TWI553013B - 作為Ｖ１ａ拮抗劑之氧基－環己基－４Ｈ，６Ｈ－５－氧雜－２，３，１０ｂ－三氮雜－苯并［ｅ］薁 - Google Patents

作為Ｖ１ａ拮抗劑之氧基－環己基－４Ｈ，６Ｈ－５－氧雜－２，３，１０ｂ－三氮雜－苯并［ｅ］薁 Download PDF

Info

Publication number: TWI553013B
Authority: TW; Taiwan
Prior art keywords: formula; compound; alkyl; alkoxy; group
Prior art date: 2011-09-26

Application number

TW101135168A

Other languages

English (en)

Chinese (zh)

Other versions

TW201315737A (zh

Inventor

可西摩多藍提

派屈克史耐德

Original Assignee

赫孚孟拉羅股份公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-26

Filing date

2012-09-25

Publication date

2016-10-11

2012-09-25 Application filed by 赫孚孟拉羅股份公司 filed Critical 赫孚孟拉羅股份公司

2013-04-16 Publication of TW201315737A publication Critical patent/TW201315737A/zh

2016-10-11 Application granted granted Critical

2016-10-11 Publication of TWI553013B publication Critical patent/TWI553013B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

TW101135168A 2011-09-26 2012-09-25 作為Ｖ１ａ拮抗劑之氧基－環己基－４Ｈ，６Ｈ－５－氧雜－２，３，１０ｂ－三氮雜－苯并［ｅ］薁 TWI553013B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP11182796		2011-09-26

Publications (2)

Publication Number	Publication Date
TW201315737A TW201315737A (zh)	2013-04-16
TWI553013B true TWI553013B (zh)	2016-10-11

Family

ID=46881068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW101135168A TWI553013B (zh)	2011-09-26	2012-09-25	作為Ｖ１ａ拮抗劑之氧基－環己基－４Ｈ，６Ｈ－５－氧雜－２，３，１０ｂ－三氮雜－苯并［ｅ］薁

Country Status (23)

Country	Link
US (1)	US8828989B2 (fr)
EP (1)	EP2760871B1 (fr)
JP (1)	JP5909554B2 (fr)
KR (1)	KR101682777B1 (fr)
CN (1)	CN103827121B (fr)
AR (1)	AR087999A1 (fr)
AU (1)	AU2012314593B2 (fr)
BR (1)	BR112014006945A2 (fr)
CA (1)	CA2844581A1 (fr)
CL (1)	CL2014000717A1 (fr)
CO (1)	CO6870036A2 (fr)
CR (1)	CR20140092A (fr)
EA (1)	EA024990B1 (fr)
EC (1)	ECSP14013271A (fr)
IN (1)	IN2014CN02169A (fr)
MA (1)	MA35535B1 (fr)
MX (1)	MX2014003643A (fr)
PE (1)	PE20141397A1 (fr)
PH (1)	PH12014500582A1 (fr)
SG (1)	SG2014010607A (fr)
TW (1)	TWI553013B (fr)
UA (1)	UA111623C2 (fr)
WO (1)	WO2013045373A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP4185570B1 (fr) *	2020-07-23	2024-10-09	F. Hoffmann-La Roche AG	Triazoles substitués par cyclohexyle utilisés en tant qu'antagonistes du récepteur v1 de la vasopressine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070167430A1 (en) *	2004-01-13	2007-07-19	Thomas Ryckmans	Compounds useful in therapy
TW201024300A (en) *	2008-11-28	2010-07-01	Hoffmann La Roche	Arylcyclohexylethers of dihydrotetraazabenzoazulenes
TW201031666A (en) *	2008-11-18	2010-09-01	Hoffmann La Roche	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1147115E (pt)	1999-01-19	2004-02-27	Ortho Mcneil Pharm Inc	Benzodiazepinas triciclicas como antagonistas do receptor da vasopressina
US6765004B1 (en)	1999-06-17	2004-07-20	Ortho-Mcneil Pharmaceutical, Inc.	Indoloazepines as vasopressin receptor antagonists
US7119088B2 (en)	2003-02-19	2006-10-10	Pfizer Inc.	Triazole compounds useful in therapy
GB0303852D0 (en) *	2003-02-19	2003-03-26	Pfizer Ltd	Triazole compounds useful in therapy
MX2007002248A (es) *	2004-08-25	2008-10-02	Pfizer	Triazolobenzodiazepinas y su uso como antagonistas de vasopresina.

