[go: up one dir, main page]

UA48989C2 - Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment - Google Patents

Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment

Info

Publication number
UA48989C2
UA48989C2 UA98052267A UA98052267A UA48989C2 UA 48989 C2 UA48989 C2 UA 48989C2 UA 98052267 A UA98052267 A UA 98052267A UA 98052267 A UA98052267 A UA 98052267A UA 48989 C2 UA48989 C2 UA 48989C2
Authority
UA
Ukraine
Prior art keywords
derivatives
carbonylpyridazine
arylsulfonyl
thio
aryl
Prior art date
Application number
UA98052267A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Дональд У. Комбз
Original Assignee
Орто-Макнейл Фармасьютікел, Інк.
Орто-Макнейл Фармасьютикел, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орто-Макнейл Фармасьютікел, Інк., Орто-Макнейл Фармасьютикел, Инк. filed Critical Орто-Макнейл Фармасьютікел, Інк.
Publication of UA48989C2 publication Critical patent/UA48989C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/36—Benzo-cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Described are derivatives of 1-arylsulfonyl, arylcarbonyl, aryl(thio)carbonylpyridazine and methods for preparation thereof. Described are new nonsteroid heterocyclic compounds showing activity of progestin and/or antiprogestin and having high in vitro likeness to progestin of receptor of uterus, breast or bones. Nonsteroid heterocyclic derivatives are used for contraception, menopause, osteoporosis or endometriosis.
UA98052267A 1995-11-06 1996-10-10 Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment UA48989C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US790095P 1995-11-06 1995-11-06
PCT/US1996/016227 WO1997017332A1 (en) 1995-11-06 1996-10-10 1-arylsulphonyl, aryl(thio)carbonyl pyridazino derivatives and methods of preparation

Publications (1)

Publication Number Publication Date
UA48989C2 true UA48989C2 (en) 2002-09-16

Family

ID=21728709

Family Applications (1)

Application Number Title Priority Date Filing Date
UA98052267A UA48989C2 (en) 1995-11-06 1996-10-10 Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment

Country Status (17)

Country Link
JP (1) JP2000501073A (en)
KR (1) KR100360614B1 (en)
CN (1) CN1110485C (en)
AU (1) AU704507B2 (en)
BR (1) BR9611407A (en)
CZ (1) CZ286789B6 (en)
HU (1) HU225162B1 (en)
IL (1) IL124320A (en)
MX (1) MX9803605A (en)
NO (1) NO310460B1 (en)
NZ (1) NZ319979A (en)
PL (1) PL185618B1 (en)
RU (1) RU2175969C2 (en)
TW (1) TW460467B (en)
UA (1) UA48989C2 (en)
WO (1) WO1997017332A1 (en)
ZA (1) ZA969298B (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816467A (en) * 1987-01-09 1989-03-28 Farmitalia Carlo Erba S.R.L Heteroaryl 3-oxo-propanenitrile derivatives, pharmaceutical compositions and use
WO1989004306A1 (en) * 1987-11-02 1989-05-18 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyridazine compounds and their medicinal uses
WO1993004069A1 (en) * 1991-08-27 1993-03-04 Yoshitomi Pharmaceutical Industries, Ltd. Fused pyridazine compound and pharmaceutical use thereof

Also Published As

Publication number Publication date
PL326669A1 (en) 1998-10-12
HUP0201305A3 (en) 2003-02-28
NO310460B1 (en) 2001-07-09
CZ286789B6 (en) 2000-07-12
BR9611407A (en) 1999-12-28
CN1207091A (en) 1999-02-03
IL124320A0 (en) 1998-12-06
TW460467B (en) 2001-10-21
ZA969298B (en) 1998-05-05
AU7263796A (en) 1997-05-29
CN1110485C (en) 2003-06-04
HUP0201305A2 (en) 2002-12-28
KR19990067340A (en) 1999-08-16
CZ138098A3 (en) 1998-09-16
IL124320A (en) 2001-10-31
RU2175969C2 (en) 2001-11-20
NO982030D0 (en) 1998-05-05
KR100360614B1 (en) 2003-06-02
PL185618B1 (en) 2003-06-30
NO982030L (en) 1998-06-23
AU704507B2 (en) 1999-04-22
HU225162B1 (en) 2006-07-28
MX9803605A (en) 1998-09-30
JP2000501073A (en) 2000-02-02
WO1997017332A1 (en) 1997-05-15
NZ319979A (en) 1999-11-29

Similar Documents

Publication Publication Date Title
ATE175353T1 (en) METHOD AND SYSTEM FOR CONTRACEPTION
AP2001002054A0 (en) Use of biogenic estrogen sulfamates for hormone replacement therapy.
HUP9902121A2 (en) Indole derivatives as antagonists of gonadotropin releasing hormone and pharmaceutical compositions containing them
DK365887D0 (en) COMBINATION DOSAGE FOR HORMONE TREATMENT OF WOMEN IN PRAE-MENOPAUSUS
NZ262569A (en) Reducing bone loss by administration of 3,4-diphenylbenzo[b]pyran derivatives
MY151187A (en) Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
AU5834101A (en) 8ss-hydrocarbyl-substituted estratrienes for use as selective estrogens
BG104544A (en) Novel acylguanadine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists
MY114394A (en) Estra-1,3,5 (10)-trien derivatives,process for their preparation and pharmaceutical compositions containing these compounds
EA201200377A1 (en) METHOD OF ORAL CONTRACEPTION IN WOMEN, METHOD OF MANAGING UNDESIRABLE BLEEDING AND INTENDED FOR USE IN THESE METHODS
PT956024E (en) MONOPHASIC ORAL CONTRACEPTIVE METHOD AND COVER ("KIT") COMPREHENDING A COMBINATION OF A PROGESTINE AND ESTROGEN
IL113178A (en) 8alpha-3-hydroxyestra-1,3,5(11)tetraen-17-one( 9(11)-dehydro-8-isoestrone) its preparation and pharmaceutical composition containing it
DE3465201D1 (en) 1-alkyl-androsta-1,4-diene-3,17-diones, process for their preparation and pharmaceutical compositions containing them
BG105804A (en) 16-hydroxyestratrienes as selective acting estrogens
UA48989C2 (en) Derivatives of 1-arylsulfonyl, aryl(thio)carbonylpyridazine, method of their preparation, pharmaceutical composition and method of treatment
IL147123A0 (en) Compositions containing soluble forms of hla-g for treating inflammatory skin pathologies
IL99123A0 (en) Pharmaceutical compositions for treatment of bone wasting diseases,comprising estrogen derivatives
ATE183740T1 (en) ALPHA-SUBSTITUTED 1-BENZYL NAPHTHYL DERIVATIVES
HUP0202371A3 (en) Diacylhydrazine derivatives, process for producing them, use of these derivatives for producing of pharmaceutical compositions and pharmaceutical compositions
BR0014952A (en) Contraceptive medicine and its mode of preparation
EP1025098A4 (en) Benzothiophenes
PL352029A1 (en) 14-beta-h-sterols, pharmaceutical compositions containing these sterols and use of these derivatives for obtaining drugs to regulate meioses
ATE73664T1 (en) PHARMACEUTICALS FOR THE REGULATION OF HORMONAL SECRETIONS AND THE TREATMENT OF FEMALE STERILITY.
HUP9903310A3 (en) Indole derivatives for the treatment of osteoporosis pharmaceutical compositions containing them, process for producing them and their medical use