UA85531C2 - Применение ингибитора il-18 для лечения или предупреждения связанной с сепсисом дисфункции сердца - Google Patents
Применение ингибитора il-18 для лечения или предупреждения связанной с сепсисом дисфункции сердца Download PDFInfo
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- UA85531C2 UA85531C2 UA20031211613A UA20031211613A UA85531C2 UA 85531 C2 UA85531 C2 UA 85531C2 UA 20031211613 A UA20031211613 A UA 20031211613A UA 20031211613 A UA20031211613 A UA 20031211613A UA 85531 C2 UA85531 C2 UA 85531C2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Данное изобретение относится к применению ингибитора IL-18 для получения лекарственного средства для лечения и/или предупреждения связанной с сепсисом дисфункции сердца.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29146301P | 2001-05-16 | 2001-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA85531C2 true UA85531C2 (ru) | 2009-02-10 |
Family
ID=23120395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20031211613A UA85531C2 (ru) | 2001-05-16 | 2002-05-16 | Применение ингибитора il-18 для лечения или предупреждения связанной с сепсисом дисфункции сердца |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20030008822A1 (ru) |
| EP (1) | EP1425028B1 (ru) |
| JP (1) | JP4502580B2 (ru) |
| KR (1) | KR100877033B1 (ru) |
| CN (1) | CN100556450C (ru) |
| AT (1) | ATE451930T1 (ru) |
| BR (1) | BR0210904A (ru) |
| CA (1) | CA2446942C (ru) |
| CY (1) | CY1109713T1 (ru) |
| DE (1) | DE60234778D1 (ru) |
| DK (1) | DK1425028T3 (ru) |
| EA (1) | EA009125B1 (ru) |
| ES (1) | ES2334773T3 (ru) |
| IL (2) | IL158866A0 (ru) |
| MX (1) | MXPA03010575A (ru) |
| PT (1) | PT1425028E (ru) |
| SI (1) | SI1425028T1 (ru) |
| UA (1) | UA85531C2 (ru) |
| WO (1) | WO2002092008A2 (ru) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2424983A1 (en) | 2000-10-11 | 2002-04-18 | Viron Therapeutics, Inc. | Nucleic acid molecules and polypeptides for immune modulation |
| US7718368B2 (en) | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| US20080076708A1 (en) | 2003-05-13 | 2008-03-27 | Valter Altarocca | Active Variants of the Il-18 Binding Protein and Medical Uses Thereof |
| AU2004241069B2 (en) | 2003-05-15 | 2010-09-09 | Genentech, Inc. | Methods and compositions for the prevention and treatment of sepsis |
| US7482376B2 (en) | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| WO2005110450A1 (ja) * | 2004-05-17 | 2005-11-24 | Keio University | 医薬組成物及び治療方法 |
| FI116804B (fi) * | 2004-05-18 | 2006-02-28 | Ekspansio Engineering Ltd Oy | Materiaalikappaleiden eri suuntiin osoittavien pintojen optinen tarkastus |
| PL1885753T3 (pl) | 2005-06-03 | 2011-12-30 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| ATE529433T1 (de) | 2005-06-10 | 2011-11-15 | Ares Trading Sa | Verfahren zur reinigung eines il-18-bindenden proteins |
| JP5583575B2 (ja) | 2007-03-28 | 2014-09-03 | ユニベルシダード デ バルセロナ | 感染症と関連炎症過程の治療のためのタンパク質生成物 |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| WO2012027723A1 (en) | 2010-08-27 | 2012-03-01 | Stem Centrx, Inc | Notum protein modulators and methods of use |
| EP2676675B1 (en) | 2011-02-18 | 2019-04-10 | Stemdr Inc. | Composition containing inducer of sirt1 expression for preventing or treating sepsis or septic shock |
| CN116694597A (zh) | 2012-05-11 | 2023-09-05 | 珍白斯凯尔有限公司 | 具有抗炎活性的肽及其在制备抗炎组合物中的应用 |
| EP2875825B1 (en) | 2012-05-11 | 2017-12-13 | KAEL-GemVax Co.,Ltd | Composition for preventing or treating rheumatoid arthritis |
| JP6272853B2 (ja) | 2012-07-11 | 2018-01-31 | ジェムバックス アンド カエル カンパニー，リミティド | 細胞透過性ペプチド、それを含んだコンジュゲート、及びそれを含んだ組成物 |
| US9907838B2 (en) | 2013-04-19 | 2018-03-06 | Gemvax & Kael Co., Ltd. | Composition and methods for treating ischemic damage |
| CN105535931A (zh) | 2013-06-07 | 2016-05-04 | 凯尔杰姆维克斯有限公司 | 在癌症免疫疗法中有用的生物标记 |
| US10561703B2 (en) | 2013-06-21 | 2020-02-18 | Gemvax & Kael Co., Ltd. | Method of modulating sex hormone levels using a sex hormone secretion modulator |
| KR102321172B1 (ko) * | 2013-09-05 | 2021-11-05 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) |
| EP3061459B1 (en) | 2013-10-23 | 2019-12-11 | Gemvax & Kael Co., Ltd. | Composition for treating and preventing benign prostatic hyperplasia |
| EP3072519B1 (en) | 2013-11-22 | 2020-08-19 | Gemvax & Kael Co., Ltd. | Peptide having angiogenesis inhibitory activity and composition containing same |
| CN105939723B (zh) | 2013-12-17 | 2020-02-28 | 珍白斯凯尔有限公司 | 前列腺癌治疗用组合物 |
| GB201400997D0 (en) * | 2014-01-21 | 2014-03-05 | Vib Vzw | Targeting of interleukin-1 and -18 in treatment of septic shock |
| CN106456697B (zh) | 2014-04-11 | 2019-12-17 | 珍白斯凯尔有限公司 | 具有纤维化抑制活性的肽和含有其的组合物 |
| US10662223B2 (en) | 2014-04-30 | 2020-05-26 | Gemvax & Kael Co., Ltd. | Composition for organ, tissue, or cell transplantation, kit, and transplantation method |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| EP3263122B1 (en) | 2015-02-27 | 2020-05-06 | Gemvax & Kael Co., Ltd. | Peptide for preventing hearing loss, and composition comprising same |
| CA2972689A1 (en) | 2015-03-05 | 2016-09-09 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
| KR102638286B1 (ko) | 2015-07-02 | 2024-02-20 | 주식회사 젬백스앤카엘 | 항바이러스 활성 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| EP4272829A3 (en) | 2016-04-07 | 2024-01-17 | Gemvax & Kael Co., Ltd. | Peptide having effects of increasing telomerase activity and extending telomere, and composition containing same |
| CA3044334A1 (en) | 2016-11-18 | 2018-05-24 | Institut D'investigacions Biomediques August Pi I Sunyer- Idibaps | Combined cd6 and imipenem therapy for treatment of infectious diseases and related inflammatory processes |
| CN107715105B (zh) * | 2017-10-26 | 2020-11-24 | 重庆医科大学 | Il-34在制备治疗或预防脓毒症药物中的应用 |
| CN109954131B (zh) * | 2017-12-14 | 2023-05-02 | 深圳市中科艾深医药有限公司 | 一种肿瘤坏死因子相关凋亡诱导配体拮抗剂作为脓毒血症治疗药物的应用 |
| CN111012899A (zh) * | 2020-01-08 | 2020-04-17 | 重庆医科大学 | Il-38的新用途 |
| US12441786B2 (en) | 2020-11-18 | 2025-10-14 | Novartis Ag | Bispecific antibodies for use in treatment of NLRC4-GOF inflammasomapathy |
| EP4329809A4 (en) * | 2021-04-30 | 2025-03-26 | The Children's Hospital Of Philadelphia | Compositions and methods of treating sepsis in patients using anti-light antibodies |
| CN115154581B (zh) * | 2022-05-31 | 2025-06-10 | 陆一鸣 | 选择性TNFR1拮抗肽Hydrostatin-SN10在治疗脓毒症中的应用 |
| CN115754304A (zh) * | 2022-11-24 | 2023-03-07 | 重庆医科大学 | 骨形态蛋白-7作为生物标志物在脓毒血症诊断、预后或治疗监测中的用途 |
| WO2024148232A2 (en) | 2023-01-06 | 2024-07-11 | Alector Llc | Anti-il18 binding protein antibodies and methods of use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| AU6952391A (en) * | 1989-11-29 | 1991-06-26 | Brigham And Women's Hospital | (ala il-8)77 as a leukocyte adhesion inhibitor |
