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MX2009003398A - Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada. - Google Patents

Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.

Info

Publication number
MX2009003398A
MX2009003398A MX2009003398A MX2009003398A MX2009003398A MX 2009003398 A MX2009003398 A MX 2009003398A MX 2009003398 A MX2009003398 A MX 2009003398A MX 2009003398 A MX2009003398 A MX 2009003398A MX 2009003398 A MX2009003398 A MX 2009003398A
Authority
MX
Mexico
Prior art keywords
analogs
cpg oligonucleotide
immunostimulatory activity
containing hydrophobic
enhanced immunostimulatory
Prior art date
Application number
MX2009003398A
Other languages
English (en)
Inventor
Herald Debelak
Eugen Uhlmann
Marion Jurk
Original Assignee
Coley Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharm Gmbh filed Critical Coley Pharm Gmbh
Publication of MX2009003398A publication Critical patent/MX2009003398A/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N2310/33—Chemical structure of the base
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Saccharide Compounds (AREA)

Abstract

La invención se refiere a oligonucleótidos que incluyen al menos un análogo nucleótido lipófilo sustituido y un dinucleótido de pirimidina- purina. La invención se refiere también a composiciones farmacéuticas y a métodos de uso de las mismas.
MX2009003398A 2006-09-27 2007-09-25 Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada. MX2009003398A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84781106P 2006-09-27 2006-09-27
PCT/IB2007/004389 WO2008068638A2 (en) 2006-09-27 2007-09-27 Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity

Publications (1)

Publication Number Publication Date
MX2009003398A true MX2009003398A (es) 2009-08-12

Family

ID=39492695

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003398A MX2009003398A (es) 2006-09-27 2007-09-25 Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.

Country Status (21)

Country Link
US (3) US8580268B2 (es)
EP (2) EP2078080B1 (es)
JP (2) JP5455629B2 (es)
KR (2) KR101251707B1 (es)
CN (1) CN101517082B (es)
AU (1) AU2007330410B2 (es)
BR (1) BRPI0717510B8 (es)
CA (1) CA2664219C (es)
DK (1) DK2078080T3 (es)
ES (1) ES2544958T3 (es)
HU (1) HUE027064T2 (es)
IL (1) IL197549A (es)
MX (1) MX2009003398A (es)
NO (1) NO342465B1 (es)
NZ (1) NZ575437A (es)
PL (1) PL2078080T3 (es)
PT (1) PT2078080E (es)
RU (1) RU2477315C2 (es)
SI (1) SI2078080T1 (es)
WO (1) WO2008068638A2 (es)
ZA (1) ZA200901735B (es)

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