本發明提供一種載劑，包含平均分子量為約8000之聚乙二醇及平均分子量為約3350之聚乙二醇，其中該平均分子量為約8000之聚乙二醇及該平均分子量為約3350之聚乙二醇之重量比為約1：1至約1：5。 範圍在本文中通常表述為「約」一個特定值及/或至「約」另一個特定值。當表述此類範圍時，一態樣為包括一個特定值及/或至另一個特定值之範圍。類似地，當值藉由使用字「約」表述為近似值時，應瞭解特定值可形成另一態樣。另外應瞭解，每一範圍之各端點皆有顯著性，一端點與另一端點既有相關性，亦彼此獨立。 如本文所用之術語「載劑」，又稱為「賦形劑」，係指自身並不為治療劑，而是用作用於將治療劑傳遞至個體之載劑及/或稀釋劑及/或佐劑或媒劑，或添加至調配物中以改善調配物之處理或儲存性質或允許或有助於組合物之劑量單位形成適於投予之劑量單位的物質。載劑不應破壞治療劑之藥理學活性，且在以足以傳遞治療量之藥劑的劑量投予時應無毒性。 根據本發明之載劑，包含聚乙二醇(polyethylene glycol)，特定言之為平均分子量為約8000之聚乙二醇（簡稱PEG-8000）及平均分子量為約3350之聚乙二醇（簡稱PEG-3350）。舉例而言，PEG-8000之分子量可為約7000 g/mol至約9000 g/mol；而PEG-3350之分子量可為約3000 g/mol至約3700 g/mol。此外，聚乙二醇之分子量可透過質譜儀(mass spectrometry)測量，或藉由測量其黏度以反推其分子量。 根據本發明之載劑，PEG-8000與PEG-3350之重量比為約1：1至約1：5；較佳為約1：2至約1：3；更佳係為約1：2.5。藉由特定分子量及特定重量比聚乙二醇之使用，使本發明之載劑可以應用於分散多種植物種類及疏水度皆不相同之疏水性植物萃取物，更可以將多種疏水性植物萃取物共同分散於單一載劑中。 於本發明之一較佳具體實施例中，該載劑另包含平均分子量為約400之聚乙二醇（簡稱PEG-400）。舉例而言，PEG-400之分子量可為約380 g/mol至約420 g/mol。PEG-8000與PEG-3350之總使用量與PEG-400之使用量的重量比例較佳為約1：1至約1：10；更佳為約1：3至約1：6；尤佳為約1：4。
根據本發明，具有不同平均分子量之聚乙二醇間之混合順序及方法並無限制，於本發明之一具體實施例中，針對包含片狀或粉末狀之固體聚乙二醇間之混合可於固體狀態混合後，加熱而得一勻相液體狀態；於本發明之另一具體實施例中，先行加熱各固體聚乙二醇，再行混合而得一勻相液體狀態；於本發明之再一具體實施例中，固體聚乙二醇係加入已呈液體狀態之聚乙二醇，再行加熱混合而得一勻相液體狀態。另一方面，針對常溫常壓下即為液體之聚乙二醇而言，亦可依前述方案與固體聚乙二醇混合。 於本發明之一較佳具體實施例中，根據本發明之載劑係先將PEG-8000及PEG-3350加熱至融化後，均勻混合而形成勻相溶液。例如將秤重定量之PEG-8000及PEG-3350固體置於一容器中，以水浴加熱，直至其開始融化時，再經攪拌混合等。上述包含PEG-8000及PEG-3350之載劑於常溫下，可能呈現固體溶液之型態，並可於使用前再行加熱溶解。 於本發明之另一較佳具體實施例中，先加熱融化並依重量比例混合PEG-8000及PEG-3350，再加入PEG-400並均勻混合。如此一來，該載劑係於常溫下呈黏稠液態之溶液，故使用上更加便利。 於本發明之再一較佳具體實施例中，依使用需求於該載劑中加入其他稀釋劑，以調整黏度、濃度及體積，適用於本發明之其他稀釋劑包含但不限於水及醇等。 較佳地，根據本發明之載劑係為一勻相溶液，亦即平均分子量不同之聚乙二醇可均勻混合並互溶。 本發明另提供一種上述之載劑的用途，係用於分散一疏水性植物萃取物。 本發明再提供一種疏水性植物萃取物之分散方法，係將至少一疏水性植物萃取物分散於上述載劑中。 於本發明中，所述「植物」不限定其種類。舉例而言，可以為喬木、灌木、藤類、青草、蕨類及綠藻等，且可以為中藥、草藥或非藥用植物，再者，本發明所述「植物」更可包含藻類及真菌類等。根據本發明之植物可意指整株植物，亦可指植物之任一部份。於本發明一實施例中，植物包含靈芝、牛樟芝、桑黃、茯苓及冬蟲夏草等，且可包含其部分或整體，例如僅包含其子實體等。 根據本發明之植物萃取物係將植物經由萃取，而獲得萃取物。舉例而言，植物可以先經乾燥、炮製後，再經破碎成小塊或經粉碎，而後以流體（例如液體或超臨界流體）進行萃取，使植物所包含之成分溶解於萃取流體中，而獲得植物萃取物，或視需要再經乾燥。由於各種植物所包含的有效成分不同，可以藉由選取不同的萃取流體及比例，而調整植物萃取物所包含之成分。 於本發明中，所述「疏水性」係指與水互相排斥之特性，亦即，係指難溶於水之特性，「疏水度」係指疏水性之程度。當物質的疏水度越高，則越難以溶於水中；反之，物質的疏水度低，則較容易溶於水中。因此，本發明所述之「疏水性植物萃取物」，係指具有疏水性之植物萃取物，為植物萃取物中所包含之疏水性成分，例如但不限於極性較低而不溶或難溶於水中之成分。亦即，所述疏水性植物萃取物係界定此類成分難溶於水之特性，而非限制其獲得之方式。所述疏水性植物萃取物可為植物經由有機溶液進行萃取而得。 較佳地，根據本發明之疏水性植物萃取物係為醇萃取物，亦即使用醇萃取植物所得之萃取物。本文中所言之「醇」乙詞係指直鏈或支鏈、具取代或不具取代、單元或多元、飽和或不飽和之醇，較佳係為不具取代、單元及飽和醇。另一方面，該醇較佳係為具有1至7碳數之醇，更佳為1至4碳數之醇。於本發明之一較佳具體實施例中，該具有1至7碳數之醇係為甲醇、乙醇、正丙醇(n-propanol)、異丙醇(isopropanol)、正丁醇、異丁醇(iso-butanol)、仲丁醇(sec-butanol)、叔丁醇(tert-butanol)、1-戊醇、2-戊醇、3-戊醇、2-甲基-1-丁醇、2-甲基-2-丁醇、3-甲基-2-丁醇、3-甲基-1-丁醇、2,2-二甲基-1-丙醇、1-己醇、2,4-己二烯-1-醇、2-甲基-环戊醇、環己醇、1-庚醇、2-庚醇或環庚醇；尤佳地，該醇係為甲醇或乙醇；最佳地，該醇為乙醇。該醇可單獨使用或混合多種使用。 本文中所言之醇較佳係為水溶液，其濃度較佳為自約20%至約99.9%之醇溶液；更佳為自約30%至約99.9%之醇溶液；尤佳為自約40%至約98.0%之醇溶液。 本發明所述「疏水性植物萃取物」包含但不限於靈芝、牛樟芝、桑黃、茯苓及冬蟲夏草之萃取物。 舉例而言，靈芝萃取物較佳包含從赤芝子實體和孢子中分離而得之三萜類化學成分，該三萜類化合物包含但不限於靈芝酸(ganoderic acid R)。 舉例而言，牛樟芝萃取物較佳包含三萜類，係為疏水性，可使用濃度較高之酒精水溶液（例如體積百分比90～95%之酒精水溶液）進行萃取。 舉例而言，桑黃萃取物包含桑黃乙醇粗萃物(PLEE)，可使用體積百分比約70%之酒精水溶液進行萃取。 舉例而言，茯苓萃取物包含三萜類化合物，茯苓素(Poriatin)、茯苓酸(Pachymic acid)、塊苓酸(Tumulosic acid)、多孔蕈酸C(polyporenic acid C)、齒孔酸(Ebricoic acid )、茯苓新酸(poricoic acid)等；可使用體積百分比約90~95%之酒精水溶液進行萃取。 舉例而言，冬蟲夏草萃取物包含蟲草素及線苷，可使用體積百分比約50%之酒精水溶液進行萃取。 根據本發明之疏水性植物萃取物之分散方法可以僅將單一疏水性植物萃取物分散於載劑中；或者，可以將數種疏水度不相同的疏水性植物萃取物共同分散於載劑中。於本發明之一具體實施例中，欲進行分散之該至少一疏水性植物萃取物包含一第一疏水性植物萃取物及一第二疏水性植物萃取物，該第一疏水性植物萃取物之疏水度高於該第二疏水性植物萃取物之疏水度，該方法包含將該第一疏水性植物萃取物及該第二疏水性植物萃取物共同分散於該載劑中。 於本發明之一具體實施例中，當該分散方法用於分散數種疏水度不同之疏水性植物萃取物時，較佳可以先將數種植物萃取物依照疏水度排列，並先將疏水度最高者（最不易溶於水）分散於該載劑中，後續再加入疏水度略低者並分散之，最後才加入疏水度最低之植物萃取物。詳言之，於本發明一實施例中，係以上述載劑分散一第一疏水性植物萃取物及一第二疏水性植物萃取物，其中該第一疏水性植物萃取物之疏水度高於該第二疏水性植物萃取物之疏水度，先將該第一疏水性植物萃取物分散於該載劑中，續將該第二疏水性植物萃取物分散於該載劑中。 於本發明之一具體實施例中，該疏水性植物萃取物之分散方法包含下列步驟： (a) 將該至少一疏水性植物萃取物分散於該平均分子量為約8000之聚乙二醇及該平均分子量為約3350之聚乙二醇中，以形成一分散組合物；及 (b) 將該分散組合物分散於該平均分子量為約400之聚乙二醇中。 