2012
- 2012-08-23 US US13/592,493 patent/US8828989B2/en active Active
- 2012-09-24 KR KR1020147010783A patent/KR101682777B1/ko not_active Expired - Fee Related
- 2012-09-24 MX MX2014003643A patent/MX2014003643A/es unknown
- 2012-09-24 BR BR112014006945A patent/BR112014006945A2/pt not_active IP Right Cessation
- 2012-09-24 CA CA2844581A patent/CA2844581A1/fr not_active Abandoned
- 2012-09-24 CN CN201280046689.0A patent/CN103827121B/zh not_active Expired - Fee Related
- 2012-09-24 JP JP2014532331A patent/JP5909554B2/ja not_active Expired - Fee Related
- 2012-09-24 UA UAA201403611A patent/UA111623C2/uk unknown
- 2012-09-24 EA EA201490558A patent/EA024990B1/ru not_active IP Right Cessation
- 2012-09-24 WO PCT/EP2012/068721 patent/WO2013045373A1/fr not_active Ceased
- 2012-09-24 IN IN2169CHN2014 patent/IN2014CN02169A/en unknown
- 2012-09-24 AU AU2012314593A patent/AU2012314593B2/en not_active Ceased
- 2012-09-24 PE PE2014000394A patent/PE20141397A1/es not_active Application Discontinuation
- 2012-09-24 SG SG2014010607A patent/SG2014010607A/en unknown
- 2012-09-24 PH PH1/2014/500582A patent/PH12014500582A1/en unknown
- 2012-09-24 EP EP12761740.5A patent/EP2760871B1/fr active Active
- 2012-09-25 TW TW101135168A patent/TWI553013B/zh not_active IP Right Cessation
- 2012-09-25 AR ARP120103514A patent/AR087999A1/es unknown
2014
- 2014-01-31 CO CO14020668A patent/CO6870036A2/es not_active Application Discontinuation
- 2014-02-26 CR CR20140092A patent/CR20140092A/es unknown
- 2014-03-24 CL CL2014000717A patent/CL2014000717A1/es unknown
- 2014-03-26 EC ECSP14013271 patent/ECSP14013271A/es unknown
- 2014-04-15 MA MA36919A patent/MA35535B1/fr unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20070167430A1 (en) *	2004-01-13	2007-07-19	Thomas Ryckmans	Compounds useful in therapy
TW201031666A (en) *	2008-11-18	2010-09-01	Hoffmann La Roche	Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
TW201024300A (en) *	2008-11-28	2010-07-01	Hoffmann La Roche	Arylcyclohexylethers of dihydrotetraazabenzoazulenes

Also Published As

Publication number	Publication date
EA201490558A1 (ru)	2014-06-30
CL2014000717A1 (es)	2014-10-03
CR20140092A (es)	2014-03-20
EA024990B1 (ru)	2016-11-30
IN2014CN02169A (fr)	2015-05-29
AR087999A1 (es)	2014-04-30
ECSP14013271A (es)	2014-05-31
MA35535B1 (fr)	2014-10-02
CA2844581A1 (fr)	2013-04-04
CN103827121A (zh)	2014-05-28
AU2012314593B2 (en)	2016-09-29
TW201315737A (zh)	2013-04-16
US20130079333A1 (en)	2013-03-28
WO2013045373A1 (fr)	2013-04-04
JP5909554B2 (ja)	2016-04-26
KR101682777B1 (ko)	2016-12-05
AU2012314593A1 (en)	2014-02-20
EP2760871A1 (fr)	2014-08-06
MX2014003643A (es)	2014-04-30
CO6870036A2 (es)	2014-02-20
AU2012314593A8 (en)	2014-03-27
UA111623C2 (uk)	2016-05-25
KR20140079790A (ko)	2014-06-27
EP2760871B1 (fr)	2018-07-18
US8828989B2 (en)	2014-09-09
PH12014500582A1 (en)	2014-04-28
PE20141397A1 (es)	2014-10-13
CN103827121B (zh)	2016-08-03
SG2014010607A (en)	2014-05-29
NZ620653A (en)	2016-03-31
JP2014527993A (ja)	2014-10-23
BR112014006945A2 (pt)	2017-04-04

Publication	Publication Date	Title
TWI409264B (zh)	2013-09-21	芳基－環己基－四氮雜苯并［ｅ］薁
JP5384659B2 (ja)	2014-01-08	ジヒドロテトラアザベンゾアズレンのアルキルシクロヘキシルエーテル
JP5579923B2 (ja)	2014-08-27	バソプレシンＶ１ａ受容体アンタゴニストとしてのヘテロアリール−シクロヘキシル−テトラアザベンゾ［ｅ］アズレン
JP5452608B2 (ja)	2014-03-26	バソプレシン介在受容体アンタゴニストとしての使用のためのジヒドロテトラアザベンゾアズレンのアリールシクロヘキシルエーテル
KR101468285B1 (ko)	2014-12-03	바소프레신 길항제로서의 아릴-/헤테로아릴-사이클로헥센일-테트라아자벤조〔ｅ〕아줄렌
TWI419891B (zh)	2013-12-21	雜雙芳基-環己基-四氮雜苯并［ｅ］薁
US9346824B2 (en)	2016-05-24	Cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[e]azulenes as V1a antagonists
TWI553013B (zh)	2016-10-11	作為Ｖ１ａ拮抗劑之氧基－環己基－４Ｈ，６Ｈ－５－氧雜－２，３，１０ｂ－三氮雜－苯并［ｅ］薁
HK1193602A (en)	2014-09-26	Oxy-cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists
HK1193602B (en)	2017-10-20	Oxy-cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists
NZ620653B2 (en)	2016-07-01	Oxy-cyclohexyl-4h,6h-5-oxa-2,3,10b-triaza-benzo[e]azulenes as v1a antagonists

Legal Events

Date	Code	Title	Description
2018-07-11	MM4A	Annulment or lapse of patent due to non-payment of fees