[go: up one dir, main page]

TWI647309B - 重組多肽之製造方法 - Google Patents

重組多肽之製造方法 Download PDF

Info

Publication number
TWI647309B
TWI647309B TW101111417A TW101111417A TWI647309B TW I647309 B TWI647309 B TW I647309B TW 101111417 A TW101111417 A TW 101111417A TW 101111417 A TW101111417 A TW 101111417A TW I647309 B TWI647309 B TW I647309B
Authority
TW
Taiwan
Prior art keywords
sequence
cells
apes
dna
nfkbia
Prior art date
Application number
TW101111417A
Other languages
English (en)
Chinese (zh)
Other versions
TW201303019A (zh
Inventor
Hisahiro Tabuchi
田淵久大
Tomoya Sugiyama
杉山朋也
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
中外製藥股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha, 中外製藥股份有限公司 filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of TW201303019A publication Critical patent/TW201303019A/zh
Application granted granted Critical
Publication of TWI647309B publication Critical patent/TWI647309B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303Liver or Pancreas
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW101111417A 2011-04-01 2012-03-30 重組多肽之製造方法 TWI647309B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-082002 2011-04-01
JP2011082002 2011-04-01

Publications (2)

Publication Number Publication Date
TW201303019A TW201303019A (zh) 2013-01-16
TWI647309B true TWI647309B (zh) 2019-01-11

Family

ID=46969084

Family Applications (2)

Application Number Title Priority Date Filing Date
TW101111417A TWI647309B (zh) 2011-04-01 2012-03-30 重組多肽之製造方法
TW106106519A TWI674272B (zh) 2011-04-01 2012-03-30 具有apes活性的核酸分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW106106519A TWI674272B (zh) 2011-04-01 2012-03-30 具有apes活性的核酸分子

Country Status (15)

Country Link
US (2) US11028149B2 (es)
EP (1) EP2695947B1 (es)
JP (3) JP6182066B2 (es)
KR (1) KR101958033B1 (es)
CN (3) CN106995831A (es)
AU (2) AU2012239382B2 (es)
BR (1) BR112013024781B1 (es)
CA (1) CA2830013C (es)
DK (1) DK2695947T3 (es)
ES (1) ES2620306T3 (es)
MX (1) MX352229B (es)
RU (1) RU2628310C2 (es)
SG (1) SG194014A1 (es)
TW (2) TWI647309B (es)
WO (1) WO2012137683A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2309508T3 (es) * 2003-03-11 2008-12-16 Laboratoires Serono Sa Vectores de expresion que comprenden el promotor de mcmv-ie2.
CN112522353A (zh) * 2012-10-10 2021-03-19 中外制药株式会社 经修饰的宿主细胞的建立方法
US9647919B1 (en) * 2014-12-04 2017-05-09 Amazon Technologies Automated determination of maximum service throughput
CN107287178B (zh) * 2016-04-12 2019-10-29 中国科学院微生物研究所 Csad蛋白及其编码基因在抗流感病毒中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1270044A2 (en) * 2001-06-18 2003-01-02 Pfizer Limited Wound healing biomarkers