於此具體實施例中，該載劑係包含PEG-8000、PEG-3350及PEG-400時，其中先行使PEG-8000及PEG-3350形成一勻相溶液，例如加熱PEG-8000及PEG-3350直至完全融化，再將該疏水性植物萃取物加入，以形成該分散組合物，接著再將該分散組合物分散於PEG-400中。 為提高分散之效果，根據本發明之疏水性植物萃取物之分散方法，較佳係於加熱狀態下將該至少一疏水性植物萃取物分散於該載劑中。加熱之溫度較佳係可使該載劑完全融化，並且避免該疏水性植物萃取物所包含之有效成分變質者，例如為於約60°C至約80°C之溫度下加熱，加熱之手段亦無限制，例如使用水浴、油浴等方式。 為提高分散之效果，根據本發明之疏水性植物萃取物之分散方法另包含均質化萃取物該載劑及該至少一疏水性植物萃取物。此均質化步驟可獨立實施，或與分散步驟同時實施，或同時與分散、加熱步驟合併實施，均質化之手段包含但不限於經由攪拌或超音波震盪等方式。舉例而言，係可使用超音波震盪或均質機（例如轉速15,000 rpm/min至20,000 rpm/min）以均質化疏水性植物萃取物與載劑，使載劑可均勻包覆疏水性植物萃取物，而形成較小粒子，以利後續使用。 根據本發明之載劑與疏水性植物萃取物之比例係為可使該載劑包覆該疏水性植物萃取物，且可使整體膠體組合物仍具有期望之效果者，於本發明一實施例中，其中該至少一疏水性植物萃取物及該載劑之重量比為約1：10至約1：50。若載劑比例過低，可能無法完全分散疏水性植物萃取物；反之，若載劑比例過高，等於使有效成分被大量稀釋，所製得之膠體組合物的體積大，使用不便。 為擴大疏水性植物萃取物之應用，根據本發明之載劑可同時調和疏水性植物萃取物與親水性植物萃取物於同一膠體組合物中，於本發明之一較佳具體實施例中，該疏水性植物萃取物之分散方法另包含將親水性植物萃取物分散於該載劑中。 該親水性植物萃取物係指可溶解於水中之植物萃取物成分，包含但不限於黑醋栗萃取物。 根據本發明之方法可將不同極性天然植物萃取物轉化為一勻相水溶液，運用不同分子量的聚乙二醇為載體，將植物萃取物之不同極性疏水性成分，轉化為一勻相水溶液，平均粒度約為250nm，粒徑小更有於利人體的吸收，且粒徑分布均勻，此方法能使疏水性植物萃取物具有良好的水溶性，有利於劑型及用途上的開發，增益疏水性植物萃取物開發應用於保健食品及醫藥品領域上，此技術具有便利性及劑型應用的創新性。 本發明再提供一種膠體組合物之製造方法，該膠體組合物包含至少一疏水性植物萃取物及一載體，該製造方法包含以上述分散方法分散該至少一疏水性植物萃取物於該載體中。 本發明又提供一種膠體組合物，包含上述載劑，及一疏水性植物萃取物。 本發明再提供一種膠體組合物，係以上述之製造方法所製得。 根據本發明之載劑係用於分散疏水性植物萃取物，雖不願為理論所限制，但咸信根據本發明之載劑可以包覆疏水性植物萃取物成分，使疏水性植物萃取物成分均勻分散於載劑中以形成膠體組合物，而不易沉澱。再者，若將上述膠體組合物加入於水或水溶液中，該載劑亦能維持疏水性植物萃取物的分散狀態，並形成膠體懸浮液。 上述膠體組合物於應用時，係能夠依據其載劑成分而以不同形態呈現。如上所述，包含PEG-8000及PEG-3350之載劑於常溫下，可能呈現固體溶液之型態，故包含此類載劑之膠體組合物亦可能呈現固體型態，而可以製作滴丸等，以方便使用者取用。另外，上述包含PEG-400之載劑則於常溫下可呈液態，故包含此類載劑之膠體組合物可以調製為膏狀。配合使用需求，上述膠體組合物亦可以進一步加水形成稀釋液態。 較佳地，該膠體組合物另包含前述之親水性植物萃取物。 以下之非限制性之實例有助於本發明所屬技術領域中具通常知識者實施本發明。該等實例不應視為過度地限制本發明。本發明所屬技術領域中具有通常知識者可在不背離本發明之精神或範疇的情況下對本文所討論之實施例進行修改及變化，而仍屬於本發明之範圍。 實例載體之製備：
取10g之PEG-8000及10g之PEG-3350，於60～80°C水浴中加熱並攪拌至完全融化，形成一勻相溶液，另秤取80g之PEG-400備用。疏水性植物萃取物及親水性植物萃取物：
分別取牛樟芝子實體、桑黃子實體及冬蟲夏草子實體等中草藥材鮮品，經粉碎冷凍乾燥後，分別以95%、70%及50%酒精進行萃取，將萃取所得之萃取物再度進行冷凍乾燥。 另取黑醋栗鮮品洗淨瀝乾後，以過濾水萃物後凍乾備用。 將前述經冷凍乾燥之牛樟芝萃取物、桑黃萃取物、冬蟲夏草萃取物及黑醋栗萃取物分別溶於純水中，其中僅有黑醋栗萃取物可完全溶於水，其他三種萃取物皆不易溶於水，因此牛樟芝萃取物、桑黃萃取物及冬蟲夏草萃取物屬於疏水性植物萃取物；黑醋栗萃取物屬於親水性植物萃取物。膠體組合物之製備：
於前述所製備之PEG-8000及PEG-3350勻相溶液中依序加入1g之牛樟芝萃取物、1g之桑黃萃取物及1g之冬蟲夏草萃取物，水浴加熱（溫度60°C至80°C）並攪拌至完全融化，以獲得一分散組合物。 而後，將上述分散組合物置於超音波震盪水浴箱中，於40°C至60°C之溫度下，加入前述秤取之PEG-400，並以均質機（轉速15,000 rpm/min至20,000 rpm/min）充分均質後，即獲得一第一膠體組合物。 進一步將1g之黑醋栗萃取物加入前述之膠體組合物，再度以均質機（轉速15,000 rpm/min至20,000 rpm/min）充分均質後，即獲得一同時包含疏水性植物萃取物及親水性植物萃取物之第二膠體組合物。膠體組合物之性質：
取100 ml純水置入玻璃瓶中，將該第一膠體組合物逐滴加入水中，輕輕攪拌快速即能呈現均勻透光之乳白色勻相水溶液，以雷射光束照射時，可觀察得雷射光束直線均勻通過，所投射穿透至白色背景亦呈現集中光點，代表疏水性植物萃取物與水均勻混合，顯示不同極性成分之疏水性植物萃取物已均勻分散於載劑中，進而可均勻分散於水中並形成膠體懸浮液。 另將該第一膠體組合物以水稀釋200倍（1 g/200 ml），再以光學顯微鏡（Leica DMR (200x)）觀察，結果如圖1所示，可見該膠體組合物均勻分散於水中。 另以粒徑分析儀(Zetasizer-ZS)進行三次分析及計算標準差、變異係數，結果顯示如表1及圖2。 表1：粒徑分析結果
粒徑分析儀之分析條件設定為溫度：25°C；折射指數：1.33；光析管類型：DTS0012（拋棄式粒徑分析光析管）；黏度：0.8872 cPs；掃描範圍：0～3000 nm。由上述粒徑分析結果可知，該膠體組合物可均勻分散於水中，並形成平均粒徑約 250 nm之粒子。 上述實施例僅為說明本發明之原理及其功效，而非限制本發明。本發明所屬技術領域中具通常知識者對上述實施例所做之修改及變化仍不違背本發明之精神。本發明之權利範圍應如後述之申請專利範圍所列。The invention provides a carrier comprising polyethylene glycol having an average molecular weight of about 8000 and polyethylene glycol having an average molecular weight of about 3350, wherein the polyethylene glycol having an average molecular weight of about 8000 and the average molecular weight is about 3350 The weight ratio of polyethylene glycol is from about 1: 1 to about 1: 5. Ranges are often expressed herein as "about" one particular value and / or to "about" another particular value. When such a range is expressed, it is in a range including one specific value and / or to another specific value. Similarly, when values are expressed as approximations by using the word "about," it should be understood that a particular value can form another aspect. In addition, it should be understood that each endpoint of each range is significant, and one endpoint is related to the other endpoint and