TWI347317B - Process for preparing 8-substituted oxy-5-(r)-2-halo-1-hydroxy-ethyl)-(1h)-quinolin-2-ones or acceptable solvates thereof and use of the product obtained therefrom - Google Patents

Process for preparing 8-substituted oxy-5-(r)-2-halo-1-hydroxy-ethyl)-(1h)-quinolin-2-ones or acceptable solvates thereof and use of the product obtained therefrom

Info

Publication number: TWI347317B
Authority: TW; Taiwan
Prior art keywords: quinolin; halo; hydroxy; ones; ethyl
Prior art date: 2004-06-22

Application number

TW094120524A

Other languages

English (en)

Other versions

TW200615265A (en

Inventor

Olivier Lohse

Caspar Vogel

Gerhard Penn

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-22

Filing date

2005-06-21

Publication date

2011-08-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32799952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI347317(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-06-21 Application filed by Novartis Ag filed Critical Novartis Ag

2006-05-16 Publication of TW200615265A publication Critical patent/TW200615265A/zh

2011-08-21 Application granted granted Critical

2011-08-21 Publication of TWI347317B publication Critical patent/TWI347317B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/04—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D251/06—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pulmonology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

TW094120524A 2004-06-22 2005-06-21 Process for preparing 8-substituted oxy-5-(r)-2-halo-1-hydroxy-ethyl)-(1h)-quinolin-2-ones or acceptable solvates thereof and use of the product obtained therefrom TWI347317B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0413960.6A GB0413960D0 (en)	2004-06-22	2004-06-22	Organic compounds

Publications (2)

Publication Number	Publication Date
TW200615265A TW200615265A (en)	2006-05-16
TWI347317B true TWI347317B (en)	2011-08-21

Family

ID=32799952

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW094120524A TWI347317B (en)	2004-06-22	2005-06-21	Process for preparing 8-substituted oxy-5-(r)-2-halo-1-hydroxy-ethyl)-(1h)-quinolin-2-ones or acceptable solvates thereof and use of the product obtained therefrom

Country Status (32)

Country	Link
US (2)	US20090054653A1 (zh)
EP (1)	EP1791820B1 (zh)
JP (1)	JP5064214B2 (zh)
KR (1)	KR101179302B1 (zh)
CN (1)	CN1968927B (zh)
AR (2)	AR049553A1 (zh)
AT (1)	ATE450512T1 (zh)
AU (1)	AU2005254698B2 (zh)
BR (1)	BRPI0512298A (zh)
CA (1)	CA2566388C (zh)
CY (1)	CY1109884T1 (zh)
DE (1)	DE602005018076D1 (zh)
DK (1)	DK1791820T3 (zh)
EC (1)	ECSP067100A (zh)
ES (1)	ES2337273T3 (zh)
GB (1)	GB0413960D0 (zh)
HR (1)	HRP20100087T1 (zh)
IL (1)	IL179600A (zh)
MA (1)	MA28687B1 (zh)
MX (1)	MXPA06014695A (zh)
MY (1)	MY142051A (zh)
NO (1)	NO339079B1 (zh)
NZ (1)	NZ551276A (zh)
PE (1)	PE20060304A1 (zh)
PL (1)	PL1791820T3 (zh)
PT (1)	PT1791820E (zh)
RU (1)	RU2383534C2 (zh)
SI (1)	SI1791820T1 (zh)
TN (1)	TNSN06408A1 (zh)
TW (1)	TWI347317B (zh)
WO (1)	WO2005123684A2 (zh)
ZA (1)	ZA200609257B (zh)

