UA79196C2 - Intranasal formulation of rotigotine - Google Patents

Intranasal formulation of rotigotine Download PDF

Info

Publication number: UA79196C2
Authority: UA; Ukraine
Prior art keywords: preparation according; intranasal; rotigotine; intranasal preparation; fact
Prior art date: 2003-12-23

Application number

UAA200508587A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Sanol Arznei Schwarz Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-23

Filing date

2004-12-22

Publication date

2007-05-25

2004-12-22 Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh

2007-05-25 Publication of UA79196C2 publication Critical patent/UA79196C2/uk

Links

KFQYTPMOWPVWEJ-INIZCTEOSA-N rotigotine Chemical compound CCCN([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 KFQYTPMOWPVWEJ-INIZCTEOSA-N 0.000 title claims abstract description 32
229960003179 rotigotine Drugs 0.000 title claims abstract description 30
239000000203 mixture Substances 0.000 title description 5
238000009472 formulation Methods 0.000 title 1
229920000858 Cyclodextrin Polymers 0.000 claims abstract description 31
239000002253 acid Substances 0.000 claims abstract description 9
239000007788 liquid Substances 0.000 claims abstract description 7
150000003839 salts Chemical class 0.000 claims abstract description 7
238000002360 preparation method Methods 0.000 claims description 52
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 42
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
239000000243 solution Substances 0.000 claims description 15
239000003795 chemical substances by application Substances 0.000 claims description 14
CEXBONHIOKGWNU-NTISSMGPSA-N hydron;(6s)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol;chloride Chemical compound [Cl-].CCC[NH+]([C@@H]1CC2=CC=CC(O)=C2CC1)CCC1=CC=CS1 CEXBONHIOKGWNU-NTISSMGPSA-N 0.000 claims description 11
235000011187 glycerol Nutrition 0.000 claims description 10
239000003755 preservative agent Substances 0.000 claims description 10
238000010521 absorption reaction Methods 0.000 claims description 9
239000007853 buffer solution Substances 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 5
229910019142 PO4 Inorganic materials 0.000 claims description 4
239000008366 buffered solution Substances 0.000 claims description 4
239000000825 pharmaceutical preparation Substances 0.000 claims description 4
239000003963 antioxidant agent Substances 0.000 claims description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
239000010452 phosphate Substances 0.000 claims description 3
230000002335 preservative effect Effects 0.000 claims description 3
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 2
239000002736 nonionic surfactant Substances 0.000 claims description 2
239000002953 phosphate buffered saline Substances 0.000 claims description 2
239000008389 polyethoxylated castor oil Substances 0.000 claims description 2
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
229920000053 polysorbate 80 Polymers 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
239000007864 aqueous solution Substances 0.000 abstract description 6
239000008194 pharmaceutical composition Substances 0.000 abstract description 3
239000003814 drug Substances 0.000 description 17
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
229940079593 drug Drugs 0.000 description 16
VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 description 12
229960004046 apomorphine Drugs 0.000 description 12
210000002850 nasal mucosa Anatomy 0.000 description 10
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 8
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 7
208000018737 Parkinson disease Diseases 0.000 description 7
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
230000000694 effects Effects 0.000 description 6
229940097362 cyclodextrins Drugs 0.000 description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
229960003638 dopamine Drugs 0.000 description 4
230000035699 permeability Effects 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
241000700159 Rattus Species 0.000 description 3
229960000686 benzalkonium chloride Drugs 0.000 description 3
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 3
230000002708 enhancing effect Effects 0.000 description 3
230000001965 increasing effect Effects 0.000 description 3
229940098779 methanesulfonic acid Drugs 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
241000283690 Bos taurus Species 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
238000005591 Swarts synthesis reaction Methods 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000003078 antioxidant effect Effects 0.000 description 2
235000006708 antioxidants Nutrition 0.000 description 2
238000003556 assay Methods 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
230000008859 change Effects 0.000 description 2
230000001886 ciliary effect Effects 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
238000001514 detection method Methods 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000035475 disorder Diseases 0.000 description 2
239000003136 dopamine receptor stimulating agent Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000011169 microbiological contamination Methods 0.000 description 2
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
239000000902 placebo Substances 0.000 description 2
229940068196 placebo Drugs 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
206010052804 Drug tolerance Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
150000000994 L-ascorbates Chemical class 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
206010028781 Nasal vestibulitis Diseases 0.000 description 1
KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
239000000556 agonist Substances 0.000 description 1
230000002009 allergenic effect Effects 0.000 description 1
208000030961 allergic reaction Diseases 0.000 description 1
HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
229940043377 alpha-cyclodextrin Drugs 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000005178 buccal mucosa Anatomy 0.000 description 1
239000000337 buffer salt Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
HESHRHUZIWVEAJ-JGRZULCMSA-N dihydroergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2[C@@H](C3=CC=CC4=NC=C([C]34)C2)C1)C)C1=CC=CC=C1 HESHRHUZIWVEAJ-JGRZULCMSA-N 0.000 description 1
229960004704 dihydroergotamine Drugs 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
229940052760 dopamine agonists Drugs 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000010579 first pass effect Methods 0.000 description 1
230000035876 healing Effects 0.000 description 1
230000006872 improvement Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000007794 irritation Effects 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
229960005181 morphine Drugs 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
229940052404 nasal powder Drugs 0.000 description 1
229940037525 nasal preparations Drugs 0.000 description 1
210000001331 nose Anatomy 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000011084 recovery Methods 0.000 description 1
239000012088 reference solution Substances 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UAA200508587A 2003-12-23 2004-12-22 Intranasal formulation of rotigotine UA79196C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP03029680A EP1547592A1 (en)	2003-12-23	2003-12-23	Intranasal formulation of rotigotine
PCT/EP2004/014626 WO2005063236A1 (en)	2003-12-23	2004-12-22	Intranasal formulation of rotigotine