independent of each other. As used herein, the term "vehicle", also known as "excipient", means that it is not itself a therapeutic agent, but rather is used as a carrier and / or diluent and / or for delivering a therapeutic agent to an individual. An adjuvant or vehicle, or substance added to the formulation to improve the handling or storage properties of the formulation or to allow or assist the dosage unit of the composition to form a dosage unit suitable for administration. The carrier should not disrupt the pharmacological activity of the therapeutic agent and should be non-toxic when administered in a dose sufficient to deliver a therapeutic amount of the agent. The carrier according to the present invention comprises polyethylene glycol, specifically polyethylene glycol having an average molecular weight of about 8000 (referred to as PEG-8000) and polyethylene glycol having an average molecular weight of about 3350 (referred to as PEG-3350). For example, the molecular weight of PEG-8000 can be from about 7000 g / mol to about 9000 g / mol; and the molecular weight of PEG-3350 can be from about 3000 g / mol to about 3700 g / mol. In addition, the molecular weight of polyethylene glycol can be measured by mass spectrometry, or its molecular weight can be reversed by measuring its viscosity. According to the carrier of the present invention, the weight ratio of PEG-8000 to PEG-3350 is about 1: 1 to about 1: 5; preferably about 1: 2 to about 1: 3; more preferably about 1: 2.5. Through the use of a specific molecular weight and a specific weight ratio of polyethylene glycol, the carrier of the present invention can be applied to disperse a variety of hydrophobic plant extracts with different plant species and different degrees of hydrophobicity, and can also use a variety of hydrophobic plant extracts. Co-dispersed in a single vehicle. In a preferred embodiment of the present invention, the carrier further comprises polyethylene glycol (PEG-400) with an average molecular weight of about 400. For example, the molecular weight of PEG-400 may be from about 380 g / mol to about 420 g / mol. The weight ratio of the total amount of PEG-8000 and PEG-3350 to the amount of PEG-400 is preferably about 1: 1 to about 1:10; more preferably about 1: 3 to about 1: 6; particularly preferably About 1: 4 . According to the present invention, the mixing order and method of polyethylene glycols having different average molecular weights are not limited. In a specific embodiment of the present invention, the mixing among solid polyethylene glycols including flakes or powders may be performed. After mixing in the solid state, heating to obtain a homogeneous liquid state; in another specific embodiment of the present invention, each solid polyethylene glycol is first heated and then mixed to obtain a homogeneous liquid state; in the present invention, In another specific embodiment, the solid polyethylene glycol is added with polyethylene glycol in a liquid state, and then heated and mixed to obtain a homogeneous liquid state. On the other hand, for polyethylene glycol which is liquid at normal temperature and pressure, it can also be mixed with solid polyethylene glycol according to the aforementioned scheme. In a preferred embodiment of the present invention, the carrier according to the present invention first heats PEG-8000 and PEG-3350 to melt and then uniformly mix to form a homogeneous solution. For example, put the weighed PEG-8000 and PEG-3350 solids in a container and heat them in a water bath until they begin to melt, and then stir and mix. The above-mentioned carrier containing PEG-8000 and PEG-3350 may be in the form of a solid solution at normal temperature, and can be dissolved