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UA87856C2 - Алкильные производные как модуляторы метаботропных рецепторов глутамата - Google Patents

Алкильные производные как модуляторы метаботропных рецепторов глутамата

Info

Publication number
UA87856C2
UA87856C2 UAA200700380A UAA200700380A UA87856C2 UA 87856 C2 UA87856 C2 UA 87856C2 UA A200700380 A UAA200700380 A UA A200700380A UA A200700380 A UAA200700380 A UA A200700380A UA 87856 C2 UA87856 C2 UA 87856C2
Authority
UA
Ukraine
Prior art keywords
modulators
glutamate receptors
alkynyl derivatives
metatropic
receptors
Prior art date
Application number
UAA200700380A
Other languages
English (en)
Ukrainian (uk)
Inventor
Анне-Софи Бессис
Христел Болеа
Беатрис Боннет
Марк Эппинг-Джордан
Нихоляс Пойрер
Соня-Мария Поли
Жан-Филип Рохер
Original Assignee
Аддекс Фарма Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аддекс Фарма Са filed Critical Аддекс Фарма Са
Publication of UA87856C2 publication Critical patent/UA87856C2/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Данное изобретение касается новых соединений формулы І, где W, n, X и W' определены в описании; соединения за изобретением представляют собой модуляторы метаботропных рецепторов глутамата - подтип 5 ("mGlu5"), которые являются полезными при лечении расстройств центральной нервной системы, а также других расстройств, модулированных рецепторами mGlu5.
UAA200700380A 2004-06-17 2005-06-17 Алкильные производные как модуляторы метаботропных рецепторов глутамата UA87856C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0413605.7A GB0413605D0 (en) 2004-06-17 2004-06-17 Novel compounds

Publications (1)

Publication Number Publication Date
UA87856C2 true UA87856C2 (ru) 2009-08-25

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ID=32750115

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Application Number Title Priority Date Filing Date
UAA200700380A UA87856C2 (ru) 2004-06-17 2005-06-17 Алкильные производные как модуляторы метаботропных рецепторов глутамата

Country Status (23)

Country Link
US (3) US8101637B2 (ru)
EP (2) EP2426115A3 (ru)
JP (2) JP5053840B2 (ru)
KR (1) KR101200175B1 (ru)
CN (2) CN101001846B (ru)
AU (1) AU2005254808B2 (ru)
BR (1) BRPI0511072B8 (ru)
CA (1) CA2570987C (ru)
CY (1) CY1114582T1 (ru)
DK (1) DK1765795T3 (ru)
EA (2) EA012206B1 (ru)
ES (1) ES2404034T3 (ru)
GB (1) GB0413605D0 (ru)
IL (1) IL179692A (ru)
MX (1) MXPA06014721A (ru)
NO (1) NO339660B1 (ru)
NZ (1) NZ551664A (ru)
PL (1) PL1765795T3 (ru)
PT (1) PT1765795E (ru)
SI (1) SI1765795T1 (ru)
UA (1) UA87856C2 (ru)
WO (1) WO2005123703A2 (ru)
ZA (1) ZA200610023B (ru)

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