UA74629C2 - A derivative of 3,7-diazabicyclo [3,3,1] compounds , pharmaceutically acceptable salts thereof, a method for producing and composition based thereon as antiarrhythmic agents - Google Patents

A derivative of 3,7-diazabicyclo [3,3,1] compounds , pharmaceutically acceptable salts thereof, a method for producing and composition based thereon as antiarrhythmic agents Download PDF

Info

Publication number: UA74629C2
Authority: UA; Ukraine
Prior art keywords: oxa; compound; salt; butyl; diazadicyclo
Prior art date: 2001-04-12

Application number

UA2003098709A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-12

Filing date

2002-12-04

Publication date

2006-01-16

2002-12-04 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2006-01-16 Publication of UA74629C2 publication Critical patent/UA74629C2/uk

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 267
150000003839 salts Chemical class 0.000 title claims abstract description 133
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238000004519 manufacturing process Methods 0.000 title claims description 7
239000003416 antiarrhythmic agent Substances 0.000 title description 2
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims abstract description 74
206010003119 arrhythmia Diseases 0.000 claims abstract description 19
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 238
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OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 162
238000000034 method Methods 0.000 claims description 155
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238000002425 crystallisation Methods 0.000 claims description 70
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 46
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229910052757 nitrogen Inorganic materials 0.000 claims description 24
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 19
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238000010438 heat treatment Methods 0.000 claims description 18
230000000694 effects Effects 0.000 claims description 17
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125000005233 alkylalcohol group Chemical group 0.000 claims description 8
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125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
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229930195733 hydrocarbon Natural products 0.000 claims description 5
150000002430 hydrocarbons Chemical class 0.000 claims description 5
239000008194 pharmaceutical composition Substances 0.000 claims description 5
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150000001983 dialkylethers Chemical class 0.000 claims description 4
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TVWQKCYNJSKYOP-UHFFFAOYSA-N 2-[(3,4-dichlorobenzoyl)amino]acetic acid Chemical compound OC(=O)CNC(=O)C1=CC=C(Cl)C(Cl)=C1 TVWQKCYNJSKYOP-UHFFFAOYSA-N 0.000 claims description 3
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125000001216 2-naphthoyl group Chemical group C1=C(C=CC2=CC=CC=C12)C(=O)* 0.000 claims description 3
206010003130 Arrhythmia supraventricular Diseases 0.000 claims description 3
206010047281 Ventricular arrhythmia Diseases 0.000 claims description 3
239000004480 active ingredient Substances 0.000 claims description 3
150000001335 aliphatic alkanes Chemical class 0.000 claims description 3
230000001746 atrial effect Effects 0.000 claims description 3
150000001242 acetic acid derivatives Chemical class 0.000 claims description 2
239000003125 aqueous solvent Chemical class 0.000 claims description 2
150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 2
PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 claims description 2
125000006308 propyl amino group Chemical group 0.000 claims description 2
KWZYUHDFABISCL-UHFFFAOYSA-N tert-butyl methanesulfonate Chemical compound CC(C)(C)OS(C)(=O)=O KWZYUHDFABISCL-UHFFFAOYSA-N 0.000 claims 2
YONLFQNRGZXBBF-UHFFFAOYSA-N 2,3-dibenzoyloxybutanedioic acid Chemical compound C=1C=CC=CC=1C(=O)OC(C(O)=O)C(C(=O)O)OC(=O)C1=CC=CC=C1 YONLFQNRGZXBBF-UHFFFAOYSA-N 0.000 claims 1
UPHOPMSGKZNELG-UHFFFAOYSA-N 2-hydroxynaphthalene-1-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 UPHOPMSGKZNELG-UHFFFAOYSA-N 0.000 claims 1
OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical class CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 1
150000001338 aliphatic hydrocarbons Chemical class 0.000 claims 1
238000001938 differential scanning calorimetry curve Methods 0.000 claims 1
239000000243 solution Substances 0.000 description 198
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238000004467 single crystal X-ray diffraction Methods 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000000371 solid-state nuclear magnetic resonance spectroscopy Methods 0.000 description 1
238000007614 solvation Methods 0.000 description 1
SETMGIIITGNLAS-UHFFFAOYSA-N spizofurone Chemical compound O=C1C2=CC(C(=O)C)=CC=C2OC21CC2 SETMGIIITGNLAS-UHFFFAOYSA-N 0.000 description 1
229950001870 spizofurone Drugs 0.000 description 1
238000000859 sublimation Methods 0.000 description 1
230000008022 sublimation Effects 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000001384 succinic acid Substances 0.000 description 1
208000014221 sudden cardiac arrest Diseases 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
238000012360 testing method Methods 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

UA2003098709A 2001-04-12 2002-12-04 A derivative of 3,7-diazabicyclo [3,3,1] compounds , pharmaceutically acceptable salts thereof, a method for producing and composition based thereon as antiarrhythmic agents UA74629C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0101327A SE0101327D0 (sv)	2001-04-12	2001-04-12	New crystalline forms
PCT/SE2002/000725 WO2002083688A1 (en)	2001-04-12	2002-04-12	3,7-diazabicyclo [3.3.1] formulations as antiarhythmic compounds