by heating before use. In another preferred embodiment of the present invention, first heat and melt and mix PEG-8000 and PEG-3350 according to the weight ratio, then add PEG-400 and mix uniformly. In this way, the carrier is a viscous liquid solution at normal temperature, so it is more convenient to use. In another preferred embodiment of the present invention, other diluents are added to the carrier to adjust the viscosity, concentration, and volume according to the needs of use. Other diluents suitable for the present invention include, but are not limited to, water and alcohol, etc. . Preferably, the carrier according to the present invention is a homogeneous solution, that is, polyethylene glycols having different average molecular weights can be uniformly mixed and mutually soluble. The present invention further provides the use of the aforementioned carrier for dispersing a hydrophobic plant extract. The present invention further provides a method for dispersing a hydrophobic plant extract by dispersing at least one hydrophobic plant extract in the carrier. In the present invention, the "plant" is not limited to its kind. For example, it can be trees, shrubs, vines, grasses, ferns, green algae, etc., and can be Chinese medicine, herbal medicine or non-medical plants. Furthermore, the "plant" described in the present invention can also include algae and fungi Class, etc. A plant according to the present invention may mean a whole plant or any part of a plant. In one embodiment of the present invention, the plant includes Ganoderma lucidum, Antrodia cinnamomea, mulberry, Poria, Cordyceps, and the like, and may include a part or the whole thereof, for example, only its fruiting bodies. The plant extract according to the present invention extracts plants to obtain an extract. For example, plants can be dried, processed, then broken into small pieces or pulverized, and then extracted with a fluid (such as a liquid or supercritical fluid) to dissolve the components contained in the plant in the extracted fluid, and Obtain plant extracts or, if necessary, dry. Because various plants contain different effective components, the components contained in plant extracts can be adjusted by selecting different extraction fluids and ratios. In the present invention, the "hydrophobicity" refers to a property that is mutually exclusive with water, that is, a property that is hardly soluble in water, and the "hydrophobicity" refers to the degree of hydrophobicity. The higher the hydrophobicity of a substance, the more difficult it is to dissolve in water; on the contrary, the lower the hydrophobicity of a substance, the easier it is to dissolve in water. Therefore, the "hydrophobic plant extract" in the present invention refers to a plant extract having hydrophobicity, which is a hydrophobic component contained in the plant extract, such as, but not limited to, low polarity, insoluble or hardly soluble Ingredients in water. That is, the hydrophobic plant extract defines the property that such ingredients are poorly soluble in water, rather than limiting the manner in which they are obtained. The hydrophobic plant extract may be obtained by extracting plants through an organic solution. Preferably, the hydrophobic plant extract according to the present invention is an alcohol extract, that is, an extract obtained by using alcohol to extract plants. The term "alcohol" as used herein refers to a straight or branched chain, substituted or unsubstituted, unit or poly, saturated or unsaturated alcohol, and preferably an unsubstituted, unit and saturated alcohol. On the other hand, the alcohol is preferably an alcohol having 1 to 7 carbon numbers, and more preferably an alcohol