416079A (pt) 2007-01-02
CN101454451A (zh) 2009-06-10
US20050239734A1 (en) 2005-10-27
AU2006201495A1 (en) 2006-04-27
NO20061857L (no) 2006-07-31
EP1728863A3 (en) 2006-12-20
AU2004285561A1 (en) 2005-05-12
KR20060109443A (ko) 2006-10-20
WO2005042018A3 (en) 2005-07-21

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