Publications (1)

Publication Number	Publication Date
UA79196C2 true UA79196C2 (en)	2007-05-25

Family

ID=34530709

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200508587A UA79196C2 (en)	2003-12-23	2004-12-22	Intranasal formulation of rotigotine

Country Status (27)

Country	Link
US (1)	US7683040B2 (is)
EP (2)	EP1547592A1 (is)
JP (1)	JP4430067B2 (is)
KR (1)	KR100718760B1 (is)
CN (1)	CN100374112C (is)
AT (1)	ATE326961T1 (is)
AU (1)	AU2004308641B2 (is)
BR (1)	BRPI0407845A (is)
CA (1)	CA2516400C (is)
CY (1)	CY1105131T1 (is)
DE (1)	DE602004000982T2 (is)
DK (1)	DK1605932T3 (is)
EA (1)	EA008005B1 (is)
ES (1)	ES2262122T3 (is)
HR (1)	HRP20060240T3 (is)
IL (1)	IL170297A (is)
IS (1)	IS2310B (is)
MX (1)	MXPA05008909A (is)
NO (1)	NO20054018L (is)
NZ (1)	NZ541875A (is)
PL (1)	PL1605932T3 (is)
PT (1)	PT1605932E (is)
RS (1)	RS50534B (is)
SI (1)	SI1605932T1 (is)
UA (1)	UA79196C2 (is)
WO (1)	WO2005063236A1 (is)
ZA (1)	ZA200506550B (is)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19814084B4 (de) *	1998-03-30	2005-12-22	Lts Lohmann Therapie-Systeme Ag	D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10041478A1 (de)	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung
DE10041479A1 (de) *	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
US20040048779A1 (en) *	2002-05-06	2004-03-11	Erwin Schollmayer	Use of rotigotine for treating the restless leg syndrome
US8246980B2 (en)	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system
US8246979B2 (en)	2002-07-30	2012-08-21	Ucb Pharma Gmbh	Transdermal delivery system for the administration of rotigotine
DE10234673B4 (de) *	2002-07-30	2007-08-16	Schwarz Pharma Ag	Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
US8211462B2 (en) *	2002-07-30	2012-07-03	Ucb Pharma Gmbh	Hot-melt TTS for administering rotigotine
ATE295726T1 (de)	2002-12-02	2005-06-15	Sanol Arznei Schwarz Gmbh	Verabreichung von rotigotine zur behandlung der parkinson'schen krankheit durch iontophorese
DE10261696A1 (de)	2002-12-30	2004-07-15	Schwarz Pharma Ag	Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10334188B4 (de) *	2003-07-26	2007-07-05	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung von Depressionen
DE10359528A1 (de) *	2003-12-18	2005-07-28	Schwarz Pharma Ag	(S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
EP1547592A1 (en)	2003-12-23	2005-06-29	Schwarz Pharma Ag	Intranasal formulation of rotigotine