having 1 to 4 carbon numbers. In a preferred embodiment of the present invention, the alcohol having a carbon number of 1 to 7 is methanol, ethanol, n-propanol, isopropanol, n-butanol, and isobutanol. (iso-butanol), sec-butanol, tert-butanol, 1-pentanol, 2-pentanol, 3-pentanol, 2-methyl-1-butanol, 2 -Methyl-2-butanol, 3-methyl-2-butanol, 3-methyl-1-butanol, 2,2-dimethyl-1-propanol, 1-hexanol, 2,4 -Hexadiene-1-ol, 2-methyl-cyclopentanol, cyclohexanol, 1-heptanol, 2-heptanol or cycloheptanol; particularly preferably, the alcohol is methanol or ethanol; best The alcohol is ethanol. This alcohol can be used individually or in mixture of multiple types. The alcohol mentioned herein is preferably an aqueous solution, and its concentration is preferably from about 20% to about 99.9% of an alcohol solution; more preferably from about 30% to about 99.9% of an alcohol solution; particularly preferably from about 40%. % To about 98.0% alcohol solution. The "hydrophobic plant extract" in the present invention includes, but is not limited to, extracts of Ganoderma lucidum, Antrodia cinnamomea, mulberry, Poria, and Cordyceps sinensis. For example, the Ganoderma lucidum extract preferably contains triterpenoids chemical components separated from the red fruit body and spores. The triterpenoids include, but are not limited to, ganoderic acid R. For example, Antrodia cinnamomea extract preferably contains triterpenes, which are hydrophobic, and can be extracted with a higher concentration of an aqueous alcohol solution (eg, a 90% to 95% by volume aqueous alcohol solution). For example, the mulberry extract contains crude mulberry ethanol (PLEE), which can be extracted with about 70% by volume of an aqueous alcohol solution. For example, the Poria extract contains triterpenoids, Poriatin, Pachymic acid, Tulumosic acid, polyporenic acid C, and Ebricoic acid ), Poricic acid, etc .; it can be extracted with about 90-95% by volume of alcohol in water. For example, Cordyceps sinensis extract contains cordycepin and linear glycosides, which can be extracted with an alcoholic water solution with a volume percentage of about 50%. The method for dispersing a hydrophobic plant extract according to the present invention may disperse only a single hydrophobic plant extract in a carrier; or, a plurality of hydrophobic plant extracts having different degrees of hydrophobicity may be dispersed together in a carrier. In a specific embodiment of the present invention, the at least one hydrophobic plant extract to be dispersed includes a first hydrophobic plant extract and a second hydrophobic plant extract. The degree of hydrophobicity is higher than the degree of hydrophobicity of the second hydrophobic plant extract. The method includes co-dispersing the first hydrophobic plant extract and the second hydrophobic plant extract in the vehicle. In a specific embodiment of the present invention, when the dispersion method is used to disperse several kinds of hydrophobic plant extracts with different hydrophobicity, it is preferable to first arrange the several plant extracts according to the degree of hydrophobicity, and first arrange the degree of hydrophobicity. The highest one (the least soluble in water) is dispersed in the carrier, and then the one with the lower hydrophobicity is added and dispersed, and then the plant extract with the lowest hydrophobicity is added. Specifically, in an embodiment of the present invention, a first hydrophobic plant extract and a second hydrophobic plant extract are dispersed with the aforementioned carrier, wherein the first hydrophobic plant extract has a higher hydrophobicity than For the degree of hydrophobicity of the second hydrophobic plant extract, first