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UA111804C2 - ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК ІНГІБІТОРИ ЯНУС-ЗАЛЕЖНИХ КІНАЗ (JAK) - Google Patents

ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК ІНГІБІТОРИ ЯНУС-ЗАЛЕЖНИХ КІНАЗ (JAK)

Info

Publication number
UA111804C2
UA111804C2 UAA201507511A UAA201507511A UA111804C2 UA 111804 C2 UA111804 C2 UA 111804C2 UA A201507511 A UAA201507511 A UA A201507511A UA A201507511 A UAA201507511 A UA A201507511A UA 111804 C2 UA111804 C2 UA 111804C2
Authority
UA
Ukraine
Prior art keywords
jak
janus
pyromidine
pyrimidine derivatives
kinase inhibitors
Prior art date
Application number
UAA201507511A
Other languages
English (en)
Inventor
Мет'ю Френк Браун
Ешлі Едвард Фенвік
Марк Едвард Фленаган
Андреа Ґонзалез
Тімоті Еллан Джонсон
Нілу Кайла
Марк Дж. Міттон-Фрай
Джозеф Волтер Стробеч
Рут Е. Тенбрінк
Джон Дейвід Трзупек
Рейоманд Джал Унвалла
Майкл Л. Вазкез
Міхір Д. Паріх
Original Assignee
Пфайзер Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Інк. filed Critical Пфайзер Інк.
Publication of UA111804C2 publication Critical patent/UA111804C2/uk

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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Abstract

Описаними в даному документі є похідні піроло[2,3-d]піримідину, їх застосування як інгібіторів Янус-кінази (JAK) та фармацевтичні композиції, що їх містять.
UAA201507511A 2013-02-22 2014-11-02 ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК ІНГІБІТОРИ ЯНУС-ЗАЛЕЖНИХ КІНАЗ (JAK) UA111804C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361767947P 2013-02-22 2013-02-22
PCT/IB2014/058889 WO2014128591A1 (en) 2013-02-22 2014-02-11 Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)

Publications (1)

Publication Number Publication Date
UA111804C2 true UA111804C2 (uk) 2016-06-10

Family

ID=50151346

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UAA201507511A UA111804C2 (uk) 2013-02-22 2014-11-02 ПОХІДНІ ПІРОЛО[2,3-d]ПІРИМІДИНУ ЯК ІНГІБІТОРИ ЯНУС-ЗАЛЕЖНИХ КІНАЗ (JAK)

Country Status (47)

Country Link
US (3) US9035074B2 (uk)
EP (2) EP2958921B1 (uk)
JP (2) JP6145179B2 (uk)
KR (1) KR101787858B1 (uk)
CN (2) CN105008362B (uk)
AP (1) AP2015008664A0 (uk)
AR (1) AR094857A1 (uk)
AU (1) AU2014220357B2 (uk)
BR (1) BR112015019634B1 (uk)
CA (1) CA2900703C (uk)
CL (1) CL2015002303A1 (uk)
CR (1) CR20150395A (uk)
CU (1) CU24275B1 (uk)
CY (3) CY1119502T1 (uk)
DK (2) DK2958921T3 (uk)
DO (1) DOP2015000206A (uk)
EA (1) EA027879B1 (uk)
ES (2) ES2713052T3 (uk)
FR (1) FR22C1006I2 (uk)
GE (1) GEP201606600B (uk)
HR (2) HRP20171599T2 (uk)
HU (3) HUE037192T2 (uk)
IL (1) IL240132B (uk)
LT (3) LT3290421T (uk)
LU (1) LUC00261I2 (uk)
MA (1) MA38347A1 (uk)
MD (1) MD4735C1 (uk)
ME (2) ME03301B (uk)
MX (1) MX374338B (uk)
MY (1) MY177476A (uk)
NL (1) NL301155I2 (uk)
NO (2) NO3052752T3 (uk)
NZ (1) NZ710411A (uk)
PE (1) PE20151764A1 (uk)
PH (1) PH12015501779B1 (uk)
PL (2) PL2958921T3 (uk)
PT (2) PT3290421T (uk)
RS (2) RS58245B1 (uk)
SG (1) SG11201505816UA (uk)
SI (2) SI2958921T1 (uk)
TN (1) TN2015000355A1 (uk)
TR (1) TR201902525T4 (uk)
TW (1) TWI507408B (uk)
UA (1) UA111804C2 (uk)
UY (1) UY35337A (uk)
WO (1) WO2014128591A1 (uk)
ZA (1) ZA201505454B (uk)

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