DE10361258A1 (de) *	2003-12-24	2005-07-28	Schwarz Pharma Ag	Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) *	2004-02-20	2005-09-08	Schwarz Pharma Ag	Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) *	2004-03-24	2006-07-06	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI392670B (zh) *	2006-06-22	2013-04-11	Ucb Pharma Gmbh	經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途
EP1987815A1 (en) *	2007-05-04	2008-11-05	Schwarz Pharma Ag	Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders
MY165575A (en)	2007-11-28	2018-04-05	Ucb Pharma Gmbh	Polymorphic form of rotigotine
US8580801B2 (en)	2008-07-23	2013-11-12	Robert I. Henkin	Phosphodiesterase inhibitor treatment
EP2281559A1 (en)	2009-06-26	2011-02-09	UCB Pharma GmbH	Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis
ES2679800T3 (es)	2009-12-22	2018-08-31	Lts Lohmann Therapie-Systeme Ag	Polivinilpirrolidona para la estabilización de una dispersión sólida de la forma no cristalina de rotigotina
EP2559435A1 (en)	2011-08-19	2013-02-20	UCB Pharma GmbH	Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke
DE102012013421A1 (de)	2012-07-03	2014-01-09	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Transdermales therapeutisches System (TTS) mit Rotigotin
WO2013075822A1 (en)	2011-11-22	2013-05-30	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Transdermal therapeutic system (tts) with rotigotine
DE102012013439A1 (de)	2012-07-03	2014-01-23	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor
CN103768043B (zh) *	2012-10-22	2015-12-09	苏州药明康德新药开发股份有限公司	采用羟丙基-β-环糊精配制四氢化萘类化合物均一稳定溶液的方法
TW201431570A (zh)	2012-11-22	2014-08-16	Ucb Pharma Gmbh	用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
CN105358139B (zh)	2013-07-03	2020-10-16	Lts罗曼治疗方法有限公司	具有电子元件的经皮治疗系统
WO2015126944A1 (en)	2014-02-18	2015-08-27	Henkin Robert I	Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell
JP6895755B2 (ja)	2014-05-20	2021-06-30	エルテーエスローマンテラピー−ジステーメアーゲー	経皮送達システムにおける活性薬剤の放出を調節するための方法
EP3145504B1 (en)	2014-05-20	2023-07-26	LTS Lohmann Therapie-Systeme AG	Transdermal delivery system including an interface mediator
EP3145502B1 (en)	2014-05-20	2022-07-06	LTS Lohmann Therapie-Systeme AG	Transdermal delivery system containing rotigotine
US9956201B2 (en)	2014-07-21	2018-05-01	Spriaso Llc	Compositions comprising bioreversible derivatives of hydroxy N-substituted-2-aminotetralins, and related dosage forms
CN110917125B (zh) *	2020-01-02	2022-08-12	安徽中医药大学	一种罗替戈汀鼻用胶束温敏凝胶的制备方法
WO2023133463A1 (en) *	2022-01-06	2023-07-13	Cyrano Therapeutics, Inc.	Improved nasal administration of parkinson's therapeutics
CN120053353A (zh) *	2024-05-31	2025-05-30	纳索菲德(上海)制药技术有限公司	一种巴氯芬鼻脑递释组合物