disperse the first hydrophobic plant extract in the vehicle, and then continue to disperse the second hydrophobic plant extract in the vehicle. In a specific embodiment of the present invention, the method for dispersing a hydrophobic plant extract includes the following steps: (a) dispersing the at least one hydrophobic plant extract in the polyethylene glycol having an average molecular weight of about 8000 and the The polyethylene glycol having an average molecular weight of about 3350 to form a dispersion composition; and (b) dispersing the dispersion composition in the polyethylene glycol having an average molecular weight of about 400. In this embodiment, when the carrier contains PEG-8000, PEG-3350, and PEG-400, PEG-8000 and PEG-3350 are first used to form a homogeneous solution, such as heating PEG-8000 and PEG-3350. Until completely melted, the hydrophobic plant extract is added to form the dispersion composition, and the dispersion composition is then dispersed in PEG-400. In order to improve the dispersion effect, according to the method for dispersing a hydrophobic plant extract of the present invention, it is preferred that the at least one hydrophobic plant extract is dispersed in the carrier under heating. The heating temperature is preferably one that can completely melt the carrier and avoid deterioration of the active ingredients contained in the hydrophobic plant extract, for example, heating at a temperature of about 60 ° C to about 80 ° C. There are no restrictions, such as using a water bath, an oil bath, and the like. In order to improve the dispersion effect, the method for dispersing a hydrophobic plant extract according to the present invention further comprises homogenizing the extract, the carrier and the at least one hydrophobic plant extract. This homogenization step can be implemented independently, or simultaneously with the dispersing step, or combined with the dispersing and heating steps. Homogenization methods include, but are not limited to, stirring or ultrasonic vibration. For example, you can use an ultrasonic oscillator or a homogenizer (such as 15,000 rpm / min to 20,000 rpm / min) to homogenize the hydrophobic plant extract and the carrier, so that the carrier can evenly coat the hydrophobic plant extract. To form smaller particles for subsequent use. The ratio of the carrier to the hydrophobic plant extract according to the present invention is such that the carrier can coat the hydrophobic plant extract and the overall colloid composition can still have the desired effect. In one embodiment of the present invention, Wherein the weight ratio of the at least one hydrophobic plant extract and the carrier is about 1:10 to about 1:50. If the proportion of the carrier is too low, the hydrophobic plant extract may not be completely dispersed. On the other hand, if the proportion of the carrier is too high, it means that the active ingredient is greatly diluted, and the resulting colloidal composition has a large volume and is inconvenient to use. In order to expand the application of hydrophobic plant extracts, the carrier according to the present invention can simultaneously reconcile hydrophobic plant extracts and hydrophilic plant extracts in the same colloidal composition. In a preferred embodiment of the present invention, the The method of dispersing the hydrophobic plant extract further comprises dispersing the hydrophilic plant extract in the vehicle. The hydrophilic plant extract refers to a plant extract component that is soluble in water, including but not limited to a black currant extract. According to the method of the present invention, natural plant extracts of different polarities can be converted into a homogeneous