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ES2396987T3 (es)	2006-06-30	2013-03-01	Novartis Ag	Derivados de quinolina y sus composiciones farmacéuticas
EP1914227A1 (en) *	2006-08-31	2008-04-23	Novartis AG	Polymorphic crystal form of a indan-2-ylamino-hydroxyethyl-quinolinone maleate derivative as beta-adrenoceptor agonist
US8877930B2 (en)	2009-11-04	2014-11-04	Massachusetts Institute Of Technology	Continuous flow synthesis of amino alcohols using microreactors
US8680303B2 (en)	2010-03-01	2014-03-25	Massachusetts Institute Of Technology	Epoxidation catalysts
EA022046B1 (ru)	2010-07-14	2015-10-30	Новартис Аг	Гетероциклические соединения, агонисты рецептора ip
JOP20120023B1 (ar)	2011-02-04	2022-03-14	Novartis Ag	صياغات مساحيق جافة من جسيمات تحتوي على واحد أو اثنين من المواد الفعالة لعلاج امراض ممرات الهواء الانسدادية او الالتهابية
AR089698A1 (es)	2012-01-13	2014-09-10	Novartis Ag	Compuestos heterociclicos antagonistas del receptor ip
US9115129B2 (en)	2012-01-13	2015-08-25	Novartis Ag	Substituted pyrido[2,3-B]pyrazines as IP receptor agonists
US20150005311A1 (en)	2012-01-13	2015-01-01	Novartis Ag	IP receptor agonist heterocyclic compounds
EP2802584B1 (en)	2012-01-13	2015-11-18	Novartis AG	Salts of an ip receptor agonist
US20140357641A1 (en)	2012-01-13	2014-12-04	Novartis Ag	IP receptor agonist heterocyclic compounds
EP2802581A1 (en)	2012-01-13	2014-11-19	Novartis AG	7,8- dihydropyrido [3, 4 - b]pyrazines as ip receptor agonists for the treatment of pulmonary arterial hypertension (pah) and related disorders
CN104379566B (zh) *	2012-07-11	2016-08-24	上海威智医药科技有限公司	茚达特罗中间体及茚达特罗的合成方法
EP3138837B1 (en)	2012-09-21	2021-11-24	Crystal Pharma, S.A.U.	Indacaterol free base in solid form
WO2014044288A1 (en)	2012-09-21	2014-03-27	Crystal Pharma Sa	Methods for the preparation of indacaterol and pharmaceutically acceptable salts thereof
CA2895448A1 (en)	2012-12-19	2014-06-26	Novartis Ag	Autotaxin inhibitors
US9604981B2 (en)	2013-02-13	2017-03-28	Novartis Ag	IP receptor agonist heterocyclic compounds
US9452139B2 (en)	2013-03-14	2016-09-27	Novartis Ag	Respirable agglomerates of porous carrier particles and micronized drug
BR112015020443A8 (pt)	2013-03-14	2019-11-12	Novartis Ag	formulação em pó para inalação, seus usos e seu processo de preparação, e composição farmacêutica
CZ306252B6 (cs)	2013-03-15	2016-10-26	Zentiva, K.S.	Způsob přípravy 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-chinolin-2-onu (indacaterolu)
WO2014154841A1 (en)	2013-03-27	2014-10-02	Laboratorios Lesvi, S.L.	Process for the manufacture of (r)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1h)-quinolin-2-one
US20160168119A1 (en)	2013-07-18	2016-06-16	Novartis Ag	Autotaxin inhibitors
US9763957B2 (en)	2013-07-18	2017-09-19	Novartis Ag	Autotaxin inhibitors
ES2815123T3 (es)	2014-01-09	2021-03-29	Davuluri Ramamohan Rao	Proceso novedoso para la preparación de indacaterol o sus sales aceptables farmacéuticamente
RU2016141948A (ru)	2014-03-27	2018-04-27	Новартис Аг	Высушенные распылением дисперсии твердое-в-масле-в-воде активных фармацевтических ингредиентов для ингаляции
EP3134398A1 (en)	2014-04-24	2017-03-01	Novartis Ag	Autotaxin inhibitors
CN105693603B (zh) *	2014-11-24	2019-11-29	上海医药工业研究院	改良的马来酸茚达特罗制备工艺
KR101769204B1 (ko) *	2015-08-04	2017-08-17	씨제이헬스케어 주식회사	크로마놀 유도체의 신규한 제조방법
ES2747905T3 (es)	2015-09-29	2020-03-12	Inke Sa	Solvato mixto de L-tartrato de (R)-5-[2-(5,6-dietilindan-2-ilamino)-1-hidroxietil]-8-hidroxi-1H-quinolin-2-ona
US10418663B2 (en)	2016-05-17	2019-09-17	Industrial Technology Research Institute	Metal-ion battery
CN107868045A (zh) *	2016-09-28	2018-04-03	四川海思科制药有限公司	一种茚达特罗中间体的制备方法
CN114591236A (zh) *	2020-12-02	2022-06-07	四川海思科制药有限公司	一种茚达特罗的改进制备方法
CN113731406B (zh) *	2021-10-12	2023-07-28	南京工业大学	一种提高钯碳活性加氢脱除保护基的方法