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5108991A (en)	1975-06-19	1992-04-28	Whitby Research, Inc.	Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4992422A (en)	1986-01-31	1991-02-12	Whitby Research, Inc.	Compositions comprising 1-substituted azacycloalkanes
EP0257086B1 (en)	1986-01-31	1993-01-20	WHITBY RESEARCH, Inc.	Skinpenetration enhancing compositions
US5218113A (en)	1986-01-31	1993-06-08	Whitby Research, Inc.	N-substituted thiolactams
US4755535A (en)	1986-04-23	1988-07-05	Nelson Research & Development Co.	Compositions comprising 1-substituted azacycloalkenes
US5073544A (en)	1986-08-15	1991-12-17	Whitby, Inc.	Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes
US4902676A (en)	1986-09-29	1990-02-20	Nelson Research & Development Co.	Compositions comprising N,N-dialkylalkanamides
ES2032570T3 (es)	1987-11-20	1993-02-16	Farmitalia Carlo Erba S.R.L.	Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe).
US5472946A (en)	1988-04-08	1995-12-05	Peck; James V.	Transdermal penetration enhancers
US5073844A (en) *	1991-01-11	1991-12-17	The Annlouise Partnership	Lighted baggage piece
US6086905A (en)	1991-03-21	2000-07-11	Peck; James V.	Topical compositions useful as skin penetration barriers
US5308625A (en)	1992-09-02	1994-05-03	Cygnus Therapeutic Systems	Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
US5989586A (en)	1992-10-05	1999-11-23	Cygnus, Inc.	Two-phase matrix for sustained release drug delivery device
PT689438E (pt)	1993-03-26	2003-10-31	Franciscus Wilhelmus He Merkus	Composicoes farmaceuticas para administracao intranasal de apomorfina
GB9324018D0 (en)	1993-11-23	1994-01-12	Merck Sharp & Dohme	Therapeutic agents
US5771890A (en)	1994-06-24	1998-06-30	Cygnus, Inc.	Device and method for sampling of substances using alternating polarity
PT766578E (pt)	1994-06-24	2001-01-31	Cygnus Therapeutic Systems	Dispositivo de colheita iontoforetica de amostras
AUPN814496A0 (en)	1996-02-19	1996-03-14	Monash University	Dermal penetration enhancer
DE19814084B4 (de)	1998-03-30	2005-12-22	Lts Lohmann Therapie-Systeme Ag	D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10041479A1 (de) *	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
AUPQ969800A0 (en)	2000-08-28	2000-09-21	Fujisawa Pharmaceutical Co., Ltd.	Pyrazolopyridine compound and pharmaceutical use thereof
ATE251901T1 (de)	2001-05-08	2003-11-15	Sanol Arznei Schwarz Gmbh	Transdermales therapeutisches system für die erzielung hoher plasmaspiegel von rotigotin in der therapie von morbus parkinson
FR2829028B1 (fr)	2001-08-29	2004-12-17	Aventis Pharma Sa	Association d'un antagoniste du recepteur cb1 et d'un produit qui active la neurotransmission dopaminergique dans le cerveau, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de
HU227543B1 (en)	2001-09-28	2011-08-29	Richter Gedeon Nyrt	N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
FR2834212B1 (fr)	2001-12-27	2004-07-09	Besins Int Belgique	Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
MXPA04009352A (es)	2002-04-18	2005-01-25	Pharmacia Corp	Terapia de combinacion para el tratamiento de la enfermedad de parkinson con inhibidores de ciclooxigenasa-2 (cox2).
CA2503381A1 (en)	2002-10-25	2004-05-13	Collegium Pharmaceutical, Inc.	Stereoisomers of p-hydroxy-milnacipran, and methods of use thereof
US9102726B2 (en)	2002-12-04	2015-08-11	Argos Therapeutics, Inc.	Nucleic acid of recombination expression vector encoding soluble forms of CD83, host cells transformed/transfected therewith and pharmaceutical compositions containing same
DE10334188B4 (de)	2003-07-26	2007-07-05	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung von Depressionen
US20050032873A1 (en)	2003-07-30	2005-02-10	Wyeth	3-Amino chroman and 2-amino tetralin derivatives
DE10359528A1 (de)	2003-12-18	2005-07-28	Schwarz Pharma Ag	(S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum
EP1547592A1 (en)	2003-12-23	2005-06-29	Schwarz Pharma Ag	Intranasal formulation of rotigotine
EP1708706A1 (en)	2004-01-22	2006-10-11	Boehringer Ingelheim International Gmbh	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and a dopamine agonist
JP2008508337A (ja)	2004-08-02	2008-03-21	シュバルツファルマアクチェンゲゼルシャフト	インドリジンカルボキサミド並びにそのアザ及びジアザ誘導体
DE102004054634A1 (de)	2004-11-12	2006-05-18	Schwarz Pharma Ag	Azaindolcarboxamide