aqueous solution. Polyethylene glycol of different molecular weight is used as a carrier to convert different polar hydrophobic components of the plant extract into a homogeneous aqueous solution. The particle size is about 250nm, and the small particle size is more conducive to absorption by the human body, and the particle size distribution is uniform. This method can make the hydrophobic plant extracts have good water solubility, which is conducive to the development of dosage forms and uses, and to enhance the hydrophobic plants. The extract is developed and applied in the field of health food and pharmaceuticals. This technology is convenient and innovative in the application of dosage forms. The present invention further provides a colloidal composition manufacturing method. The colloidal composition includes at least one hydrophobic plant extract and a carrier. The manufacturing method includes dispersing the at least one hydrophobic plant extract in the carrier by the above-mentioned dispersion method. The present invention also provides a colloidal composition comprising the aforementioned carrier and a hydrophobic plant extract. The present invention further provides a colloidal composition prepared by the above-mentioned manufacturing method. The carrier according to the present invention is used to disperse hydrophobic plant extracts. Although it is not intended to be limited by theory, it is believed that the carrier according to the present invention can coat the hydrophobic plant extract components to make the hydrophobic plant extract components. It is uniformly dispersed in a carrier to form a colloidal composition without being easily precipitated. Furthermore, if the colloidal composition is added to water or an aqueous solution, the carrier can also maintain the dispersed state of the hydrophobic plant extract and form a colloidal suspension. When the above-mentioned colloidal composition is applied, it can be presented in different forms according to its carrier component. As mentioned above, the carrier containing PEG-8000 and PEG-3350 may show the form of a solid solution at normal temperature, so the colloidal composition containing such a carrier may also show the form of a solid, and it is possible to make drip pills, etc. To facilitate user access. In addition, the above-mentioned carrier containing PEG-400 can be in a liquid state at normal temperature, so the colloidal composition containing such a carrier can be prepared into a paste. In accordance with the use requirements, the above-mentioned colloidal composition can be further added with water to form a diluted liquid. Preferably, the colloidal composition further comprises the aforementioned hydrophilic plant extract. The following non-limiting examples are helpful to those having ordinary knowledge in the technical field to which the present invention pertains. These examples should not be seen as unduly limiting the invention. Those with ordinary knowledge in the technical field to which the present invention pertains can make modifications and changes to the embodiments discussed herein without departing from the spirit or scope of the present invention, and still fall within the scope of the present invention. Example carrier preparation: Take 10g of PEG-8000 and 10g of PEG-3350, heat and stir in a 60-80 ° C water bath to completely melt to form a homogeneous solution, and weigh 80g of PEG-400 for later use. Hydrophobic plant extracts and hydrophilic plant extracts: Fresh Chinese herbal medicines such as Antrodia sylvestris fruit bodies, mulberry fruit bodies and Cordyceps sinensis fruit bodies are crushed and freeze-dried, respectively, with 95%, 70% and 50% alcohol. After