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GB9405019D0 (en) *	1994-03-15	1994-04-27	Smithkline Beecham Plc	Novel compounds
EP0952832B1 (en) *	1996-05-20	2008-08-27	Darwin Discovery Limited	Quinoline carboxamides as tnf inhibitors and as pde-iv inhibitors
GB9913083D0 (en) *	1999-06-04	1999-08-04	Novartis Ag	Organic compounds
TWI249515B (en) *	2001-11-13	2006-02-21	Theravance Inc	Aryl aniline beta2 adrenergic receptor agonists
TWI324150B (en) *	2003-02-28	2010-05-01	Novartis Ag	Process for preparing 5-[(r)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1h)-quinolin-2-one salt
PE20100399A1 (es) *	2003-04-02	2010-06-01	Novartis Ag	Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas

2004
- 2004-06-22 GB GBGB0413960.6A patent/GB0413960D0/en not_active Ceased
2005
- 2005-06-17 AR ARP050102511A patent/AR049553A1/es not_active Application Discontinuation
- 2005-06-20 PE PE2005000704A patent/PE20060304A1/es active IP Right Grant
- 2005-06-20 MY MYPI20052795A patent/MY142051A/en unknown
- 2005-06-21 ES ES05770221T patent/ES2337273T3/es not_active Expired - Lifetime
- 2005-06-21 DK DK05770221.9T patent/DK1791820T3/da active
- 2005-06-21 PL PL05770221T patent/PL1791820T3/pl unknown
- 2005-06-21 BR BRPI0512298-8A patent/BRPI0512298A/pt not_active Application Discontinuation
- 2005-06-21 SI SI200530921T patent/SI1791820T1/sl unknown
- 2005-06-21 AT AT05770221T patent/ATE450512T1/de active
- 2005-06-21 MX MXPA06014695A patent/MXPA06014695A/es active IP Right Grant
- 2005-06-21 DE DE602005018076T patent/DE602005018076D1/de not_active Expired - Lifetime
- 2005-06-21 CA CA2566388A patent/CA2566388C/en not_active Expired - Lifetime
- 2005-06-21 PT PT05770221T patent/PT1791820E/pt unknown
- 2005-06-21 NZ NZ551276A patent/NZ551276A/en not_active IP Right Cessation
- 2005-06-21 EP EP05770221A patent/EP1791820B1/en not_active Expired - Lifetime
- 2005-06-21 WO PCT/EP2005/006686 patent/WO2005123684A2/en not_active Ceased
- 2005-06-21 HR HR20100087T patent/HRP20100087T1/hr unknown
- 2005-06-21 TW TW094120524A patent/TWI347317B/zh active
- 2005-06-21 AU AU2005254698A patent/AU2005254698B2/en not_active Expired
- 2005-06-21 RU RU2007102228/04A patent/RU2383534C2/ru active
- 2005-06-21 CN CN2005800195899A patent/CN1968927B/zh not_active Expired - Lifetime
- 2005-06-21 US US11/569,140 patent/US20090054653A1/en not_active Abandoned
- 2005-06-21 KR KR1020067026958A patent/KR101179302B1/ko not_active Expired - Lifetime
- 2005-06-21 JP JP2007517180A patent/JP5064214B2/ja not_active Expired - Lifetime
2006
- 2006-11-07 ZA ZA200609257A patent/ZA200609257B/en unknown
- 2006-11-27 IL IL179600A patent/IL179600A/en active IP Right Grant
- 2006-12-08 TN TNP2006000408A patent/TNSN06408A1/en unknown
- 2006-12-20 EC EC2006007100A patent/ECSP067100A/es unknown
- 2006-12-28 MA MA29571A patent/MA28687B1/fr unknown
2007
- 2007-01-22 NO NO20070400A patent/NO339079B1/no unknown
2010
- 2010-03-01 CY CY20101100199T patent/CY1109884T1/el unknown
2011
- 2011-09-14 AR ARP110103340A patent/AR082981A2/es unknown
2012
- 2012-05-01 US US13/461,204 patent/US20120220775A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DK1791820T3 (da)	2010-04-06
TW200615265A (en)	2006-05-16
AR049553A1 (es)	2006-08-16
EP1791820A2 (en)	2007-06-06
EP1791820B1 (en)	2009-12-02
PL1791820T3 (pl)	2010-05-31
WO2005123684A2 (en)	2005-12-29
ES2337273T3 (es)	2010-04-22
ECSP067100A (es)	2007-01-26
IL179600A0 (en)	2007-05-15
CN1968927A (zh)	2007-05-23
US20090054653A1 (en)	2009-02-26
NZ551276A (en)	2010-06-25
ATE450512T1 (de)	2009-12-15
MY142051A (en)	2010-08-30
RU2007102228A (ru)	2008-07-27
ZA200609257B (en)	2008-07-30
TNSN06408A1 (en)	2008-02-22
MA28687B1 (fr)	2007-06-01
DE602005018076D1 (de)	2010-01-14
RU2383534C2 (ru)	2010-03-10
AU2005254698B2 (en)	2008-09-25
US20120220775A1 (en)	2012-08-30
NO20070400L (no)	2007-03-21
GB0413960D0 (en)	2004-07-28
WO2005123684A3 (en)	2006-06-01
JP5064214B2 (ja)	2012-10-31
MXPA06014695A (es)	2007-02-12
HK1105121A1 (zh)	2008-02-01
PT1791820E (pt)	2010-02-23
CN1968927B (zh)	2010-07-21
CY1109884T1 (el)	2014-09-10
SI1791820T1 (sl)	2010-04-30
BRPI0512298A (pt)	2008-03-25
IL179600A (en)	2011-11-30
CA2566388A1 (en)	2005-12-29
CA2566388C (en)	2013-04-16
AR082981A2 (es)	2013-01-23
PE20060304A1 (es)	2006-05-19
AU2005254698A1 (en)	2005-12-29
HRP20100087T1 (hr)	2010-06-30
JP2008503526A (ja)	2008-02-07
KR20070029752A (ko)	2007-03-14
KR101179302B1 (ko)	2012-09-03
NO339079B1 (no)	2016-11-07