Publications (1)

Publication Number	Publication Date
UA74629C2 true UA74629C2 (en)	2006-01-16

Family

ID=20283783

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2003098709A UA74629C2 (en)	2001-04-12	2002-12-04	A derivative of 3,7-diazabicyclo [3,3,1] compounds , pharmaceutically acceptable salts thereof, a method for producing and composition based thereon as antiarrhythmic agents

Country Status (29)

Country	Link
US (1)	US7217708B2 (et)
EP (2)	EP1550663A1 (et)
JP (1)	JP2004525970A (et)
KR (1)	KR20030087078A (et)
CN (1)	CN1269823C (et)
AR (1)	AR035452A1 (et)
AT (1)	ATE323095T1 (et)
BR (1)	BR0208829A (et)
CA (1)	CA2443470A1 (et)
CZ (1)	CZ20032760A3 (et)
DE (1)	DE60210598T2 (et)
DK (1)	DK1389213T3 (et)
EE (1)	EE200300504A (et)
ES (1)	ES2261721T3 (et)
HU (1)	HUP0303487A3 (et)
IL (1)	IL158250A0 (et)
IS (1)	IS6980A (et)
MX (1)	MXPA03009206A (et)
NO (1)	NO20034527L (et)
NZ (1)	NZ528560A (et)
PL (1)	PL367179A1 (et)
PT (1)	PT1389213E (et)
RU (1)	RU2286993C2 (et)
SE (1)	SE0101327D0 (et)
SK (1)	SK12572003A3 (et)
TW (1)	TWI237025B (et)
UA (1)	UA74629C2 (et)
WO (1)	WO2002083688A1 (et)
ZA (1)	ZA200307759B (et)

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TWI259836B (en) *	2001-04-12	2006-08-11	Astrazeneca Ab	Modified release formulation suitable for antiarrhythmic compounds
SE0401539D0 (sv) *	2004-06-15	2004-06-15	Astrazeneca Ab	New compounds
SE0401540D0 (sv) *	2004-06-15	2004-06-15	Astrazeneca Ab	New compounds
JP2008543750A (ja) *	2005-06-13	2008-12-04	アストラゼネカアクチボラグ	心不整脈の処置用の新規オキサビスピジン化合物
AR053901A1 (es) *	2005-06-20	2007-05-23	Astrazeneca Ab	Formas fisicas de oxabispidinas n,n'- disustituidas
WO2006137770A1 (en) *	2005-06-20	2006-12-28	Astrazeneca Ab	Process for the preparation of n,n´- disubstituted oxabispidines
TW200734342A (en) *	2005-12-15	2007-09-16	Astrazeneca Ab	New compounds for the treatment of cardiac arrhythmias
WO2007103970A2 (en) *	2006-03-07	2007-09-13	Endacea, Inc.	Compositions and methods for treating respiratory disorders
LT3357911T (lt)	2006-06-26	2022-08-10	Akebia Therapeutics Inc.	Prolilo hidroksilazės inhibitoriai ir naudojimo būdai
JP2014522410A (ja)	2011-06-06	2014-09-04	アケビアセラピューティクスインコーポレイテッド	がん治療のための方法として低酸素誘導因子−２αを安定化するための、化合物および組成物
NO2686520T3 (et)	2011-06-06	2018-03-17
SG11201509998WA (en)	2013-06-13	2016-01-28	Akebia Therapeutics Inc	Compositions and methods for treating anemia
RU2021125455A (ru)	2013-11-15	2021-10-05	Экебиа Терапьютикс, Инк.	Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения
BR112017015852A2 (pt)	2015-01-23	2018-03-27	Akebia Therapeutics Inc	forma de cristal, sal hemicálcico, sal hemicálcico di-hidratado, sal monossódico hidratado, sal bissódico monoidratado, sal monossódico anidro e método para preparar o composto 1
TWI794725B (zh)	2015-04-01	2023-03-01	美商阿克比治療有限公司	用於治療貧血之組合物及方法
EP3790863A1 (en)	2018-05-09	2021-03-17	Akebia Therapeutics Inc.	Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
JP7604387B2 (ja) *	2019-03-28	2024-12-23	ファースト・バイオセラピューティクス・インコーポレイテッド	ベンゾチアゾール化合物の薬学的塩、多形体及びその製造方法
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3732094A1 (de)	1987-09-24	1989-04-06	Basf Ag	Bispidinderivate als klasse iii-antiarrhythmika
US5110933A (en) *	1989-11-13	1992-05-05	Board Of Regents Of Oklahoma State University	Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
SE9704709D0 (sv)	1997-12-17	1997-12-17	Astra Ab	Pharmaceutically active compounds
SE9902268D0 (sv)	1999-06-16	1999-06-16	Astra Ab	Pharmaceutically active compounds
SE9903759D0 (sv) *	1999-10-18	1999-10-18	Astra Ab	Pharmaceutically active compounds