extraction, the extract obtained by the extraction is freeze-dried again. Another fresh blackcurrant product was washed, drained, filtered, and then lyophilized for later use. The freeze-dried Antrodia cinnamomea extract, mulberry extract, Cordyceps sinensis extract and black currant extract were separately dissolved in pure water, of which only the black currant extract was completely soluble in water, the other three extracts were all Not easily soluble in water, so Antrodia cinnamomea extract, mulberry extract and Cordyceps extract are hydrophobic plant extracts; black currant extract is a hydrophilic plant extract. Preparation of colloidal composition: 1 g of Antrodia cinnamomea extract, 1 g of mulberry yellow extract and 1 g of Cordyceps sinensis were added to the PEG-8000 and PEG-3350 homogeneous solution prepared above, and heated in a water bath (temperature 60 ° C to 80 ° C) and stirred until completely melted to obtain a dispersed composition. Then, the dispersion composition is placed in an ultrasonic oscillating water bath, and the PEG-400 weighed out is added at a temperature of 40 ° C to 60 ° C, and the homogenizer (speed of 15,000 rpm / min to 20,000 rpm / min) After fully homogenizing, a first colloidal composition is obtained. 1g of blackcurrant extract was further added to the aforementioned colloidal composition, and after homogenizing with a homogenizer (rotation speed 15,000 rpm / min to 20,000 rpm / min), the mixture containing both hydrophobic plant extracts and hydrophilic plants was obtained. The second colloidal composition of the extract. Properties of the colloidal composition: Put 100 ml of pure water into a glass bottle, add the first colloidal composition dropwise to the water, stir gently and quickly to show a milky white homogeneous aqueous solution that is uniform and transparent, and irradiate with a laser beam It can be observed that the laser beam passes straight in a straight line, and the projected light penetrates to a white background and presents a concentrated light spot, representing that the hydrophobic plant extract is evenly mixed with water, showing that the hydrophobic plant extracts of different polar components have been uniformly dispersed in In the carrier, it can be further uniformly dispersed in water to form a colloidal suspension. In addition, the first colloidal composition was diluted 200 times with water (1 g / 200 ml), and then observed with an optical microscope (Leica DMR (200x)). As shown in FIG. 1, the colloidal composition was uniformly dispersed in water. . In addition, a particle size analyzer (Zetasizer-ZS) was used to perform three analyses and calculate the standard deviation and coefficient of variation. The results are shown in Table 1 and Figure 2. Table 1: Results of particle size analysis The analysis conditions of the particle size analyzer are set to temperature: 25 ° C; refractive index: 1.33; photoanalysis tube type: DTS0012 (disposable particle size analysis photoanalysis tube); viscosity: 0.8872 cPs; scanning range: 0 to 3000 nm. From the above particle size analysis results, it can be seen that the colloidal composition can be uniformly dispersed in water and form particles having an average particle diameter of about 250 nm. The above embodiments are only for explaining the principle of the present invention and its effects, but not for limiting the present invention. Modifications and changes made by those with ordinary knowledge in the technical field to which the present invention pertains to the above embodiments still do not violate the spirit of the present invention. The scope of rights of the present invention should be listed in the scope of patent application described later.