Publication	Publication Date	Title
TWI347317B (en)	2011-08-21	Process for preparing 8-substituted oxy-5-(r)-2-halo-1-hydroxy-ethyl)-(1h)-quinolin-2-ones or acceptable solvates thereof and use of the product obtained therefrom
TWI365887B (en)	2012-06-11	Process for the preparation of polycarbonates
IL210679A0 (en)	2011-03-31	Process and apparatus for controlling the preparation of beverages
IL173456A0 (en)	2006-06-11	Process for the preparation of 4-amino-3-quinolinecarbonitriles
GB0522434D0 (en)	2005-12-14	Merchandisers having anti-fog coatings and methods for making the same
PL1747075T3 (pl)	2014-12-31	Sposoby i urządzenie do formowania pustych wyrobów metalowych
IL188919A (en)	2015-04-30	Process for the preparation of mandipropamide and its derivatives as well as its intermediates
IL182996A0 (en)	2007-08-19	Process for preparing quinoline compounds and products obtained therefrom
SI1620396T1 (sl)	2015-03-31	Postopek za pripravo N-substituiranih 2-cianopirolidinov
IL176472A0 (en)	2006-10-05	Process for the preparation of pyridine derivatives
GB0623764D0 (en)	2007-01-10	Process for the synthesis of hydromorphone
IL171053A (en)	2010-12-30	Process for the preparation of 5-(haloacetyl)-8- (substituted oxy)-(1h)-quinolin-2-ones
ZA200704259B (en)	2009-01-28	Modified cocoa product and process for its manufacture
GB0208986D0 (en)	2002-05-29	Apparatus for the game of latrey
TWI347945B (en)	2011-09-01	Process for the preparation of thiazolopyrimidines
IL188010A0 (en)	2009-02-11	Procedure for the treatment of purines and products thereof
ZA200605059B (en)	2008-12-31	Apparatus for the treatment of wood or wood products
SG111997A1 (en)	2005-06-29	Improved process for the preparation of polyalkylphenoxyaminoalkanes
HU0401379D0 (en)	2004-09-28	Process for the preparation of risperidon
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ZA200509495B (en)	2009-03-25	Process for the preparation of nicotinaldehydes
PL1547473T3 (pl)	2008-03-31	Kompozycja zawierająca warzywa z rodzaju Capsicum [papryka] oraz sposobu jej wytwarzania
GB0415863D0 (en)	2004-08-18	Process for the roasting of food products