| US5536637A (en) * | 1993-04-07 | 1996-07-16 | Genetics Institute, Inc. | Method of screening for cDNA encoding novel secreted mammalian proteins in yeast |
| CA2268103A1 (en) * | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors |
| WO1998041232A2 (en) * | 1997-03-18 | 1998-09-24 | Basf Aktiengesellschaft | Compositions for modulating responsiveness to corticosteroids |
| US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| IL131047A0 (en) * | 1999-07-22 | 2001-01-28 | Yeda Res & Dev | Use of il-18 inhibitors |
| CN102206277A (zh) * | 2000-02-10 | 2011-10-05 | 雅培制药有限公司 | 结合人白介素-18的抗体及制备和使用方法 |
| KR20070087256A (ko) * | 2000-02-21 | 2007-08-27 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | Ｉｌ-18 저해물질의 용도 |
| AU2002224417A1 (en) * | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
-
2002
- 2002-05-16 IL IL15886602A patent/IL158866A0/xx active IP Right Grant
- 2002-05-16 SI SI200230874T patent/SI1425028T1/sl unknown
- 2002-05-16 EP EP02736912A patent/EP1425028B1/en not_active Expired - Lifetime
- 2002-05-16 BR BR0210904-2A patent/BR0210904A/pt not_active Application Discontinuation
- 2002-05-16 DE DE60234778T patent/DE60234778D1/de not_active Expired - Lifetime
- 2002-05-16 ES ES02736912T patent/ES2334773T3/es not_active Expired - Lifetime
- 2002-05-16 KR KR1020037014798A patent/KR100877033B1/ko not_active Expired - Lifetime
- 2002-05-16 EA EA200301248A patent/EA009125B1/ru not_active IP Right Cessation
- 2002-05-16 CA CA2446942A patent/CA2446942C/en not_active Expired - Lifetime
- 2002-05-16 AT AT02736912T patent/ATE451930T1/de active
- 2002-05-16 UA UA20031211613A patent/UA85531C2/ru unknown
- 2002-05-16 MX MXPA03010575A patent/MXPA03010575A/es active IP Right Grant
- 2002-05-16 JP JP2002588927A patent/JP4502580B2/ja not_active Expired - Lifetime
- 2002-05-16 US US10/147,341 patent/US20030008822A1/en not_active Abandoned
- 2002-05-16 CN CNB028140605A patent/CN100556450C/zh not_active Expired - Lifetime
- 2002-05-16 DK DK02736912.3T patent/DK1425028T3/da active
- 2002-05-16 WO PCT/US2002/015556 patent/WO2002092008A2/en not_active Ceased
- 2002-05-16 PT PT02736912T patent/PT1425028E/pt unknown
-
2003
- 2003-11-13 IL IL158866A patent/IL158866A/en unknown
-
2010
- 2010-01-11 CY CY20101100029T patent/CY1109713T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20030008822A1 (en) | 2003-01-09 |
| KR100877033B1 (ko) | 2009-01-07 |
| ATE451930T1 (de) | 2010-01-15 |
| JP2004531546A (ja) | 2004-10-14 |
| EP1425028A4 (en) | 2006-03-01 |
| KR20040045400A (ko) | 2004-06-01 |
| MXPA03010575A (es) | 2005-03-07 |
| PT1425028E (pt) | 2010-01-06 |
| DE60234778D1 (de) | 2010-01-28 |
| DK1425028T3 (da) | 2010-03-01 |
| EA200301248A1 (ru) | 2005-06-30 |
| JP4502580B2 (ja) | 2010-07-14 |
| IL158866A (en) | 2011-01-31 |
| EP1425028B1 (en) | 2009-12-16 |
| WO2002092008A3 (en) | 2004-04-08 |
| IL158866A0 (en) | 2004-05-12 |
| HK1066723A1 (en) | 2005-04-01 |
| CA2446942C (en) | 2010-07-20 |
| EA009125B1 (ru) | 2007-10-26 |
| CN100556450C (zh) | 2009-11-04 |
| WO2002092008A2 (en) | 2002-11-21 |
| CY1109713T1 (el) | 2014-08-13 |
| CA2446942A1 (en) | 2002-11-21 |
| EP1425028A2 (en) | 2004-06-09 |
| SI1425028T1 (sl) | 2010-02-26 |
| ES2334773T3 (es) | 2010-03-16 |
| CN1529611A (zh) | 2004-09-15 |
| BR0210904A (pt) | 2005-08-16 |
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