2001
- 2001-04-12 SE SE0101327A patent/SE0101327D0/xx unknown
2002
- 2002-04-01 TW TW091106493A patent/TWI237025B/zh not_active IP Right Cessation
- 2002-04-02 AR ARP020101189A patent/AR035452A1/es not_active Application Discontinuation
- 2002-04-12 IL IL15825002A patent/IL158250A0/xx unknown
- 2002-04-12 NZ NZ528560A patent/NZ528560A/en unknown
- 2002-04-12 US US10/474,592 patent/US7217708B2/en not_active Expired - Fee Related
- 2002-04-12 ES ES02761972T patent/ES2261721T3/es not_active Expired - Lifetime
- 2002-04-12 KR KR10-2003-7013320A patent/KR20030087078A/ko not_active Withdrawn
- 2002-04-12 CN CNB028116283A patent/CN1269823C/zh not_active Expired - Fee Related
- 2002-04-12 WO PCT/SE2002/000725 patent/WO2002083688A1/en not_active Ceased
- 2002-04-12 EE EEP200300504A patent/EE200300504A/et unknown
- 2002-04-12 SK SK1257-2003A patent/SK12572003A3/sk not_active Application Discontinuation
- 2002-04-12 EP EP05007851A patent/EP1550663A1/en not_active Withdrawn
- 2002-04-12 CZ CZ20032760A patent/CZ20032760A3/cs unknown
- 2002-04-12 HU HU0303487A patent/HUP0303487A3/hu unknown
- 2002-04-12 BR BR0208829-0A patent/BR0208829A/pt not_active IP Right Cessation
- 2002-04-12 RU RU2003129231/04A patent/RU2286993C2/ru not_active IP Right Cessation
- 2002-04-12 PL PL02367179A patent/PL367179A1/xx unknown
- 2002-04-12 DK DK02761972T patent/DK1389213T3/da active
- 2002-04-12 AT AT02761972T patent/ATE323095T1/de not_active IP Right Cessation
- 2002-04-12 PT PT02761972T patent/PT1389213E/pt unknown
- 2002-04-12 MX MXPA03009206A patent/MXPA03009206A/es active IP Right Grant
- 2002-04-12 CA CA002443470A patent/CA2443470A1/en not_active Abandoned
- 2002-04-12 DE DE60210598T patent/DE60210598T2/de not_active Expired - Fee Related
- 2002-04-12 EP EP02761972A patent/EP1389213B1/en not_active Expired - Lifetime
- 2002-04-12 JP JP2002581443A patent/JP2004525970A/ja active Pending
- 2002-12-04 UA UA2003098709A patent/UA74629C2/uk unknown
2003
- 2003-10-03 ZA ZA200307759A patent/ZA200307759B/en unknown
- 2003-10-08 IS IS6980A patent/IS6980A/is unknown
- 2003-10-09 NO NO20034527A patent/NO20034527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0303487A3 (en)	2005-04-28
DK1389213T3 (da)	2006-07-10
IS6980A (is)	2003-10-08
MXPA03009206A (es)	2004-01-29
PL367179A1 (en)	2005-02-21
ZA200307759B (en)	2005-01-03
ES2261721T3 (es)	2006-11-16
NZ528560A (en)	2005-05-27
BR0208829A (pt)	2004-03-09
EP1389213B1 (en)	2006-04-12
CZ20032760A3 (cs)	2004-01-14
JP2004525970A (ja)	2004-08-26
EE200300504A (et)	2003-12-15
DE60210598D1 (de)	2006-05-24
WO2002083688A1 (en)	2002-10-24
ATE323095T1 (de)	2006-04-15
PT1389213E (pt)	2006-07-31
EP1389213A1 (en)	2004-02-18
NO20034527D0 (no)	2003-10-09
CA2443470A1 (en)	2002-10-24
EP1550663A1 (en)	2005-07-06
SE0101327D0 (sv)	2001-04-12
US20040143000A1 (en)	2004-07-22
CN1514837A (zh)	2004-07-21
SK12572003A3 (sk)	2004-07-07
KR20030087078A (ko)	2003-11-12
TWI237025B (en)	2005-08-01
US7217708B2 (en)	2007-05-15
IL158250A0 (en)	2004-05-12
AR035452A1 (es)	2004-05-26
RU2003129231A (ru)	2005-04-10
CN1269823C (zh)	2006-08-16
HK1061026A1 (en)	2004-09-03
NO20034527L (no)	2003-12-10
DE60210598T2 (de)	2007-02-08
RU2286993C2 (ru)	2006-11-10
HUP0303487A2 (hu)	2004-01-28

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UA74629C2 (en)	2006-01-16	A derivative of 3,7-diazabicyclo [3,3,1] compounds , pharmaceutically acceptable salts thereof, a method for producing and composition based thereon as antiarrhythmic agents
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