2003
- 2003-12-23 EP EP03029680A patent/EP1547592A1/en not_active Withdrawn
2004
- 2004-12-22 PL PL04804221T patent/PL1605932T3/pl unknown
- 2004-12-22 HR HR20060240T patent/HRP20060240T3/xx unknown
- 2004-12-22 CA CA002516400A patent/CA2516400C/en not_active Expired - Fee Related
- 2004-12-22 US US10/545,530 patent/US7683040B2/en not_active Expired - Fee Related
- 2004-12-22 NZ NZ541875A patent/NZ541875A/en unknown
- 2004-12-22 EA EA200501159A patent/EA008005B1/ru not_active IP Right Cessation
- 2004-12-22 WO PCT/EP2004/014626 patent/WO2005063236A1/en not_active Ceased
- 2004-12-22 AT AT04804221T patent/ATE326961T1/de active
- 2004-12-22 BR BRPI0407845-4A patent/BRPI0407845A/pt not_active IP Right Cessation
- 2004-12-22 DE DE602004000982T patent/DE602004000982T2/de not_active Expired - Lifetime
- 2004-12-22 AU AU2004308641A patent/AU2004308641B2/en not_active Ceased
- 2004-12-22 DK DK04804221T patent/DK1605932T3/da active
- 2004-12-22 RS YUP-2006/0653A patent/RS50534B/sr unknown
- 2004-12-22 ES ES04804221T patent/ES2262122T3/es not_active Expired - Lifetime
- 2004-12-22 MX MXPA05008909A patent/MXPA05008909A/es active IP Right Grant
- 2004-12-22 SI SI200430027T patent/SI1605932T1/sl unknown
- 2004-12-22 JP JP2006508291A patent/JP4430067B2/ja not_active Expired - Fee Related
- 2004-12-22 CN CNB2004800109827A patent/CN100374112C/zh not_active Expired - Fee Related
- 2004-12-22 EP EP04804221A patent/EP1605932B1/en not_active Expired - Lifetime
- 2004-12-22 PT PT04804221T patent/PT1605932E/pt unknown
- 2004-12-22 KR KR1020057017173A patent/KR100718760B1/ko not_active Expired - Fee Related
- 2004-12-22 UA UAA200508587A patent/UA79196C2/uk unknown
2005
- 2005-08-16 IL IL170297A patent/IL170297A/en not_active IP Right Cessation
- 2005-08-16 ZA ZA200506550A patent/ZA200506550B/en unknown
- 2005-08-30 NO NO20054018A patent/NO20054018L/no not_active Application Discontinuation
2006
- 2006-05-26 IS IS8487A patent/IS2310B/is unknown
- 2006-08-09 CY CY20061101113T patent/CY1105131T1/el unknown