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9222931D0 (en) 1992-11-02 1992-12-16 Sandoz Ltd Organic compounds
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
WO2002031114A2 (en) 2000-10-11 2002-04-18 Digital Gene Technologies, Inc. Gene expression modulated in ileitis
EP1784501B1 (en) * 2004-05-14 2015-11-18 Rosetta Genomics Ltd VIRAL AND VIRUS ASSOCIATED MicroRNAS AND USES THEREOF
CA2544692C (en) 2004-07-09 2014-04-01 Chugai Seiyaku Kabushiki Kaisha Anti-glypican 3 antibody
ES2931949T3 (es) * 2005-03-29 2023-01-05 Univ Pennsylvania Minoxidilo para generar nuevos folículos pilosos y tratar la calvicie
WO2007119774A1 (ja) * 2006-04-13 2007-10-25 Chugai Seiyaku Kabushiki Kaisha タウリントランスポーター遺伝子
HRP20120175T1 (hr) 2006-06-02 2012-03-31 Regeneron Pharmaceuticals Antitijela s visokim afinitetom za humani il-6 receptor
US20100233759A1 (en) 2007-03-15 2010-09-16 Chugai Seiyaku Kabushiki Kaisha Method for production of polypeptide
US8062864B2 (en) * 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
EP2186905B1 (en) * 2007-08-07 2016-07-13 Chugai Seiyaku Kabushiki Kaisha Method of producing heterogeneous protein
WO2009051109A1 (ja) * 2007-10-15 2009-04-23 Chugai Seiyaku Kabushiki Kaisha 異種タンパク質を高生産する細胞の作製方法
JP5337044B2 (ja) * 2007-10-24 2013-11-06 中外製薬株式会社 異種タンパク質製造のための細胞及びそれを用いた製造方法
WO2009094084A1 (en) * 2007-12-21 2009-07-30 Danisco Us Inc., Genencor Division Enhanced protein production in bacillus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1270044A2 (en) * 2001-06-18 2003-01-02 Pfizer Limited Wound healing biomarkers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Lan, YQ et al., "Suppression of IκBα increases the expression of matrix metalloproteinase-2 in human ciliary muscle cells", Molecular Vision, 15:1977-1987, 2009/09/26 *
Lei, X et al., "Regulation of NF-κB inhibitor IκBα and viral replication by a KSHV microRNA", Nat Cell Biol., 12(2): 193–199, 2010/02 *

Also Published As

Publication number Publication date
JP6444968B2 (ja) 2018-12-26
BR112013024781A2 (pt) 2018-06-05
US20210246193A1 (en) 2021-08-12
CN103459608B (zh) 2018-05-01
CA2830013A1 (en) 2012-10-11
KR20140015506A (ko) 2014-02-06
ES2620306T3 (es) 2017-06-28
US11905325B2 (en) 2024-02-20
TW201726729A (zh) 2017-08-01
CN108546295A (zh) 2018-09-18
CN108546295B (zh) 2022-08-09
RU2013148804A (ru) 2015-05-10
JP6626160B2 (ja) 2019-12-25
AU2016201744A1 (en) 2016-04-07
AU2016201744B2 (en) 2017-09-28
WO2012137683A1 (ja) 2012-10-11
DK2695947T3 (en) 2017-05-08
TWI674272B (zh) 2019-10-11
TW201303019A (zh) 2013-01-16
BR112013024781B1 (pt) 2021-09-08
US20140030758A1 (en) 2014-01-30
MX2013011355A (es) 2013-12-16
EP2695947A4 (en) 2014-10-29
US11028149B2 (en) 2021-06-08
KR101958033B1 (ko) 2019-03-13
EP2695947A1 (en) 2014-02-12
AU2012239382B2 (en) 2016-04-21
AU2012239382A1 (en) 2013-10-17
RU2628310C2 (ru) 2017-08-15
SG194014A1 (en) 2013-11-29
CA2830013C (en) 2020-01-07
EP2695947B1 (en) 2017-03-01
JP2018161146A (ja) 2018-10-18
JPWO2012137683A1 (ja) 2014-07-28
JP6182066B2 (ja) 2017-08-16
CN106995831A (zh) 2017-08-01
CN103459608A (zh) 2013-12-18
MX352229B (es) 2017-11-15
JP2017074065A (ja) 2017-04-20

Similar Documents

Publication Publication Date Title
US11905325B2 (en) Recombinant polypeptide production method
JP6680848B2 (ja) 改変宿主細胞の樹立方法
HK1257919B (en) Recombinant polypeptide production method
HK1257919A1 (en) Recombinant polypeptide production method
HK1187958A (en) Recombinant polypeptide production method
HK1187958B (en) Recombinant polypeptide production method
HK1240979A1 (en) Recombinant polypeptide production method

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees