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UA81640C2 - Противомикобактериальные соединения, способ их получения, фармацевтическая композиция на их основе - Google Patents

Противомикобактериальные соединения, способ их получения, фармацевтическая композиция на их основе

Info

Publication number
UA81640C2
UA81640C2 UAA200503537A UA2005003537A UA81640C2 UA 81640 C2 UA81640 C2 UA 81640C2 UA A200503537 A UAA200503537 A UA A200503537A UA 2005003537 A UA2005003537 A UA 2005003537A UA 81640 C2 UA81640 C2 UA 81640C2
Authority
UA
Ukraine
Prior art keywords
compounds
preparation
formula
thererof
pharmaceutical composition
Prior art date
Application number
UAA200503537A
Other languages
English (en)
Ukrainian (uk)
Inventor
Судершан Кумар Арора
Неелима Синха
Санджай Джаин
Рам Шанкар Упадхайайа
Гурхари Джана
Шанкар Аджай
Ракеш Кумар Синха
Original Assignee
Люпин Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Люпин Лимитед filed Critical Люпин Лимитед
Publication of UA81640C2 publication Critical patent/UA81640C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Новые производные пиррола формулы (І), (І)и их фармацевтически приемлемые кислотно-аддитивные соли, которые имеют лучшую противомикобактериальную активность по отношению, как к чувствительным, так и к резистентным лекарственным препаратам штаммов Mycobacterium tuberculosis, и являются менее токсичными по сравнению с известными соединениями. Применение новых соединений формулы (І) для лечения латентного туберкулеза, включая туберкулез, вызванный полирезистентными микобактериями. Способы получения новых соединений, фармацевтических композиций, которые содержат новые соединения, и способы лечения туберкулеза, который вызывается полирезистентными к лекарственным препаратам туберкулезными микобактериями, путем введения соединений формулы (І).
UAA200503537A 2002-09-20 2002-09-20 Противомикобактериальные соединения, способ их получения, фармацевтическая композиция на их основе UA81640C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2002/000189 WO2004026828A1 (en) 2002-09-20 2002-09-20 Pyrrole derivatives as antimycobacterial compounds

Publications (1)

Publication Number Publication Date
UA81640C2 true UA81640C2 (ru) 2008-01-25

Family

ID=32012142

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200503537A UA81640C2 (ru) 2002-09-20 2002-09-20 Противомикобактериальные соединения, способ их получения, фармацевтическая композиция на их основе

Country Status (19)

Country Link
US (2) US7691837B2 (ru)
EP (2) EP1857442A3 (ru)
JP (1) JP2006503837A (ru)
CN (1) CN1668584A (ru)
AP (1) AP1979A (ru)
AU (1) AU2002343200B2 (ru)
BR (1) BR0215873A (ru)
CA (1) CA2499701A1 (ru)
EA (1) EA012461B1 (ru)
HR (1) HRP20050347A2 (ru)
HU (1) HUP0500598A2 (ru)
IS (1) IS7795A (ru)
MX (1) MXPA05003022A (ru)
NO (1) NO20051901L (ru)
NZ (1) NZ539449A (ru)
RS (1) RS20050231A (ru)
TN (1) TNSN05080A1 (ru)
UA (1) UA81640C2 (ru)
WO (1) WO2004026828A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491721B2 (en) * 2004-05-12 2009-02-17 Lupin Limited Antimycobacterial pharmaceutical composition
CA2598423C (en) * 2005-02-18 2014-05-27 Astrazeneca Ab Antibacterial piperidine derivatives
ITRM20050094A1 (it) 2005-03-04 2006-09-05 Univ Siena Derivati del 1-(1,5-di(4-clorofenil)-2metil-1h-3-pirroli)metil)-4-metilpiperazina (bm 212), procedimento per la loro produzione e uso di essi come antitubercolari.
US20090118509A1 (en) * 2005-04-11 2009-05-07 Lupin Limited Preparation of [2-methyl-5-phenyl-3-(piperazin-1-ylmethyl)] pyrrole derivatives
CN101190894A (zh) * 2006-11-23 2008-06-04 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸合成酶抑制剂及其制药用途
EP2311457A1 (en) 2009-10-19 2011-04-20 Forschungszentrum Borstel Pharmaceutical compositions for treating infections with drug resistant mycobacteria
HUP1000033A2 (en) * 2010-01-21 2011-07-28 Uratim Kft Piperazine derivatives useful against mycobacteriums
WO2011117708A1 (en) * 2010-03-22 2011-09-29 Council Of Scientific & Industrial Research Antituberculosis compositions of byttneria species
KR100998556B1 (ko) 2010-04-08 2010-12-07 강원대학교산학협력단 신규한 다치환 피롤 유도체와 이의 제조방법
CN103122370B (zh) * 2011-11-21 2014-06-18 华中农业大学 一种三嗪类化合物作为抗结核分枝杆菌抑制剂的应用
WO2014009766A2 (en) 2012-07-13 2014-01-16 Corning Incorporated Methods and apparatuses for producing laminated glass sheets
IN2013DE01663A (ru) 2013-06-03 2015-07-10 Council Scient Ind Res
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
RU2767542C1 (ru) * 2021-05-24 2022-03-17 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Противотуберкулезное средство на основе 4-((гет)ароил)-3- гидрокси-1-(2-гидроксифенил)-5-(фенилтио)-1,5-дигидро-2Н-пиррол-2-онов

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2986564A (en) * 1959-02-20 1961-05-30 Rips Richard Pyrrole compounds
US3246010A (en) * 1963-06-10 1966-04-12 Parke Davis & Co 1, 5-diaryl-2-pyrrole propanols and ethers
US3168532A (en) * 1963-06-12 1965-02-02 Parke Davis & Co 1, 5-diarylpyrrole-2-propionic acid compounds
US3168531A (en) * 1963-06-12 1965-02-02 Parke Davis & Co 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds
GB1263940A (en) 1968-08-02 1972-02-16 Innothera Lab Sa 0-phenyl-pyrroles

Also Published As

Publication number Publication date
NZ539449A (en) 2007-08-31
AU2002343200A1 (en) 2004-04-08
CA2499701A1 (en) 2004-04-01
AU2002343200B2 (en) 2009-08-13
CN1668584A (zh) 2005-09-14
US7691837B2 (en) 2010-04-06
EP1857442A3 (en) 2008-02-06
US7763602B2 (en) 2010-07-27
HRP20050347A2 (en) 2006-03-31
EP1857442A2 (en) 2007-11-21
AP1979A (en) 2009-03-20
BR0215873A (pt) 2005-07-12
IS7795A (is) 2005-04-11
US20080242676A1 (en) 2008-10-02
EA200500500A1 (ru) 2006-02-24
NO20051901L (no) 2005-04-19
RS20050231A (sr) 2007-06-04
JP2006503837A (ja) 2006-02-02
US20050107370A1 (en) 2005-05-19
EP1546097A1 (en) 2005-06-29
EA012461B1 (ru) 2009-10-30
WO2004026828A1 (en) 2004-04-01
HUP0500598A2 (en) 2006-02-28
TNSN05080A1 (en) 2007-05-14
MXPA05003022A (es) 2005-05-27
AP2005003277A0 (en) 2005-06-30

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