Also Published As

Publication number	Publication date
JP2006526004A (ja)	2006-11-16
ZA200506550B (en)	2006-05-31
EA200501159A1 (ru)	2006-02-24
PL1605932T3 (pl)	2006-09-29
IS2310B (is)	2007-11-15
CY1105131T1 (el)	2009-11-04
CA2516400C (en)	2009-10-27
AU2004308641B2 (en)	2006-10-26
DE602004000982T2 (de)	2007-05-10
WO2005063236A1 (en)	2005-07-14
ATE326961T1 (de)	2006-06-15
SI1605932T1 (sl)	2006-08-31
US20070191308A1 (en)	2007-08-16
CA2516400A1 (en)	2005-07-14
DK1605932T3 (da)	2006-09-18
CN100374112C (zh)	2008-03-12
MXPA05008909A (es)	2005-10-05
HRP20060240T3 (hr)	2007-05-31
CN1777422A (zh)	2006-05-24
JP4430067B2 (ja)	2010-03-10
EP1547592A1 (en)	2005-06-29
KR100718760B1 (ko)	2007-05-15
NZ541875A (en)	2008-08-29
RS50534B (sr)	2010-05-07
KR20060040578A (ko)	2006-05-10
AU2004308641A1 (en)	2005-07-14
BRPI0407845A (pt)	2006-02-14
IL170297A (en)	2010-06-30
PT1605932E (pt)	2006-08-31
NO20054018L (no)	2005-08-30
EP1605932B1 (en)	2006-05-24
EA008005B1 (ru)	2007-02-27
IS8487A (is)	2006-05-26
US7683040B2 (en)	2010-03-23
DE602004000982D1 (de)	2006-06-29
EP1605932A1 (en)	2005-12-21
ES2262122T3 (es)	2006-11-16
HK1083596A1 (en)	2006-07-07

Publication	Publication Date	Title
UA79196C2 (en)	2007-05-25	Intranasal formulation of rotigotine
JP2012505172A5 (is)	2014-05-01
JP4106232B2 (ja)	2008-06-25	医薬組成物
JP2008024700A (ja)	2008-02-07	ベルベリン含有水性組成物
KR102733397B1 (ko)	2024-11-21	비강내 에피네프린 제제 및 질환의 치료 방법
EP2838510A1 (en)	2015-02-25	Atomoxetine solution
JP2003128583A (ja)	2003-05-08	清涼化組成物
JP5682005B2 (ja)	2015-03-11	トラニラスト含有水性組成物
JP2009096793A (ja)	2009-05-07	プラノプロフェン含有水性医薬組成物
JP2007269786A (ja)	2007-10-18	パンテチン含有経口液剤
MXPA06009094A (es)	2007-02-02	Formulaciones de liberacion controlada.
EP1647273A1 (en)	2006-04-19	Ophthalmic composition
ITBO20090775A1 (it)	2011-06-02	Composizioni comprendenti antiinfiammatori non steroidei
JP5019923B2 (ja)	2012-09-05	プラノプロフェン含有医薬組成物
JPWO2002017932A1 (ja)	2003-10-14	Ｏｃｔ製剤
JP2003055224A (ja)	2003-02-26	安定化された組成物
JP2002037735A (ja)	2002-02-06	カフェイン類の安定化方法および粘膜適用組成物
KR20190078455A (ko)	2019-07-04	플루르비프로펜 함유 스프레이 조성물 및 그 제조방법
JP2011173801A (ja)	2011-09-08	ケトチフェン配合水性組成物
JP2012224629A (ja)	2012-11-15	ペミロラストを含有する安定な水性組成物
HK1083596B (en)	2006-09-01	Intranasal formulation of rotigotine
JP2007008852A (ja)	2007-01-18	プラバスタチンを含有する水性製剤の安定化方法
KR20030047503A (ko)	2003-06-18	소브레롤·아세트아미노펜 복합 건조시럽제 및 액제
KR20180003413A (ko)	2018-01-09	오셀타미비어 함유 경구용 고형제제 및 그 제조방법